paroxetine has been researched along with Disease Models, Animal in 125 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (8.00) | 18.2507 |
| 2000's | 38 (30.40) | 29.6817 |
| 2010's | 65 (52.00) | 24.3611 |
| 2020's | 12 (9.60) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cai, X; Huang, Y; Lao, L; Qu, S; Yao, Z; Zhang, J; Zhang, Z; Zheng, Y; Zhong, Z | 1 |
| Finsen, B; Gramsbergen, JB; Hasselstrøm, J; Lambertsen, KL; Metaxas, A; Olesen, LØ; Severino, M; Sivasaravanaparan, M; von Linstow, CU; Wiborg, O | 1 |
| Carrasco-Carballo, A; Chamorro-Arenas, D; Hernández-Arrambide, PE; Luna, F; Martínez, I; Mendieta, L; Parra, I; Sartillo-Piscil, F; Tizabi, Y | 1 |
| Garabadu, D; Krishnamurthy, S; Prajapati, SK; Singh, N | 1 |
| Arroo, R; Jaddoa, E; Masania, J; Masiero, E; Sgamma, T; Sillence, D; Zetterström, T | 1 |
| Guo, P; Han, Y; Lai, J; Tai, Y; Tao, J; Wang, M; Wang, Q; Wang, Z; Zhou, W | 1 |
| Chamorro-Arenas, D; Godínez-Chaparro, B; Martinez-Mendieta, L; Quintero, L; Salgado-Moreno, G; Sartillo-Piscil, F | 1 |
| Krishnamurthy, S; Prajapati, SK | 1 |
| Ghafghazi, S; Mortazavi, SE; Parvardeh, S; Pouriran, R; Sheikholeslami, MA | 1 |
| Cai, J; Huang, Y; Jiang, W; Lu, Y; Peng, L; Sun, X; Wen, G; Wu, J; Yuan, H; Zhou, M | 1 |
| Bambico, FR; Blundell, J; Conway, JD; Dinesh, OC; Hasan, SN; Nobrega, JN; Raymond, R; Waye, SC | 1 |
| Han, Y; Hu, S; Sun, W; Wang, L; Wang, Q; Wang, R; Wang, X; Wei, W; Wu, L; Wu, Y; Zhang, L; Zhang, M | 1 |
| Bermudez, I; Csanova, A; Franklin, M; Hlavacova, N; Jezova, D; Li, Y; Sanchez, C | 1 |
| Jiang, H; Liu, D; Liu, Y; Pan, F; Xu, J | 1 |
| Huang, HP; Li, XF; Lin, MX; Lin, WH; Zhou, Y | 1 |
| Bao, G; Cui, Z; Jiang, B; Sun, Y; Wang, C; Wang, F; Wang, H; Wang, Y; Xu, D; Zhao, W | 1 |
| Frokjaer, VG; Galea, LAM; Lieblich, SE; Overgaard, A; Richardson, R | 1 |
| Biber, K; Bischofberger, J; Clark, K; Dorner, A; Frase, S; Haug, V; Horn, M; Klugbauer, N; Münzer, P; Nissen, C; Normann, C; Scholliers, J; Seifert, G; Serchov, T; Vo Van, T; von Wolff, G | 1 |
| Bermudez, I; Csanova, A; Franklin, M; Hlavacova, N; Jezova, D; Li, Y; Pehrson, A; Sanchez, C | 1 |
| Aungier, J; Cuesta, M; Morton, AJ; Ouk, K | 1 |
| Adefegha, SA; Dada, FA; Oboh, G; Olasehinde, TA; Oyeleye, SI | 1 |
| Clinton, SM; Glover, ME; Jackson, NL; McCoy, CR; Shupe, EA; Unroe, KA | 1 |
| Franc, B; Lanfumey, L; Martin, V; Mongeau, R; Poilbout, C; Règue, M | 1 |
| Adebayo, AA; Ademosun, AO; Oboh, G | 1 |
| Casarotto, PC; Guimarães, FS; Hiroaki-Sato, VA; Joca, SR; Pereira, VS; Sartim, AG | 1 |
| Liebl, C; Müller, MB; Scharf, SH; Schmidt, MV; Sterlemann, V | 1 |
| Campos, FL; Carvalho, MM; Coimbra, B; Lima, R; Pêgo, JM; Rodrigues, AJ; Rodrigues, C; Salgado, AJ; Sousa, N | 1 |
| Fellous, JM; Krahl, SE; Langevin, JP; Stidd, DA; Vogelsang, K | 1 |
| Garabadu, D; Joy, KP; Krishnamurthy, S | 1 |
| Hisaoka-Nakashima, K; Kajitani, N; Morinobu, S; Okada-Tsuchioka, M; Segawa, M; Shibasaki, C; Takebayashi, M | 1 |
| Bijlsma, EY; Chan, JS; Millan, MJ; Olivier, B; Oosting, RS; Veening, JG; Waldinger, MD | 1 |
| Ajiboye, TO; Nurudeen, QO; Yakubu, MT | 1 |
| Bortolatto, CF; Brüning, CA; Gai, BM; Nogueira, CW; Stein, AL; Zborowski, VA; Zeni, G | 1 |
| Moini Zanjani, T; Sabetkasaei, M; Zarei, M | 1 |
| Bennett, KL; Berger, J; Ghafari, M; Kotlowski, C; Kotlowsky, C; Lubec, G; Miklósi, AG; Schmuckermair, C; Singewald, N; Whittle, N | 1 |
| Kikuchi, S; Konno, S; Saito, H; Sekiguchi, M; Wakai, J | 1 |
| Engle, EL; Graham, DR; Liu, J; Mankowski, JL; Meulendyke, KA; Nath, A; Queen, SE; Shirk, EN; Steiner, JP; Tarwater, PM; Zink, MC | 1 |
| Cook, A; Forster, GL; Mears, M; Renner, KJ; Scholl, JL; Tu, W; Watt, MJ | 1 |
| Beeské, S; Belzung, C; Griebel, G; Philbert, J | 1 |
| Akil, H; Clinton, SM; Cohen, JL; Fant, AD; Glover, ME; Jackson, NL; Pugh, PC | 1 |
| Blier, P; Chenu, F; El Iskandrani, KS; El Mansari, M; Manta, S; Oosterhof, C; Shim, S | 1 |
| Bétry, C; Bundgaard, C; Haddjeri, N; Mørk, A; Overstreet, D; Pehrson, AL; Sanchez, C | 1 |
| De Gobbi, JI; Matsubara, BB; Matsubara, LS; Omoto, AC; Roscani, MG; Siqueira, TF | 1 |
| Benetti, F; Blandina, P; Cassano, T; Corradetti, R; Galeotti, N; Munari, L; Passani, MB; Provensi, G | 1 |
| Li, F; Ling, Z; Liu, C; Liu, L; Liu, X; Shu, N; Xu, D; Zhang, M; Zhong, Z | 1 |
| Baas, JM; Bijlsma, EY; Groenink, L; Hendriksen, H; Millan, MJ | 1 |
| Furukawa, T; Migita, K; Nakashima, T; Nikaido, Y; Shiba, Y; Ueno, S; Yamada, J | 1 |
| Ali, J; Baboota, S; Gupta, BK; Kumar, S; Pandey, YR | 1 |
| Ba-M'hamed, S; Bennis, M; Bentefour, Y; Garcia, R; Rakibi, Y | 1 |
| Conti, AC; Eagle, AL; Galloway, MP; George, SA; Gerard, J; Ghoddoussi, F; Harutyunyan, A; Hool, SM; Kohler, RJ; Liberzon, I; Mulo, K; Perrine, SA; Schneider, BL; Susick, LL | 1 |
| Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN | 1 |
| Brüning, CA; Duarte, T; Mantovani, AC; Nogueira, CW; Pesarico, AP; Sartori, G; Zeni, G | 1 |
| Huang, S; Liu, C; Liu, X; Ye, Y | 1 |
| Arai, A; Hirota, Y; Mitsui, S; Miyase, N; Miyata, S; Osako, Y; Young, LJ; Yuri, K | 1 |
| Bouzinova, EV; Finsen, B; Hasselstrøm, JB; Olesen, LØ; Severino, M; Sivasaravanaparan, M; Wiborg, O | 1 |
| Dudka, J; Poleszak, E; Serefko, A; Stasiuk, W; Świąder, K; Szopa, A; Wlaź, P; Wyska, E | 1 |
| Chen, YC; Jin, X; Liu, Y; Luo, XX; Tan, QR; Wang, HN; Wang, W; Zheng, H; Zheng, LN | 1 |
| Deussing, JM; Henniger, MS; Holsboer, F; Kühne, C; Ohl, F; Paez-Pereda, M; Panhuysen, M; Pohl, T; Pütz, B; Sillaber, I | 1 |
| DU, HG; Fu, XC; Ma, GY; Zheng, H | 1 |
| Breuer, ME; Campbell, U; Chan, JS; Groenink, L; Hanania, T; Korte, SM; Olivier, B; Oosting, RS; Schreiber, R; Snoeren, EM; Waldinger, M | 1 |
| Abe, H; Ikeda, T; Ishida, Y; Nakamura, T; Naono, R; Nishimori, T; Takeda, R | 1 |
| Becker, A; Bock, N; Manzke, T; Roessner, V; Rothenberger, A | 1 |
| David, DJ; Deltheil, T; Gardier, AM; Hen, R; Reperant, C; Tanaka, K | 1 |
| Glubb, DM; Joyce, PR; Kennedy, MA; McHugh, PC; Rogers, GR | 1 |
| Imai, T; Inoue, K; Nagata, K; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T | 1 |
| Aznar, S; Knudsen, GM; Licht, CL; Marcussen, AB; Overstreet, DH; Wegener, G | 1 |
| Funato, H; Hobara, T; Matsubara, T; Matsuo, K; Otsuki, K; Suetsugi, M; Uchida, S; Watanabe, Y | 1 |
| Iannucci, AR; Scialli, AR | 1 |
| Fuchikami, M; Liberzon, I; Matsuki, A; Morinobu, S; Takei, S; Yamamoto, S; Yamawaki, S | 1 |
| Blokland, A; Dawson, N; Ferrington, L; Kelly, PA; Prickaerts, J; Steinbusch, HW; van Donkelaar, EL | 1 |
| Joel, D; Klavir, O; Schilman, EA; Sohr, R; Winter, C | 1 |
| Scialli, AR | 1 |
| Del Rio, J; Elizalde, N; García-García, AL; Gendive, N; Ramirez, MJ; Tordera, RM; Totterdell, S; Venzala, E | 1 |
| Gay, BM; Nogueira, CW; Prigol, M; Stein, AL | 1 |
| Chan, JS; de Jong, TR; Olivier, B; Oosting, RS; Snoeren, EM; Waldinger, MD | 1 |
| Audi, EA; Biesdorf de Almeida, C; de Mello, JC; Klein, T; Roncon, CM | 1 |
| David, DJ; Deltheil, T; Gardier, AM; Guiard, BP; Guilloux, JP; Hen, R; Nguyen, HT; Rainer, Q; Repérant, C; Toth, M; Xia, L | 1 |
| Hetzenauer, A; Sartori, SB; Singewald, N; Whittle, N | 1 |
| Chi, H; Eguchi, S; Kawano, T; Soga, T; Yamazaki, F; Yokoyama, M | 1 |
| Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N | 1 |
| Neumann, ID; Slattery, DA; Toth, I | 1 |
| Fukunaga, K; Tagashira, H | 1 |
| He, B; Qiao, F; Wang, H; Wu, Y; Zhao, M; Zuo, D | 1 |
| Bazanella Sampaio, T; Mozzaquatro Gai, B; Nogueira, CW; Pinton, S; Trevisan da Rocha, J; Zeni, G | 1 |
| Jun, IG; Kim, SH; Lee, BS; Park, JY | 1 |
| Holsboer, F; Keck, ME; Landgraf, R; Müller, MB; Ohl, F; Toschi, N; Uhr, M; Welt, T; Wigger, A | 1 |
| Landgraf, R | 1 |
| Bush, VL; Fone, KC; Marsden, CA; Middlemiss, DN | 1 |
| Balcioglu, A; Tarazi, FI; Zhang, K | 1 |
| Bourin, M; Dailly, E; David, DJ; Hascoët, M; Ripoll, N | 1 |
| Kadioglu, M; Kalyoncu, NI; Kesim, M; Ozyavuz, R; Ulku, C; Yaris, E | 1 |
| Nibuya, M; Nomura, S; Sawamura, T; Shimizu, K; Suzuki, G; Takahashi, Y; Tsunoda, T; Wakizono, T | 1 |
| Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY | 1 |
| Doljansky, J; Joel, D; Rehavi, M; Roz, N | 1 |
| Nakai, K; Nibuya, M; Nomura, S; Sawamura, T; Shimizu, K; Takahashi, Y | 1 |
| Holsboer, F; Keck, ME; Landgraf, R; Müller, MB; Ohl, F; Sartori, SB; Singewald, N; Welt, T | 1 |
| Bonikovski, V; Futuro-Neto, HA; Pires, JG | 1 |
| Kikuchi, A; Nibuya, M; Sawamura, T; Shimizu, K; Soichiro, N; Suzuki, G; Takahashi, Y; Toda, H; Wakizono, T | 1 |
| Ishii, S; Ito, T; Kaneko, Y; Kashiwa, A; Nishikawa, T; Umino, A | 1 |
| Bourin, M; Chenu, F; Gardier, AM; Guiard, BP | 1 |
| Iwamoto, Y; Morinobu, S; Takahashi, T; Yamawaki, S | 1 |
| Brimberg, L; Flaisher-Grinberg, S; Joel, D; Schilman, EA | 1 |
| Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R; Orito, K | 1 |
| Brown, M; Clark, RF; Gray, AJ; Guo, Z; Halagappa, VM; Iyun, T; Martin, B; Matsuoka, Y; Mattson, MP; Maudsley, S; Nelson, RL; Pearson, M | 1 |
| Alam, S; Ganea, K; Greetfeld, M; Harbich, D; Holsboer, F; Liebl, C; Müller, MB; Schmidt, MV; Sterlemann, V; Uhr, M | 1 |
| Andreatini, R; Casarotto, PC | 1 |
| Ikeda, S; Jiang, J; Kuhara, T; Ogawa, H; Suto, H; Ueki, R; Zheng, Y | 1 |
| Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM | 1 |
| Bales, KR | 1 |
| Corbett, R; Kongsamut, S; Roehr, J; Woods, A | 1 |
| Gray, AM; Rafieian-Kopaei, M; Sewell, RD; Spencer, PS | 1 |
| McCook, EC; Ritchie, JC; Seidler, FJ; Slotkin, TA | 1 |
| Keith, SJ; Nurnberg, HG; Paxton, DM | 1 |
| Costentin, J; Passera, G; Vaugeois, JM; Zuccaro, F | 1 |
| Cryan, JF; Leonard, BE; McGrath, C; Norman, TR | 2 |
| Bourin, M; Redrobe, JP | 1 |
| Becker, A; Frank, C; Grecksch, G; Huether, G; Pilz, J; Zhou, D | 1 |
| De Vry, J; Maurel, S; Schreiber, R | 1 |
| Duxon, MS; Starr, KR; Upton, N | 1 |
| Behr, J; Gentsch, K; Heinemann, U; Schmitz, B | 1 |
| Bourin, M; David, DJ; Hascoët, M; Jolliet, P; Nic Dhonnchadha, BA | 1 |
| Connor, TJ; Harkin, A; Kelly, JP; Leonard, BE; Mulrooney, J | 1 |
6 review(s) available for paroxetine and Disease Models, Animal
| Article | Year |
|---|---|
Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release?
Topics: Animals; Antidepressive Agents; Aza Compounds; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Buspirone; Cyclohexanols; Disease Models, Animal; Dopamine; Female; Humans; Indoles; Male; Norepinephrine; Paroxetine; Pyridines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Sexual Behavior, Animal; Sexual Dysfunction, Physiological; Synaptic Transmission; Venlafaxine Hydrochloride | 2014 |
Single prolonged stress: toward an animal model of posttraumatic stress disorder.
Topics: Animals; Antidepressive Agents, Second-Generation; Antimetabolites; Arousal; Brain; Conditioning, Classical; Cycloserine; Disease Models, Animal; Extinction, Psychological; Fear; Glucocorticoids; Humans; Mental Recall; Paroxetine; Rats; Stress Disorders, Post-Traumatic | 2009 |
[Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist].
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Disease Models, Animal; Fluvoxamine; Heart Ventricles; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type III; Paroxetine; Proto-Oncogene Proteins c-akt; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Signal Transduction | 2012 |
[An animal model of posttraumatic stress disorder and its validity: effect of paroxetine on a PTSD model in rats].
Topics: Animals; Behavior, Animal; Disease Models, Animal; Male; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic | 2004 |
[An animal model of posttraumatic stress disorder in rats using a shuttle box].
Topics: Animals; Disease Models, Animal; Male; Paroxetine; Rats; Rats, Inbred F344; Rats, Wistar; Stress Disorders, Post-Traumatic | 2006 |
Paroxetine administration decreases AD-like pathology and reverses memory impairments in a transgenic model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Memory; Memory Disorders; Mice; Paroxetine | 2007 |
1 trial(s) available for paroxetine and Disease Models, Animal
| Article | Year |
|---|---|
Chronic social stress during adolescence: interplay of paroxetine treatment and ageing.
Topics: Adrenal Glands; Aging; Animals; Arginine Vasopressin; Body Weight; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; Dexamethasone; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Longitudinal Studies; Male; Mice; Paroxetine; Receptors, Glucocorticoid; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress, Psychological; Thymus Gland | 2013 |
118 other study(ies) available for paroxetine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Dopaminergic signaling in prefrontal cortex contributes to the antidepressant effect of electroacupuncture: An iTRAQ-based proteomics analysis in a rat model of CUMS.
Topics: Anhedonia; Animals; Antidepressive Agents; Combined Modality Therapy; Disease Models, Animal; Dopamine; Electroacupuncture; Male; Paroxetine; Prefrontal Cortex; Proteomics; Rats; Rats, Wistar; Signal Transduction; Stress, Psychological; Treatment Outcome | 2021 |
Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Paroxetine; Plaque, Amyloid; Presenilin-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2022 |
Antidepressant and Neuroprotective Effects of 3-Hydroxy Paroxetine, an Analog of Paroxetine in Rats.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Male; Neuroprotective Agents; Parkinson Disease; Paroxetine; Rats; Rats, Wistar; Serotonin Plasma Membrane Transport Proteins; Substantia Nigra; Tyrosine 3-Monooxygenase | 2023 |
A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Cues; Depression; Disease Models, Animal; Electric Stimulation; Hypothalamo-Hypophyseal System; Male; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic | 2020 |
Effect of antidepressant drugs on the brain sphingolipid system.
Topics: Acid Ceramidase; Adrenergic Uptake Inhibitors; Animals; Brain; Depressive Disorder, Major; Desipramine; Disease Models, Animal; Male; Mice; Paroxetine; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Selective Serotonin Reuptake Inhibitors; Sphingolipids; Sphingomyelin Phosphodiesterase | 2020 |
Sustaining Circulating Regulatory T Cell Subset Contributes to the Therapeutic Effect of Paroxetine on Mice With Diabetic Cardiomyopathy.
Topics: Animals; Carvedilol; Cell Differentiation; Cells, Cultured; Diabetic Cardiomyopathies; Diet, High-Fat; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; Immunity; Insulin; Male; Mice; Mice, Inbred C57BL; Paroxetine; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Treatment Outcome | 2020 |
Stereoselective Synthesis and Antiallodynic Activity of 3-Hydroxylated Paroxetines.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydroxylation; Molecular Structure; Pain; Paroxetine; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2021 |
Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: Behavioural and neurochemical analyses.
Topics: Amygdala; Animals; Azepines; Corticosterone; Disease Models, Animal; Male; Orexin Receptor Antagonists; Orexins; Paroxetine; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Selective Serotonin Reuptake Inhibitors; Serotonin; Stress Disorders, Post-Traumatic; Triazoles | 2021 |
Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity.
Topics: Animals; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Hippocampus; Male; Malondialdehyde; Memory; Memory Disorders; Neuronal Plasticity; Nitric Oxide; Nitrosative Stress; Oxidative Stress; Paroxetine; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2021 |
Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catecholamines; Cytochrome P-450 CYP2D6 Inhibitors; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; Gene Knockout Techniques; Hypertension; Paroxetine; Rats; Receptors, Adrenergic, beta-1; Signal Transduction | 2021 |
Antidepressant action of transcranial direct current stimulation in olfactory bulbectomised adolescent rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Combined Modality Therapy; Depression; Disease Models, Animal; Male; Olfactory Bulb; Paroxetine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Transcranial Direct Current Stimulation | 2021 |
Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Movement; Chemokine CX3CL1; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; Immunosuppressive Agents; Interleukin-1beta; Lymphocyte Activation; Male; Methotrexate; Paroxetine; Rats; Rats, Wistar; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tumor Necrosis Factor-alpha | 2017 |
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats.
Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Female; Glutamic Acid; Melatonin; Norepinephrine; Paroxetine; Pineal Gland; Piperazines; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA-Binding Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Tryptophan; Vortioxetine | 2017 |
Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats.
Topics: Age Factors; Animals; Anxiety; Disease Models, Animal; Hippocampus; Male; MicroRNAs; Paroxetine; Prefrontal Cortex; Pyrimidines; Pyrroles; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Corticotropin-Releasing Hormone; Selective Serotonin Reuptake Inhibitors; Spatial Memory; Stress, Psychological | 2017 |
Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy; Hippocampus; Immunohistochemistry; Male; Paroxetine; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Rats; Serotonin Plasma Membrane Transport Proteins | 2017 |
Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine.
Topics: Animals; Disease Models, Animal; Food Preferences; Gene Expression Regulation; Green Fluorescent Proteins; Hindlimb Suspension; Hippocampus; Infusions, Intraventricular; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Paroxetine; RNA, Small Interfering; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Stress, Psychological; Sucrose; Swimming; TOR Serine-Threonine Kinases | 2018 |
Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression.
Topics: Animals; Corticosterone; Depression; Depression, Postpartum; Disease Models, Animal; Female; Male; Paroxetine; Peripartum Period; Postpartum Period; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stress, Psychological; Swimming | 2018 |
Antidepressants Rescue Stress-Induced Disruption of Synaptic Plasticity via Serotonin Transporter-Independent Inhibition of L-Type Calcium Channels.
Topics: Age Factors; Animals; Antidepressive Agents; Cadmium Chloride; Calcium Channel Blockers; Calcium Channels, L-Type; CHO Cells; Cricetulus; Disease Models, Animal; Electric Stimulation; Female; Fluvoxamine; HEK293 Cells; Hindlimb Suspension; Hippocampus; Humans; In Vitro Techniques; Male; Membrane Potentials; Nifedipine; Paroxetine; Patch-Clamp Techniques; Piperazines; Pyridines; Rats; Rats, Transgenic; Rats, Wistar; RNA-Binding Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Stress, Psychological; Swimming; Synaptic Transmission; Transfection | 2018 |
Effects of vortioxetine on biomarkers associated with glutamatergic activity in an SSRI insensitive model of depression in female rats.
Topics: Administration, Oral; Animals; Biomarkers; Depressive Disorder; Disease Models, Animal; Female; Glutamic Acid; Paroxetine; Random Allocation; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Vortioxetine | 2018 |
Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease.
Topics: Animals; Central Nervous System Stimulants; Circadian Clocks; Circadian Rhythm; Cocaine; Disease Models, Animal; Female; Huntington Disease; Male; Methamphetamine; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Motor Activity; Paroxetine; Receptors, Dopamine; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptic Transmission; Vesicular Monoamine Transport Proteins | 2018 |
Modulatory effect of quercetin and its glycosylated form on key enzymes and antioxidant status in rats penile tissue of paroxetine-induced erectile dysfunction.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzymes; Erectile Dysfunction; Male; Malondialdehyde; Paroxetine; Penile Erection; Quercetin; Rats; Rutin; Sildenafil Citrate | 2018 |
Perinatal exposure to the SSRI paroxetine alters the methylome landscape of the developing dentate gyrus.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Behavior, Animal; Dentate Gyrus; Depression; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Female; Gene Expression; Male; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Selective Serotonin Reuptake Inhibitors; Sex Factors | 2019 |
Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cytokines; Disease Models, Animal; Fear; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Paroxetine; Receptor, Serotonin, 5-HT2C; RNA Editing; RNA, Messenger; Signal Transduction; Stress Disorders, Post-Traumatic | 2019 |
Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats.
Topics: Acetylcholinesterase; Adenosine Deaminase; Animals; Antidepressive Agents, Second-Generation; Antioxidants; Arginase; Citrus sinensis; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Erectile Dysfunction; Female; GPI-Linked Proteins; Humans; Male; Membrane Proteins; Nitric Oxide; Paroxetine; Penile Erection; Penis; Plant Extracts; Rats; Sexual Behavior; Sildenafil Citrate; Treatment Outcome | 2019 |
Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide.
Topics: Animals; Antidepressive Agents; Brain; Compulsive Behavior; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Hippocampus; Immobility Response, Tonic; Male; Maze Learning; Nitric Oxide; Nitric Oxide Synthase Type II; Paroxetine; Purinergic Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic; Swimming | 2013 |
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits.
Topics: Adrenergic Agents; Animals; Antidepressive Agents; Antiparkinson Agents; Behavior, Animal; Bupropion; Disease Models, Animal; Immunohistochemistry; Levodopa; Mood Disorders; Motor Activity; Oxidopamine; Parkinsonian Disorders; Paroxetine; Rats; Rats, Wistar | 2013 |
Amygdala deep brain stimulation is superior to paroxetine treatment in a rat model of posttraumatic stress disorder.
Topics: Amygdala; Animals; Deep Brain Stimulation; Disease Models, Animal; Male; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic | 2013 |
Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model.
Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brain; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Immobility Response, Tonic; Male; Maze Learning; Paroxetine; Rats; Risperidone; Stress Disorders, Post-Traumatic; Swimming; Time Factors | 2013 |
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus.
Topics: ADAM Proteins; ADAMTS1 Protein; Analysis of Variance; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Electroshock; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Male; Paroxetine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Thrombin; Thrombospondin 1; Time Factors | 2014 |
Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats.
Topics: Administration, Oral; Animals; Aphrodisiacs; Disease Models, Animal; Dose-Response Relationship, Drug; Gonadal Hormones; Male; Paroxetine; Plant Extracts; Plant Roots; Rats, Wistar; Sapindaceae; Sexual Behavior, Animal; Sexual Dysfunction, Physiological; Water | 2014 |
Depression-related behavior and mechanical allodynia are blocked by 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene in a mouse model of neuropathic pain induced by partial sciatic nerve ligation.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Molecular Structure; Neuralgia; Neuropsychological Tests; Organoselenium Compounds; Pain Measurement; Pain Threshold; Paroxetine; Sciatic Neuropathy; Time Factors; Touch | 2014 |
Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain.
Topics: Animals; Disease Models, Animal; Male; Neuralgia; Pain Measurement; Paroxetine; Rats; Rats, Wistar; Sciatic Neuropathy | 2014 |
Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice.
Topics: Amygdala; Analysis of Variance; Animals; Depression; Diet; Disease Models, Animal; Gene Expression Regulation; Hypothalamus; Magnesium; Magnesium Deficiency; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Paroxetine; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 2015 |
The effect of selective serotonin reuptake inhibitor (SSRI) on pain-related behavior in a rat model of neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcium-Binding Proteins; Disease Models, Animal; Ganglia, Spinal; Immunohistochemistry; Meloxicam; Microfilament Proteins; Microglia; Neuralgia; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Fluconazole; Gene Expression; Humans; Macaca nemestrina; Neurofilament Proteins; Neurons; Nootropic Agents; Paroxetine; Primary Cell Culture; Rats; Selective Serotonin Reuptake Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Viral Load; Virus Replication | 2014 |
Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal.
Topics: 5,7-Dihydroxytryptamine; Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Central Nervous System Stimulants; Disease Models, Animal; Hippocampus; Male; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Substance Withdrawal Syndrome | 2014 |
The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine.
Topics: Animals; Brain; Cycloserine; Disease Models, Animal; Electroencephalography; Electroshock; Hydrocarbons, Halogenated; Male; Mice; Paroxetine; Receptors, Corticotropin-Releasing Hormone; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Sleep; Sleep Wake Disorders; Stress Disorders, Post-Traumatic; Stress, Psychological; Thiazines; Wakefulness | 2015 |
Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.
Topics: Amygdala; Animals; Animals, Newborn; Anxiety Disorders; Depressive Disorder; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Hippocampus; Male; Maternal Behavior; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2015 |
Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Bupropion; CA3 Region, Hippocampal; Depressive Disorder, Major; Disease Models, Animal; Dorsal Raphe Nucleus; Locus Coeruleus; Male; Olfactory Bulb; Paroxetine; Piperazines; Pyramidal Cells; Pyridines; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonergic Neurons; Serotonin Antagonists; Ventral Tegmental Area | 2014 |
A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant.
Topics: Animals; Depression; Disease Models, Animal; Dorsal Raphe Nucleus; Drug Synergism; Electrophysiological Phenomena; Hippocampus; Male; Microdialysis; Ondansetron; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT3 Receptor Antagonists | 2015 |
Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Aortic Valve Insufficiency; Blood Pressure; Depression; Disease Models, Animal; Drinking; Echocardiography; Heart Rate; Male; Myocardium; Organ Size; Paroxetine; Potassium; Rats; Rats, Wistar; Sodium Chloride; Time Factors; Water-Electrolyte Balance | 2015 |
Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antidepressive Agents; Brain; Citalopram; Cyclic AMP Response Element-Binding Protein; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Female; Histamine; Histidine Decarboxylase; Male; Methylhistidines; Methysergide; Mice, Knockout; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2015 |
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution.
Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors.
Topics: Animals; Basolateral Nuclear Complex; Disease Models, Animal; Dorsal Raphe Nucleus; Fear; Gene Knockout Techniques; Learning; Learning Disabilities; Male; Neurotransmitter Agents; Paroxetine; Prepulse Inhibition; Pyrimidines; Pyrroles; Rats, Transgenic; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reflex, Startle; RNA-Binding Proteins; RNA, Messenger | 2015 |
cis-3-Hexenol and trans-2-hexenal mixture prevents development of PTSD-like phenotype in rats.
Topics: Aldehydes; Animals; Conditioning, Psychological; Disease Models, Animal; Drug Evaluation, Preclinical; Exploratory Behavior; Extinction, Psychological; Fear; Fenclonine; Hexanols; Male; Motor Activity; Paroxetine; Phenotype; Prepulse Inhibition; Psychotropic Drugs; Random Allocation; Rats, Sprague-Dawley; Reflex, Startle; Stress Disorders, Post-Traumatic | 2016 |
Intranasal delivery of paroxetine nanoemulsion via the olfactory region for the management of depression: formulation, behavioural and biochemical estimation.
Topics: Administration, Intranasal; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Chemistry, Pharmaceutical; Depression; Disease Models, Animal; Emulsions; Female; Male; Paroxetine; Particle Size; Rats; Rats, Wistar; Swine | 2016 |
Paroxetine treatment, following behavioral suppression of PTSD-like symptoms in mice, prevents relapse by activating the infralimbic cortex.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Antidepressive Agents, Second-Generation; Avoidance Learning; Cerebral Cortex; Conditioning, Classical; Cues; Disease Models, Animal; Electroshock; Freezing Reaction, Cataleptic; Male; Maze Learning; Mice; Oncogene Proteins v-fos; Paroxetine; Recurrence; Stress Disorders, Post-Traumatic; Tetrodotoxin; Time Factors | 2016 |
Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Corticosterone; Cues; Disease Models, Animal; Extinction, Psychological; Fear; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Paroxetine; Prefrontal Cortex; Receptors, Glucocorticoid; Restraint, Physical; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Stress, Psychological; Swimming | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Food Preferences; Imipramine; Male; Motor Activity; Paroxetine; Rats; Reserpine; Sertraline; Venlafaxine Hydrochloride | 2016 |
A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice.
Topics: Adrenal Glands; Animals; Antidepressive Agents; Cytokines; Depression; Disease Models, Animal; Grooming; Hindlimb Suspension; Hormones; Locomotion; Male; Mice; Paroxetine; Prefrontal Cortex; Quinolines; Serotonin; Stress, Psychological; Swimming; Synaptosomes; Tritium | 2016 |
Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Doxepin; Estrogens; Female; Hindlimb Suspension; Menopause; Mice; Mice, Inbred ICR; Ovariectomy; Paroxetine; Venlafaxine Hydrochloride | 2016 |
A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.
Topics: Animals; Arvicolinae; Brain; Disease Models, Animal; Exploratory Behavior; Female; Male; Neurons; Oxytocin; Pair Bond; Paroxetine; Receptors, Glucocorticoid; Receptors, Vasopressin; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Supraoptic Nucleus; Time Factors; Tyrosine 3-Monooxygenase | 2016 |
Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorders; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Paroxetine; Presenilin-1; Social Behavior | 2016 |
Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Bupropion; Chromatography, High Pressure Liquid; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2017 |
A modified single-prolonged stress model for post-traumatic stress disorder.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Freezing Reaction, Cataleptic; Male; Motor Activity; Paroxetine; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic; Time Factors | 2008 |
Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Darkness; Depression; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Light; Male; Mice; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Paroxetine; Selective Serotonin Reuptake Inhibitors; Swimming | 2008 |
[Effects of paroxetine on protein kinase PKA, PKC and CaMKII activity in different brain regions in a rat depression model].
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; Depression; Disease Models, Animal; Hippocampus; Male; Paroxetine; Protein Kinase C; Random Allocation; Rats | 2008 |
The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects.
Topics: Animals; Antidepressive Agents; Aza Compounds; Behavior, Animal; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Ejaculation; Exploratory Behavior; Male; Olfactory Bulb; Paroxetine; Rats; Rats, Sprague-Dawley; Reaction Time; Statistics, Nonparametric | 2008 |
Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain.
Topics: Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Fluvoxamine; Hyperalgesia; Injections, Spinal; Male; Milnacipran; Pain Threshold; Paroxetine; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Selective Serotonin Reuptake Inhibitors; Serotonin; Spinal Cord | 2009 |
Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methylphenidate; Paroxetine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Drug; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2009 |
Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Depression; Disease Models, Animal; Drug Synergism; Hippocampus; In Situ Hybridization; Male; Mice; Microdialysis; Microinjections; Motor Activity; Paroxetine; Receptor, trkB; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors | 2009 |
Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Hippocampus; Image Processing, Computer-Assisted; Male; Paroxetine; Proteins; Proteomics; Rats; Rats, Sprague-Dawley | 2010 |
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief.
Topics: Action Potentials; Animals; Antidepressive Agents; Cell Line, Tumor; Citalopram; Disease Models, Animal; Fluvoxamine; Humans; Injections, Spinal; Male; Pain; Pain Measurement; Paroxetine; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2X4; Serotonin Antagonists; Spinal Cord | 2009 |
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depression; Disease Models, Animal; Fenclonine; Fenfluramine; Fluorobenzenes; Freezing Reaction, Cataleptic; Male; Paroxetine; Piperidines; Protein Binding; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Swimming; Time Factors; Tritium | 2009 |
Altered gene expression of histone deacetylases in mood disorder patients.
Topics: Animals; Antidepressive Agents; Clomipramine; Corticotropin-Releasing Hormone; Dexamethasone; Disease Models, Animal; Female; Gene Expression Regulation; Histone Deacetylases; Humans; Hydrocortisone; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Mood Disorders; Paroxetine; RNA, Messenger; Swimming | 2010 |
Whole embryo culture and the identification of "teratogenicity".
Topics: Abnormalities, Drug-Induced; Animals; Cardiovascular Abnormalities; Disease Models, Animal; Embryo Culture Techniques; Embryo, Mammalian; Female; Humans; Maternal Exposure; Paroxetine; Selective Serotonin Reuptake Inhibitors; Teratogens; Terminology as Topic | 2010 |
Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats.
Topics: Animals; Binding, Competitive; Brain; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Depressive Disorder; Disease Models, Animal; Hyperemia; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tryptophan; Vasodilation | 2010 |
The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system.
Topics: Animals; Compulsive Behavior; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Extinction, Psychological; Feeding Behavior; GABA Agonists; Male; Microinjections; Muscimol; Neurotransmitter Agents; Paroxetine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reward; Selective Serotonin Reuptake Inhibitors | 2010 |
Paroxetine exposure during pregnancy and cardiac malformations.
Topics: Abnormalities, Drug-Induced; Animals; Data Interpretation, Statistical; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Heart Defects, Congenital; Humans; Meta-Analysis as Topic; Mice; Odds Ratio; Paroxetine; Pregnancy; Pregnancy Trimester, First; Rabbits; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity; Uncertainty | 2010 |
Sustained stress-induced changes in mice as a model for chronic depression.
Topics: Animals; Cell Proliferation; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Paroxetine; Stress, Psychological; Time Factors | 2010 |
Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzene Derivatives; Brain; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Freezing Reaction, Cataleptic; Hindlimb Suspension; Male; Mice; Monoamine Oxidase; Organoselenium Compounds; Paroxetine; Protein Binding; Serotonin; Serotonin Agents; Swimming; Synaptosomes; Time Factors; Tritium | 2010 |
A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Female; Male; Paroxetine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Agonists; Sexual Behavior, Animal; Sexual Dysfunctions, Psychological | 2011 |
Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Escape Reaction; Locomotion; Male; Maze Learning; Metergoline; Panic; Paroxetine; Paullinia; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Seeds; Serotonin Agents; Sulpiride | 2011 |
Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Temperature Regulation; Disease Models, Animal; Frontal Lobe; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Paroxetine; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2011 |
Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Dark Adaptation; Desipramine; Disease Models, Animal; Exploratory Behavior; Fever; Food Deprivation; Hypothalamo-Hypophyseal System; Magnesium; Magnesium Deficiency; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Paroxetine; Pituitary-Adrenal System; Protein Precursors; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Reaction Time; RNA, Messenger; Stress, Psychological | 2012 |
The involvement of the neurosteroid allopregnanolone in the antihyperalgesic effect of paroxetine in a rat model of neuropathic pain.
Topics: Animals; Brain; Central Nervous System Stimulants; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; Pain Threshold; Paroxetine; Pregnanolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 2011 |
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity.
Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholamines; Chromatography, High Pressure Liquid; Corticosterone; Depression; Diet; Disease Models, Animal; DNA-Binding Proteins; Kynurenic Acid; Kynurenine; Male; Nerve Tissue Proteins; Nucleobindins; Paroxetine; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Swimming; Time Factors; Tritium; Tryptophan | 2012 |
Social fear conditioning: a novel and specific animal model to study social anxiety disorder.
Topics: Animals; Anti-Anxiety Agents; Conditioning, Psychological; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Exploratory Behavior; Extinction, Psychological; Fear; Male; Maze Learning; Mental Recall; Paroxetine; Phobic Disorders; Swimming; Time Factors | 2012 |
Conditioned fear stress combined with single-prolonged stress: a new PTSD mouse model.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Fear; Male; Mice; Paroxetine; Random Allocation; Stress Disorders, Post-Traumatic; Stress, Psychological | 2012 |
Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.
Topics: Animals; Antidepressive Agents; Benzene Derivatives; Cerebral Cortex; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Hippocampus; Immobility Response, Tonic; Menopause; Mice; Mice, Inbred Strains; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Ondansetron; Organoselenium Compounds; Ovariectomy; Pargyline; Paroxetine; Piperazines; Pyridines; Ritanserin; Serotonergic Neurons; Serotonin Antagonists; Stress, Psychological | 2012 |
Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Citalopram; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Temperature; Time Factors | 2012 |
Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.
Topics: Animals; Anxiety Disorders; Disease Models, Animal; Hypothalamus; Male; Neurosecretory Systems; Paroxetine; Rats; RNA, Messenger; Species Specificity; Vasopressins | 2003 |
[Neurobiology and genetics of anxiety in an animal model].
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Arginine Vasopressin; Arousal; Corticotropin-Releasing Hormone; Depression; Dexamethasone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Motor Activity; Paroxetine; Phenotype; Pituitary-Adrenal System; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Rats; Rats, Inbred Strains; Receptors, Vasopressin | 2003 |
Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain.
Topics: Adrenal Glands; Animals; Body Weight; Carrier Proteins; Corticosterone; Depression; Disease Models, Animal; Drug Implants; Frontal Lobe; Hippocampus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organ Size; Paroxetine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time | 2003 |
Dopamine depletion abolishes apomorphine- and amphetamine-induced increases in extracellular serotonin levels in the striatum of conscious rats: a microdialysis study.
Topics: Afferent Pathways; Amphetamine; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Denervation; Disease Models, Animal; Dopamine; Dopamine Agonists; Extracellular Matrix; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Neostriatum; Nerve Tissue Proteins; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission | 2003 |
Antidepressant-like effects in various mice strains in the tail suspension test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Citalopram; Depression; Desipramine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Paroxetine; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2003 |
The effects of paroxetine on rat isolated vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epididymis; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Paroxetine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reserpine; Vas Deferens | 2003 |
Effect of paroxetine on a model of posttraumatic stress disorder in rats.
Topics: Animals; Arousal; Avoidance Learning; Cues; Disease Models, Animal; Electric Stimulation; Male; Motor Activity; Paroxetine; Photic Stimulation; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Frontal Lobe; Imipramine; Male; Obsessive-Compulsive Disorder; Paroxetine; Protein Binding; Random Allocation; Rats; Rats, Wistar; Serotonin; Tritium | 2005 |
Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Autoradiography; Behavior, Animal; Binding Sites; Chromatography, High Pressure Liquid; Dexamethasone; Disease Models, Animal; Hippocampus; In Situ Hybridization; Male; Maze Learning; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Paroxetine; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stress, Psychological | 2005 |
Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice.
Topics: Animals; Anti-Dyskinesia Agents; Catalepsy; Disease Models, Animal; Female; Fluoxetine; Haloperidol; Male; Mice; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Sex Factors; Time Factors | 2005 |
Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Fluoxetine; Head Movements; Locomotion; Methamphetamine; Mice; Paroxetine; Psychoses, Substance-Induced; Secondary Prevention; Selective Serotonin Reuptake Inhibitors | 2007 |
Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Escape Reaction; Male; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Uptake Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Swimming; Tetrazoles | 2006 |
Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ether; Fear; Freezing Reaction, Cataleptic; Male; Motor Activity; Pain Measurement; Pain Threshold; Paroxetine; Rats; Rats, Sprague-Dawley; Restraint, Physical; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Swimming; Vocalization, Animal | 2006 |
Strain differences in 'compulsive' lever-pressing.
Topics: Analysis of Variance; Animals; Association Learning; Compulsive Behavior; Conditioning, Operant; Cues; Disease Models, Animal; Male; Paroxetine; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2007 |
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
Topics: Animals; Behavior, Animal; Brain; Butyrates; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Fluvoxamine; Male; Mice; Mice, Inbred ICR; Morpholines; Obsessive-Compulsive Disorder; Paroxetine; Phenazocine; Piperazines; Psychotropic Drugs; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Tropanes | 2007 |
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice.
Topics: Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Male; Maze Learning; Mental Disorders; Mice; Mice, Transgenic; Motor Activity; Paroxetine; Peptide Fragments; Selective Serotonin Reuptake Inhibitors; Swimming; Tauopathies | 2007 |
Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence.
Topics: Adaptation, Physiological; Adaptation, Psychological; Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Corticosterone; Disease Models, Animal; Exploratory Behavior; Hierarchy, Social; Hippocampus; Hypothalamo-Hypophyseal System; Male; Mice; Paroxetine; Pituitary-Adrenal System; Receptors, Steroid; Social Behavior; Stress, Psychological | 2007 |
Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Body Weight; Depression; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Food Preferences; Glucocorticoids; Male; Paroxetine; Rats; Rats, Wistar; Stress, Psychological; Time Factors | 2007 |
Inhibitory effects of paroxetine on the development of atopic dermatitis-like lesions in NC/Nga mice.
Topics: Administration, Oral; Animals; Antipruritics; Dermatitis, Atopic; Disease Models, Animal; Female; Inflammation; Mice; Mice, Transgenic; Paroxetine; Selective Serotonin Reuptake Inhibitors; Skin; Time Factors | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine | 2007 |
Changes in paroxetine binding in the cerebral cortex of polydipsic rats.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Drinking Behavior; Fluoxetine; Food Deprivation; Isotope Labeling; Obsessive-Compulsive Disorder; Paroxetine; Random Allocation; Rats; Thirst; Tritium | 1995 |
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning.
Topics: Analysis of Variance; Animals; Conditioning, Psychological; Disease Models, Animal; Drug Administration Schedule; Fluvoxamine; Injections, Subcutaneous; Male; Morphine; Naloxone; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model.
Topics: Animals; Blood Platelets; Brain; Carrier Proteins; Depressive Disorder; Dexamethasone; Disease Models, Animal; Gene Expression; Glucocorticoids; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins | 1996 |
Consideration of the relevance of ethological animal models for human repetitive behavioral spectrum disorders.
Topics: Acepromazine; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Ethology; Female; Horse Diseases; Horses; Humans; Naltrexone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Opioid Peptides; Paroxetine; Reaction Time; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotyped Behavior; Stress, Psychological | 1997 |
Individual differences in response to imipramine in the mouse tail suspension test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Imipramine; Individuality; Male; Mice; Mice, Inbred Strains; Motor Activity; Paroxetine; Restraint, Physical | 1997 |
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Therapy, Combination; Exploratory Behavior; Hypothermia; Male; Olfactory Bulb; Paroxetine; Pindolol; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1998 |
Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Buspirone; Citalopram; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exercise Test; Fluoxetine; Fluvoxamine; Male; Mice; Motor Activity; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Swimming | 1998 |
Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat.
Topics: Animals; Apoenzymes; Binding Sites; Brain Chemistry; Carrier Proteins; Cerebral Cortex; Chromatography, High Pressure Liquid; Depressive Disorder; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydroxyindoleacetic Acid; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Olfactory Bulb; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synapses; Tryptophan Hydroxylase | 1998 |
Comparison of the effects of the selective serotonin-reuptake inhibitors fluoxetine, paroxetine, citalopram and fluvoxamine in alcohol-preferring cAA rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Citalopram; Disease Models, Animal; Eating; Ethanol; Female; Fluoxetine; Fluvoxamine; Food Preferences; Male; Paroxetine; Rats; Rats, Mutant Strains; Selective Serotonin Reuptake Inhibitors | 1999 |
Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Drug Synergism; Exploratory Behavior; Hypothermia; Male; Motor Activity; Olfactory Bulb; Paroxetine; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 1999 |
Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT(1A) receptor antagonist WAY100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Drug Interactions; Hyperkinesis; Interpersonal Relations; Male; Paroxetine; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 2000 |
Fenfluramine blocks low-Mg2+-induced epileptiform activity in rat entorhinal cortex.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Extracellular Space; Fenfluramine; Hippocampus; In Vitro Techniques; Magnesium; Paroxetine; Piperazines; Presynaptic Terminals; Pyridines; Rats; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Antagonists | 2000 |
Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?
Topics: Animals; Arousal; Body Temperature Regulation; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Imipramine; Male; Mice; Motivation; Motor Activity; Paroxetine; Sex Factors | 2001 |
Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats.
Topics: Animals; Brain; Dextroamphetamine; Disease Models, Animal; Exploratory Behavior; Hallucinogens; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Video Recording | 2001 |