Compounds > paxilline
Page last updated: 2024-08-26

paxilline and Invasiveness, Neoplasm

paxilline has been researched along with Invasiveness, Neoplasm in 120 studies

Research

Studies (120)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (3.33)18.2507
2000's45 (37.50)29.6817
2010's61 (50.83)24.3611
2020's10 (8.33)2.80

Authors

AuthorsStudies
Bartley, JW; Wondergem, R1
Fan, H; Li, F; Wang, S1
Alpha, KM; Turner, CE; Xu, W; Zehrbach, NM1
Chen, C; Chen, S; Deng, G; Gao, J; Liao, H; Ruan, X; Sun, J; Wang, Y; Zhang, Y1
Abu-Thuraia, A; Apcher, C; Bagci, H; Boulais, J; Chidiac, R; Côté, JF; Daly, RJ; Davidson, D; Delliaux, C; Ferron, M; Gingras, AC; Goyette, MA; Gratton, JP; Schott, C; Thibault, MP; Veillette, A1
Chen, S; Hu, J; Ma, Y; Wang, J; Wang, X; Wen, L; Wu, T; Yue, T; Zhang, J; Zhang, X; Zhu, J1
Alpha, KM; Turner, CE; Xu, W1
Gao, X; Liu, X; Tang, C; Xu, D; Xu, X; Xue, Q1
Gu, H; Wen, J1
Bello-Alvarez, C; Camacho-Arroyo, I; González-Arenas, A; Moral-Morales, AD1
Hu, J; Quan, HY; Song, M1
Bednarczyk-Cwynar, B; Lisiak, N; Pakuła, M; Paszel-Jaworska, A; Rubiś, B; Rybczyńska, M; Totoń, E; Zaprutko, L1
Bo, P; Cui, S; Qian, J; Wang, J; Wu, Q; Yang, C1
Li, BH; Yuan, L1
Li, J; Mei, S; Niu, H; Yang, X1
Jiang, WG; Mason, MD; Sanders, AJ; Sobkowicz, AD1
Hu, X; Jiang, H; Li, W; Zhang, H1
Chen, XP; Lu, JJ; Luo, WW; Wang, YT; Zhao, WW1
Deng, Y; Ding, Q; He, K; Li, H; Mu, G; Wu, L; Xu, M; Yang, D; Yu, H; Zhang, L; Zhou, J1
Deakin, NO; Dubois, F; Goreczny, GJ; Gulvady, AC; Turner, CE1
Ferrari, A; Giampietro, C; Lendenmann, T; Panagiotakopoulou, M; Poulikakos, D; Pramotton, FM; Stefopoulos, G1
Chang, YS; Chung, AK; Hsu, T; Hsueh, C; Jiang, SS; Liu, SC; Liu, YP; OuYang, CN; Tsang, NM; Yuh, CH1
Al-aidaroos, AQ; Guo, K; Li, J; Liu, H; Wang, H; Zeng, Q; Zhang, HF1
Mu, W; Yue, S; Zöller, M1
Anacker, J; Beer-Grondke, K; Dürst, M; Hölters, S; Jansen, L; Rubio, I1
Burdyga, A; Conant, A; Costello, E; Haynes, L; Jalink, K; Neoptolemos, J; Sutton, R; Tepikin, A; Zhang, J1
Díaz, J; Leyton, L; Mendoza, P; Ortiz, R; Quest, AF; Stupack, D; Torres, VA1
Akita, K; Furukawa, K; Hamamura, K; Matsumoto, Y; Nakada, H; Okajima, T; Tsuchida, A; Urano, T; Zhang, Q1
Chen, SH; Hung, WC; Konstantopoulos, K; Lo, YC; Paul, CD; Stroka, KM; Yang, JT1
Kong, CZ; Wang, Y; Zhang, YX; Zhang, Z; Zhu, YY1
Hwan Kim, S; Kim, J1
Chang, HH; Che, MI; Chou, CH; Ho, WL; Hsu, WM; Huang, MC; Jeng, YM; Lin, KH1
Bi, H; Bi, Y; Gao, F; Han, Y; Wang, X1
Chan, SH; Chang, JW; Cheng, AJ; Chiang, SL; Chiang, WF; Huang, WC; Jang, TH; Juang, JL; Ko, YC; Liao, CT; Lu, YC; Shieh, TY; Wang, HC; Wang, LH; Yen, TC1
Duan, YT; Hu, L; Li, JF; Liu, BY; Su, LP; Yan, M; Yang, QM; Zhu, ZG1
Du, T; Li, C; Li, H; Li, J; Liu, B; Qu, Y; Su, L; Yan, M; Zhou, Q; Zhu, Z1
Akl, MR; Ebrahim, HY; El Sayed, KA; Elsayed, HE; Haggag, EG; Kamal, AM; Sallam, AA1
Chen, H; Jiang, L; Wang, P1
Chen, PN; Chu, SC; Hsieh, YS; Hsu, LS; Kuo, DY; Lin, CY1
Hameed, FM; Kaushik, S; Low, BC; Ravi, A1
Ackerman, WE; Blackstone, BN; Ghadiali, SN; Kniss, DA; Li, R; Powell, HM1
Cheng, H; Lv, H; Peng, W; Qin, H; Qiu, Y; Shen, W; Wu, W; Xue, Q; Yu, Z; Zhang, H; Zhang, X; Zhang, Y1
Huang, CC; Lee, H; Lin, PL; Wu, DW1
Fukumoto, M; Kurisu, S; Takenawa, T; Yamada, T1
Jiang, H; Jiang, Y; Qin, J; Wang, F; Wang, Z; Xu, J1
Davidson, D; Li, J; Martins Souza, C; Muller, WJ; Park, M; Veillette, A; Wu, N; Zhong, MC1
Matsuyama, R; Okada, M; Okuzaki, D; Oneyama, C1
Hu, XJ; Li, Y; Liu, CM; Xiong, XY1
Chia, CH; Chiu, KY; Hsu, SL; Tzeng, YM; Wu, CC1
Chen, J; Fan, T; Gao, P; Hui, Y; Liu, H; Xu, P; Zhang, L; Zhang, X1
Flamini, MI; Neira, FJ; Sanchez, AM; Shortrede, JE; Uzair, ID1
Cemeli, T; Colomina, N; Dolcet, X; Fernández-Hernández, R; Ferrezuelo, F; Fusté, NP; Garí, E; Mirantes, C; Pedraza, N; Rafel, M; Torres-Rosell, J1
Barrett, A; Brandner, S; Evans, IM; Frankel, P; Frolov, A; Li, N; Lockwood, N; Paliashvili, K; Sidlauskas, K; Zachary, IC1
Furukawa, K; Hamamura, K; Miyata, M; Miyazaki, S; Ohkawa, Y1
Ando, K; Kaneda, T; Kasahara, T; Oshio, T; Sasaki, Y; Sonoda, Y; Suzuki, T; Tago, M1
Albitar, L; Aponte, M; Cramer, DW; Edwards, D; Jiang, W; Lakkis, M; Li, MJ; Mok, SC; Vitonis, A; Ye, B1
Chen, ZN; Jiang, JL; Tang, J; Wu, YM; Yang, XM; Zhao, P1
Chen, ZN; Jiang, JL; Tang, J; Wu, YM; Zhao, P2
Bai, XM; Jiang, H; Leng, J; Liu, NB; Lou, KX; Ma, J; Peng, T; Zhang, H; Zhang, L; Zhang, W1
Chan, KT; Cortesio, CL; Huttenlocher, A1
Allen, J; Bermingham, A; Boyer, B; Carragher, N; Costello, GF; Curwen, J; Davies, BR; Elvin, P; Fennell, M; Green, TP; Hargreaves, J; Hennequin, LF; Hickinson, DM; Holdgate, GA; Jacobs, V; Logie, A; Plé, PA; Ward, WH; Whittaker, R; Wilkinson, RW1
Jenkins, AR; Romero, AE; Steelant, WF; Van Slambrouck, S1
Kim, HS; Lee, ES; Lee, JO; Lee, YM; Park, SH; Uhm, KO1
Haga, H; Ishihara, S; Kawaguchi, H; Nakamura, H; Nishioka, T; Ohba, Y; Shirato, H; Tsuda, M; Tsutsumi, K; Yamazaki, R; Yasuda, M; Yazawa, N1
Fang, M; Shi, J; Shi, L; Wang, S; Xu, X; Zhao, E1
Alberghina, L; Baffa, R; Genua, M; Gomella, LG; Iozzo, RV; Lovat, F; Metalli, D; Morrione, A; Spinelli, M; Tripodi, F; Vanoni, M; Xu, SQ1
Furukawa, K; Hamamura, K; Nakashima, H; Ohkawa, Y; Zhang, Q1
Balavenkatraman, KK; Böhmer, FD; Friedrich, S; Gührs, KH; Haase, D; Mawrin, C; Nakamura, M; Petermann, A; Tenev, T; Wetzel, A1
Deakin, NO; Turner, CE1
Chen, CY; Cheng, YW; Lee, H; Wang, J; Wu, DW1
Bennin, DA; Boateng, LR; Cortesio, CL; Huttenlocher, A; Piazza, TM1
Jiang, WG; Martin, TA; Mason, MD; Sanders, AJ; Ye, L1
Condeelis, J; Cox, D; Pixley, FJ; Sampaio, NG; Stanley, ER; Wyckoff, J; Yu, W1
Aroukatos, P; Athanasopoulou, A; Bravou, V; Nakas, D; Papadaki, H; Repanti, M1
Chen, MY; Hsu, PC; Huang, SM; Li, WS; Lu, KT; More, SV; Wang, YC1
Aparicio, LA; Figueroa, A; Haz-Conde, M; Rodríguez-Rigueiro, T; Valladares-Ayerbes, M1
Cai, HX; Chen, YB; Dong, GK; Liu, ZR; Song, XH; Yang, LC1
Calcabrini, A; Gómez-Domínguez, D; Gómez-López, G; Martín-Forero, E; Martín-Pérez, J; Molinari, A; Morte, B; Sánchez-Bailón, MP; Wagner, KU1
Chen, SY; Chiu, HY; Jwo, SC; Lee, MY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC; Wang, HH1
Chen, J; Gallo, KA1
Belfiore, A; Buraschi, S; Genua, M; Gomella, LG; Iozzo, RV; Morrione, A; Peiper, SC; Xu, SQ1
Ludwig, FT; Schwab, A; Stock, C1
Chen, DL; Kang, TB; Li, YH; Luo, HY; Qiu, MZ; Ren, C; Wang, DS; Wang, FH; Wang, ZQ; Wu, WJ; Xu, RH; Zeng, ZL; Zhang, DS1
Aingorn, H; Cohen, I; Cohen, M; Geiger, B; Goldshmidt, O; Katz, BZ; Nadav, L; Vlodavsky, I; Zcharia, E1
Davies, G; Jiang, WG; Lane, J; Mansel, RE; Martin, TA; Matsumoto, K; Nakamura, T; Parr, C; Watkins, G1
Abu-Ali, S; Hiraki, A; Ikari, T; Matsuki, R; Seki, K; Shirasuna, K; Shiratsuchi, T; Sugiura, T; Takahashi, M1
Adachi, M; Hashimoto, A; Hashimoto, S; Manabe, T; Matsuura, N; Mazaki, Y; Morishige, M; Ogawa, E; Onodera, Y; Sabe, H; Sakurai, T; Wada, H; Yamada, A1
Hashimoto, K; Morishige, K; Murata, Y; Sakata, M; Sawada, K; Shimizu, S; Tahara, M; Tasaka, K1
Brábek, J; Constancio, SS; Hanks, SK; Pozzi, A; Shin, NY; Siesser, PF1
Furukawa, K; Hamamura, K; Hattori, H; Hattori, T; Hayashi, T; Lloyd, KO; Mizutani, H; Nakano, J; Nakashima, H; Okuda, T; Ueda, M; Urano, T1
Chang, LC; Chen, BH; Chen, HC; Cheng, CH; Huang, CH1
Donato, NJ; Johnson, FM; Saigal, B; Talpaz, M1
Barrow, D; Gee, J; Green, TP; Hiscox, S; Morgan, L; Nicholson, RI1
Asahara, T; Hino, S; Kikuchi, A; Kobayashi, T; Oue, N; Yasui, W; Zollo, M1
Hashimoto, S; Onodera, Y1
Baffa, R; Gomella, LG; Gonzalez, EM; Hellman, M; Iozzo, RV; Monami, G; Morrione, A1
Hashimoto, S; Mazaki, Y; Onodera, Y; Sabe, H1
Califano, JA; Chang, X; Chatterjee, A; Gollin, SM; Guo, Z; Huang, X; Mambo, E; Moon, C; Osada, M; Ratovitski, EA; Rubin, E; Sidransky, D; Sook Kim, M; Sukumar, S; Trink, B; Wu, F; Wu, G1
Aixinjueluo, W; Furukawa, K; Hamamura, K1
Antico, G; Clevenger, CV; Miller, SL; Raghunath, PN; Tomaszewski, JE1
Bar-Shavit, R; Lotem, M; Maoz, M; Pokroy, E; Salah, Z; Uziely, B1
Che, MI; Chen, HY; Huang, HC; Huang, J; Huang, MC; Liang, JT; Lin, NY; Lin, WC; Shen, TL1
Csiszar, K; Fong, KS; Hinek, A; Hollosi, P; Jansen, MK; Laczko, R; Molnar, J; Muranyi, M; Szauter, KM1
Anderson, GM; Chen, Q; Doshi, P; Ferrante, C; Manning, CD; McCabe, FL; Millar, H; Nakada, MT; Shahied-Arruda, L; Sharp, C1
Furukawa, K; Hamamura, K; Miyazaki, S; Nakashima, H; Ohkawa, Y; Tsuji, M; Ueda, M; Urano, T; Yamamoto, N1
Ahmed, S; Bindokas, VP; Bueno, R; Faoro, L; Ferguson, MK; Girard, L; Gordon, GJ; Husain, AN; Jagadeeswaran, R; Janamanchi, V; Kanteti, R; Krausz, T; Krishnaswamy, S; Lingen, MW; Loganathan, S; Mackinnon, AC; Minna, J; Nallasura, V; Natarajan, V; Reichman, T; Salgia, R; Sattler, M; Schwartz, S; Seiwert, TY; Soulii, L; Sugarbaker, D; Surawska, H; Szeto, LL; Tretiakova, MS; Vigneswaran, W; Vokes, EE; Wang, YC; Zumba, O1
Donahue, HJ; Li, Z; Zhou, Z1
Jiao, X; Ju, X; Katiyar, S; Li, A; Li, Z; Lisanti, MP; Liu, M; Mueller, SC; Pestell, RG; Pestell, TG; Takeya, T; Wagner, EF; Wang, C; Wu, K1
Bellon, G; Dedieu, S; Devy, J; Emonard, H; Henriet, P; Langlois, B; Martiny, L; Sartelet, H; Sid, B1
Jiang, WG; Lane, J; Martin, TA; Mason, MD; Parr, C; Sanders, AJ1
Akedo, H; Imamura, F; Iwasaki, T; Komagome, R; Mukai, M; Shinkai, K; Yoshioka, K1
Aprikian, AG; Chevalier, S; Han, K; Tremblay, L1
Gómez-Mouton, C; Lacalle, RA; Mañes, S; Martínez-A, C; Mira, E; Zhao, ZJ1
Barth, M; Bowden, ET; Glazer, RI; Mueller, SC; Thomas, D1
Akedo, H; Ayaki, M; Imamura, F; Mukai, M1
Blume-Jensen, P; Hunter, T; Jiang, G; Lu, Z1
Davies, G; Jiang, WG; Mason, MD; Matsumoto, K; Nakamura, T; Parr, C1
Akedo, H; Iwasaki, T; Kakishita, E; Mukai, M; Nakata, A; Sabe, H; Schaefer, E; Shinkai, K; Tatsuta, M; Terada, N; Tsujimura, T; Yano, H1
Avraham, H; Avraham, S; Fu, Y; McShan, GD; Park, SY; Zagozdzon, R; Zrihan-Licht, S1

Reviews

4 review(s) available for paxilline and Invasiveness, Neoplasm

ArticleYear
[Molecular complex in the vicinity of cell membrane generating cancer phenotypes].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2008, Volume: 53, Issue:12 Suppl

    Topics: Animals; Antigens, Neoplasm; Cell Adhesion; Cell Division; Cell Survival; Crk-Associated Substrate Protein; Epitopes; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Integrins; Neoplasm Invasiveness; Neoplasms; Paxillin; Signal Transduction

2008
[Breast cancer invasiveness: how does it emerge?].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2006, Volume: 51, Issue:6 Suppl

    Topics: Adaptor Proteins, Signal Transducing; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Breast Neoplasms; Cadherins; Cell Adhesion; Female; Humans; Hypoxia-Inducible Factor 1; Integrins; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Protein Binding; Transcription, Genetic

2006
ArfGAP family proteins in cell adhesion, migration and tumor invasion.
    Current opinion in cell biology, 2006, Volume: 18, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; ADP-Ribosylation Factors; Animals; Cell Adhesion; Cell Cycle Proteins; Cell Movement; GTPase-Activating Proteins; Humans; Neoplasm Invasiveness; Neoplasms; Paxillin; Superoxides

2006
Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.
    Annals of the New York Academy of Sciences, 2006, Volume: 1086

    Topics: Anoikis; Antibodies, Monoclonal; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Glycosphingolipids; Humans; Lung Neoplasms; Melanoma; Neoplasm Invasiveness; Paxillin; Phosphorylation; Tyrosine

2006

Other Studies

116 other study(ies) available for paxilline and Invasiveness, Neoplasm

ArticleYear
Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration.
    Journal of biomedical science, 2009, Sep-24, Volume: 16

    Topics: Brain Neoplasms; Calcium; Calcium Signaling; Cell Line, Tumor; Cell Movement; Glioblastoma; Humans; Indoles; Ion Transport; Large-Conductance Calcium-Activated Potassium Channels; Menthol; Neoplasm Invasiveness; Patch-Clamp Techniques; TRPM Cation Channels

2009
Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma.
    Scientific reports, 2021, 10-01, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Movement; Cells, Cultured; Cytoskeleton; Gene Expression Regulation, Neoplastic; Humans; Mouth Neoplasms; Neoplasm Invasiveness; Nuclear Proteins; Paxillin; Tongue Neoplasms

2021
Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity.
    Molecular biology of the cell, 2022, 02-01, Volume: 33, Issue:2

    Topics: Adherens Junctions; Animals; Breast; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelial Cells; Female; Focal Adhesions; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Invasiveness; Paxillin; rho GTP-Binding Proteins

2022
Genistein inhibits migration and invasion of cervical cancer HeLa cells by regulating FAK-paxillin and MAPK signaling pathways.
    Taiwanese journal of obstetrics & gynecology, 2020, Volume: 59, Issue:3

    Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Genistein; HeLa Cells; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Paxillin; Phosphorylation; Uterine Cervical Neoplasms

2020
AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network.
    Nature communications, 2020, 07-17, Volume: 11, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Movement; Focal Adhesions; Humans; Neoplasm Invasiveness; Neoplasms; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction

2020
Paxillin knockdown suppresses metastasis and epithelial‑mesenchymal transition in colorectal cancer via the ERK signalling pathway.
    Oncology reports, 2020, Volume: 44, Issue:3

    Topics: Aged; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colon; Colorectal Neoplasms; Desmosomes; Disease Progression; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Female; Follow-Up Studies; Humans; Intestinal Mucosa; Liver; Liver Neoplasms; Lymphatic Metastasis; Male; MAP Kinase Signaling System; Mice; Microscopy, Electron, Transmission; Microvilli; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Paxillin; Retrospective Studies; Xenograft Model Antitumor Assays

2020
Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.
    International review of cell and molecular biology, 2020, Volume: 355

    Topics: Focal Adhesions; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Neoplasm Invasiveness; Neoplasms; Paxillin; Signal Transduction

2020
MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN.
    Pathology, research and practice, 2021, Volume: 218

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Paxillin; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction; Stomach Neoplasms

2021
Abnormal level of paxillin in cervical cancer cells is involved in tumor progression and invasion.
    Acta biochimica Polonica, 2021, Feb-20, Volume: 68, Issue:1

    Topics: Carcinogenesis; Carcinoma, Squamous Cell; Cell Movement; Cells, Cultured; Disease Progression; DNA, Viral; Female; Human papillomavirus 16; Humans; Neoplasm Invasiveness; Papillomavirus E7 Proteins; Papillomavirus Infections; Paxillin; Prognosis; Transfection; Up-Regulation; Uterine Cervical Neoplasms

2021
Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glioblastoma; Humans; Neoplasm Invasiveness; Paxillin; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrosine

2021
Abnormal expression of FAK and paxillin correlates with oral cancer invasion and metastasis.
    Acta biochimica Polonica, 2021, Apr-16, Volume: 68, Issue:2

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Humans; Matrix Metalloproteinase 11; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; RNA Interference; Side-Population Cells

2021
Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.
    Chemico-biological interactions, 2017, Apr-25, Volume: 268

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Focal Adhesion Kinase 1; Humans; Integrin beta1; Neoplasm Invasiveness; Oleanolic Acid; Paxillin; Signal Transduction

2017
Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways.
    Oncotarget, 2017, Mar-28, Volume: 8, Issue:13

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Genistein; In Situ Nick-End Labeling; MAP Kinase Signaling System; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Paxillin; Real-Time Polymerase Chain Reaction; Signal Transduction

2017
[Inhibitory effects of capsaicin on migration and invasion of breast cancer MDA-MB-231 cells and its mechanism].
    Sheng li xue bao : [Acta physiologica Sinica], 2017, Apr-25, Volume: 69, Issue:2

    Topics: Breast Neoplasms; Capsaicin; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Down-Regulation; Focal Adhesion Kinase 1; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Paxillin; Phosphorylation; src-Family Kinases

2017
Nicotinic acid impairs assembly of leading edge in glioma cells.
    Oncology reports, 2017, Volume: 38, Issue:2

    Topics: Actins; Animals; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glioma; HEK293 Cells; Humans; Male; Mice; Neoplasm Invasiveness; Niacin; NIH 3T3 Cells; Paraffin Embedding; Paxillin; Signal Transduction; Stress Fibers

2017
Potential Implication of Paxillin in Cancer Establishment Within the Bone Environment.
    Anticancer research, 2017, Volume: 37, Issue:8

    Topics: Bone Matrix; Bone Neoplasms; Breast Neoplasms; Cell Extracts; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatocyte Growth Factor; Humans; Male; Neoplasm Invasiveness; Paxillin; Prostatic Neoplasms

2017
Knockdown of long non-coding RNA XIST inhibits cell viability and invasion by regulating miR-137/PXN axis in non-small cell lung cancer.
    International journal of biological macromolecules, 2018, Volume: 111

    Topics: 3' Untranslated Regions; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MicroRNAs; Neoplasm Invasiveness; Paxillin; RNA, Long Noncoding; Signal Transduction

2018
Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells.
    Chinese journal of natural medicines, 2018, Volume: 16, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Female; Fibronectins; Focal Adhesion Kinase 1; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphorylation; Reactive Oxygen Species; Triterpenes

2018
Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13-RhoA-ROCK signaling pathway.
    Experimental & molecular medicine, 2018, 05-01, Volume: 50, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Polarity; Disease Progression; Focal Adhesions; Gastrins; Golgi Apparatus; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasm Invasiveness; Organic Chemicals; Pancreatic Neoplasms; Paxillin; Phosphorylation; Phosphotyrosine; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Time Factors

2018
Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices.
    Molecular biology of the cell, 2018, 07-15, Volume: 29, Issue:13

    Topics: Amino Acid Motifs; Cell Line, Tumor; Cell Movement; Cell Plasticity; Cell Shape; Extracellular Matrix; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Mesoderm; Neoplasm Invasiveness; Neoplasms; Paxillin; Phenotype; Phosphorylation; Protein Binding; Protein Domains; Vinculin

2018
Cell cycle-dependent force transmission in cancer cells.
    Molecular biology of the cell, 2018, 10-15, Volume: 29, Issue:21

    Topics: Biomechanical Phenomena; Cell Cycle; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Focal Adhesion Protein-Tyrosine Kinases; HEK293 Cells; HeLa Cells; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasms; Paxillin; Phenotype; Phosphorylation; Tamoxifen

2018
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.
    Nature communications, 2018, 11-30, Volume: 9, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Epithelial-Mesenchymal Transition; Female; Focal Adhesion Kinase 1; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Leukemia Inhibitory Factor; Male; Mice; Mice, SCID; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphoproteins; Receptors, OSM-LIF; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Young Adult

2018
PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells.
    BMC cancer, 2013, Feb-18, Volume: 13

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Integrin alpha2; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Paxillin; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-fos; Transplantation, Heterologous; Tumor Burden; Up-Regulation

2013
Tspan8 and CD151 promote metastasis by distinct mechanisms.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:13

    Topics: Adenocarcinoma; Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Collagen Type IV; Focal Adhesion Kinase 1; Integrin alpha3; Integrin alpha6beta4; Laminin; Lung Neoplasms; Lymphatic Metastasis; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pancreatic Neoplasms; Paxillin; Phosphorylation; ras Proteins; Rats; RNA Interference; src-Family Kinases; Tetraspanin 24; Tetraspanins; Time Factors; Transfection; Tumor Burden

2013
Tetraspanin 1 promotes invasiveness of cervical cancer cells.
    International journal of oncology, 2013, Volume: 43, Issue:2

    Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; Matrix Metalloproteinase 14; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Paxillin; Phosphatidylinositol 3-Kinases; ras GTPase-Activating Proteins; Signal Transduction; Tetraspanins; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2013
cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.
    Biochimica et biophysica acta, 2013, Volume: 1833, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Focal Adhesions; Guanine Nucleotide Exchange Factors; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Paxillin; Protein Transport

2013
Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.
    Journal of cell science, 2013, Sep-01, Volume: 126, Issue:Pt 17

    Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Enzyme Activation; Female; Focal Adhesions; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; rab5 GTP-Binding Proteins; RNA Interference; RNA, Small Interfering; Vinculin

2013
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
    The Journal of biological chemistry, 2013, Aug-16, Volume: 288, Issue:33

    Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Base Sequence; Carcinoma, Lewis Lung; Cell Adhesion; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockdown Techniques; Integrin alpha5beta1; Matrix Metalloproteinase 9; Membrane Microdomains; Mice; Models, Biological; Molecular Sequence Data; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphotyrosine; Polypeptide N-acetylgalactosaminyltransferase; Protein Multimerization; Signal Transduction; Syndecan-1

2013
Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.
    The Journal of cell biology, 2013, Sep-02, Volume: 202, Issue:5

    Topics: 3T3 Cells; Animals; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Focal Adhesions; Heterocyclic Compounds, 4 or More Rings; Humans; Integrin alpha4; Integrin alpha4beta1; Jurkat Cells; Melanoma; Mice; Mutant Proteins; Mutation; Myosin Type II; Neoplasm Invasiveness; Paxillin; Phenotype; Protein Binding; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Signal Transduction; Stress Fibers

2013
Loss of P53 facilitates invasion and metastasis of prostate cancer cells.
    Molecular and cellular biochemistry, 2013, Volume: 384, Issue:1-2

    Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Cortactin; Cytoskeleton; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Humans; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphorylation; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering; src-Family Kinases; Tumor Suppressor Protein p53; Wound Healing

2013
CK2 inhibitor CX-4945 blocks TGF-β1-induced epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cadherins; Casein Kinase II; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; Naphthyridines; Neoplasm Invasiveness; Paxillin; Phenazines; Protein Kinase Inhibitors; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Wnt Proteins

2013
B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma.
    Cancer science, 2013, Volume: 104, Issue:12

    Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Protein-Tyrosine Kinases; Glycosylation; Humans; Male; N-Acetylglucosaminyltransferases; Neoplasm Invasiveness; Neuroblastoma; Paxillin; Prognosis; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Survival Rate; Transfection

2013
miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin.
    Human cell, 2014, Volume: 27, Issue:3

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Humans; Lung Neoplasms; MicroRNAs; Molecular Targeted Therapy; Neoplasm Invasiveness; Paxillin

2014
miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis.
    Cancer research, 2014, Feb-01, Volume: 74, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Disease Models, Animal; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesions; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; MicroRNAs; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Proteolysis; RNA Interference; Signal Transduction

2014
Biglycan enhances gastric cancer invasion by activating FAK signaling pathway.
    Oncotarget, 2014, Apr-15, Volume: 5, Issue:7

    Topics: Aged; Animals; Biglycan; Cell Line, Tumor; Cell Movement; Endothelial Cells; Female; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Paxillin; Peptides; Phosphorylation; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Up-Regulation; Wound Healing

2014
Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.
    Molecular cancer, 2014, May-04, Volume: 13

    Topics: Actin Cytoskeleton; Aged; Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Fluorouracil; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Paxillin; Phosphorylation; Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Xenograft Model Antitumor Assays

2014
Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.
    Chemical biology & drug design, 2015, Volume: 85, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Discovery; Female; Humans; Models, Molecular; Neoplasm Invasiveness; Neoplasm Proteins; Oleanolic Acid; Paxillin; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; Signal Transduction; Terminalia

2015
Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma.
    Upsala journal of medical sciences, 2014, Volume: 119, Issue:4

    Topics: Adult; Aged; Carcinoma; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microfilament Proteins; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Thiostrepton

2014
Inhibition of the invasion and migration of renal carcinoma 786‑o‑si3 cells in vitro and in vivo by Koelreuteria formosana extract.
    Molecular medicine reports, 2014, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line; Cell Line, Tumor; Cell Movement; Cell Survival; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kidney Neoplasms; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myosin Light Chains; Neoplasm Invasiveness; Paxillin; Plant Extracts

2014
Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.
    Cytoskeleton (Hoboken, N.J.), 2014, Volume: 71, Issue:12

    Topics: Cell Movement; Fibroblasts; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; GTPase-Activating Proteins; Humans; Immunoblotting; Neoplasm Invasiveness; Paxillin; Photobleaching; Transfection; Tumor Suppressor Proteins

2014
Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells.
    American journal of physiology. Cell physiology, 2015, Apr-15, Volume: 308, Issue:8

    Topics: Breast Neoplasms; Calcium-Binding Proteins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell-Matrix Junctions; Extracellular Matrix; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; MCF-7 Cells; Membrane Proteins; Muscle Proteins; Neoplasm Invasiveness; Paxillin; Phosphorylation; RNA Interference; RNA, Small Interfering

2015
Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.
    Oncology reports, 2015, Volume: 33, Issue:5

    Topics: Actin Cytoskeleton; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Movement; Enzyme Activation; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesions; Genes, src; HEK293 Cells; Hep G2 Cells; Humans; Neoplasm Invasiveness; Nerve Tissue Proteins; Paxillin; Signal Transduction

2015
Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.
    Oncotarget, 2015, Apr-20, Volume: 6, Issue:11

    Topics: Animals; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Colorectal Neoplasms; Dasatinib; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Heterografts; Humans; Kaplan-Meier Estimate; Leupeptins; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Paxillin; Phosphorylation; Proportional Hazards Models; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Sulfonamides

2015
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Actinin; Caco-2 Cells; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Focal Adhesions; HT29 Cells; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; Paxillin; Protein Binding; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Zyxin

2015
MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:2

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Paxillin

2015
Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
    Molecular and cellular biology, 2015, Volume: 35, Issue:23

    Topics: Animals; Anoikis; Breast; Breast Neoplasms; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Female; Focal Adhesion Kinase 2; Gene Deletion; Gene Knockout Techniques; Humans; Mice; Neoplasm Invasiveness; Paxillin; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Receptor, ErbB-2; Tumor Cells, Cultured

2015
MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling.
    Cancer science, 2016, Volume: 107, Issue:1

    Topics: Animals; Colonic Neoplasms; CSK Tyrosine-Protein Kinase; Disease Models, Animal; Disease Progression; Focal Adhesions; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; HCT116 Cells; Heterografts; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Paxillin; src-Family Kinases

2016
Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer.
    Nutrition and cancer, 2015, Volume: 67, Issue:8

    Topics: 4-Butyrolactone; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclins; Cytoskeleton; Focal Adhesion Kinase 1; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression; Humans; Ki-67 Antigen; Lignans; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Proliferating Cell Nuclear Antigen; RNA, Messenger; S Phase; Signal Transduction

2015
Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms.
    Cancer letters, 2016, Apr-10, Volume: 373, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lactones; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-fos; Sesquiterpenes; Urinary Bladder Neoplasms

2016
Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway.
    Molecular cancer, 2016, Mar-08, Volume: 15

    Topics: Animals; Apoptosis; Carboxylic Ester Hydrolases; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Focal Adhesion Protein-Tyrosine Kinases; Gene Knockdown Techniques; Humans; Matrix Metalloproteinase 2; Mice, Nude; Mitochondrial Proteins; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Paxillin; Protein Binding; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays

2016
Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.
    Molecular and cellular endocrinology, 2016, 07-15, Volume: 430

    Topics: Actin Cytoskeleton; Actin-Related Protein 2-3 Complex; Breast Neoplasms; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Line, Tumor; Cell Movement; Estrogen Receptor alpha; Estrogens; Female; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; Humans; Neoplasm Invasiveness; Paxillin; Phosphorylation; Protein Transport; Raloxifene Hydrochloride; Signal Transduction; src-Family Kinases; Wiskott-Aldrich Syndrome Protein, Neuronal

2016
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
    Nature communications, 2016, 05-16, Volume: 7

    Topics: Animals; Cell Line, Tumor; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cytoplasm; Down-Regulation; Fibroblasts; Gene Knockdown Techniques; HEK293 Cells; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Paxillin; Phosphorylation; Phosphoserine; Protein Binding; rac1 GTP-Binding Protein; Rats; Substrate Specificity

2016
Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.
    Scientific reports, 2016, 06-13, Volume: 6

    Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Discoidin Domain Receptor 1; Focal Adhesion Kinase 1; Glioblastoma; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Invasiveness; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction

2016
Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3.
    Biochemical and biophysical research communications, 2008, Aug-15, Volume: 373, Issue:1

    Topics: Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Extracellular Matrix; Focal Adhesions; Gangliosides; Humans; Integrin beta1; Melanoma; Neoplasm Invasiveness; Paxillin; Phosphorylation; Signal Transduction; Skin Neoplasms

2008
Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis.
    Cancer letters, 2008, Nov-08, Volume: 270, Issue:2

    Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphorylation; Transfection; Vascular Endothelial Growth Factor A

2008
Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.
    Cancer research, 2008, Jul-15, Volume: 68, Issue:14

    Topics: Cell Line, Tumor; Disease Progression; ErbB Receptors; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Tyrosine

2008
Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways.
    Cellular and molecular life sciences : CMLS, 2008, Volume: 65, Issue:18

    Topics: Basigin; Calcium; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytoskeleton; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Silencing; Humans; Integrin alpha3beta1; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors

2008
Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells.
    Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cytoskeleton; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Integrin alpha3beta1; Liver Neoplasms; Neoplasm Invasiveness; Paxillin; Transfection; Transforming Growth Factor beta

2009
Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells.
    Oncology reports, 2009, Volume: 21, Issue:1

    Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Liver Neoplasms; Neoplasm Invasiveness; Paxillin; Phosphorylation; RNA Interference; Signal Transduction

2009
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
    The Journal of cell biology, 2009, Apr-20, Volume: 185, Issue:2

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Female; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Neoplasm Invasiveness; Paxillin; Recombinant Fusion Proteins; RNA, Small Interfering; src-Family Kinases; Tyrosine

2009
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.
    Molecular oncology, 2009, Volume: 3, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Proliferation; Clinical Trials, Phase II as Topic; Focal Adhesion Kinase 1; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; NIH 3T3 Cells; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Nude; src-Family Kinases; Transplantation, Heterologous; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2009
Reorganization of the integrin alpha2 subunit controls cell adhesion and cancer cell invasion in prostate cancer.
    International journal of oncology, 2009, Volume: 34, Issue:6

    Topics: Blotting, Western; Cell Adhesion; Cell Movement; Collagen Type I; Flow Cytometry; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Humans; Immunoprecipitation; Integrin alpha2; Male; MAP Kinase Kinase 4; Matrix Metalloproteinases; Neoplasm Invasiveness; Paxillin; Phosphorylation; Prostatic Neoplasms; rac GTP-Binding Proteins; Signal Transduction; src-Family Kinases; Tumor Cells, Cultured

2009
Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model.
    Experimental and molecular pathology, 2009, Volume: 87, Issue:2

    Topics: Basement Membrane; Basigin; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cytoskeleton; Extracellular Matrix; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Gene Expression Profiling; Humans; Liver Neoplasms; Matrix Metalloproteinases; Microscopy, Confocal; Neoplasm Invasiveness; Paxillin

2009
Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma.
    Journal of cancer research and clinical oncology, 2010, Volume: 136, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cell Line, Tumor; Cholangiocarcinoma; CpG Islands; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Integrin alpha4; Integrin beta1; Lymphatic Metastasis; Male; Methyltransferases; Middle Aged; Molecular Sequence Data; Neoplasm Invasiveness; Paxillin; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sequence Analysis, DNA; Transfection

2010
Increased motility and invasiveness in tumor cells that survive 10 Gy irradiation.
    Cell structure and function, 2009, Volume: 34, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Focal Adhesion Kinase 1; Humans; Integrin beta1; Lung Neoplasms; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Paxillin; Radiation Dosage; Vinculin

2009
Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2010, Aug-01, Volume: 39, Issue:7

    Topics: Adult; Aged; Carcinoma, Adenoid Cystic; Coloring Agents; Cytoplasm; Extracellular Space; Female; Histocytochemistry; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Parotid Neoplasms; Paxillin; Salivary Gland Neoplasms; Salivary Glands, Minor; Submandibular Gland Neoplasms; Young Adult

2010
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.
    The American journal of pathology, 2010, Volume: 176, Issue:6

    Topics: Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Urinary Bladder Neoplasms

2010
Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.
    Brain pathology (Zurich, Switzerland), 2011, Volume: 21, Issue:4

    Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Movement; Gene Knockdown Techniques; Humans; Immunoblotting; Immunohistochemistry; Loss of Heterozygosity; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude; Neoplasm Invasiveness; Paxillin; Polymerase Chain Reaction; Receptor-Like Protein Tyrosine Phosphatases, Class 3; RNA, Small Interfering; Signal Transduction; Transfection

2011
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.
    Molecular biology of the cell, 2011, Feb-01, Volume: 22, Issue:3

    Topics: Animals; Breast Neoplasms; Cattle; Cell Adhesion; Cell Line, Tumor; Cell Movement; Extracellular Matrix; Female; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; rhoA GTP-Binding Protein; Signal Transduction

2011
Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting.
    Cancer research, 2010, Dec-15, Volume: 70, Issue:24

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Male; MicroRNAs; Molecular Targeted Therapy; Neoplasm Invasiveness; Oncogene Proteins, Viral; Paxillin; Repressor Proteins; RNA, Messenger; Transcription, Genetic; Up-Regulation

2010
Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.
    The Journal of biological chemistry, 2011, Mar-25, Volume: 286, Issue:12

    Topics: Amino Acid Motifs; Amino Acid Substitution; Calpain; Cell Movement; Cytoskeletal Proteins; Focal Adhesions; Glycoproteins; HEK293 Cells; HeLa Cells; Humans; Neoplasm Invasiveness; Neoplasms; Paxillin; Point Mutation; Zyxin

2011
EPLIN is a negative regulator of prostate cancer growth and invasion.
    The Journal of urology, 2011, Volume: 186, Issue:1

    Topics: Cell Proliferation; Cytoskeletal Proteins; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Invasiveness; Paxillin; Prostatic Neoplasms; Tumor Cells, Cultured

2011
Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion.
    Journal of cell science, 2011, Jun-15, Volume: 124, Issue:Pt 12

    Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Growth Processes; Cell Movement; Cells, Cultured; Coculture Techniques; Female; Gene Expression Regulation; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasm Invasiveness; Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Signal Transduction

2011
Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression.
    Urologic oncology, 2013, Volume: 31, Issue:6

    Topics: Antigens, CD; beta Catenin; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Disease Progression; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Multivariate Analysis; Neoplasm Invasiveness; Paxillin; Signal Transduction; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms; Urothelium

2013
The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse.
    International journal of cancer, 2012, Aug-01, Volume: 131, Issue:3

    Topics: Actin Cytoskeleton; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cytochromes c; DNA Damage; Esophageal Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasm Invasiveness; Neoplasms, Experimental; Paxillin; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; rhoA GTP-Binding Protein; Signal Transduction; Xenograft Model Antitumor Assays; Xylenes

2012
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion.
    BMC cancer, 2011, Nov-03, Volume: 11

    Topics: Adherens Junctions; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell-Matrix Junctions; Epithelial Cells; Focal Adhesion Kinase 1; Humans; Neoplasm Invasiveness; Paxillin; Ubiquitin-Protein Ligases; Vinculin

2011
Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma.
    Molecular medicine reports, 2012, Volume: 5, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Esophageal Neoplasms; Female; Focal Adhesion Kinase 1; Gene Expression Regulation; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Paxillin; RNA, Messenger

2012
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.
    Cellular signalling, 2012, Volume: 24, Issue:6

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Female; Humans; Indoles; Neoplasm Invasiveness; Paxillin; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Sulfonamides; Thiazoles

2012
Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells.
    Cytokine, 2012, Volume: 59, Issue:2

    Topics: Animals; Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Chemokine CCL2; Enzyme Activation; Female; Gene Knockdown Techniques; Humans; Mice; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, CCR2; Urinary Bladder Neoplasms

2012
MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.
    Cancer research, 2012, Aug-15, Volume: 72, Issue:16

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Female; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neoplasm Invasiveness; Paxillin; Phosphorylation

2012
Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Carcinoma; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesions; GRB2 Adaptor Protein; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Urinary Bladder Neoplasms; Urothelium

2012
The Na+ /H+ -exchanger (NHE1) generates pH nanodomains at focal adhesions.
    Journal of cellular physiology, 2013, Volume: 228, Issue:6

    Topics: Cation Transport Proteins; Cell Line, Tumor; Cell Movement; Fluoresceins; Fluorescent Dyes; Focal Adhesions; Guanidines; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Melanoma; Microscopy, Fluorescence; Neoplasm Invasiveness; Paxillin; Recombinant Fusion Proteins; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sulfones; Transfection; Wheat Germ Agglutinins

2013
Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer.
    Carcinogenesis, 2013, Volume: 34, Issue:4

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Paxillin; Prognosis; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transplantation, Heterologous

2013
Heparanase mediates cell adhesion independent of its enzymatic activity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:9

    Topics: Animals; Cell Adhesion; Cell Membrane; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Endothelium; Extracellular Matrix; Glucuronidase; Lymphoma; Mice; Neoplasm Invasiveness; Oligopeptides; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured; Tyrosine

2003
Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
    Carcinogenesis, 2003, Volume: 24, Issue:8

    Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine

2003
Expression of the urokinase receptor regulates focal adhesion assembly and cell migration in adenoid cystic carcinoma cells.
    Journal of cellular physiology, 2005, Volume: 203, Issue:2

    Topics: Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Movement; Collagen Type I; Collagen Type IV; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesions; Humans; Integrin alpha2; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Antisense; Salivary Gland Neoplasms; Vinculin

2005
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.
    The EMBO journal, 2005, Mar-09, Volume: 24, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cortactin; Cytoskeletal Proteins; Female; Gene Expression; Gene Silencing; GTPase-Activating Proteins; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Microfilament Proteins; Molecular Sequence Data; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Proline; Protein Binding; RNA, Small Interfering

2005
Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro.
    Cancer, 2005, Apr-01, Volume: 103, Issue:7

    Topics: Actins; Acute-Phase Proteins; Cell Shape; Cell Survival; Cytoskeletal Proteins; Diterpenes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Tumor Cells, Cultured

2005
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:6

    Topics: Animals; Binding Sites; Cell Line, Transformed; Cell Movement; Cells, Cultured; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, src; Injections, Subcutaneous; Laminin; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogene Protein v-crk; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Retroviridae Proteins, Oncogenic; src Homology Domains; Tyrosine

2005
Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Aug-02, Volume: 102, Issue:31

    Topics: Cell Division; Cell Line, Tumor; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Gangliosides; Humans; Melanoma; Neoplasm Invasiveness; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; RNA, Small Interfering; Sialyltransferases; Transfection; Tyrosine

2005
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
    Journal of biomedical science, 2005, Volume: 12, Issue:4

    Topics: Actins; Agar; Androstadienes; Animals; Anoikis; Binding Sites; Cell Adhesion; Cell Cycle; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Collagen; Crk-Associated Substrate Protein; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gelatin; Genes, Dominant; Immunoblotting; Immunoprecipitation; Laminin; Matrix Metalloproteinase 2; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Talin; Time Factors; Transfection; Tyrosine; Vinculin; Wortmannin

2005
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 1

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Crk-Associated Substrate Protein; Dasatinib; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; G1 Phase; Gentian Violet; Head and Neck Neoplasms; Humans; Immunoprecipitation; Inhibitory Concentration 50; Laminin; Lung Neoplasms; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrimidines; Retinoblastoma Protein; S Phase; Signal Transduction; src-Family Kinases; Thiazoles; Time Factors; Trypan Blue

2005
Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.
    Breast cancer research and treatment, 2006, Volume: 97, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Female; Focal Adhesion Kinase 1; Gefitinib; Humans; Microscopy, Fluorescence; Neoplasm Invasiveness; Paxillin; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; src-Family Kinases; Tamoxifen

2006
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
    Molecular and cellular biology, 2006, Volume: 26, Issue:3

    Topics: Animals; Carrier Proteins; Cell Movement; Cells, Cultured; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glycogen Synthase Kinase 3; Humans; Neoplasm Invasiveness; Neoplasms; Paxillin; Phosphoric Monoester Hydrolases; Protein Interaction Mapping; Proto-Oncogene Proteins c-akt; RNA Interference

2006
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex.
    Cancer research, 2006, Jul-15, Volume: 66, Issue:14

    Topics: Carcinoma, Transitional Cell; Cell Movement; Enzyme Activation; Focal Adhesion Kinase 1; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Paxillin; Progranulins; Protein Precursors; Recombinant Proteins; Urinary Bladder Neoplasms

2006
Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer.
    Cancer research, 2006, Oct-15, Volume: 66, Issue:20

    Topics: Acyltransferases; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Cloning, Molecular; Gene Amplification; Gene Dosage; Glycosylphosphatidylinositols; Humans; Membrane Glycoproteins; Neoplasm Invasiveness; Oncogenes; Paxillin; Phosphorylation; Protein Subunits

2006
Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.
    Oncogene, 2007, Jul-12, Volume: 26, Issue:32

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Cytoskeleton; Female; Humans; Neoplasm Invasiveness; NIMA-Related Kinases; Paxillin; Phosphorylation; Prolactin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; RNA, Small Interfering; Serine; Transfection

2007
Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression.
    Molecular cancer research : MCR, 2007, Volume: 5, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Survival; Disease Progression; DNA, Antisense; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Paxillin; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, PAR-1

2007
Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells.
    Molecular cancer research : MCR, 2007, Volume: 5, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; N-Acetylgalactosaminyltransferases; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phenotype

2007
Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes.
    Neuropathology and applied neurobiology, 2007, Volume: 33, Issue:6

    Topics: Astrocytes; Astrocytoma; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunohistochemistry; Neoplasm Invasiveness; Paxillin; Protein-Lysine 6-Oxidase; Reverse Transcriptase Polymerase Chain Reaction

2007
CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells.
    Clinical & experimental metastasis, 2008, Volume: 25, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Focal Adhesion Kinase 1; Humans; Integrin alphaV; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Invasiveness; Paxillin; Phosphorylation; Signal Transduction; Transplantation, Heterologous; Vitronectin

2008
Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.
    Biochimica et biophysica acta, 2008, Volume: 1780, Issue:3

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Line, Tumor; Cell Proliferation; Crk-Associated Substrate Protein; Focal Adhesion Protein-Tyrosine Kinases; Gangliosides; Humans; Immunoprecipitation; Mass Spectrometry; Melanoma; Molecular Sequence Data; Mutation; Neoplasm Invasiveness; Paxillin; Phosphorylation; Phosphotyrosine; Protein Binding; Serum; Transfection

2008
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.
    Cancer research, 2008, Jan-01, Volume: 68, Issue:1

    Topics: Animals; Cell Proliferation; Gene Dosage; Genes, erbB-1; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Mutation; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-met; RNA Interference

2008
Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential.
    Clinical & experimental metastasis, 2008, Volume: 25, Issue:3

    Topics: Blotting, Western; Bone Neoplasms; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Communication; Cell Movement; Connexin 26; Connexin 43; Connexins; Focal Adhesion Protein-Tyrosine Kinases; Gap Junctions; Humans; Neoplasm Invasiveness; Paxillin; Proto-Oncogene Proteins c-crk; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured

2008
Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.
    Molecular biology of the cell, 2008, Volume: 19, Issue:4

    Topics: 3T3 Cells; Actins; Animals; Cell Movement; Cells, Cultured; Epithelial Cells; Female; Focal Adhesions; Gene Deletion; Genes, jun; Genes, src; Mammary Glands, Animal; Mice; Mice, Transgenic; Neoplasm Invasiveness; Paxillin; Phosphorylation; rho-Associated Kinases; RNA, Messenger

2008
LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities.
    Molecular and cellular biology, 2008, Volume: 28, Issue:9

    Topics: Cell Line, Tumor; Cell Movement; Cell Shape; Endocytosis; Focal Adhesion Kinase 1; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Paxillin; Receptors, LDL; RNA Interference; Talin; Tumor Suppressor Proteins; Urokinase-Type Plasminogen Activator

2008
Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation.
    Journal of cellular physiology, 2008, Volume: 216, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Mice; Neoplasm Invasiveness; Paxillin; Prostatic Neoplasms; Serine Endopeptidases; Up-Regulation

2008
rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion.
    International journal of cancer, 1996, Mar-01, Volume: 65, Issue:5

    Topics: Animals; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; GTP-Binding Proteins; Isoflavones; Liver Neoplasms, Experimental; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; rho GTP-Binding Proteins; Signal Transduction; Tumor Cells, Cultured

1996
Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.
    International journal of cancer, 1997, Jul-29, Volume: 72, Issue:3

    Topics: Bombesin; Cell Adhesion Molecules; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosorbent Techniques; Integrins; Male; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphotyrosine; Prostatic Neoplasms; Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured

1997
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.
    Molecular and cellular biology, 1999, Volume: 19, Issue:4

    Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Chemokine CCL5; Chemotactic Factors; Chemotaxis; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Integrins; Intracellular Signaling Peptides and Proteins; Models, Biological; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptor Cross-Talk; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured

1999
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation.
    Oncogene, 1999, Aug-05, Volume: 18, Issue:31

    Topics: Actins; Breast Neoplasms; Cell Adhesion Molecules; Cell Membrane; Cortactin; Cytoskeletal Proteins; Extracellular Matrix; Female; Gelatin; Humans; Integrin beta1; Microfilament Proteins; Microscopy, Electron; Models, Biological; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Protein Kinase C; Tumor Cells, Cultured

1999
Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:8

    Topics: Actins; Amides; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Drug Interactions; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; rho-Associated Kinases; Tumor Cells, Cultured; Tyrosine

2000
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase.
    Molecular and cellular biology, 2001, Volume: 21, Issue:12

    Topics: 3T3 Cells; Alu Elements; Animals; Base Sequence; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; DNA Primers; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phenotype; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured

2001
The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant.
    Biochemical and biophysical research communications, 2001, Aug-03, Volume: 285, Issue:5

    Topics: Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Extracellular Matrix; Fluorescent Antibody Technique; Hepatocyte Growth Factor; Humans; Male; Mitogens; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine

2001
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
    International journal of cancer, 2002, Jan-20, Volume: 97, Issue:3

    Topics: Amiloride; Animals; Blotting, Western; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Fibronectins; Immunoblotting; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Pseudopodia; Rats; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine

2002
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Blotting, Western; Breast Neoplasms; Cell Movement; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Down-Regulation; Female; Focal Adhesion Kinase 2; Focal Adhesions; Humans; Megakaryocytes; Neoplasm Invasiveness; Neuregulin-1; Paxillin; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptor, ErbB-2; Recombinant Proteins; Signal Transduction; src-Family Kinases; Transfection; Tumor Cells, Cultured; Tyrosine

2002