paxilline and Disease Models, Animal

Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Dystroglycans; Glycosylation; Glycosyltransferases; Humans; Muscle Development; Muscular Dystrophy, Animal; Mutation; NAD; Neuromuscular Junction; Paxillin; Up-Regulation; Zebrafish; Zebrafish Proteins

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Isolated Heart Preparation; Large-Conductance Calcium-Activated Potassium Channels; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Potassium Channel Blockers; Rats, Wistar; Simendan; Ventricular Function, Left

Topics: Analysis of Variance; Animals; Anticonvulsants; Cannabidiol; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Intraventricular; Large-Conductance Calcium-Activated Potassium Channels; Male; Mice; Pentylenetetrazole; Potassium Channel Blockers; Seizures

Topics: Animals; Cell Hypoxia; Disease Models, Animal; Energy Metabolism; Indoles; Ischemic Preconditioning; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Muscle Fibers, Skeletal; Muscle, Skeletal; Myocardium; Myocytes, Cardiac; Oxidative Phosphorylation; Reactive Oxygen Species; Reperfusion Injury; Tetrazoles; Thiourea

Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Fibroblasts; Indoles; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Matrix Metalloproteinase 2; Potassium Channel Blockers; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Synovial Membrane; Terpenes

Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Indoles; Mice; Mice, Inbred C57BL; Neocortex; Pentylenetetrazole; Picrotoxin; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Seizures; Time Factors

Topics: Animals; Benzimidazoles; Blood Glucose; Body Weight; Cerebral Arteries; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Electromyography; In Vitro Techniques; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Models, Biological; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Serotonin; Streptozocin; Tetraethylammonium

Topics: Action Potentials; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; In Vitro Techniques; Indoles; Mice; Mice, Inbred C57BL; Numerical Analysis, Computer-Assisted; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Pyramidal Cells; Seizures; Synapses

Topics: Amides; Analgesics; Animals; Dequalinium; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Glyburide; Hyperalgesia; Indoles; KATP Channels; Male; Palmitic Acids; Rats; Rats, Wistar

Topics: Animals; Blood-Brain Barrier; Brain Injuries; Disease Models, Animal; Gene Expression; Intercellular Signaling Peptides and Proteins; Intraoperative Complications; Male; Nerve Tissue Proteins; Organ Specificity; Paxillin; Permeability; rac1 GTP-Binding Protein; Rats; Receptors, Cell Surface; Recombinant Proteins; Signal Transduction

Topics: Adult; Aged; Animals; Apoptosis; Case-Control Studies; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; Female; Gene Expression; Gene Knockdown Techniques; Humans; Mice; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Paxillin; Prognosis; Radiation Tolerance; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

Topics: Animals; Biophysical Phenomena; Cell Adhesion; Collagen; Cytoskeleton; Disease Models, Animal; Disease Progression; Elastic Modulus; Glomerulonephritis; HIV; Kidney Glomerulus; Mice; Mice, Transgenic; Microscopy, Atomic Force; Microscopy, Fluorescence; Nephrosis, Lipoid; Paxillin; Podocytes; Protamines; Real-Time Polymerase Chain Reaction

Topics: Animals; Astrocytes; Axons; Complement C3; Cortactin; Disease Models, Animal; Intraocular Pressure; Male; Microscopy, Confocal; Ocular Hypertension; Optic Disk; Optic Nerve; Optic Nerve Injuries; Paxillin; Phosphorylation; Rats; Rats, Inbred BN; Retinal Ganglion Cells; Tonometry, Ocular; Tubulin

Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Integrin alpha2; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Paxillin; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-fos; Transplantation, Heterologous; Tumor Burden; Up-Regulation

Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Disease Models, Animal; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesions; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; MicroRNAs; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Proteolysis; RNA Interference; Signal Transduction

Topics: Active Transport, Cell Nucleus; Animals; Antihypertensive Agents; Apoptosis; Becaplermin; Benzamides; Cell Adhesion; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine; Vascular Remodeling

Topics: Animals; Colonic Neoplasms; CSK Tyrosine-Protein Kinase; Disease Models, Animal; Disease Progression; Focal Adhesions; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; HCT116 Cells; Heterografts; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Paxillin; src-Family Kinases

Topics: Airway Remodeling; Animals; Asthma; Blotting, Western; Cells, Cultured; Disease Models, Animal; Focal Adhesions; Guinea Pigs; Integrin beta1; Male; Muscle, Smooth; Paxillin; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Talin

Topics: Aged; Aged, 80 and over; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Case-Control Studies; Cell Differentiation; Cell Line, Tumor; Dilatation, Pathologic; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Female; Focal Adhesion Kinase 2; Glucagon-Like Peptide 1; Humans; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Paxillin; RNA Interference; Transfection

Topics: Animals; Benzoxazines; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice, Inbred C57BL; Models, Biological; Oxygen; Paxillin; Retinal Neovascularization; Signal Transduction; Small Molecule Libraries; src-Family Kinases; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoblotting; Mice; Neoplastic Processes; Neovascularization, Pathologic; Paxillin; Phosphorylation; src-Family Kinases; Transfection

Topics: Actinin; Animals; Animals, Newborn; Cardiomegaly; Cytoskeletal Proteins; Cytoskeleton; Disease Models, Animal; DNA-Binding Proteins; Fetus; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Heart Failure; Heart Ventricles; LIM Domain Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Paxillin; Phenylephrine; Protein Transport; Rats; Reproducibility of Results; RNA, Small Interfering; Transfection

Topics: Actinin; Animals; Antibodies, Monoclonal; Cell Aggregation; Cell Death; Cell Differentiation; Cell Line; Cell Membrane; Cytoskeletal Proteins; Disease Models, Animal; Embryonic Stem Cells; Humans; Mice; Mice, SCID; Microscopy, Electron, Scanning; Paxillin; Sialoglycoproteins; Talin; Teratoma; Vinculin

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; DNA Damage; Dose-Response Relationship, Drug; Female; Humans; Melanoma; Mice; Mice, SCID; Paxillin; Pyrogallol; Skin Neoplasms; Stilbenes; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: 4-Aminopyridine; Animals; Arterioles; Biophysical Phenomena; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heparin-binding EGF-like Growth Factor; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Membrane Potentials; Muscle Cells; Oxyhemoglobins; Patch-Clamp Techniques; Paxillin; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Signal Transduction; Subarachnoid Hemorrhage

Topics: Adult; Animals; Apoptosis; Cell Adhesion; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Familial Primary Pulmonary Hypertension; Female; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lung; Male; Mice; Middle Aged; Muscle Proteins; Myocytes, Smooth Muscle; Paxillin; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Signal Transduction

Topics: Animals; Antigens, CD; Cell Adhesion; Disease Models, Animal; Dystroglycans; Dystrophin; Extracellular Matrix; Integrin alpha Chains; Integrin alpha6; Laminin; Muscle, Skeletal; Muscular Dystrophies; NAD; Paxillin; Zebrafish; Zebrafish Proteins

Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Movement; Cytoskeletal Proteins; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Mitogens; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Survival Rate; Tumor Cells, Cultured; Tyrosine

Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Apoptosis; Cells, Cultured; Collagen; Crk-Associated Substrate Protein; Disease Models, Animal; Dogs; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Hypertrophy, Left Ventricular; Metoprolol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitral Valve Insufficiency; Myocardium; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, beta-1; Signal Transduction; Sympathetic Nervous System; Ventricular Function, Left; Ventricular Remodeling

Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Follow-Up Studies; Nephrotic Syndrome; Paxillin; Phosphoproteins; Protein-Tyrosine Kinases; Puromycin; Rats; Rats, Sprague-Dawley; Receptor, Insulin; rho GTP-Binding Proteins

Topics: 3T3 Cells; Animals; Bone Diseases, Metabolic; Bone Resorption; Cell Adhesion Molecules; Cell Survival; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Disease Models, Animal; Enzyme Inhibitors; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Mice; Oncogene Protein pp60(v-src); Osteoblasts; Ovariectomy; Paxillin; Phosphoproteins; Phosphorylation; Pregnancy; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; src-Family Kinases

Topics: Adenoviridae; Animals; Calcium Channel Blockers; Cardiomegaly; Cell Adhesion; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart; Myocardium; Myosin Heavy Chains; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine