Page last updated: 2024-11-02

pargyline and Depression

pargyline has been researched along with Depression in 24 studies

Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"We describe an animal model of long-term depression based on active immunization of albino rats against BSA-conjugated inhibitor of monoamine oxidase, antidepressant, pargyline."7.70Pargyline conjugate-induced long-term activation of monoamine oxidase as an immunological model for depression. ( Ashmarin, IP; Belopolskaya, MV; Danilova, RA; Moskvityna, TA; Obukhova, MF, 1999)
"Behavioral depression produced by exposing animals to a stressor that they cannot control (uncontrollable shock) was reversed by infusion of the monoamine oxidase (MAO) inhibitor pargyline into the locus coeruleus (LC) region of the brain stem."3.67Infusion of a monoamine oxidase inhibitor into the locus coeruleus can prevent stress-induced behavioral depression. ( Ambrose, MJ; Simson, PG; Webster, A; Weiss, JM, 1986)
"Both paroxetine and pargyline were effective in reducing the immobility time of stressed OVX mice in the FST."1.38Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system. ( Bazanella Sampaio, T; Mozzaquatro Gai, B; Nogueira, CW; Pinton, S; Trevisan da Rocha, J; Zeni, G, 2012)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199021 (87.50)18.7374
1990's2 (8.33)18.2507
2000's0 (0.00)29.6817
2010's1 (4.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Trevisan da Rocha, J1
Mozzaquatro Gai, B1
Pinton, S1
Bazanella Sampaio, T1
Nogueira, CW1
Zeni, G1
OLTMAN, JE1
FRIEDMAN, S1
SIEGLER, PE1
KLINE, NS1
MCCURDY, RL1
KAN, FJ1
TURNER, WJ1
MERLIS, S1
BLACKWELL, B1
MABBITT, LA1
JACOBS, MA1
PILLARD, R1
Ashmarin, IP2
Danilova, RA2
Obukhova, MF2
Belopol'skaia, MV1
Moskvityna, TA1
Belopolskaya, MV1
Lynch, MA1
Leonard, BE1
Slater, SL1
Lipper, S5
Shiling, DJ2
Murphy, DL5
Slater, S2
Buchsbaum, MS1
Nies, AS1
Lerner, P1
Major, LF1
Lake, CR1
Lovenberg, W1
Campbell, IC1
Major, LJ1
Gordon, E1
Weiss, JM2
Simson, PG2
Ambrose, MJ1
Webster, A1
McNair, DM1
Wyatt, RJ1
Kupfer, DJ1
Scott, J1
Robinson, DS1
Snyder, F1
Plotnikoff, NP1
Kastin, AJ1
Anderson, MS1
Schally, AV1
Matussek, N1
Iriye, TT1
Simmonds, FA1

Reviews

2 reviews available for pargyline and Depression

ArticleYear
CURRENT STATUS OF DRUG TREATMENT IN THE DEPRESSIVE STATE.
    The Medical clinics of North America, 1964, Volume: 48

    Topics: Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Aspartic Acid; Benactyzine; Classif

1964
Self-evaluations of antidepressants.
    Psychopharmacologia, 1974, Volume: 37, Issue:4

    Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipr

1974

Trials

4 trials available for pargyline and Depression

ArticleYear
Elevation of plasma-prolactin by monoamine-oxidase inhibitors.
    Lancet (London, England), 1977, Aug-06, Volume: 2, Issue:8032

    Topics: Clorgyline; Depression; Female; Humans; Hydrocortisone; Male; Pargyline; Placebos; Prolactin; Propyl

1977
Comparative behavioral effects of clorgyline and pargyline in man: a preliminary evaluation.
    Psychopharmacology, 1979, Apr-11, Volume: 62, Issue:2

    Topics: Clinical Trials as Topic; Clorgyline; Depression; Double-Blind Method; Female; Humans; Male; Pargyli

1979
Self-evaluations of antidepressants.
    Psychopharmacologia, 1974, Volume: 37, Issue:4

    Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipr

1974
Clinical and animal experiments concerning the function of brain catecholamines.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:3

    Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca

1971

Other Studies

19 other studies available for pargyline and Depression

ArticleYear
Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system.
    Psychopharmacology, 2012, Volume: 222, Issue:4

    Topics: Animals; Antidepressive Agents; Benzene Derivatives; Cerebral Cortex; Depression; Disease Models, An

2012
PARGYLINE IN THE TREATMENT OF DEPRESSIVE ILLNESSES.
    The American journal of psychiatry, 1963, Volume: 120

    Topics: Antidepressive Agents; Antihypertensive Agents; Depression; Depressive Disorder; Hypotension; Imipra

1963
THE PRACTICAL MANAGEMENT OF DEPRESSION.
    JAMA, 1964, Nov-23, Volume: 190

    Topics: Amitriptyline; Antidepressive Agents; Benzoates; Classification; Depression; Depressive Disorder; Dr

1964
TRANSIENT BRAIN SYNDROME AS A NON-FATAL REACTION TO COMBINED PARGYLINE-IMIPRAMINE TREATMENT.
    The American journal of psychiatry, 1964, Volume: 121

    Topics: Brain; Depression; Depressive Disorder; Drug Therapy; Geriatrics; Hypertension; Imipramine; Mental D

1964
A CLINICAL TRIAL OF PARGYLINE AND DOPA IN PSYCHOTIC SUBJECTS.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Adolescent; Biomedical Research; Brain; Brain Damage, Chronic; Depression; Depressive Disorder, Majo

1964
TYRAMINE IN CHEESE RELATED TO HYPERTENSIVE CRISES AFTER MONOAMINE-OXIDASE INHIBITION.
    Lancet (London, England), 1965, May-01, Volume: 1, Issue:7392

    Topics: Cheese; Chromatography; Colorimetry; Depression; Depressive Disorder; Drug Therapy; Electrophoresis;

1965
APPROACH TO STUDYING DRUG EFFECTS IN AMBULATORY PATIENTS.
    Archives of general psychiatry, 1965, Volume: 13

    Topics: Biomedical Research; Depression; Depressive Disorder; Drug Therapy; Pargyline; Placebos; Psychologic

1965
[Induction of long-term depression (with anxiety and fear components) by immunization of rats against pargyline].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1998, Issue:8

    Topics: Animals; Anxiety; Depression; Fear; Male; Monoamine Oxidase Inhibitors; Pargyline; Rats; Rats, Wista

1998
Pargyline conjugate-induced long-term activation of monoamine oxidase as an immunological model for depression.
    Neurochemical research, 1999, Volume: 24, Issue:9

    Topics: Animals; Behavior, Animal; Depression; Enzyme Activation; Male; Models, Biological; Monoamine Oxidas

1999
Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:12

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dextroamphetamine; Huma

1978
Adverse reactions and interactions limiting the use of antihypertensive drugs.
    The American journal of medicine, 1975, Volume: 58, Issue:4

    Topics: Antihypertensive Agents; Blood Pressure; Depression; Dose-Response Relationship, Drug; Drug Interact

1975
Dopamine-beta-hydroxylase and norepinephrine in human cerebrospinal fluid: effects of monoamine oxidase inhibitors.
    Neuropharmacology, 1979, Volume: 18, Issue:4

    Topics: Clorgyline; Depression; Depression, Chemical; Dopamine beta-Hydroxylase; Humans; Monoamine Oxidase I

1979
A biochemical measure of monoamine oxidase type A and B inhibitor effects in man.
    Journal of psychiatric research, 1979, Volume: 15, Issue:2

    Topics: Animals; Blood Platelets; Brain; Clorgyline; Culture Techniques; Depression; Dose-Response Relations

1979
Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine and serotonin in human cerebrospinal fluid.
    Journal of neurochemistry, 1979, Volume: 32, Issue:1

    Topics: Clorgyline; Depression; Dopamine; Homovanillic Acid; Humans; Norepinephrine; Pargyline; Propylamines

1979
Depression in an animal model: focus on the locus ceruleus.
    Ciba Foundation symposium, 1986, Volume: 123

    Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Clonidine; Depression; Electroshock; Locus Co

1986
Infusion of a monoamine oxidase inhibitor into the locus coeruleus can prevent stress-induced behavioral depression.
    Biological psychiatry, 1986, Volume: 21, Issue:8-9

    Topics: Animals; Depression; Electroshock; Locus Coeruleus; Male; Norepinephrine; Pargyline; Rats; Stress, P

1986
Longitudinal studies of the effect of monoamine oxidase inhibitors on sleep in man.
    Psychopharmacologia, 1969, Volume: 15, Issue:3

    Topics: Blood Platelets; Depression; Female; Humans; Hydrazines; Isocarboxazid; Isoniazid; Male; Monoamine O

1969
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
    Neuroendocrinology, 1973, Volume: 11, Issue:1

    Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Dru

1973
Possible involvement of glycogen phosphorylase of brain in the affective states.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:2

    Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorpromazine; Depression; Desipramine; Drug In

1971