Page last updated: 2024-11-02

pargyline and Pregnancy

pargyline has been researched along with Pregnancy in 48 studies

Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" This model of peripheral aromatization was utilized to evaluate in vivo pharmacological parameters of MDL 18,962 (10-(2-propynyl)estr-4-ene-3,17-dione) such as bioavailability of several formulations, time course and dose responses following different routes of drug administration, pharmacokinetics and tissue distribution of [14C]MDL 18,962."1.28Human trophoblast xenografts in athymic mice: a model for peripheral aromatization. ( Johnston, JO; Shumaker, RC; Wright, CL, 1989)
"[3H]Pargyline has been covalently linked to active sites of both type A and type B monoamine oxidase (MAO) obtained from various tissues."1.26Studies on the pargyline-binding site of different types of monoamine oxidase. ( Yu, PH, 1981)
"[3H]Pargyline was bound to MAO A in a crude mitochondrial fraction from the placental trophoblast of a male newborn and to MAO B in blood platelets from the umbilical vein of the same newborn."1.26Differences in the structure of A and B forms of human monoamine oxidase. ( Breakefield, XO; Cawthon, RM; Haseltine, FP; Pintar, JE, 1981)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199042 (87.50)18.7374
1990's4 (8.33)18.2507
2000's1 (2.08)29.6817
2010's1 (2.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Szkilnik, R1
Brus, R1
Malinowska-Borowska, J1
Nowak, D1
Waliczek, M1
Kostrzewa, RM1
Nowak, P1
Larsen, TR1
Rossen, S1
Gramsbergen, JB1
Meyerson, BJ5
Waldmann, EB1
Nickas, G1
Dörner, G2
Walker, RF1
Johnston, JO2
Wright, CL2
Metcalf, BW1
Yu, PH1
Phillippe, M1
Niloff, JM1
Koike, K1
Aono, T1
Chatani, F1
Takemura, T1
Kurachi, K1
Cawthon, RM1
Pintar, JE1
Haseltine, FP1
Breakefield, XO1
Brown, GK1
Powell, JF1
Craig, IW1
Zheng, MQ1
Reum, T1
Morgenstern, R1
Pons, C1
Dansette, PM1
Gregeois, J1
Homberg, JC1
Billett, EE1
Mansuy, D1
Hernández, RJ1
Breese, GR1
Vogel, RA1
Kuhn, CM1
Mailman, RB1
Mueller, RA1
Schanberg, SM1
Hinz, G1
Döcke, F1
Tönjes, R1
Rajaofetra, N1
Poulat, P1
Marlier, L1
Geffard, M1
Privat, A1
Mistry, AM1
Vidal, G1
Voogt, JL1
Cohen, ML1
Wittenauer, LA1
di Salle, E1
Briatico, G1
Giudici, D1
Ornati, G1
Zaccheo, T1
Borisova, NA1
Gallant, KR1
Cherian, MG1
Riley, LA1
Waguespack, MA1
Denney, RM2
Shumaker, RC1
Riley, L1
Brandt, ME1
Puett, D1
Covey, DF1
Zimniski, SJ1
Cohen, G1
Mytilineou, C1
Sadovsky, E3
Weinstein, D1
Pfeifer, Y6
Polishuk, WZ1
Sulman, FG6
King, CT1
Horigan, E1
Wilk, AL1
Carrer, H1
Eliasson, M1
Loo, YH1
Murphy, DL1
Donnelly, CH1
Polishuk, WA1
Harrison, TS1
Freier, DT1
Cohen, EL1
Huidobro, F1
Tamayo, L1
Contreras, E1
Ratner, A1
McCann, SM1
Sawyer, CH1
Lindström, LH1
Lewander, T1
Polishuk, Z1
Lippmann, W1
Sadowsky, E1
Koren, Z3

Reviews

2 reviews available for pargyline and Pregnancy

ArticleYear
Sex hormones and neurotransmitters as mediators for sexual differentiation of the brain.
    Endokrinologie, 1981, Volume: 78, Issue:2-3

    Topics: Acetylcholinesterase; Androgens; Animals; Avoidance Learning; Brain; Castration; Disorders of Sex De

1981
Monoamine oxidase in man: enzyme characteristics in platelets, plasma, and other human tissues.
    Advances in biochemical psychopharmacology, 1974, Volume: 12, Issue:0

    Topics: Age Factors; Benzyl Compounds; Bipolar Disorder; Blood Platelets; Brain; Cyanides; Diseases in Twins

1974

Other Studies

46 other studies available for pargyline and Pregnancy

ArticleYear
Ontogenetic manganese exposure with perinatal 6-OHDA lesioning alters behavioral responses of rats to dopamine D₁ and D2 agonist treatments.
    Environmental toxicology and pharmacology, 2014, Volume: 37, Issue:1

    Topics: Animals; Behavior, Animal; Desipramine; Dopamine; Dopamine Agonists; Exploratory Behavior; Female; H

2014
Dopamine release in organotypic cultures of foetal mouse mesencephalon: effects of depolarizing agents, pargyline, nomifensine, tetrodotoxin and calcium.
    The European journal of neuroscience, 2008, Volume: 28, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Dopamine; Dopamine Uptake Inhibitors; Female; Fetu

2008
Oestrous behaviour in oestrogen treated ovariectomized rats after chlorpromazine alone or in combination with progesterone, tetrabenazine or reserpine.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:4

    Topics: Animals; Body Temperature; Castration; Chlorpromazine; Drug Antagonism; Drug Synergism; Estradiol; E

1966
Pargyline hydrochloride combined with methyclothiazide in the treatment of hypertension.
    Arizona medicine, 1967, Volume: 24, Issue:4

    Topics: Adult; Aged; Drug Synergism; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Parg

1967
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
    Neurobiology of aging, 1982,Fall, Volume: 3, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi

1982
Time-dependent inhibition of aromatase in trophoblastic tumor cells in tissue culture.
    Journal of steroid biochemistry, 1984, Volume: 20, Issue:6A

    Topics: Androstenedione; Aromatase Inhibitors; Cell Line; Choriocarcinoma; Estrogens; Female; Humans; Kineti

1984
Studies on the pargyline-binding site of different types of monoamine oxidase.
    Canadian journal of biochemistry, 1981, Volume: 59, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Clorgyline; Female; Humans; In Vitro Techniques

1981
Metabolism of 3H-dopamine by human chorioamnion in vitro.
    American journal of obstetrics and gynecology, 1982, Aug-01, Volume: 143, Issue:7

    Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Chromatography, Ion Exchange; Dopa

1982
Improved method for determination of catecholamines in rat brain by isolation on boric acid gel and high-performance liquid chromatography with electrochemical detection.
    Life sciences, 1982, Jun-21, Volume: 30, Issue:25

    Topics: Animals; Boric Acids; Brain Chemistry; Catecholamines; Chromatography, Gel; Chromatography, High Pre

1982
Differences in the structure of A and B forms of human monoamine oxidase.
    Journal of neurochemistry, 1981, Volume: 37, Issue:2

    Topics: Adult; Binding Sites; Blood Platelets; Cell Line; Female; Fibroblasts; Humans; Infant, Newborn; Male

1981
Molecular weight differences between human platelet and placental monoamine oxidase.
    Biochemical pharmacology, 1980, Oct-01, Volume: 29, Issue:19

    Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; Female; Humans; In Vitro Techniques; Kinetics;

1980
[Experimental studies of intra-amniotic pargyline and/or reserpine for termination of midterm pregnancy (author's transl)].
    Zhonghua fu chan ke za zhi, 1980, Volume: 15, Issue:2

    Topics: Abortion, Induced; Amnion; Animals; Female; Pargyline; Pregnancy; Pregnancy Trimester, Second; Rabbi

1980
Fetal mesencephalic grafts influence the dopamine release in the non-lesioned striatum of 6-OHDA-lesioned rats: a behavioral and in vivo voltammetric study.
    Neuroscience letters, 1994, May-23, Volume: 173, Issue:1-2

    Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Dopamine; Electro

1994
Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.
    Biochemical and biophysical research communications, 1996, Jan-05, Volume: 218, Issue:1

    Topics: Antibody Specificity; Antigen-Antibody Reactions; Autoantibodies; Chemical and Drug Induced Liver In

1996
Na+-K+-ATPase activity in the brain cortex of rats ontogenetically malnourished, and treated with serotonin precursors.
    Brain research, 1979, Feb-23, Volume: 162, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Activation;

1979
Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.
    Brain research, 1978, Oct-27, Volume: 155, Issue:2

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Behavior, Animal; Benserazi

1978
Effects of psychotrophic drugs on brain differentiation in female rats.
    Endokrinologie, 1977, Volume: 70, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg

1977
Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study.
    Brain research. Developmental brain research, 1992, Jun-19, Volume: 67, Issue:2

    Topics: Aging; Animals; Embryonic and Fetal Development; Female; Gestational Age; Immunohistochemistry; Moto

1992
Dopaminergic and serotonergic activity in the hypothalamus during early and late pregnancy.
    Brain research, 1991, Jun-07, Volume: 550, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Dopamine; Female; Hydroxyindoleacetic Acid

1991
Serotonin receptor activation of phosphoinositide turnover in uterine, fundal, vascular, and tracheal smooth muscle.
    Journal of cardiovascular pharmacology, 1987, Volume: 10, Issue:2

    Topics: Animals; Aorta, Thoracic; Ergolines; Female; Gastric Fundus; Guinea Pigs; In Vitro Techniques; Muscl

1987
Aromatase inhibition and experimental antitumor activity of FCE 24304, MDL 18962 and SH 489.
    Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstadienes; Androstenedione; Animals; Antineoplastic Agents; A

1989
[The formation of catecholaminergic structures in the mediobasal hypothalamus of the rat].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 107, Issue:4

    Topics: Animals; Catecholamines; Female; Glyoxylates; Histological Techniques; Hypothalamus, Middle; Microsc

1989
Metabolic changes in glutathione and metallothionein in newborn rat liver.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2

    Topics: Alkynes; Animals; Animals, Newborn; Buthionine Sulfoximine; Cysteine; Female; gamma-Glutamyltransfer

1989
Characterization and quantitation of monoamine oxidases A and B in mitochondria from human placenta.
    Molecular pharmacology, 1989, Volume: 36, Issue:1

    Topics: Binding Sites; Female; Humans; Immunoblotting; Mitochondria; Monoamine Oxidase; Pargyline; Phenethyl

1989
Human trophoblast xenografts in athymic mice: a model for peripheral aromatization.
    Journal of steroid biochemistry, 1989, Volume: 33, Issue:4A

    Topics: Androstenedione; Animals; Aromatase Inhibitors; Choriocarcinoma; Female; Humans; Mice; Mice, Inbred

1989
Characterization of MAO A and MAO B in human placental mitochondria by activity, immunoblotting and radioimmunoassay with monoclonal antibodies and active site labeling with 3H-pargyline.
    Pharmacological research communications, 1988, Volume: 20 Suppl 4

    Topics: Antibodies, Monoclonal; Binding Sites; Female; Humans; Immunoblotting; In Vitro Techniques; Mitochon

1988
Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione.
    Journal of steroid biochemistry, 1988, Volume: 31, Issue:3

    Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Female; Gonadotropins, Equine; Humans; Ki

1988
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Life sciences, 1985, Jan-21, Volume: 36, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Culture Techniques; Female; Kinetics; Monoami

1985
Prevention of serotonin abortion by serotonin antagonists in rats.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:2

    Topics: Abortion, Induced; Animals; Atropine; Benzocycloheptenes; Dimethylamines; Ergolines; Female; Gestati

1973
Fetal outcome from prolonged versus acute drug administration in the pregnant rat.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Collagen; Demyelinating Dise

1972
5-Hydroxytryptamine and sexual behavior in the female rat.
    Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0

    Topics: Amino Acids; Animals; Apomorphine; Castration; Circadian Rhythm; Electroshock; Estrus; Exploratory B

1974
Serotonin deficiency in experimental hyperphenylalaninemia.
    Journal of neurochemistry, 1974, Volume: 23, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa

1974
The use of antiserotonin-cyproheptadine HCL in pregnancy: an experimental and clinical study.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abortion, Habitual; Abortion, Spontaneous; Animals; Cyproheptadine; Female; Fetus; Humans; Hydroxyin

1972
Proceedings: Recurrent pheochromocytoma.
    Archives of surgery (Chicago, Ill. : 1960), 1974, Volume: 108, Issue:4

    Topics: Abdominal Neoplasms; Adolescent; Adrenal Gland Neoplasms; Adult; Child; Epinephrine; Female; Hormone

1974
Effects of methadone on the action of catecholamines in isolated preparations.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:1

    Topics: Acetylcholine; Animals; Barium; Cats; Cocaine; Drug Antagonism; Drug Synergism; Epinephrine; Female;

1971
Effect of reserpine on plasma LH levels in ovariectomized and cycling proestrus rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 138, Issue:3

    Topics: Animals; Castration; Estrus; Female; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Monoamine

1971
Monoamines and ovulation in the rat.
    Endocrinology, 1968, Volume: 83, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Brain; Catecholamines; Depression, Chemical; Dihydro

1968
Monoamines and hormone activated oestrous behaviour in the ovariectomized hamster.
    Psychopharmacologia, 1970, Aug-19, Volume: 18, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Castration; Cricetinae; Depression, Chemical;

1970
The effect of pilocarpine in combination with monoamine oxidase inhibitors, imipramine or desmethylimipramine on oestrous behaviour in female rats.
    Psychopharmacologia, 1970, Volume: 17, Issue:2

    Topics: Amines; Animals; Body Temperature; Castration; Central Nervous System; Desipramine; Drug Synergism;

1970
Serotonin synthesis inhibition and estrous behavior in female rats.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Jun-15, Volume: 9, Issue:12

    Topics: Animals; Brain Chemistry; Castration; Dopamine; Estradiol; Estrus; Female; Pargyline; Phenylalanine;

1970
Effect of cyproheptadiae (periactin) on accumulation of (14C)5-hydroxytryptamine in pregnant rats.
    The Journal of endocrinology, 1971, Volume: 50, Issue:3

    Topics: Animals; Carbon Isotopes; Cyproheptadine; Drug Synergism; Female; Fetus; Injections, Subcutaneous; M

1971
Relationship between hypothalamic norepinephrine and serotonin and gonadotrophin secretion in the hamster.
    Nature, 1968, Apr-13, Volume: 218, Issue:5137

    Topics: Animals; Cricetinae; Estrus; Female; Gonadotropins; Hypothalamus; Methyltyrosines; Norepinephrine; O

1968
Prevention of serotonin abortion in pregnant rats by five serotonin antagonists.
    Obstetrics and gynecology, 1969, Volume: 33, Issue:5

    Topics: Abortion, Habitual; Abortion, Spontaneous; Anilides; Animals; Cyproheptadine; Ergolines; Female; Fet

1969
Accumulation of [14C]5-hydroxytryptamine in the pregnant rat uterus after treatment with a monoamine oxidase inhibitor.
    The Journal of endocrinology, 1969, Volume: 43, Issue:3

    Topics: Animals; Carbon Isotopes; Estrogens; Female; Fetus; Pargyline; Pregnancy; Progesterone; Rats; Seroto

1969
The significance of mono-amine oxidase in amniotic fluid in human foetal development.
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1965, Volume: 72, Issue:5

    Topics: Abortion, Therapeutic; Adult; Amniotic Fluid; Female; Fetus; Humans; Injections; Monoamine Oxidase;

1965
Induction of legal abortion by intra-uterine instillation of pargyline hydrochloride (eutonyl).
    Journal of reproduction and fertility, 1966, Volume: 12, Issue:1

    Topics: Abortion, Legal; Adult; Female; Humans; Pargyline; Pregnancy

1966