Page last updated: 2024-11-02

pargyline and Blood Pressure, High

pargyline has been researched along with Blood Pressure, High in 106 studies

Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.

Research Excerpts

Excerpt	Relevance	Reference
"This study on the role of the sympathetic nervous system in the development of hypertension involves the measurement of dopamine and norepinephrine accumulation in various tissues of the hypertensive and random-bred normotensive strains of mice at basal levels, and following a pargyline-L-dopa treatment."	3.67	L-dopa metabolism in genetically hypertensive mice: effect of pargyline. ( Buu, NT; Duhaime, J; Kuchel, O; Racz, K; Schlager, G, 1987)
"A case is described of a 47-year-old man who developed a manic psychosis while receiving pargyline treatment for concurrent depression and hypertension."	3.66	Pargyline-induced mania in primary affective disorder: case report. ( Arnold, ES; Folks, D, 1983)

Research

Studies (106)

Timeframe	Studies, this research(%)	All Research%
pre-1990	105 (99.06)	18.7374
1990's	1 (0.94)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
FORD, RV	1
POLLACK, PJ	2
MONTUSCHI, E	1
ROBINSON, DK	1
MOSER, M	1
BRODOFF, B	1
MILLER, A	1
GOLDMAN, AG	1
GLAZENER, FS	1
MORGAN, WA	1
SIMPSON, JM	1
JOHNSON, PK	1
LEONARD, JW	1
GIFFORD, RW	1
WILLIAMS, GH	1
BREST, AN	6
MOYER, JH	5
HODGE, JV	1
NYE, ER	1
EMERSON, GW	1
SHEE, JC	1
MECHIE, AM	1
BEASLEY, EW	1
GOLDBERG, LI	1
WINSOR, T	1
MCCURDY, RL	1
KAN, FJ	1
ONESTI, G	5
HEIDER, C	1
SELLER, RH	1
GROSSI, F	1
MUSCHOLL, E	1
NOVACK, P	1
RAMIREZ, O	1
BLACKWELL, B	2
MABBITT, LA	1
HUTCHISON, JC	2
KINLAW, WB	1
KRAVITZ, B	1
KAVANAUGH, GJ	1
SHEPS, SG	1
FAIRBAIRN, JF	1
OSMUNDSON, PJ	1
SCHIRGER, A	1
MIZGALA, HF	1
BERNABO, JG	1
DIEZ, ET	1
HAHAN, AG	1
DELRIO, C	1
RANGLE, RV	1
VAN DYNE, JR	1
HORLER, AR	1
WYNNE, NA	1
BARTOLI, AJ	1
GESSLER, C	1
BARRERAARENAS, F	1
Marley, E	1
Price, J	1
Taylor, D	1
Waldmann, EB	1
Nickas, G	1
Folks, D	1
Arnold, ES	1
del Carmen Urdin, M	1
Fuentes, JA	3
Campione, KM	1
Khattri, HN	1
Wahi, PL	1
Nies, AS	1
Ordaz, A	2
Neff, NH	1
Sjoerdsma, A	3
Anselmi, B	1
Buffoni, F	2
Curradi, C	2
Del Bianco, PL	2
Sicuteri, F	2
Griffing, GT	2
Melby, JC	2
Holbrook, M	2
Johnston, ON	1
Koulu, M	1
Saavedra, JM	1
Bjelogrlic, N	1
Niwa, M	1
Agren, H	1
Linnoila, M	1
Buu, NT	1
Duhaime, J	1
Racz, K	1
Kuchel, O	1
Schlager, G	1
Johnston, JO	1
McMahon, T	1
Sumners, C	1
Muther, TF	1
Raizada, MK	1
Vidt, DG	2
DeQuattro, V	2
Miura, Y	1
Lynes, TE	1
Seedat, YK	1
Gilmore, HR	1
Yamori, Y	1
De Jong, W	1
Yamabe, H	1
Lovenberg, W	1
Anselmi, R	1
Harrison, TS	1
Freier, DT	1
Cohen, EL	1
Burke, GE	1
Holt, MC	1
Herting, RL	1
Hunter, HL	1
Völkner, E	1
Schwartz, AB	1
Kim, KE	1
Swartz, C	1
Sannerstedt, R	1
Levy, BF	1
Hamm, HJ	1
Beato, V	1
Duarte, R	1
Alvarez del Puerto, H	1
Fletcher, FW	1
Faria, E	1
Selmi, A	1
Simão, C	1
Lion, MF	1
Macedo, MM	1
Oates, JA	1
Seligmann, AW	1
Clark, MA	1
Rousseau, P	1
Lee, RE	1
Borrero, J	1
Martínez, G	1
Cárdenas, C	1
Restrepo, D	1
Escobar, A	1
Esbenshade, JH	2
Fewell, JW	2
Frankl, WS	2
Sutnick, AI	2
Turner, LW	1
Shafer, N	1
Lewis, RG	1
Young, AY	1
Pupita, F	1
Bartoli, E	1
Colongo, PG	1
Brusasco, L	1
Cruz, J	1
Bezas, AG	1
Cruz, HM	1
de Almeida, SS	1
Hergueta, G	1
Hilton, JG	1
Saldanha, RV	1
Adachi, T	1
Silve, PP	1
Giannini, SD	1
Thome, O	1
Diament, J	1
Rojas Duarte, M	1
Pickering, BI	1
Vukusic, A	2
Garcia, R	1
Perez-Olea, J	2
Cantalapiedra Alsedo, JL	1
Del Pozo, P	1
Carrière, S	1
Beaudry, C	1
Barcelo, R	1
Kayaalp, SO	1
Kaymakçalan, S	1
Ozer, A	1
Pomerantz, HZ	1
Datey, KK	1
Namda, NC	1
Dalvi, CP	1
Foz, M	1
Montoreano, F	2
Abrahim, H	2
Plotquin, J	2
Purriel, P	1
Castro Bianchino, O	1
Armas Cruz, R	1
Melfi, M	1
Faivovich, R	1
Alvo, M	1
Breall, WS	1
Gibbs, RH	1
Paykel, ES	1
Carmichael, DB	1
Bello, CT	1
Stroescu, V	1
Rosselot, E	1
Tcherdakoff, P	1
Leroux-Robert, C	1
Milliez, P	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335]			Phase 2	10 participants (Actual)	Interventional	2011-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Blood Pressure After Intrathecal Injection of Clonidine.

"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection

Intervention	mm Hg (Mean)
	Change in mean SBP after clonidine injection	Change in DBP after clonidine injection
Intrathecal Clonidine	79	37

Changes in Visual Analogue Scale (VAS) Ratings of Sedation and Sensation of Dry Mouth Reported by the Subjects, Pre and 1 Hour Post Injection

Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.

Intervention	cm (Mean)
	Change in level of sedation	Change in sensation of dry mouth
Intrathecal Clonidine	3.36	3.47

Likert Scale Pain Rating

Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.

Intervention	units on a scale (Mean)
	Pre-injection average Likert score	Post-injection average Likert score
Intrathecal Clonidine	6.5	3.6

Reviews

5 reviews available for pargyline and Blood Pressure, High

Article	Year
MONOAMINE OXIDASE INHIBITORS. ADVERSE REACTIONS AND POSSIBLE MECHANISMS. JAMA, 1964, Nov-02, Volume: 190 Topics: Amphetamine; Amphetamines; Chemical and Drug Induced Liver Injury; Headache; Hematologic Diseases; H	1964
NEWER DRUGS IN THE TREATMENT OF HYPERTENSION. Canadian Medical Association journal, 1965, Apr-24, Volume: 92 Topics: Antihypertensive Agents; Bretylium Compounds; Chlorothiazide; Chlorthalidone; Diuretics; Drug Therap	1965
Choice of antihypertensive drugs for the treatment of hypertension, including hypertensive emergencies. Cardiovascular clinics, 1974, Volume: 6, Issue:2 Topics: Antihypertensive Agents; Bethanechol Compounds; Clonidine; Diazoxide; Diuretics; Emergencies; Ferric	1974
The treatment of chronic hypertension. The Medical clinics of North America, 1971, Volume: 55, Issue:2 Topics: Adult; Blood Pressure Determination; Chronic Disease; Diuretics; Female; Ganglionic Blockers; Guanet	1971
The physiologic and pharmacologic basis for the clinical treatment of hypertension. The Medical clinics of North America, 1967, Volume: 51, Issue:1 Topics: Antihypertensive Agents; Benzothiadiazines; Emergencies; Guanethidine; Humans; Hydralazine; Hyperten	1967

Trials

12 trials available for pargyline and Blood Pressure, High

Article	Year
Effect of antihypertensive (pargyline hydrochloride-methyclothiazide) therapy in three types of hypertension: preliminary report after one year of observation. Journal of the American Geriatrics Society, 1966, Volume: 14, Issue:5 Topics: Antihypertensive Agents; Blood Pressure; Cardiac Output; Diuretics; Drug Combinations; Humans; Hyper	1966
Hypertension: effectiveness of two drugs. Texas medicine, 1967, Volume: 63, Issue:5 Topics: Antihypertensive Agents; Benzothiadiazines; Clinical Trials as Topic; Diuretics; Enzyme Therapy; Hum	1967
Paryline hydrochloride in essential hypertension. The British journal of clinical practice, 1967, Sep-09, Volume: 21, Issue:9 Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Pargyline	1967
[Ambulatory treatment of hypertension with a monoamine oxidase inhibitor]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Sep-15, Volume: 23, Issue:18 Topics: Aged; Ambulatory Care; Blood Pressure; Clinical Trials as Topic; Depression, Chemical; Diuretics; Dr	1968
Effect of pargyline on blood pressure and mood of hypertensive patients. Current therapeutic research, clinical and experimental, 1966, Volume: 8, Issue:11 Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Mi	1966
A unique antihypertensive combination--pargyline hydrochloride and methyclothiazide: a controlled study of twenty-five patients over a nine-month period. Current therapeutic research, clinical and experimental, 1968, Volume: 10, Issue:8 Topics: Antihypertensive Agents; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyclothiaz	1968
The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents. The New England journal of medicine, 1965, Sep-30, Volume: 273, Issue:14 Topics: Clinical Trials as Topic; Guanethidine; Humans; Hypertension; Hypotension, Orthostatic; Methyldopa;	1965
[Clinical evaluation of the hypotensive effect of pargyline hydrochloride and methyclothiazide]. Antioquia medica, 1965, Volume: 15, Issue:3 Topics: Adult; Aged; Clinical Trials as Topic; Humans; Hypertension; Methyclothiazide; Middle Aged; Pargylin	1965
A long-term evaluation of pargyline hydrochloride in hypertension. The American journal of the medical sciences, 1966, Volume: 251, Issue:1 Topics: Clinical Trials as Topic; Humans; Hypertension; Pargyline	1966
Combined therapy for the treatment of hypertension: pargyline hydrochloride and methyclothiazide. Vascular diseases, 1966, Volume: 3, Issue:1 Topics: Clinical Trials as Topic; Drug Synergism; Humans; Hypertension; Methyclothiazide; Pargyline	1966
A long-term study with pargyline in the treatment of hypertension. The Medical journal of Australia, 1967, Feb-18, Volume: 1, Issue:7 Topics: Adult; Blood Pressure; Blood Pressure Determination; Clinical Trials as Topic; Female; Humans; Hyper	1967
Antihypertensive effect of pargyline and methyclothiazide in combination. Vascular diseases, 1966, Volume: 3, Issue:3 Topics: Adult; Aged; Drug Synergism; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Parg	1966

Other Studies

89 other studies available for pargyline and Blood Pressure, High

Article	Year
Clinical and pharmacologic observations on a monoamine oxidase inhibitor (pargyline hydrochloride) in hypertension. Current therapeutic research, clinical and experimental, 1961, Volume: 3 Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Humans; Hypertension; Monoamine Oxidase Inhibitors;	1961
The use of pargyline hydrochloride in the treatment of hypertension. Current therapeutic research, clinical and experimental, 1963, Volume: 5 Topics: Antihypertensive Agents; Hypertension; Monoamine Oxidase Inhibitors; Pargyline	1963
PARGYLINE HYDROCHLORIDE IN HYPERTENSION. Lancet (London, England), 1963, Dec-14, Volume: 2, Issue:7320 Topics: Humans; Hypertension; Monoamine Oxidase Inhibitors; Pargyline	1963
PARGYLINE TREATMENT OF HYPERTENSION. EXPERIENCE WITH A NONHYDRAZINE AMINE OXIDASE INHIBITOR. JAMA, 1964, Jan-18, Volume: 187 Topics: Antihypertensive Agents; Diuretics; Erectile Dysfunction; Geriatrics; Humans; Hypertension; Hypotens	1964
PARGYLINE, CHEESE AND ACUTE HYPERTENSION. JAMA, 1964, May-25, Volume: 188 Topics: Antihypertensive Agents; Cheese; Hypertension; Monoamine Oxidase Inhibitors; Pargyline; Toxicology;	1964
PARGYLINE AND CHEESE. Lancet (London, England), 1964, Apr-18, Volume: 1, Issue:7338 Topics: Cheese; Hypertension; Monoamine Oxidase Inhibitors; Pargyline; Sympathomimetics; Toxicology	1964
[THE MEDICAL TREATMENT OF HYPERTENSION]. Therapie der Gegenwart, 1964, Volume: 103 Topics: Alkaloids; Antihypertensive Agents; Diuretics; Ganglionic Blockers; Guanethidine; Hydralazine; Hyper	1964
MONOAMINE-OXIDASE INHIBITORS, BROAD BEANS, AND HYPERTENSION. Lancet (London, England), 1964, May-16, Volume: 1, Issue:7342 Topics: Dihydroxyphenylalanine; Fabaceae; Headache; Hypertension; Monoamine Oxidase Inhibitors; Oxidoreducta	1964
PARGYLINE AND THE CHEESE REACTION. British medical journal, 1964, May-30, Volume: 1, Issue:5395 Topics: Cheese; Dreams; Humans; Hypertension; Monoamine Oxidase Inhibitors; Pargyline; Toxicology	1964
DRUG THERAPY OF HYPERTENSION. Diseases of the chest, 1964, Volume: 45 Topics: Alkaloids; Antihypertensive Agents; Chlorothiazide; Diuretics; Ganglionic Blockers; Guanethidine; Hy	1964
NEW DRUGS FOR HYPERTENSION. Scottish medical journal, 1964, Volume: 9 Topics: Humans; Hypertension; Pargyline	1964
HYPERTENSIVE REACTION TO PARGYLINE AND CHEESE. Lancet (London, England), 1964, Sep-12, Volume: 2, Issue:7359 Topics: Antihypertensive Agents; Cheese; Geriatrics; Headache; Hypertension; Juvenile Delinquency; Monoamine	1964
PARGYLINE HYDROCHLORIDE, HYPERTENSION, URINARY TRYPTAMINE, AND VASCULAR REFLEXES. Geriatrics, 1964, Volume: 19 Topics: Blood Pressure; Blood Pressure Determination; Drug Therapy; Ganglia; Ganglia, Autonomic; Hypertensio	1964
TRANSIENT BRAIN SYNDROME AS A NON-FATAL REACTION TO COMBINED PARGYLINE-IMIPRAMINE TREATMENT. The American journal of psychiatry, 1964, Volume: 121 Topics: Brain; Depression; Depressive Disorder; Drug Therapy; Geriatrics; Hypertension; Imipramine; Mental D	1964
COMPARATIVE EFFECTIVENESS OF PARGYLINE AS AN ANTIHYPERTENSIVE AGENT. American heart journal, 1964, Volume: 68 Topics: Antihypertensive Agents; Biomedical Research; Drug Therapy; Guanethidine; Hemodynamics; Humans; Hydr	1964
[AN EFFECTOVE HYPOTENSIVE DRUG, PARGYLINE, DERIVED FROM THE MONOAMINE OXIDASE INHIBITOR GROUP]. La Clinica terapeutica, 1964, Oct-15, Volume: 31 Topics: Drug Therapy; Hypertension; Monoamine Oxidase Inhibitors; Pargyline	1964
[ACUTE HYPERTENSION DUE TO MONOAMINE OXIDASE INHIBITORS AND THE EATING OF CHEESE]. Deutsche medizinische Wochenschrift (1946), 1965, Jan-01, Volume: 90 Topics: Cheese; Hypertension; Monoamine Oxidase Inhibitors; Nialamide; Pargyline; Phenelzine; Toxicology; Tr	1965
HEMODYNAMIC EFFECTS OF PARGYLINE IN HYPERTENSIVE PATIENTS. Circulation, 1964, Volume: 30 Topics: Blood Circulation; Blood Flow Velocity; Cardiac Output; Drug Therapy; Dye Dilution Technique; Glomer	1964
PARGYLINE HYDROCHLORIDE AND METHYCLOTHIAZIDE COMBINED IN THE TREATMENT OF HYPERTENSION. Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Biomedical Research; Blood Coagulation Tests; Drug Therapy; Geriatrics; Hematocrit; Hemoglobins; Hum	1965
HEMODYNAMIC RESPONSE TO ANTIHYPERTENSIVE DRUG THERAPY. JAMA, 1965, Apr-05, Volume: 192 Topics: Antihypertensive Agents; Blood Circulation; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dru	1965
TYRAMINE IN CHEESE RELATED TO HYPERTENSIVE CRISES AFTER MONOAMINE-OXIDASE INHIBITION. Lancet (London, England), 1965, May-01, Volume: 1, Issue:7392 Topics: Cheese; Chromatography; Colorimetry; Depression; Depressive Disorder; Drug Therapy; Electrophoresis;	1965
PARGYLINE HYDROCHLORIDE AND AMINE HYPERTENSION. Angiology, 1965, Volume: 16 Topics: Amines; Drug Therapy; Electrocardiography; Humans; Hypertension; Methyclothiazide; Pargyline; Pharma	1965
EXPERIENCE WITH PARGYLINE HYDROCHLORIDE (NONHYDRAZINE MONOAMINE OXIDASE INHIBITOR) AS AN ANTIHYPERTENSIVE AGENT: PRELIMINARY OBSERVATIONS IN 32 PATIENTS. Minnesota medicine, 1965, Volume: 48 Topics: Antihypertensive Agents; Biomedical Research; Drug Therapy; Hypertension; Minnesota; Monoamine Oxida	1965
[OUR CLINICAL EXPERIENCE WITH PARGYLINE HYDROCHLORIDE]. Prensa medica argentina, 1965, Jan-01, Volume: 52 Topics: Drug Therapy; Humans; Hypertension; Pargyline	1965
THE ANTIHYPERTENSIVE AND HYPOGLYCEMIC EFFECTS OF PARGYLINE HYDROCHLORIDE. Angiology, 1965, Volume: 16 Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Pressure Determination; Drug Therapy;	1965
PARGYLINE HYDROCHLORIDE IN TREATMENT OF RESISTANT HYPERTENSION. New York state journal of medicine, 1965, Jun-15, Volume: 65 Topics: Drug Therapy; Geriatrics; Hypertension; Pargyline; Toxicology	1965
HYPERTENSIVE CRISIS DUE TO PARGYLINE AND METARAMINOL. British medical journal, 1965, Aug-21, Volume: 2, Issue:5459 Topics: Autonomic Nervous System Diseases; Drug Synergism; Drug Therapy; Headache; Hypertension; Metaraminol	1965
A CLINICAL STUDY OF PARGYLINE HYDROCHLORIDE. Western medicine; the medical journal of the west, 1965, Volume: 6 Topics: Biomedical Research; Drug Therapy; Geriatrics; Hypertension; Pargyline; Toxicology	1965
[1ST IMPRESSIONS IN THE TREATMENT OF ARTERIAL HYPERTENSION WITH PARGYLINE]. Verhandelingen - Koninklijke Vlaamse Academie voor Geneeskunde van Belgie, 1965, Volume: 27 Topics: Biomedical Research; Drug Therapy; Hypertension; Pargyline; Rauwolfia; Toxicology	1965
[CLINICAL TRIAL WITH THE COMBINATION OF PARGYLINE AND METHYCLOTHIAZIDE IN THE TREATMENT OF ESSENTIAL ARTERIAL HYPERTENSION]. Medicina, 1965, Mar-10, Volume: 45 Topics: Drug Therapy; Essential Hypertension; Humans; Hypertension; Methyclothiazide; Pargyline	1965
Hypertensive interactions between monoamine oxidase inhibitors and foodstuffs. The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:497 Topics: Adolescent; Adult; Cerebral Hemorrhage; Cheese; Female; Humans; Hypertension; Male; Middle Aged; Mon	1967
Pargyline hydrochloride combined with methyclothiazide in the treatment of hypertension. Arizona medicine, 1967, Volume: 24, Issue:4 Topics: Adult; Aged; Drug Synergism; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Parg	1967
Drugs for hypertension. The Medical letter on drugs and therapeutics, 1984, Dec-07, Volume: 26, Issue:676 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arterioles; Benzothiadiazines	1984
Pargyline-induced mania in primary affective disorder: case report. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:1 Topics: Affective Disorders, Psychotic; Bipolar Disorder; Depressive Disorder; Humans; Hypertension; Male; M	1983
Enzyme activity of an amine oxidase to pargyline in the cardiovascular system of hypertensive rats. Biochemical pharmacology, 1983, Aug-01, Volume: 32, Issue:15 Topics: Amine Oxidase (Copper-Containing); Animals; Cardiovascular System; Drug Resistance; Hypertension; Ma	1983
Drug treatment of hypertension. Indian heart journal: teaching series, 1976, Volume: 1, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Debrisoquin; Diazoxide; Diuretics; Female; Hum	1976
Adverse reactions and interactions limiting the use of antihypertensive drugs. The American journal of medicine, 1975, Volume: 58, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Depression; Dose-Response Relationship, Drug; Drug Interact	1975
Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. European journal of pharmacology, 1979, Jul-15, Volume: 57, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Hypertension; Injections, Intraventricular;	1979
[The antihypertensive effect of pargyline in spontaneously hypertensive rats]. Archivos de farmacologia y toxicologia, 1978, Volume: 4, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Pargyline; Rats	1978
Central action as a key to past and future therapy of hypertension. Progress in brain research, 1977, Volume: 47 Topics: Atropine; Brain; Humans; Hypertension; Methyldopa; Pargyline; Phenobarbital; Propranolol; Receptors,	1977
Monoamine oxidase defect in essential arterial hypertension. A single dose pargyline test. Monographs in neural sciences, 1976, Volume: 3 Topics: Adult; Blood Platelets; Female; Half-Life; Humans; Hypertension; Male; Monoamine Oxidase; Pargyline;	1976
Antihypertensive effects of an aromatase inhibitor in inbred salt-sensitive rats. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:6 Pt 1 Topics: Aldosterone; Androstenedione; Animals; Antihypertensive Agents; Aromatase Inhibitors; Cortisone; Des	1991
Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats. Brain research, 1986, Aug-06, Volume: 379, Issue:2 Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Hypertension; Hypothalamus; Kinetics;	1986
L-dopa metabolism in genetically hypertensive mice: effect of pargyline. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:12 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Brain; Dopamine; Dopamine beta-Hydroxylase; Dr	1987
Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979), 1987, Volume: 10, Issue:5 Topics: Aging; Androstenedione; Animals; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Pargyline	1987
Bipolar affective symptoms associated with use of captopril and abrupt withdrawal of pargyline and propranolol. The American journal of psychiatry, 1985, Volume: 142, Issue:6 Topics: Bipolar Disorder; Captopril; Drug Therapy, Combination; Female; Humans; Hypertension; Middle Aged; N	1985
Altered norepinephrine uptake in neuronal cultures from spontaneously hypertensive rat brain. The American journal of physiology, 1985, Volume: 248, Issue:5 Pt 1 Topics: Animals; Brain; Cells, Cultured; Hypertension; Kinetics; Neurons; Norepinephrine; Pargyline; Rats; R	1985
Neurogenic factors in human hypertension: mechanism or myth? The American journal of medicine, 1973, Volume: 55, Issue:3 Topics: Angiotensin II; Blood Pressure; Catecholamines; Chemical Phenomena; Chemistry; Dihydroxyphenylalanin	1973
Hypertension past 60. Geriatrics, 1967, Volume: 22, Issue:3 Topics: Aged; Benzothiadiazines; Chlorthalidone; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa	1967
Pargyline on blood pressure in spinal and decerebrate cats. The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:11 Topics: Animals; Blood Pressure; Cats; Electric Stimulation; Heart Rate; Hypertension; Iproniazid; Pargyline	1966
The medical treatment of hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1970, Jun-13, Volume: 44, Issue:24 Topics: Antihypertensive Agents; Chlorothiazide; Diet Therapy; Emergencies; Furosemide; Ganglionic Blockers;	1970
Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline levels and blood pressure in spontaneously hypertensive rats. The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:9 Topics: Animals; Blood Pressure; Brain Chemistry; Brain Stem; Carboxy-Lyases; Cresols; Dihydroxyphenylalanin	1972
Proceedings: Monoamine oxidase defect in essential arterial hypertension: 'a single dose pargyline test'. British journal of pharmacology, 1974, Volume: 52, Issue:3 Topics: Blood Platelets; Humans; Hypertension; Monoamine Oxidase; Pargyline	1974
Proceedings: Recurrent pheochromocytoma. Archives of surgery (Chicago, Ill. : 1960), 1974, Volume: 108, Issue:4 Topics: Abdominal Neoplasms; Adolescent; Adrenal Gland Neoplasms; Adult; Child; Epinephrine; Female; Hormone	1974
Pharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155). Circulation, 1969, Volume: 39, Issue:2 Topics: Antihypertensive Agents; Blood Pressure; Cardiac Output; Cardiovascular System; Chlorthalidone; Dye	1969
Hemodynamic effects of pargyline hydrochloride at rest and during exercise in hypertension. Acta medica Scandinavica, 1967, Volume: 181, Issue:6 Topics: Adult; Blood Pressure; Cardiac Output; Exercise; Female; Hemodynamics; Humans; Hypertension; Male; M	1967
Treatment of hypertension with pargyline hydrochloride. Current therapeutic research, clinical and experimental, 1966, Volume: 8, Issue:7 Topics: Adult; Aged; Humans; Hypertension; Middle Aged; Pargyline	1966
Pargyline hydrochloride combined with methyclothiazide in the treatment of essential hypertension. Current therapeutic research, clinical and experimental, 1966, Volume: 8, Issue:8 Topics: Adult; Aged; Drug Synergism; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Parg	1966
Pargyline hydrochloride, methyclothiazide, and deserpidine in therapy of hypertension and prevention of "cheese reaction". Current therapeutic research, clinical and experimental, 1968, Volume: 10, Issue:3 Topics: Adult; Body Weight; Drug Synergism; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Meth	1968
[Preliminary findings on the use of pargyline in the management of systemic arterial hypertension]. Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:6 Topics: Adult; Aged; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Pargyline	1968
[Clinical observation of hypertensive patients treated with parglyline hydrochloride]. Hospital (Rio de Janeiro, Brazil), 1969, Volume: 76, Issue:6 Topics: Aged; Female; Humans; Hydrochloric Acid; Hypertension; Male; Middle Aged; Pargyline	1969
[Clinical and renal hemodynamic effects of pargyline]. La Clinica terapeutica, 1967, Mar-15, Volume: 40, Issue:5 Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Pargyline	1967
[Treatment of arterial hypertension with a pargyline and methyclothiazide compound]. Revista brasileira de medicina, 1967, Volume: 24, Issue:5 Topics: Adult; Aged; Arteries; Blood Vessels; Female; Humans; Hypertension; Male; Methyclothiazide; Middle A	1967
[Clinical evaluation of pargyline hydrochloride in the therapy of arterial hypertension]. Revista espanola de cardiologia, 1967, Volume: 20, Issue:3 Topics: Adult; Arteries; Humans; Hypertension; Middle Aged; Pargyline	1967
Effect of various drugs upon the neostigmine pressor response. Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 171, Issue:1 Topics: Acetylcholine; Animals; Benzene Derivatives; Blood Pressure; Chlorisondamine; Diphenhydramine; Dogs;	1968
[Hypotensive action of the pargyline-methyclothiazide combination]. Revista brasileira de medicina, 1968, Volume: 25, Issue:2 Topics: Adult; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Pargyline	1968
Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs. The Journal of clinical investigation, 1968, Volume: 47, Issue:10 Topics: Adolescent; Adult; Blood Pressure; Catecholamines; Chromatography; Dihydroxyphenylalanine; Dopamine;	1968
[Management of hypertension using methyclothiazide pargyline]. Prensa medica argentina, 1968, Sep-27, Volume: 55, Issue:31 Topics: Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Aged; Parg	1968
Parglyline hydrochloride and methyclothiazide combined in the treatment of hypertension in diabetic patients. Arizona medicine, 1968, Volume: 25, Issue:11 Topics: Adult; Aged; Diabetes Complications; Female; Humans; Hypertension; Male; Methyclothiazide; Middle Ag	1968
[Vascular reactivity of hypertensive patients treated with pargyline-methylchlorothiazide]. Revista medica de Chile, 1968, Volume: 96, Issue:1 Topics: Drug Synergism; Female; Humans; Hypertension; Male; Methyclothiazide; Pargyline; Valsalva Maneuver;	1968
[Clinical experience using pargyline hydrochloride in the treatment of arterial hypertension]. Revista clinica espanola, 1968, Apr-15, Volume: 109, Issue:1 Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Pargyline	1968
[Effects of parglyine as a long-term antihypertensive agent]. L'union medicale du Canada, 1968, Volume: 97, Issue:11 Topics: Adolescent; Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Pargyline; Reserpine; Thia	1968
Interaction between some cheeses and monoamine oxydase inhibitors. Arzneimittel-Forschung, 1968, Volume: 18, Issue:9 Topics: Animals; Blood Pressure; Cats; Cheese; Depression, Chemical; Female; Hydrazines; Hypertension; Male;	1968
An approach to the medical treatment of hypertension in the aged. Geriatrics, 1969, Volume: 24, Issue:4 Topics: Age Factors; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Diuretics;	1969
Hypotensive drug therapy in the management of hypertension. American heart journal, 1969, Volume: 78, Issue:4 Topics: Antihypertensive Agents; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Methy	1969
Management of hypertension with pargyline hydrochloride (Eutonyl). Journal of postgraduate medicine, 1965, Volume: 11, Issue:3 Topics: Adult; Aged; Humans; Hypertension; Middle Aged; Pargyline	1965
[Clinical trial of a new hypotensive drug: pargyline hydrochloride]. Medicina clinica, 1965, Volume: 45, Issue:1 Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Pargyline	1965
[Treatment of arterial hypertension with pargyline hydrochloride]. Prensa medica argentina, 1965, Aug-13, Volume: 52, Issue:29 Topics: Humans; Hypertension; Pargyline	1965
[Treatment of arterial hypertension with pargyline chlorhydrate]. El Torax, 1965, Volume: 14, Issue:2 Topics: Female; Humans; Hypertension; Male; Pargyline	1965
[Pargyline hydrochloride in the treatment of arterial hypertension]. Revista medica de Chile, 1965, Volume: 93, Issue:10 Topics: Humans; Hypertension; Pargyline	1965
Treatment of hypertension with a combination of pargyline hydrochloride and methyclothiazide. Journal of the American Geriatrics Society, 1966, Volume: 14, Issue:1 Topics: Adult; Aged; Humans; Hypertension; Methyclothiazide; Middle Aged; Pargyline	1966
Essential hypertension in general practice. An evaluation of pargyline hydrochloride. The Practitioner, 1966, Volume: 196, Issue:173 Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Pargyline	1966
Hallucinosis on combined methyldopa and pargyline. British medical journal, 1966, Mar-26, Volume: 1, Issue:5490 Topics: Drug Synergism; Female; Hallucinations; Humans; Hypertension; Methyldopa; Middle Aged; Pargyline	1966
Aged cheese, pargyline hydrochloride, and paradoxical hypertension. The Journal-lancet, 1966, Volume: 86, Issue:5 Topics: Adult; Cheese; Humans; Hypertension; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Pargyl	1966
Renal pharmacodynamics of antihypertensive drugs: clinical applications. The American journal of cardiology, 1966, Volume: 17, Issue:5 Topics: Glomerular Filtration Rate; Guanethidine; Humans; Hydralazine; Hypertension; Kidney Diseases; Methyl	1966
[Treatment of arterial hypertension with guanethidine, 1-alpha-methyldopa and pargyline hydrochloride]. Prensa medica argentina, 1966, Jun-03, Volume: 53, Issue:22 Topics: Guanethidine; Humans; Hypertension; Methyldopa; Pargyline	1966
[Pargyline hydrochloride, a new antihypertensive drug]. Medicina interna, 1966, Volume: 18, Issue:10 Topics: Humans; Hypertension; Pargyline	1966
[Pargyline hydrochloride and hypertension]. Revista medica de Chile, 1966, Volume: 94, Issue:3 Topics: Adult; Aged; Female; Humans; Hypertension; Middle Aged; Pargyline	1966
[Treatment of arterial hypertension with pargyline hydrochloride]. Semaine therapeutique, 1966, Volume: 42, Issue:10 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Hypertension; Male; Middle Aged; P	1966