paxilline has been researched along with Lung Neoplasms in 45 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.22) | 18.2507 |
2000's | 15 (33.33) | 29.6817 |
2010's | 25 (55.56) | 24.3611 |
2020's | 4 (8.89) | 2.80 |
Authors | Studies |
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Chen, H; He, P; Lin, G; Lin, Z; Liu, C; Liu, G; Lu, Z; Mu, D; Shi, Y; Zhang, Y; Zheng, H | 1 |
Gan, L; Han, D; Liu, S; Lu, S; Lu, T; Qin, W; Wen, W; Wu, X; Xu, C; Yang, F; Zhang, J; Zhang, K | 1 |
Awanis, G; Banerjee, S; Elmeligy, A; Gavrilovic, J; Johnson, R; Raveenthiraraj, S; Sobolewski, A; Warren, D | 1 |
Chang, Y; Ding, X; Li, M; Li, Y; Liu, B; Shen, H; Wang, Y; Xie, SM; Xing, L | 1 |
He, Q; Li, M; Liu, J; Rao, J; Tang, X; Wan, D; Wang, X; Wang, Y; Wei, J; Xia, C; Yin, S; Zhang, Z | 1 |
Chen, G; Jiang, WG; Li, S; Ye, L; Yu, H; Zhao, H | 1 |
De Rycker, M; Hibbert, A; Kermorgant, S; Lachmann, S; Milanovic, M; Parker, PJ; Radtke, S; Rossé, C | 1 |
Chen, XP; Dang, YY; Lu, JJ; Wang, YT; Xu, WS | 1 |
Mu, W; Yue, S; Zöller, M | 1 |
Arif, Q; Bindokas, VP; Brand, TM; Carey, G; Ferguson, MK; Hasina, R; Hseu, RD; Husain, AN; Iida, M; Kawada, I; Krishnaswamy, S; Lennon, FE; Natarajan, V; Robinson, M; Salgia, R; Singleton, PA; Tan, YH; Tretiakova, M; Usatyuk, P; Vokes, EE; Wheeler, DL | 1 |
Díaz, J; Leyton, L; Mendoza, P; Ortiz, R; Quest, AF; Stupack, D; Torres, VA | 1 |
Hwan Kim, S; Kim, J | 1 |
Chen, CY; Chen, YC; Cheng, YW; Lee, H; Lee, MC; Wu, DW; Wu, JY; Wu, TC | 1 |
Bi, H; Bi, Y; Gao, F; Han, Y; Wang, X | 1 |
Chan, SH; Chang, JW; Cheng, AJ; Chiang, SL; Chiang, WF; Huang, WC; Jang, TH; Juang, JL; Ko, YC; Liao, CT; Lu, YC; Shieh, TY; Wang, HC; Wang, LH; Yen, TC | 1 |
Li, Y; Liu, BL; Liu, DZ; Wang, F; Wang, W; Xu, H; Zhang, LY | 1 |
Bianco, C; Bianco, R; Ciardiello, F; Cipolletta, A; D'Amato, C; D'Amato, V; De Placido, S; Di Mauro, C; Formisano, L; Fulciniti, F; Marciano, R; Nappi, L; Raimondo, L; Rosa, R; Servetto, A; Veneziani, BM | 1 |
Huang, CC; Lee, H; Lin, PL; Wu, DW | 1 |
Chen, CY; Chu, CL; Lee, H; Wu, DW | 1 |
Choi, WJ; Jung, J; Kim, J; Kim, SH; Lee, JO; Moon, SH; Park, JK | 1 |
Blons, H; Cazes, A; Houllier, AM; Laurent-Puig, P; Le Corre, D; Pallier, K | 1 |
Haga, H; Ishihara, S; Kawaguchi, H; Nakamura, H; Nishioka, T; Ohba, Y; Shirato, H; Tsuda, M; Tsutsumi, K; Yamazaki, R; Yasuda, M; Yazawa, N | 1 |
Ferguson, MK; Kanteti, R; Salgia, R; Yala, S | 1 |
Cagle, PT; Husain, AN; Li, M; Salgia, R; Song, J; Tretiakova, M | 1 |
Henderson, L; Husain, AN; Joseph, L; Krausz, T; Mackinnon, AC; Mehta, RG; Reid, ME; Salgia, R; Tretiakova, M; Yan, BC | 1 |
Deakin, NO; Turner, CE | 1 |
Chen, CY; Cheng, YW; Lee, H; Wang, J; Wu, DW | 1 |
Balraj, G; Chang, TT; Chen, JY; Cheng, HC; Huang, SM; Juan, HF; Li, WS; Sun, YC; Tang, YA; Wang, SC; Wang, YC; Wu, KW; Wu, LW | 1 |
Azzalis, LA; de Abreu, LC; Feder, D; Fonseca, FL; Junqueira, VB; Nogoceke, E; Valenti, VE | 1 |
Callison, C; Chen, H; Gonzalez, AL; Massion, PP; Ocak, S | 1 |
Chen, MY; Hsu, PC; Huang, SM; Li, WS; Lu, KT; More, SV; Wang, YC | 1 |
Frame, MC; Lahlou, H; Muller, WJ; Sanguin-Gendreau, V | 1 |
Li, H; Zuo, W | 1 |
Fox, EA; Griffin, JD; Johnson, BE; Kijima, T; Ma, PC; Maulik, G; Salgia, R; Sattler, M | 1 |
Beinke, C; Cordes, N; Van Beuningen, D | 1 |
Cordes, N | 1 |
Brábek, J; Constancio, SS; Hanks, SK; Pozzi, A; Shin, NY; Siesser, PF | 1 |
Donato, NJ; Johnson, FM; Saigal, B; Talpaz, M | 1 |
Aixinjueluo, W; Furukawa, K; Hamamura, K | 1 |
Han, IO; Hwang, JS; Hwang, SY; Jung, JW; Oh, ES; Park, S | 1 |
Anderson, GM; Chen, Q; Doshi, P; Ferrante, C; Manning, CD; McCabe, FL; Millar, H; Nakada, MT; Shahied-Arruda, L; Sharp, C | 1 |
Ahmed, S; Bindokas, VP; Bueno, R; Faoro, L; Ferguson, MK; Girard, L; Gordon, GJ; Husain, AN; Jagadeeswaran, R; Janamanchi, V; Kanteti, R; Krausz, T; Krishnaswamy, S; Lingen, MW; Loganathan, S; Mackinnon, AC; Minna, J; Nallasura, V; Natarajan, V; Reichman, T; Salgia, R; Sattler, M; Schwartz, S; Seiwert, TY; Soulii, L; Sugarbaker, D; Surawska, H; Szeto, LL; Tretiakova, MS; Vigneswaran, W; Vokes, EE; Wang, YC; Zumba, O | 1 |
Clack, G; Dixon, JM; Elvin, P; Fennell, M; Green, TP; Jacobs, V; Jones, RJ; Marshall, A; Renshaw, L; Womack, C; Young, O | 1 |
Chen, LB; Chen, WC; Ewaniuk, DS; Griffin, JD; Li, JL; Pisick, E; Richards, W; Rollins, BJ; Salgia, R; Sattler, M; Shapiro, GI; Sugarbaker, DJ; Wang, YB | 1 |
Garcia-Marin, LJ; Jensen, RT; Leyton, J; Moody, TW; Tapia, JA | 1 |
1 review(s) available for paxilline and Lung Neoplasms
Article | Year |
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Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.
Topics: Anoikis; Antibodies, Monoclonal; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Glycosphingolipids; Humans; Lung Neoplasms; Melanoma; Neoplasm Invasiveness; Paxillin; Phosphorylation; Tyrosine | 2006 |
44 other study(ies) available for paxilline and Lung Neoplasms
Article | Year |
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Biomimetic nanoparticles blocking autophagy for enhanced chemotherapy and metastasis inhibition via reversing focal adhesion disassembly.
Topics: Animals; Antineoplastic Agents; Autophagy; Biomimetic Materials; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Carriers; Drug Liberation; Focal Adhesions; Humans; Hydroxychloroquine; Lung Neoplasms; Mice; Nanoparticles; Neoplasms; Oxaliplatin; Paxillin; Polylactic Acid-Polyglycolic Acid Copolymer | 2021 |
CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Integrin beta1; Lung Neoplasms; Mice; Mice, Nude; Osteosarcoma; Paxillin | 2023 |
HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells.
Topics: Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; Hepatocyte Growth Factor; Humans; Integrins; Lung Neoplasms; Paxillin; Phosphatidylinositol 3-Kinases | 2023 |
ETV4 overexpression promotes progression of non-small cell lung cancer by upregulating PXN and MMP1 transcriptionally.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 1; Mice, Inbred BALB C; Mice, Nude; Paxillin; Proto-Oncogene Proteins c-ets; Transcriptional Activation | 2020 |
Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line; Humans; Hydroxychloroquine; Integrin alphaVbeta3; Liposomes; Lung Neoplasms; Melanoma; Mice, Inbred C57BL; Neuropilin-1; Oligopeptides; Paclitaxel; Paxillin; Phosphatidylethanolamines; Polyethylene Glycols; Receptors, CXCR4 | 2018 |
DOK7V1 influences the malignant phenotype of lung cancer cells through PI3K/AKT/mTOR and FAK/paxillin signaling pathways.
Topics: A549 Cells; Alternative Splicing; Cell Line, Tumor; Down-Regulation; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Muscle Proteins; Paxillin; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Signal Transduction; Survival Analysis | 2019 |
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Movement; Focal Adhesions; Glycogen Synthase Kinase 3; HeLa Cells; Hepatocyte Growth Factor; Humans; Lung Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Paxillin; Proto-Oncogene Proteins c-met | 2013 |
Furanodiene presents synergistic anti-proliferative activity with paclitaxel via altering cell cycle and integrin signaling in 95-D lung cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Curcuma; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase 6; Drug Synergism; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Focal Adhesion Kinase 1; Furans; Heterocyclic Compounds, 2-Ring; Humans; Integrin beta4; Lung Neoplasms; Paclitaxel; Paxillin; Proto-Oncogene Proteins c-myc; Signal Transduction | 2014 |
Tspan8 and CD151 promote metastasis by distinct mechanisms.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Collagen Type IV; Focal Adhesion Kinase 1; Integrin alpha3; Integrin alpha6beta4; Laminin; Lung Neoplasms; Lymphatic Metastasis; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pancreatic Neoplasms; Paxillin; Phosphorylation; ras Proteins; Rats; RNA Interference; src-Family Kinases; Tetraspanin 24; Tetraspanins; Time Factors; Transfection; Tumor Burden | 2013 |
Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer.
Topics: Focal Adhesions; HEK293 Cells; Humans; Lung Neoplasms; Mitochondrial Dynamics; Mutation; Paxillin | 2013 |
Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Enzyme Activation; Female; Focal Adhesions; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; rab5 GTP-Binding Proteins; RNA Interference; RNA, Small Interfering; Vinculin | 2013 |
CK2 inhibitor CX-4945 blocks TGF-β1-induced epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cadherins; Casein Kinase II; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; Naphthyridines; Neoplasm Invasiveness; Paxillin; Phenazines; Protein Kinase Inhibitors; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Wnt Proteins | 2013 |
Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Paxillin; Phosphorylation; Pyrimidines; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Humans; Lung Neoplasms; MicroRNAs; Molecular Targeted Therapy; Neoplasm Invasiveness; Paxillin | 2014 |
miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Disease Models, Animal; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesions; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; MicroRNAs; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Proteolysis; RNA Interference; Signal Transduction | 2014 |
Thapsigargin induces apoptosis by impairing cytoskeleton dynamics in human lung adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Line, Tumor; Cofilin 1; Cytoskeletal Proteins; Cytoskeleton; Endoplasmic Reticulum Stress; Humans; Lung Neoplasms; Paxillin; Thapsigargin | 2014 |
Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells.
Topics: Actin Cytoskeleton; Actins; Animals; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Everolimus; Hedgehog Proteins; Humans; Indoles; Inhibitory Concentration 50; Kidney Neoplasms; Kruppel-Like Transcription Factors; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Micrometastasis; Nuclear Proteins; Paxillin; Proto-Oncogene Proteins c-akt; Pyridines; Pyrroles; Receptors, G-Protein-Coupled; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Smoothened Receptor; Sunitinib; Transcription Factors; Tumor Burden; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2 | 2014 |
Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.
Topics: Animals; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Colorectal Neoplasms; Dasatinib; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Heterografts; Humans; Kaplan-Meier Estimate; Leupeptins; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Paxillin; Phosphorylation; Proportional Hazards Models; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Sulfonamides | 2015 |
Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Paxillin; Protein Kinase Inhibitors; Protein Stability; Proto-Oncogene Proteins; Random Allocation; Xenograft Model Antitumor Assays | 2016 |
Micropillar arrays as potential drug screens: Inhibition of micropillar-mediated activation of the FAK-Src-paxillin signaling pathway by the CK2 inhibitor CX-4945.
Topics: Apoptosis; Biological Assay; Casein Kinase II; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Equipment Design; Equipment Failure Analysis; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; Mechanotransduction, Cellular; Naphthyridines; Paxillin; Phenazines; src-Family Kinases; Tissue Array Analysis; Treatment Outcome | 2015 |
No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer.
Topics: Axons; Base Sequence; Carcinoma, Non-Small-Cell Lung; DNA Primers; Humans; Introns; Lung Neoplasms; Paxillin; Polymerase Chain Reaction | 2009 |
Increased motility and invasiveness in tumor cells that survive 10 Gy irradiation.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Focal Adhesion Kinase 1; Humans; Integrin beta1; Lung Neoplasms; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Paxillin; Radiation Dosage; Vinculin | 2009 |
MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance.
Topics: Adenocarcinoma; Base Sequence; Cell Line, Tumor; DNA Primers; DNA, Neoplasm; ErbB Receptors; Gene Dosage; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Paxillin; Polymerase Chain Reaction; Prognosis; Proto-Oncogene Proteins c-met | 2009 |
Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung.
Topics: Humans; Immunohistochemistry; Lung Neoplasms; Neuroendocrine Tumors; PAX5 Transcription Factor; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-met; Tissue Array Analysis | 2010 |
Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Bronchiolo-Alveolar; Aged; Biopsy; Chromosomes, Human, Pair 12; Female; Gene Dosage; Genes, erbB-1; Humans; In Situ Hybridization, Fluorescence; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Proteins; Paxillin; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins | 2011 |
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.
Topics: Animals; Breast Neoplasms; Cattle; Cell Adhesion; Cell Line, Tumor; Cell Movement; Extracellular Matrix; Female; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; rhoA GTP-Binding Protein; Signal Transduction | 2011 |
Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Male; MicroRNAs; Molecular Targeted Therapy; Neoplasm Invasiveness; Oncogene Proteins, Viral; Paxillin; Repressor Proteins; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2010 |
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways.
Topics: Animals; Cell Line; Cell Line, Tumor; Focal Adhesion Kinase 1; Humans; Integrins; Lithocholic Acid; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neovascularization, Pathologic; Paxillin; Proteomics; Sialyltransferases; Signal Transduction | 2011 |
Adhesion molecules affected by treatment of lung cancer cells with epidermal growth factor.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Catenins; Cell Adhesion Molecules; Cell Line, Tumor; Crk-Associated Substrate Protein; Delta Catenin; Epidermal Growth Factor; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; Paxillin; rap1 GTP-Binding Proteins; Talin; Vinculin | 2011 |
Expression of focal adhesion kinase in small-cell lung carcinoma.
Topics: Aged; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Paxillin; Phosphorylation; Small Cell Lung Carcinoma; Survival Analysis | 2012 |
The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse.
Topics: Actin Cytoskeleton; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cytochromes c; DNA Damage; Esophageal Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasm Invasiveness; Neoplasms, Experimental; Paxillin; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; rhoA GTP-Binding Protein; Signal Transduction; Xenograft Model Antitumor Assays; Xylenes | 2012 |
Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Crk-Associated Substrate Protein; Female; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Gene Deletion; Integrases; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Paxillin; Phosphorylation; Receptor, ErbB-2; Tumor Burden | 2012 |
[Relationship of the expression of CD44v6 and paxillin to the prognosis of non-small cell lung carcinoma].
Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Glycoproteins; Humans; Hyaluronan Receptors; Immunohistochemistry; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Paxillin; Phosphoproteins; Prognosis | 2003 |
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions.
Topics: Alternative Splicing; Animals; Carcinoma, Small Cell; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Cytoskeleton; DNA Mutational Analysis; Humans; Lung Neoplasms; Mice; Mutation, Missense; Paxillin; Phosphoproteins; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Rats; Signal Transduction; Transfection | 2003 |
Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro.
Topics: Cell Line, Tumor; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Dose-Response Relationship, Radiation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Radiation Dosage; Radiation, Ionizing; Retinoblastoma-Like Protein p130; Tyrosine; X-Rays | 2003 |
Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity.
Topics: Actins; Cell Line, Tumor; Cyclin D1; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesions; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Integrin beta1; Lung Neoplasms; MAP Kinase Signaling System; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Retinoblastoma Protein; Subcellular Fractions; Transfection; Tyrosine | 2004 |
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
Topics: Animals; Binding Sites; Cell Line, Transformed; Cell Movement; Cells, Cultured; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Injections, Subcutaneous; Laminin; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogene Protein v-crk; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Retroviridae Proteins, Oncogenic; src Homology Domains; Tyrosine | 2005 |
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Crk-Associated Substrate Protein; Dasatinib; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; G1 Phase; Gentian Violet; Head and Neck Neoplasms; Humans; Immunoprecipitation; Inhibitory Concentration 50; Laminin; Lung Neoplasms; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrimidines; Retinoblastoma Protein; S Phase; Signal Transduction; src-Family Kinases; Thiazoles; Time Factors; Trypan Blue | 2005 |
Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells.
Topics: Actins; Adenocarcinoma; Cell Adhesion; Cell Movement; Cell Transformation, Neoplastic; Epithelial Cells; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphorylation; Radiation, Ionizing; RNA, Messenger; Tumor Cells, Cultured | 2007 |
CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Focal Adhesion Kinase 1; Humans; Integrin alphaV; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Invasiveness; Paxillin; Phosphorylation; Signal Transduction; Transplantation, Heterologous; Vitronectin | 2008 |
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.
Topics: Animals; Cell Proliferation; Gene Dosage; Genes, erbB-1; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-met; RNA Interference | 2008 |
Src inhibitors in early breast cancer: a methodology, feasibility and variability study.
Topics: Animals; Benzodioxoles; Breast Neoplasms; CSK Tyrosine-Protein Kinase; Feasibility Studies; Female; Focal Adhesion Kinase 1; Humans; Immunoenzyme Techniques; Lung Neoplasms; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Nude; src-Family Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
Topics: 3T3 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Gene Expression; Humans; Lung Neoplasms; Mice; Paxillin; Phosphoproteins; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1999 |
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bombesin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; Genistein; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |