pargyline has been researched along with Neuroblastoma in 7 studies
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have assessed the toxic effects of dopamine and L-DOPA toward catecholaminergic neuroblastoma SH-SY5Y cells and whether R(-)-deprenyl and several structurally related compounds possess antioxidant effects in this system." | 1.30 | R(-)-deprenyl potentiates dopamine-induced cytotoxicity toward catecholaminergic neuroblastoma SH-SY5Y cells. ( Lai, CT; Yu, PH, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, SS | 1 |
| Wang, X | 1 |
| Jiang, N | 1 |
| Yu, W | 1 |
| Wang, KD | 1 |
| Lan, JS | 1 |
| Li, ZR | 1 |
| Kong, LY | 1 |
| Manoharan, A | 1 |
| Oh, JM | 1 |
| Benny, F | 1 |
| Kumar, S | 1 |
| Abdelgawad, MA | 1 |
| Ghoneim, MM | 1 |
| Shaker, ME | 1 |
| El-Sherbiny, M | 1 |
| Almohaimeed, HM | 1 |
| Gahtori, P | 1 |
| Kim, H | 1 |
| Mathew, B | 1 |
| Silalai, P | 1 |
| Pruksakorn, D | 1 |
| Chairoungdua, A | 1 |
| Suksen, K | 1 |
| Saeeng, R | 1 |
| Zindo, FT | 1 |
| Malan, SF | 1 |
| Omoruyi, SI | 1 |
| Enogieru, AB | 1 |
| Ekpo, OE | 1 |
| Joubert, J | 1 |
| Naoi, M | 1 |
| Maruyama, W | 1 |
| Yi, H | 1 |
| Akao, Y | 1 |
| Yamaoka, Y | 1 |
| Shamoto-Nagai, M | 1 |
| Buckman, TD | 1 |
| Sutphin, MS | 1 |
| Mitrovic, B | 1 |
| Lai, CT | 1 |
| Yu, PH | 1 |
7 other studies available for pargyline and Neuroblastoma
| Article | Year |
|---|---|
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cel | 2015 |
Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease.
Topics: Antipsychotic Agents; Dopamine Agents; Humans; Isatin; Microwaves; Molecular Docking Simulation; Mon | 2023 |
Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2021 |
Design, synthesis and evaluation of pentacycloundecane and hexacycloundecane propargylamine derivatives as multifunctional neuroprotective agents.
Topics: Cell Line, Tumor; Drug Design; Humans; Monoamine Oxidase; Neuroblastoma; Neuroprotective Agents; Par | 2019 |
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.
Topics: Alkynes; Cell Death; Cell Line, Tumor; Energy Metabolism; Genetic Markers; Glial Cell Line-Derived N | 2007 |
Oxidative stress in a clonal cell line of neuronal origin: effects of antioxidant enzyme modulation.
Topics: Animals; Brain; Carmustine; Catalase; Cell Fractionation; Cell Survival; Clone Cells; Cytosol; Gliom | 1993 |
R(-)-deprenyl potentiates dopamine-induced cytotoxicity toward catecholaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Dopamine; Drug Synergism; Humans; Levodopa; Monoamine Oxidase Inhibitors; Neuroblastom | 1997 |