pargyline has been researched along with Chemical and Drug Induced Liver Injury in 10 studies
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| GOLDBERG, LI | 1 |
| DeMaster, EG | 1 |
| Sumner, HW | 1 |
| Kaplan, E | 1 |
| Shirota, FN | 1 |
| Nagasawa, HT | 1 |
| Pons, C | 1 |
| Dansette, PM | 1 |
| Gregeois, J | 1 |
| Homberg, JC | 1 |
| Billett, EE | 1 |
| Mansuy, D | 1 |
| Obata, T | 1 |
| Yamanaka, Y | 1 |
| Lowe, MC | 1 |
1 review available for pargyline and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
MONOAMINE OXIDASE INHIBITORS. ADVERSE REACTIONS AND POSSIBLE MECHANISMS.
Topics: Amphetamine; Amphetamines; Chemical and Drug Induced Liver Injury; Headache; Hematologic Diseases; H | 1964 |
9 other studies available for pargyline and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Pargyline-induced hepatotoxicity: possible mediation by the reactive metabolite, propiolaldehyde.
Topics: Aldehydes; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Pargyline; Pro | 1982 |
Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.
Topics: Antibody Specificity; Antigen-Antibody Reactions; Autoantibodies; Chemical and Drug Induced Liver In | 1996 |
Monoamine oxidase released into plasma treated with the hepatotoxin allyl formate.
Topics: Animals; Chemical and Drug Induced Liver Injury; Formic Acid Esters; Lipid Peroxidation; Liver; Male | 1996 |
Hepatotoxicity of pargyline hydrochloride.
Topics: Animals; Chemical and Drug Induced Liver Injury; Male; Pargyline; Rats | 1978 |