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patulin and Abnormalities, Autosome

patulin has been researched along with Abnormalities, Autosome in 10 studies

Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.
patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.

Research Excerpts

ExcerptRelevanceReference
"The aneuploidogenic and clastogenic potentials of the mycotoxins citrinin (CIT) and patulin (PAT) were studied by determining inhibition of microtubule assembly under cell-free conditions and by measuring induction of mitotic arrest and micronuclei in cultured Chinese hamster V79 cells."7.70Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. ( Gross, K; Metzler, M; Pfeiffer, E, 1998)
"The aneuploidogenic and clastogenic potentials of the mycotoxins citrinin (CIT) and patulin (PAT) were studied by determining inhibition of microtubule assembly under cell-free conditions and by measuring induction of mitotic arrest and micronuclei in cultured Chinese hamster V79 cells."3.70Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. ( Gross, K; Metzler, M; Pfeiffer, E, 1998)
"Patulin (PAT) is a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys."1.40Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration. ( Dong, W; Song, E; Song, Y; Su, C; Wang, W; Xia, X; Xian, Y, 2014)
"Patulin (PAT) is a mycotoxin produced in fruits, mainly in apples, by certain species of Penicillium, Aspergillus, and Byssochlamys."1.39Antioxidative and antigenotoxic effect of vitamin E against patulin cytotoxicity and genotoxicity in HepG2 cells. ( Abassi, H; Ayed, Y; Ayed-Boussema, I; Bacha, H; Bouaziz, C; Hlima, WB, 2013)
"Patulin is a frequently found food contaminant mainly produced by the fungi Aspergillus and Penicillium."1.38Patulin: Mechanism of genotoxicity. ( Glaser, N; Stopper, H, 2012)
"Patulin is a mycotoxin produced by several species of Penicillium, Aspergillus and BYSSOCHLAMYS: Patulin is a common contaminant of ripe apples used for the production of apple juice concentrates and is also present in other fruits, vegetables and food products."1.31Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity. ( Alves, I; Laires, A; Oliveira, NG; Rodrigues, AS; Rueff, J, 2000)
"Patulin is a potent inducer of chromatid-type aberrations in Chinese hamster V79-E cells, but loses its activity when 9000 g supernatant of rat-liver homogenate is added."1.26Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro. ( Kneist, S; Mendel, J; Thust, R, 1982)
"However, the rate of chromosomal aberrations induced by the direct mutagen PA was clearly suppressed in ethanol drinking animals."1.26The influence of ethanol treatment of cytogenetic effects in bone marrow cells of Chinese hamsters by cyclophosphamide, aflatoxin B1 and patulin. ( Korte, A; Obe, G; Slacik-Erben, R, 1979)
"Incidence of chromosome aberrations by the treatment with these mycotoxins correlated fairly well with their mutagenic activity."1.26Mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations by various mycotoxins. ( Saito, M; Tsutsui, T; Umeda, M, 1977)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, E1
Xia, X1
Su, C1
Dong, W1
Xian, Y1
Wang, W1
Song, Y1
Ayed-Boussema, I1
Abassi, H1
Bouaziz, C1
Hlima, WB1
Ayed, Y1
Bacha, H1
Glaser, N1
Stopper, H1
Thust, R1
Kneist, S1
Mendel, J1
Korte, A2
Pfeiffer, E1
Gross, K1
Metzler, M1
Alves, I1
Oliveira, NG1
Laires, A1
Rodrigues, AS1
Rueff, J1
Slacik-Erben, R1
Obe, G1
Umeda, M1
Tsutsui, T1
Saito, M1

Reviews

1 review available for patulin and Abnormalities, Autosome

ArticleYear
Patulin.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1976, Volume: 10

    Topics: Animals; Carcinogens; Chromosome Aberrations; Drug Evaluation, Preclinical; Lethal Dose 50; Male; Mi

1976

Other Studies

9 other studies available for patulin and Abnormalities, Autosome

ArticleYear
Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 71

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bone Marrow; Chromosome Aberrations; Glu

2014
Antioxidative and antigenotoxic effect of vitamin E against patulin cytotoxicity and genotoxicity in HepG2 cells.
    Environmental toxicology, 2013, Volume: 28, Issue:6

    Topics: Antioxidants; Carcinogens; Cell Survival; Chromosome Aberrations; DNA Damage; Hep G2 Cells; Humans;

2013
Patulin: Mechanism of genotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:5

    Topics: Chromosome Aberrations; Comet Assay; DNA Damage; Glutathione; Micronucleus Tests; Mutagens; Patulin

2012
Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro.
    Mutation research, 1982, Volume: 103, Issue:1

    Topics: Animals; Biotransformation; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Crossing Over

1982
Chromosomal analysis in bone-marrow cells of Chinese hamsters after treatment with mycotoxins.
    Mutation research, 1980, Volume: 78, Issue:1

    Topics: Administration, Oral; Aflatoxins; Animals; Bone Marrow; Chromosome Aberrations; Chromosomes; Criceti

1980
Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin.
    Carcinogenesis, 1998, Volume: 19, Issue:7

    Topics: Aneuploidy; Animals; Anti-Bacterial Agents; Cattle; Cells, Cultured; Chromosome Aberrations; Chromos

1998
Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity.
    Mutagenesis, 2000, Volume: 15, Issue:3

    Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Cell Division; Cell Line; Cell Survival; Cells, Cultur

2000
The influence of ethanol treatment of cytogenetic effects in bone marrow cells of Chinese hamsters by cyclophosphamide, aflatoxin B1 and patulin.
    Toxicology, 1979, Volume: 12, Issue:1

    Topics: Aflatoxins; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Cricetinae

1979
Mutagenicity and inducibility of DNA single-strand breaks and chromosome aberrations by various mycotoxins.
    Gan, 1977, Volume: 68, Issue:5

    Topics: Aflatoxins; Animals; Azaguanine; Cell Line; Chromosome Aberrations; DNA, Single-Stranded; Drug Evalu

1977