paullone has been researched along with Trypanosomiasis--African* in 2 studies
2 other study(ies) available for paullone and Trypanosomiasis--African
| Article | Year |
|---|---|
Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction-Optimization Strategy Applied to Paullones.
The parasitic kinetoplastid diseases Leishmaniasis, Chagas disease and Human African Trypanosomiasis constitute serious threats for populations throughout the (sub-)tropics. Most available drugs to treat these diseases possess inadequate properties and candidates to fill the drug pipeline are urgently needed. Paullone-N Topics: Animals; Antiprotozoal Agents; Humans; Mammals; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2023 |
9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
Trypanosomes from the "brucei" complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock. In order to identify new antitrypanosomal chemotypes against African trypanosomes, 4-azapaullones carrying α,β-unsaturated carbonyl chains in 9- or 11-position were synthesized employing a procedure with a Heck reaction as key step. Among the so prepared compounds, 5a and 5e proved to be potent antiparasitic agents with antitrypanosomal activity in the submicromolar range. Topics: Animals; Benzazepines; Cell Line; Cell Proliferation; Drug Design; Humans; Macrophages; Mice; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2014 |