pazopanib and Histiocytoma--Malignant-Fibrous

A consensus has not been reached regarding the optimal pazopanib dosing schedule, which we determined in patients who received pazopanib at our Institution.. Twenty-five patients who were prescribed pazopanib between 2012 and 2015 were included in this retrospective analysis.. The median progression-free survival (PFS) time was 7.7 months. This time (various doses) was similar to that achieved by high-dose pazopanib in the PALETTE study. The log-rank test revealed no significant differences in the PFS times between the low- and high-dose pazopanib groups, with the majority of patients receiving a dose of 400 mg, indicating that controlling the side-effects might be more critical than administering higher doses.. Pazopanib should be started from a low dose with careful increase to avoid pazopanib-related side-effects, which is necessary to provide a balance between the life-prolonging effects of pazopanib and quality of life (QoL) of patients.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Female; Histiocytoma, Malignant Fibrous; Humans; Indazoles; Male; Middle Aged; Pyrimidines; Quality of Life; Retrospective Studies; Sarcoma; Sulfonamides

Topics: Aged, 80 and over; Female; Histiocytoma, Malignant Fibrous; Humans; Indazoles; Leg Ulcer; Protein-Tyrosine Kinases; Pyrimidines; Soft Tissue Neoplasms; Sulfonamides