parthenolide and Leukemia, Myeloid, Acute

parthenolide has been researched along with Leukemia, Myeloid, Acute in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (21.43)29.6817
2010's22 (78.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crooks, PA; Guzman, ML; Jordan, CT; Nasim, S; Neelakantan, S1
Chen, Y; Ding, Y; Fan, H; Gao, Y; Han, B; Ji, Q; Jia, Y; Li, D; Li, LY; Li, Q; Lin, J; Long, J; Lu, Y; Ma, W; Ma, X; Qiu, C; Shi, Q; Shi, Y; Tong, Z; Yang, M; Zhai, J; Zhang, H; Zhang, J; Zhang, Q; Zhang, W1
Borrelli, MJ; Crooks, PA; Janganati, V; Jordan, CT; Penthala, NR; Ponder, J1
Albayati, ZAF; Breen, PJ; Chen, Z; Crooks, PA; Janganati, V; Jordan, CT; Ponder, J1
Chen, Y; Ding, Y; Gao, Y; Ge, W; Kang, N; Kuang, B; Lian, L; Wei, Y; Yang, Z; Zhang, Q1
Chen, Y; Ding, YH; Gao, HE; Gao, YD; Ji, Q; Li, YH; Liu, XL; Long, J; Sun, Y; Yang, M; Zhang, Q1
Chen, L; Gallucci, JC; Kinghorn, AD; Li, X; Ren, Y; Yu, J1
Chen, Y; Ding, Y; Ge, W; Kuang, B; Xu, J; Yang, J; Yang, Z; Zhang, Q1
Chen, X; Chen, Y; Ding, Y; Ge, W; Guo, H; Li, S; Liu, Z; Sun, Y; Wang, M; Wang, T; Zhang, Q1
Anber, N; Azmy, E; Bharali, DJ; Darwish, NHE; El-Ghaffar, HAA; Elbaz, O; Godugu, K; Mousa, SA; Sudha, T1
Becker, MW; Corbett, C; Guzman, ML; Hassane, DC; Jordan, CT; Sen, S1
Ashton, JM; Balys, M; Becker, MW; Benes, C; Callahan, KP; Corbett, C; Crooks, PA; Greninger, P; Hagen, FK; Jordan, CT; Lagadinou, ED; Li, Z; Liesveld, JL; Minhajuddin, M; Munger, J; Neering, SJ; O'Dwyer, KM; Pei, S; Settleman, J; Shi, L; Ye, H1
Fasan, R; Jordan, CT; Kolev, JN; O'Dwyer, KM1
Abdel-Wahab, O; Balys, M; Becker, MW; Corbett, CA; Guzman, ML; Hassane, DC; Jordan, CT; Levine, RL; Marcucci, G; Roboz, GJ; Sharma, KK; Steidl, U; Yang, N1
Andrews, TE; Harki, DA; Hexum, JK; Kempema, AM; Largaespada, DA; Meece, FA; Noble, KE; Rathe, SK; Sachs, Z; Wang, D; Widen, JC1
Albayati, ZF; Crooks, PA; Ferrari, M; Gorenstein, DG; Guzman, ML; Liu, X; Mu, C; Roboz, GJ; Sen, S; Shen, H; Zhang, G; Zong, H1
Alas, MA; Bystrom, LM; Compadre, CM; Enriquez, RG; Guzman, ML; Jones, DE; Malagón, O; Ordóñez, PE; Sharma, KK1
Adane, B; Ashton, JM; Crooks, PA; D'Alessandro, A; De, S; Gutman, JA; Hagen, FK; Hansen, KC; Jordan, CT; Khan, N; Minhajuddin, M; Nemkov, T; Pei, S; Pollyea, DA; Smith, C; Stevens, BM; Yadav, VK1
Tallman, M1
Cheong, JW; Eom, JI; Jeung, HK; Kim, JS; Kim, SJ; Kim, YR; Min, YH1
Chen, S; Dai, Y; Dent, P; Grant, S; Guzman, ML; Jordan, CT; Pei, XY; Wang, L; Yeung, SK1
Balys, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Minhajuddin, M; Rossi, RM; Sen, S; Wei, L1
Bai, S; Lu, J; Sheng, G; Wang, C; Wang, L; Wang, Y1
Bujnicki, T; Feldmann, F; Klempnauer, KH; Müller-Tidow, C; Schlenke, P; Schmidt, TJ; Schomburg, C; Wilczek, C1
Guzman, ML; Howard, DS; Jordan, CT; Karnischky, L; Li, X; Peterson, DR; Rossi, RM1
Guzman, ML; Jordan, CT1
Becker, MW; Bennett, JM; Carroll, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Lachowicz, JL; Li, X; Liesveld, JL; Matthews, W; Neelakantan, S; Rossi, RM; Sullivan, E; Sweeney, CJ; Vaughan, A1
Abboud, R; Carroll, M; Corbett, C; Guzman, ML; Hassane, DC; Jordan, CT; Li, X; Liesveld, JL; Young, F1

Trials

2 trial(s) available for parthenolide and Leukemia, Myeloid, Acute

ArticleYear
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
    Experimental hematology, 2013, Volume: 41, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Cell Line, Tumor; Ciclopirox; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyridones; Sesquiterpenes; TOR Serine-Threonine Kinases

2013
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
    The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD34; Dioxolanes; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leukemia, Myeloid, Acute; Male; Oxidation-Reduction; Oxidative Stress; Sesquiterpenes; Tumor Cells, Cultured

2013

Other Studies

26 other study(ies) available for parthenolide and Leukemia, Myeloid, Acute

ArticleYear
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Animals; Antineoplastic Agents; Cell Death; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid, Acute; Models, Chemical; NF-kappa B; Rats; Sesquiterpenes; Solubility; Water

2009
Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
    Journal of medicinal chemistry, 2012, Oct-25, Volume: 55, Issue:20

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Prodrugs; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Transplantation, Heterologous

2012
Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
    Journal of medicinal chemistry, 2015, Nov-25, Volume: 58, Issue:22

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Dimerization; Drug Screening Assays, Antitumor; Gliosarcoma; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Neoplasms; Primary Cell Culture; Rats; Sesquiterpenes; Structure-Activity Relationship; Tumor Stem Cell Assay

2015
Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Neoplasms, Experimental; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured

2017
Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Sesquiterpenes; Structure-Activity Relationship

2017
Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.
    Oncotarget, 2017, Jun-13, Volume: 8, Issue:24

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mice; Mice, Inbred NOD; Mice, SCID; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2017
Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
    Journal of natural products, 2018, 03-23, Volume: 81, Issue:3

    Topics: Apoptosis; Asteraceae; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes

2018
Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents.
    Journal of enzyme inhibition and medicinal chemistry, 2018, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esters; Heterografts; Humans; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Mice; Molecular Structure; Sesquiterpenes; Thiocarbamates

2018
Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia.
    Bioorganic chemistry, 2019, Volume: 87

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Vorinostat

2019
Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia.
    Molecules (Basel, Switzerland), 2019, Jun-03, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Aged; Antigens, CD; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dynamic Light Scattering; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Nanoparticles; NF-kappa B; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Sesquiterpenes; Young Adult

2019
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
    ACS chemical biology, 2014, Jan-17, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Cytochrome P-450 Enzyme System; Drug Discovery; Humans; Leukemia, Myeloid, Acute; Models, Molecular; Oxidation-Reduction; Sesquiterpenes; Tumor Cells, Cultured

2014
Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:8

    Topics: Animals; Antineoplastic Agents; Caspases; Cell Survival; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Phenylbutyrates; Sesquiterpenes; Transcriptome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
    Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

    Topics: Alkenes; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Conformation; Neoplastic Stem Cells; Reactive Oxygen Species; Sesquiterpenes

2015
In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche.
    Leukemia, 2016, Volume: 30, Issue:7

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Neoplastic Stem Cells; Sesquiterpenes; Stem Cell Niche; Xenograft Model Antitumor Assays

2016
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Antineoplastic Agents; Asteraceae; Blotting, Western; Drug Screening Assays, Antitumor; Ecuador; HeLa Cells; HL-60 Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Medicine, Traditional; Molecular Structure; Sesquiterpenes

2016
Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
    The Journal of biological chemistry, 2016, Oct-14, Volume: 291, Issue:42

    Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxyglucose; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Male; NADP; Neoplasm Proteins; Neoplastic Stem Cells; NF-E2-Related Factor 2; Sesquiterpenes; Sirolimus; Up-Regulation

2016
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin

2008
Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Glutathione; Humans; Leukemia, Myeloid, Acute; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Neoplastic Stem Cells; Peroxidase; Reactive Oxygen Species; RNA, Small Interfering; Sesquiterpenes; Transfection; Xenograft Model Antitumor Assays

2010
The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
    British journal of haematology, 2010, Volume: 151, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Activation; Histone Deacetylase Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes; Signal Transduction; Tumor Cells, Cultured

2010
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
    Blood, 2010, Dec-23, Volume: 116, Issue:26

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Blotting, Western; Bone Marrow; Cell Proliferation; Cells, Cultured; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases

2010
Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.
    Journal of biochemical and molecular toxicology, 2012, Volume: 26, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cyclin D1; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Nuclear Receptor Co-Repressor 2; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays

2012
Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
    Leukemia, 2012, Volume: 26, Issue:4

    Topics: Acetyltransferases; Animals; Cell Line; Cell Proliferation; Chickens; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Lactones; Leukemia, Myeloid, Acute; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myb; Sesquiterpenes

2012
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
    Blood, 2005, Jun-01, Volume: 105, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blast Crisis; Cells, Cultured; Humans; Lactones; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Transplantation, Heterologous; Tumor Stem Cell Assay; Tumor Suppressor Protein p53

2005
Feverfew: weeding out the root of leukaemia.
    Expert opinion on biological therapy, 2005, Volume: 5, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; NF-kappa B; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium; Xenograft Model Antitumor Assays

2005
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
    Blood, 2007, Dec-15, Volume: 110, Issue:13

    Topics: Animals; Biological Availability; Dogs; Drug Design; Humans; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; NF-kappa B; Oxidative Stress; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
    Blood, 2008, Jun-15, Volume: 111, Issue:12

    Topics: Aldehydes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Death; Cysteine Proteinase Inhibitors; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Models, Genetic; Neoplastic Stem Cells; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Sesquiterpenes; Terpenes; Triterpenes; Xenograft Model Antitumor Assays

2008