pci-32765 has been researched along with Neuroaspergillosis* in 3 studies
3 other study(ies) available for pci-32765 and Neuroaspergillosis
| Article | Year |
|---|---|
Cerebral aspergillosis in a patient on ibrutinib therapy-A predisposition not to overlook.
Ibrutinib has revolutionized the treatment of B-cell malignancies since its approval for chronic lymphocytic leukemia. It is also used in mantle cell lymphoma, diffuse large B-cell lymphoma, Waldenstrom's macroglobulinemia, among others. It is a Bruton's tyrosine kinase inhibitor that acts on B-cell receptor signaling pathway and predisposes to various infections due to its effects on neutrophils, monocytes and T cells. We present a case of cerebral invasive aspergillosis in a patient being treated with ibrutinib for relapsed chronic lymphocytic leukemia. It was hard to associate the condition to ibrutinib versus the chronic lymphocytic leukemia. The patient was successfully treated with a combination of voriconazole and micafungin, resulting in complete recovery and no residual deficits. This highlights the importance of recognizing the rare complication in those on ibrutinib and initiating the treatment immediately with appropriate antifungal agents to improve prognosis of this potentially fatal condition. Topics: Adenine; Aged; Antifungal Agents; Aspergillus fumigatus; B-Lymphocytes; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neuroaspergillosis; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines | 2019 |
The Muddied Waters of Ibrutinib Therapy.
A 37-year-old male was admitted with an atypical presentation of central nervous system (CNS) aspergillosis while on ibrutinib therapy for a CNS relapse of mantle cell lymphoma. This case highlights the importance of a high clinical suspicion of opportunistic infections in patients receiving small-molecule kinase inhibitors. This report includes a review of reported cases of Aspergillus infections in patients receiving ibrutinib and the shared features of these cases. Topics: Adenine; Adult; Humans; Lymphoma, Mantle-Cell; Male; Neuroaspergillosis; Piperidines; Pyrazoles; Pyrimidines; Recurrence | 2019 |
Cerebral aspergillosis: An emerging opportunistic infection in patients receiving ibrutinib for chronic lymphocytic leukemia?
Topics: Adenine; Aged; Brain Diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neuroaspergillosis; Opportunistic Infections; Piperidines; Pyrazoles; Pyrimidines | 2018 |