Page last updated: 2024-08-23

paroxetine and Alzheimer Disease

paroxetine has been researched along with Alzheimer Disease in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.00)18.2507
2000's10 (50.00)29.6817
2010's5 (25.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Finsen, B; Gramsbergen, JB; Hasselstrøm, J; Lambertsen, KL; Metaxas, A; Olesen, LØ; Severino, M; Sivasaravanaparan, M; von Linstow, CU; Wiborg, O1
Ai, PH; Chen, S; Feng, DF; Liu, XD; Pan, YB; Sun, S; Xu, NJ; Zhu, XN1
Baroni, M; Boccardi, V; Ercolani, S; Giordano, M; Longo, A; Mecocci, P; Paolacci, L; Ruggiero, C1
Bouzinova, EV; Finsen, B; Hasselstrøm, JB; Olesen, LØ; Severino, M; Sivasaravanaparan, M; Wiborg, O1
Alexopoulos, GS1
Ellison, JM1
Bertoletti, E; Chilovi, BV; Conti, M; Padovani, A; Rozzini, L; Trabucchi, M; Zanetti, M1
Collins, A; Gragg, M; Sherrod, RA; Wynn, S1
Fang, Y; Jia, Y; Lian, Y; Wei, J; Xu, Y; Zeng, Z; Zhang, L; Zhao, X; Zhu, H1
Lebert, F1
Cahill, CM; Gullans, SR; Payton, S; Randall, JD; Rogers, JT1
Cuny, GD; Morse, LJ; Payton, SM; Rogers, JT1
Ahl, M; Bush, A; Huang, X; Rogers, JT; Tucker, S; Westaway, D1
Ahl, M; Bandyopadhyay, S; Bush, AI; Cho, HH; Cuny, GD; Goldstein, LE; Huang, X; Rogers, JT; Tucker, S; Westaway, D1
Brown, M; Clark, RF; Gray, AJ; Guo, Z; Halagappa, VM; Iyun, T; Martin, B; Matsuoka, Y; Mattson, MP; Maudsley, S; Nelson, RL; Pearson, M1
Bales, KR1
Reynolds, CF1
Burke, WJ; Dewan, V; Folks, DG; Nadolny, GC; Roccaforte, WH; Wengel, SP1
Cohen, CI; Trappler, B1
Bensasi, S; Houck, PR; Mazumdar, S; Miller, MD; Mulsant, BH; Nebes, R; Pollock, BG; Reynolds, CF; Stack, J; Sweet, RA1

Reviews

3 review(s) available for paroxetine and Alzheimer Disease

ArticleYear
[Serotonin reuptake inhibitors in depression of Alzheimer's disease and other dementias].
    Presse medicale (Paris, France : 1983), 2003, Jul-26, Volume: 32, Issue:25

    Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Dementia; Depression; Fluoxetine; Humans; Neuropsychological Tests; Paroxetine; Placebos; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone

2003
Paroxetine administration decreases AD-like pathology and reverses memory impairments in a transgenic model of Alzheimer disease.
    Experimental neurology, 2007, Volume: 207, Issue:1

    Topics: Alzheimer Disease; Animals; Disease Models, Animal; Memory; Memory Disorders; Mice; Paroxetine

2007
Depression: making the diagnosis and using SSRIs in the older patient.
    Geriatrics, 1996, Volume: 51, Issue:10

    Topics: 1-Naphthylamine; Adult; Aged; Alzheimer Disease; Depressive Disorder; Diagnosis, Differential; Dose-Response Relationship, Drug; Fluoxetine; Humans; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline

1996

Trials

2 trial(s) available for paroxetine and Alzheimer Disease

ArticleYear
Use of SSRIs in "very old" depressed nursing home residents.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1998,Winter, Volume: 6, Issue:1

    Topics: 1-Naphthylamine; Aged; Aged, 80 and over; Alzheimer Disease; Central Nervous System Diseases; Dementia, Vascular; Depressive Disorder; Female; Fluoxetine; Homes for the Aged; Humans; Male; Matched-Pair Analysis; New York; Nursing Homes; Paroxetine; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline; Statistics, Nonparametric

1998
A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2001,Fall, Volume: 9, Issue:4

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Tricyclic; Depression; Double-Blind Method; Female; Humans; Male; Nortriptyline; Paroxetine; Selective Serotonin Reuptake Inhibitors

2001

Other Studies

15 other study(ies) available for paroxetine and Alzheimer Disease

ArticleYear
Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice.
    Journal of Alzheimer's disease : JAD, 2022, Volume: 87, Issue:2

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Paroxetine; Plaque, Amyloid; Presenilin-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins

2022
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer's disease mice.
    Translational neurodegeneration, 2020, 05-12, Volume: 9, Issue:1

    Topics: Affective Symptoms; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; Paroxetine; Presenilin-1; Prodromal Symptoms; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Time Factors

2020
Anticholinergic Burden and Functional Status in Older People with Cognitive Impairment: Results from the Regal Project.
    The journal of nutrition, health & aging, 2017, Volume: 21, Issue:4

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinergic Antagonists; Cognitive Dysfunction; Cross-Sectional Studies; Female; Hospitalization; Humans; Italy; Longitudinal Studies; Male; Memory; Outpatients; Paroxetine; Risperidone; Trazodone

2017
Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorders; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Paroxetine; Presenilin-1; Social Behavior

2016
Personalizing the care of geriatric depression.
    The American journal of psychiatry, 2008, Volume: 165, Issue:7

    Topics: Aged; Alzheimer Disease; Antidepressive Agents, Tricyclic; Brain; Case Management; Comorbidity; Depressive Disorder, Major; Health Services for the Aged; Humans; Magnetic Resonance Imaging; Nortriptyline; Paroxetine; Patient-Centered Care; Psychology; Selective Serotonin Reuptake Inhibitors; Socioeconomic Factors

2008
A 60-year-old woman with mild memory impairment: review of mild cognitive impairment.
    JAMA, 2008, Oct-01, Volume: 300, Issue:13

    Topics: Aging; Alzheimer Disease; Cognition; Cognition Disorders; Counseling; Diagnosis, Differential; Diet; Female; Humans; Life Style; Magnetic Resonance Imaging; Memory Disorders; Middle Aged; Neurotransmitter Agents; Paroxetine; Positron-Emission Tomography; Psychotropic Drugs; Risk Factors

2008
Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors.
    International psychogeriatrics, 2010, Volume: 22, Issue:1

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Citalopram; Cognition; Cognition Disorders; Depressive Disorder, Major; Female; Fluoxetine; Humans; Male; Movement Disorders; Neuropsychological Tests; Paroxetine; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index

2010
Dissecting dementia, depression, and drug effects in older adults.
    Journal of psychosocial nursing and mental health services, 2010, Volume: 48, Issue:1

    Topics: Aged; Alzheimer Disease; Antidepressive Agents; Depressive Disorder; Diagnosis, Differential; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Nootropic Agents; Nursing Diagnosis; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Substance Withdrawal Syndrome

2010
BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 26, Issue:3

    Topics: Aged; Alleles; Alzheimer Disease; Antidepressive Agents; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; Depression; Female; Genotype; Humans; Linkage Disequilibrium; Male; Paroxetine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol.
    Journal of molecular neuroscience : MN, 2003, Volume: 20, Issue:3

    Topics: 5' Untranslated Regions; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Azithromycin; Cell Line, Tumor; Chelating Agents; Dimercaprol; Drug Evaluation, Preclinical; Genes, Reporter; Humans; Luciferases; Paroxetine; Protein Synthesis Inhibitors; RNA, Messenger; Selective Serotonin Reuptake Inhibitors

2003
FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein.
    Journal of molecular neuroscience : MN, 2004, Volume: 24, Issue:1

    Topics: 5' Untranslated Regions; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Chelating Agents; Dimercaprol; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Epithelial Cells; Humans; Iron; Neuroprotective Agents; Organometallic Compounds; Paroxetine; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Receptors, Transferrin; RNA, Messenger

2004
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.
    Current Alzheimer research, 2005, Volume: 2, Issue:2

    Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Drug Approval; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Pilot Projects

2005
RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.
    Current Alzheimer research, 2006, Volume: 3, Issue:3

    Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Drug Evaluation, Preclinical; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Peptide Fragments; Pilot Projects; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Messenger

2006
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice.
    Experimental neurology, 2007, Volume: 205, Issue:1

    Topics: Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Male; Maze Learning; Mental Disorders; Mice; Mice, Transgenic; Motor Activity; Paroxetine; Peptide Fragments; Selective Serotonin Reuptake Inhibitors; Swimming; Tauopathies

2007
The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia.
    International journal of geriatric psychiatry, 1997, Volume: 12, Issue:5

    Topics: 1-Naphthylamine; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Depressive Disorder; Female; Humans; Male; Paroxetine; Psychotic Disorders; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Sertraline

1997