pargyline has been researched along with Aging in 38 studies
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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"Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species." | 6.41 | Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002) |
"The etiology of idiopathic Parkinson's disease remains as an enigma." | 2.41 | [Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease]. ( Maruyama, W; Naoi, M, 2000) |
"Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species." | 2.41 | Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002) |
"Pargyline treatment caused an increase in the DA concentrations in the anterior lobe by about 150%." | 1.27 | Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis. ( Cohen, G; Cooper, T; Holzbauer, M; Krause, U; Mann, SP; Racké, K; Sharman, DF, 1984) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (68.42) | 18.7374 |
1990's | 8 (21.05) | 18.2507 |
2000's | 3 (7.89) | 29.6817 |
2010's | 1 (2.63) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Bar-Am, O | 1 |
Amit, T | 1 |
Youdim, MB | 1 |
Weinreb, O | 1 |
Kitahama, K | 1 |
Jouvet, A | 1 |
Fujimiya, M | 1 |
Nagatsu, I | 1 |
Arai, R | 1 |
Walker, RF | 1 |
Baker, PC | 1 |
Hoff, KM | 1 |
Goodrich, CA | 1 |
McNamara, MC | 1 |
Lawson, EE | 1 |
Holzbauer, M | 1 |
Racké, K | 1 |
Mann, SP | 1 |
Cooper, T | 1 |
Cohen, G | 1 |
Krause, U | 1 |
Sharman, DF | 1 |
Mirmiran, M | 1 |
van de Poll, NE | 1 |
Corner, MA | 1 |
van Oyen, HG | 1 |
Bour, HL | 1 |
Venero, JL | 2 |
Machado, A | 2 |
Cano, J | 2 |
Barber, AJ | 1 |
Yu, PH | 1 |
Boulton, AA | 1 |
Moura, D | 1 |
Vaz-da-Silva, MJ | 1 |
Azevedo, I | 1 |
Brandão, F | 1 |
Guimarães, S | 1 |
Nakano, M | 1 |
Mizuno, T | 1 |
Penit-Soria, J | 1 |
Durand, C | 1 |
Herve, D | 1 |
Besson, MJ | 1 |
Maruyama, W | 1 |
Naoi, M | 1 |
Kitani, K | 1 |
Minami, C | 1 |
Yamamoto, T | 1 |
Kanai, S | 1 |
Ivy, GO | 1 |
Carrillo, MC | 1 |
Dörner, G | 2 |
Breese, GR | 2 |
Mueller, RA | 2 |
Vogel, RA | 1 |
Nelson, DL | 1 |
Herbet, A | 1 |
Glowinski, J | 1 |
Hamon, M | 1 |
Edwards, DJ | 1 |
Venetti, MC | 1 |
Hinz, G | 1 |
Döcke, F | 1 |
Tönjes, R | 1 |
Corte, LD | 1 |
Callingham, BA | 2 |
Simpkins, JW | 1 |
Mueller, GP | 1 |
Huang, HH | 1 |
Meites, J | 1 |
Tissari, AH | 2 |
Raunu, EM | 1 |
Sprengeler, T | 1 |
Rakow, D | 1 |
Schulze, G | 1 |
Christ, W | 1 |
Rajaofetra, N | 1 |
Poulat, P | 1 |
Marlier, L | 1 |
Geffard, M | 1 |
Privat, A | 1 |
Tatton, WG | 1 |
Greenwood, CE | 1 |
Salo, PT | 1 |
Seniuk, NA | 1 |
Koulu, M | 1 |
Saavedra, JM | 1 |
Bjelogrlic, N | 1 |
Niwa, M | 1 |
Agren, H | 1 |
Linnoila, M | 1 |
Kalaria, RN | 1 |
Harik, SI | 1 |
Ricaurte, GA | 1 |
DeLanney, LE | 1 |
Finnegan, KT | 1 |
Irwin, I | 1 |
Langston, JW | 1 |
Eble, JP | 1 |
Goodrich, C | 1 |
Melby, JC | 1 |
Holbrook, M | 1 |
Griffing, GT | 1 |
Johnston, JO | 1 |
Cousin, KM | 2 |
Gerald, MC | 2 |
Uretsky, NJ | 2 |
Lyles, GA | 1 |
Horita, A | 2 |
Lowe, MC | 1 |
4 reviews available for pargyline and Aging
Article | Year |
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Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets.
Topics: Aging; Animals; Brain; Humans; Mitochondria; Neuroprotective Agents; Pargyline; Propylamines | 2016 |
[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease].
Topics: Aging; Animals; Apoptosis; Dopamine; Humans; Methyltransferases; Mitochondria; Neurotoxins; Pargylin | 2000 |
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents; | 2002 |
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami | 1975 |
34 other studies available for pargyline and Aging
Article | Year |
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5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Cats; Decarboxylation; Drug Combinatio | 2002 |
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi | 1982 |
Changes in 5-HT and 5-HIAA stores in maturing mouse brain following MAO blockade with pargyline.
Topics: Aging; Animals; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Pargyline; Serotonin | 1981 |
Biogenic amine turnover in newborn and adult rabbit brainstem nuclei after pargyline administration.
Topics: Aging; Animals; Animals, Newborn; Biogenic Amines; Brain Stem; Dopamine; Locus Coeruleus; Norepineph | 1984 |
Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis.
Topics: Aging; Animals; Dopamine; Median Eminence; Microscopy, Fluorescence; Norepinephrine; Pargyline; Pitu | 1984 |
Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat.
Topics: Aggression; Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Bra | 1981 |
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Dopamine; Homovanillic Acid; Hy | 1993 |
Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Drinking; Isoenzymes; Locomotion; Male; Memory | 1993 |
Release and disposition of 3H-noradrenaline in the saphenous vein of neonate and adult dogs.
Topics: Aging; Animals; Animals, Newborn; Dogs; Electric Stimulation; Female; Hydrocortisone; In Vitro Techn | 1993 |
Age-related changes in the metabolism of neurotransmitters in rat striatum: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Male; Microdialysis; Mono | 1996 |
Morphological and biochemical adaptations to unilateral dopamine denervation of the neostriatum in newborn rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Basal Ganglia; Denervation; Dopami | 1997 |
Hormone dependent differentiation, maturation and function of the brain and sexual behavior.
Topics: Aging; Androgens; Animals; Brain; Cell Differentiation; Homosexuality; Humans; Luteinizing Hormone; | 1977 |
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Central Nervous System Agents; Desipramin | 1978 |
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal; | 1978 |
[3H]Harmaline as a specific ligand of MAO A--II. Measurement of the turnover rates of MAO A during ontogenesis in the rat brain.
Topics: Aging; Alkaloids; Animals; Binding, Competitive; Brain; Female; Harmaline; Kinetics; Ligands; Male; | 1979 |
Developmental aspects of rat heart monoamine oxidase.
Topics: Aging; Animals; Heart; Hot Temperature; In Vitro Techniques; Kinetics; Mitochondria, Heart; Monoamin | 1979 |
Effects of psychotrophic drugs on brain differentiation in female rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg | 1977 |
The influence of age and adrenalectomy on rat heart monoamine oxidase.
Topics: Adrenalectomy; Aging; Animals; Body Weight; Heart; Kinetics; Male; Mathematics; Monoamine Oxidase; M | 1977 |
Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion.
Topics: Aging; Animals; Brain; Catecholamines; Dopamine; Gonadotropins, Pituitary; Hydroxyindoleacetic Acid; | 1977 |
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S | 1975 |
Proceedings: Age dependent recovery of rat brain MAO activity after administration of a single dose of iproniazid and pargyline.
Topics: Aging; Animals; Brain; Half-Life; Iproniazid; Monoamine Oxidase; Pargyline; Rats | 1975 |
Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study.
Topics: Aging; Animals; Embryonic and Fetal Development; Female; Gestational Age; Immunohistochemistry; Moto | 1992 |
Transmitter synthesis increases in substantia nigra neurons of the aged mouse.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Axonal Transport; Corpus Striatum; Dihydroxyphenylal | 1991 |
Age effects on monoamine turnover of the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxyla | 1991 |
Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Hypertension; Hypothalamus; Kinetics; | 1986 |
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat.
Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculat | 1987 |
The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Hydroxydopamines; Injections, Intraventricular; Male; Mic | 1988 |
The maturational onset of the 5-HT mediated head twitch in mice.
Topics: 5-Hydroxytryptophan; Aging; Animals; Carbidopa; Female; Humans; Male; Mice; Motor Activity; Pargylin | 1987 |
Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat.
Topics: Aging; Androstenedione; Animals; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Pargyline | 1987 |
Effect of nialamide on the metabolism of dopamine injected into the nucleus accumbens of old rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mo | 1986 |
Locomotor response of nialamide pretreated old rats to intraaccumbens dopamine.
Topics: Aging; Animals; Dopamine; Ergonovine; Injections; Male; Monoamine Oxidase; Motor Activity; Nialamide | 1985 |
Proceedings: An effect of thyroid hormones upon monoamine oxidase activity.
Topics: Aging; Animals; Half-Life; Hyperthyroidism; Hypothyroidism; Male; Monoamine Oxidase; Myocardium; Org | 1974 |
On the extraneuronal nature of cardiac monoamine oxidase in the rat.
Topics: Aging; Animals; Body Weight; Dopamine; Female; Heart; Heart Atria; Heart Septum; Heart Ventricles; H | 1972 |
The influence of age on the recovery of cardiac monoamine oxidase after irreversible inhibition.
Topics: Aging; Animals; Brain; Depression, Chemical; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhib | 1968 |