parthenolide has been researched along with Leukemia, Myeloid, Acute in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 22 (78.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crooks, PA; Guzman, ML; Jordan, CT; Nasim, S; Neelakantan, S | 1 |
| Chen, Y; Ding, Y; Fan, H; Gao, Y; Han, B; Ji, Q; Jia, Y; Li, D; Li, LY; Li, Q; Lin, J; Long, J; Lu, Y; Ma, W; Ma, X; Qiu, C; Shi, Q; Shi, Y; Tong, Z; Yang, M; Zhai, J; Zhang, H; Zhang, J; Zhang, Q; Zhang, W | 1 |
| Borrelli, MJ; Crooks, PA; Janganati, V; Jordan, CT; Penthala, NR; Ponder, J | 1 |
| Albayati, ZAF; Breen, PJ; Chen, Z; Crooks, PA; Janganati, V; Jordan, CT; Ponder, J | 1 |
| Chen, Y; Ding, Y; Gao, Y; Ge, W; Kang, N; Kuang, B; Lian, L; Wei, Y; Yang, Z; Zhang, Q | 1 |
| Chen, Y; Ding, YH; Gao, HE; Gao, YD; Ji, Q; Li, YH; Liu, XL; Long, J; Sun, Y; Yang, M; Zhang, Q | 1 |
| Chen, L; Gallucci, JC; Kinghorn, AD; Li, X; Ren, Y; Yu, J | 1 |
| Chen, Y; Ding, Y; Ge, W; Kuang, B; Xu, J; Yang, J; Yang, Z; Zhang, Q | 1 |
| Chen, X; Chen, Y; Ding, Y; Ge, W; Guo, H; Li, S; Liu, Z; Sun, Y; Wang, M; Wang, T; Zhang, Q | 1 |
| Anber, N; Azmy, E; Bharali, DJ; Darwish, NHE; El-Ghaffar, HAA; Elbaz, O; Godugu, K; Mousa, SA; Sudha, T | 1 |
| Becker, MW; Corbett, C; Guzman, ML; Hassane, DC; Jordan, CT; Sen, S | 1 |
| Ashton, JM; Balys, M; Becker, MW; Benes, C; Callahan, KP; Corbett, C; Crooks, PA; Greninger, P; Hagen, FK; Jordan, CT; Lagadinou, ED; Li, Z; Liesveld, JL; Minhajuddin, M; Munger, J; Neering, SJ; O'Dwyer, KM; Pei, S; Settleman, J; Shi, L; Ye, H | 1 |
| Fasan, R; Jordan, CT; Kolev, JN; O'Dwyer, KM | 1 |
| Abdel-Wahab, O; Balys, M; Becker, MW; Corbett, CA; Guzman, ML; Hassane, DC; Jordan, CT; Levine, RL; Marcucci, G; Roboz, GJ; Sharma, KK; Steidl, U; Yang, N | 1 |
| Andrews, TE; Harki, DA; Hexum, JK; Kempema, AM; Largaespada, DA; Meece, FA; Noble, KE; Rathe, SK; Sachs, Z; Wang, D; Widen, JC | 1 |
| Albayati, ZF; Crooks, PA; Ferrari, M; Gorenstein, DG; Guzman, ML; Liu, X; Mu, C; Roboz, GJ; Sen, S; Shen, H; Zhang, G; Zong, H | 1 |
| Alas, MA; Bystrom, LM; Compadre, CM; Enriquez, RG; Guzman, ML; Jones, DE; Malagón, O; Ordóñez, PE; Sharma, KK | 1 |
| Adane, B; Ashton, JM; Crooks, PA; D'Alessandro, A; De, S; Gutman, JA; Hagen, FK; Hansen, KC; Jordan, CT; Khan, N; Minhajuddin, M; Nemkov, T; Pei, S; Pollyea, DA; Smith, C; Stevens, BM; Yadav, VK | 1 |
| Tallman, M | 1 |
| Cheong, JW; Eom, JI; Jeung, HK; Kim, JS; Kim, SJ; Kim, YR; Min, YH | 1 |
| Chen, S; Dai, Y; Dent, P; Grant, S; Guzman, ML; Jordan, CT; Pei, XY; Wang, L; Yeung, SK | 1 |
| Balys, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Minhajuddin, M; Rossi, RM; Sen, S; Wei, L | 1 |
| Bai, S; Lu, J; Sheng, G; Wang, C; Wang, L; Wang, Y | 1 |
| Bujnicki, T; Feldmann, F; Klempnauer, KH; Müller-Tidow, C; Schlenke, P; Schmidt, TJ; Schomburg, C; Wilczek, C | 1 |
| Guzman, ML; Howard, DS; Jordan, CT; Karnischky, L; Li, X; Peterson, DR; Rossi, RM | 1 |
| Guzman, ML; Jordan, CT | 1 |
| Becker, MW; Bennett, JM; Carroll, M; Corbett, CA; Crooks, PA; Guzman, ML; Hassane, DC; Jordan, CT; Lachowicz, JL; Li, X; Liesveld, JL; Matthews, W; Neelakantan, S; Rossi, RM; Sullivan, E; Sweeney, CJ; Vaughan, A | 1 |
| Abboud, R; Carroll, M; Corbett, C; Guzman, ML; Hassane, DC; Jordan, CT; Li, X; Liesveld, JL; Young, F | 1 |
2 trial(s) available for parthenolide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Cell Line, Tumor; Ciclopirox; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyridones; Sesquiterpenes; TOR Serine-Threonine Kinases | 2013 |
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD34; Dioxolanes; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leukemia, Myeloid, Acute; Male; Oxidation-Reduction; Oxidative Stress; Sesquiterpenes; Tumor Cells, Cultured | 2013 |
26 other study(ies) available for parthenolide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Topics: Animals; Antineoplastic Agents; Cell Death; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid, Acute; Models, Chemical; NF-kappa B; Rats; Sesquiterpenes; Solubility; Water | 2009 |
Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Prodrugs; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Transplantation, Heterologous | 2012 |
Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Dimerization; Drug Screening Assays, Antitumor; Gliosarcoma; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Neoplasms; Primary Cell Culture; Rats; Sesquiterpenes; Structure-Activity Relationship; Tumor Stem Cell Assay | 2015 |
Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Neoplasms, Experimental; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Sesquiterpenes; Structure-Activity Relationship | 2017 |
Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Mice; Mice, Inbred NOD; Mice, SCID; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays | 2017 |
Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
Topics: Apoptosis; Asteraceae; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes | 2018 |
Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esters; Heterografts; Humans; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Mice; Molecular Structure; Sesquiterpenes; Thiocarbamates | 2018 |
Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Molecular Docking Simulation; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Vorinostat | 2019 |
Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia.
Topics: Adolescent; Adult; Aged; Antigens, CD; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dynamic Light Scattering; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Nanoparticles; NF-kappa B; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Sesquiterpenes; Young Adult | 2019 |
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
Topics: Antineoplastic Agents; Apoptosis; Biocatalysis; Cytochrome P-450 Enzyme System; Drug Discovery; Humans; Leukemia, Myeloid, Acute; Models, Molecular; Oxidation-Reduction; Sesquiterpenes; Tumor Cells, Cultured | 2014 |
Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia.
Topics: Animals; Antineoplastic Agents; Caspases; Cell Survival; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Phenylbutyrates; Sesquiterpenes; Transcriptome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2014 |
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Topics: Alkenes; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Conformation; Neoplastic Stem Cells; Reactive Oxygen Species; Sesquiterpenes | 2015 |
In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Neoplastic Stem Cells; Sesquiterpenes; Stem Cell Niche; Xenograft Model Antitumor Assays | 2016 |
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.
Topics: Antineoplastic Agents; Asteraceae; Blotting, Western; Drug Screening Assays, Antitumor; Ecuador; HeLa Cells; HL-60 Cells; Humans; Lactones; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Medicine, Traditional; Molecular Structure; Sesquiterpenes | 2016 |
Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxyglucose; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Male; NADP; Neoplasm Proteins; Neoplastic Stem Cells; NF-E2-Related Factor 2; Sesquiterpenes; Sirolimus; Up-Regulation | 2016 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Glutathione; Humans; Leukemia, Myeloid, Acute; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Neoplastic Stem Cells; Peroxidase; Reactive Oxygen Species; RNA, Small Interfering; Sesquiterpenes; Transfection; Xenograft Model Antitumor Assays | 2010 |
The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Activation; Histone Deacetylase Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; NF-kappa B; Sesquiterpenes; Signal Transduction; Tumor Cells, Cultured | 2010 |
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Blotting, Western; Bone Marrow; Cell Proliferation; Cells, Cultured; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases | 2010 |
Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cyclin D1; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Nuclear Receptor Co-Repressor 2; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
Topics: Acetyltransferases; Animals; Cell Line; Cell Proliferation; Chickens; Gene Expression Regulation, Neoplastic; Humans; K562 Cells; Lactones; Leukemia, Myeloid, Acute; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myb; Sesquiterpenes | 2012 |
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blast Crisis; Cells, Cultured; Humans; Lactones; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Transplantation, Heterologous; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2005 |
Feverfew: weeding out the root of leukaemia.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; NF-kappa B; Plants, Medicinal; Sesquiterpenes; Tanacetum parthenium; Xenograft Model Antitumor Assays | 2005 |
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Topics: Animals; Biological Availability; Dogs; Drug Design; Humans; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; NF-kappa B; Oxidative Stress; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Death; Cysteine Proteinase Inhibitors; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Models, Genetic; Neoplastic Stem Cells; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Sesquiterpenes; Terpenes; Triterpenes; Xenograft Model Antitumor Assays | 2008 |