pargyline and Aging
pargyline has been researched along with Aging in 38 studies
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species." | 6.41 | Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002) |
| "The etiology of idiopathic Parkinson's disease remains as an enigma." | 2.41 | [Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease]. ( Maruyama, W; Naoi, M, 2000) |
| "Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species." | 2.41 | Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002) |
| "Pargyline treatment caused an increase in the DA concentrations in the anterior lobe by about 150%." | 1.27 | Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis. ( Cohen, G; Cooper, T; Holzbauer, M; Krause, U; Mann, SP; Racké, K; Sharman, DF, 1984) |
Research
Studies (38)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (68.42) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bar-Am, O | 1 |
| Amit, T | 1 |
| Youdim, MB | 1 |
| Weinreb, O | 1 |
| Kitahama, K | 1 |
| Jouvet, A | 1 |
| Fujimiya, M | 1 |
| Nagatsu, I | 1 |
| Arai, R | 1 |
| Walker, RF | 1 |
| Baker, PC | 1 |
| Hoff, KM | 1 |
| Goodrich, CA | 1 |
| McNamara, MC | 1 |
| Lawson, EE | 1 |
| Holzbauer, M | 1 |
| Racké, K | 1 |
| Mann, SP | 1 |
| Cooper, T | 1 |
| Cohen, G | 1 |
| Krause, U | 1 |
| Sharman, DF | 1 |
| Mirmiran, M | 1 |
| van de Poll, NE | 1 |
| Corner, MA | 1 |
| van Oyen, HG | 1 |
| Bour, HL | 1 |
| Venero, JL | 2 |
| Machado, A | 2 |
| Cano, J | 2 |
| Barber, AJ | 1 |
| Yu, PH | 1 |
| Boulton, AA | 1 |
| Moura, D | 1 |
| Vaz-da-Silva, MJ | 1 |
| Azevedo, I | 1 |
| Brandão, F | 1 |
| Guimarães, S | 1 |
| Nakano, M | 1 |
| Mizuno, T | 1 |
| Penit-Soria, J | 1 |
| Durand, C | 1 |
| Herve, D | 1 |
| Besson, MJ | 1 |
| Maruyama, W | 1 |
| Naoi, M | 1 |
| Kitani, K | 1 |
| Minami, C | 1 |
| Yamamoto, T | 1 |
| Kanai, S | 1 |
| Ivy, GO | 1 |
| Carrillo, MC | 1 |
| Dörner, G | 2 |
| Breese, GR | 2 |
| Mueller, RA | 2 |
| Vogel, RA | 1 |
| Nelson, DL | 1 |
| Herbet, A | 1 |
| Glowinski, J | 1 |
| Hamon, M | 1 |
| Edwards, DJ | 1 |
| Venetti, MC | 1 |
| Hinz, G | 1 |
| Döcke, F | 1 |
| Tönjes, R | 1 |
| Corte, LD | 1 |
| Callingham, BA | 2 |
| Simpkins, JW | 1 |
| Mueller, GP | 1 |
| Huang, HH | 1 |
| Meites, J | 1 |
| Tissari, AH | 2 |
| Raunu, EM | 1 |
| Sprengeler, T | 1 |
| Rakow, D | 1 |
| Schulze, G | 1 |
| Christ, W | 1 |
| Rajaofetra, N | 1 |
| Poulat, P | 1 |
| Marlier, L | 1 |
| Geffard, M | 1 |
| Privat, A | 1 |
| Tatton, WG | 1 |
| Greenwood, CE | 1 |
| Salo, PT | 1 |
| Seniuk, NA | 1 |
| Koulu, M | 1 |
| Saavedra, JM | 1 |
| Bjelogrlic, N | 1 |
| Niwa, M | 1 |
| Agren, H | 1 |
| Linnoila, M | 1 |
| Kalaria, RN | 1 |
| Harik, SI | 1 |
| Ricaurte, GA | 1 |
| DeLanney, LE | 1 |
| Finnegan, KT | 1 |
| Irwin, I | 1 |
| Langston, JW | 1 |
| Eble, JP | 1 |
| Goodrich, C | 1 |
| Melby, JC | 1 |
| Holbrook, M | 1 |
| Griffing, GT | 1 |
| Johnston, JO | 1 |
| Cousin, KM | 2 |
| Gerald, MC | 2 |
| Uretsky, NJ | 2 |
| Lyles, GA | 1 |
| Horita, A | 2 |
| Lowe, MC | 1 |
Reviews
4 reviews available for pargyline and Aging
| Article | Year |
|---|---|
Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets.
Topics: Aging; Animals; Brain; Humans; Mitochondria; Neuroprotective Agents; Pargyline; Propylamines | 2016 |
[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease].
Topics: Aging; Animals; Apoptosis; Dopamine; Humans; Methyltransferases; Mitochondria; Neurotoxins; Pargylin | 2000 |
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents; | 2002 |
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami | 1975 |
Other Studies
34 other studies available for pargyline and Aging
| Article | Year |
|---|---|
5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Cats; Decarboxylation; Drug Combinatio | 2002 |
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi | 1982 |
Changes in 5-HT and 5-HIAA stores in maturing mouse brain following MAO blockade with pargyline.
Topics: Aging; Animals; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Pargyline; Serotonin | 1981 |
Biogenic amine turnover in newborn and adult rabbit brainstem nuclei after pargyline administration.
Topics: Aging; Animals; Animals, Newborn; Biogenic Amines; Brain Stem; Dopamine; Locus Coeruleus; Norepineph | 1984 |
Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis.
Topics: Aging; Animals; Dopamine; Median Eminence; Microscopy, Fluorescence; Norepinephrine; Pargyline; Pitu | 1984 |
Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat.
Topics: Aggression; Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Bra | 1981 |
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Dopamine; Homovanillic Acid; Hy | 1993 |
Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Drinking; Isoenzymes; Locomotion; Male; Memory | 1993 |
Release and disposition of 3H-noradrenaline in the saphenous vein of neonate and adult dogs.
Topics: Aging; Animals; Animals, Newborn; Dogs; Electric Stimulation; Female; Hydrocortisone; In Vitro Techn | 1993 |
Age-related changes in the metabolism of neurotransmitters in rat striatum: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Male; Microdialysis; Mono | 1996 |
Morphological and biochemical adaptations to unilateral dopamine denervation of the neostriatum in newborn rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Basal Ganglia; Denervation; Dopami | 1997 |
Hormone dependent differentiation, maturation and function of the brain and sexual behavior.
Topics: Aging; Androgens; Animals; Brain; Cell Differentiation; Homosexuality; Humans; Luteinizing Hormone; | 1977 |
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Central Nervous System Agents; Desipramin | 1978 |
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal; | 1978 |
[3H]Harmaline as a specific ligand of MAO A--II. Measurement of the turnover rates of MAO A during ontogenesis in the rat brain.
Topics: Aging; Alkaloids; Animals; Binding, Competitive; Brain; Female; Harmaline; Kinetics; Ligands; Male; | 1979 |
Developmental aspects of rat heart monoamine oxidase.
Topics: Aging; Animals; Heart; Hot Temperature; In Vitro Techniques; Kinetics; Mitochondria, Heart; Monoamin | 1979 |
Effects of psychotrophic drugs on brain differentiation in female rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg | 1977 |
The influence of age and adrenalectomy on rat heart monoamine oxidase.
Topics: Adrenalectomy; Aging; Animals; Body Weight; Heart; Kinetics; Male; Mathematics; Monoamine Oxidase; M | 1977 |
Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion.
Topics: Aging; Animals; Brain; Catecholamines; Dopamine; Gonadotropins, Pituitary; Hydroxyindoleacetic Acid; | 1977 |
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S | 1975 |
Proceedings: Age dependent recovery of rat brain MAO activity after administration of a single dose of iproniazid and pargyline.
Topics: Aging; Animals; Brain; Half-Life; Iproniazid; Monoamine Oxidase; Pargyline; Rats | 1975 |
Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study.
Topics: Aging; Animals; Embryonic and Fetal Development; Female; Gestational Age; Immunohistochemistry; Moto | 1992 |
Transmitter synthesis increases in substantia nigra neurons of the aged mouse.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Axonal Transport; Corpus Striatum; Dihydroxyphenylal | 1991 |
Age effects on monoamine turnover of the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxyla | 1991 |
Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Hypertension; Hypothalamus; Kinetics; | 1986 |
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat.
Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculat | 1987 |
The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Hydroxydopamines; Injections, Intraventricular; Male; Mic | 1988 |
The maturational onset of the 5-HT mediated head twitch in mice.
Topics: 5-Hydroxytryptophan; Aging; Animals; Carbidopa; Female; Humans; Male; Mice; Motor Activity; Pargylin | 1987 |
Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat.
Topics: Aging; Androstenedione; Animals; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Pargyline | 1987 |
Effect of nialamide on the metabolism of dopamine injected into the nucleus accumbens of old rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mo | 1986 |
Locomotor response of nialamide pretreated old rats to intraaccumbens dopamine.
Topics: Aging; Animals; Dopamine; Ergonovine; Injections; Male; Monoamine Oxidase; Motor Activity; Nialamide | 1985 |
Proceedings: An effect of thyroid hormones upon monoamine oxidase activity.
Topics: Aging; Animals; Half-Life; Hyperthyroidism; Hypothyroidism; Male; Monoamine Oxidase; Myocardium; Org | 1974 |
On the extraneuronal nature of cardiac monoamine oxidase in the rat.
Topics: Aging; Animals; Body Weight; Dopamine; Female; Heart; Heart Atria; Heart Septum; Heart Ventricles; H | 1972 |
The influence of age on the recovery of cardiac monoamine oxidase after irreversible inhibition.
Topics: Aging; Animals; Brain; Depression, Chemical; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhib | 1968 |