Page last updated: 2024-11-02

pargyline and Aging

pargyline has been researched along with Aging in 38 studies

Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species."6.41Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002)
"The etiology of idiopathic Parkinson's disease remains as an enigma."2.41[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease]. ( Maruyama, W; Naoi, M, 2000)
"Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species."2.41Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use. ( Carrillo, MC; Ivy, GO; Kanai, S; Kitani, K; Minami, C; Yamamoto, T, 2002)
"Pargyline treatment caused an increase in the DA concentrations in the anterior lobe by about 150%."1.27Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis. ( Cohen, G; Cooper, T; Holzbauer, M; Krause, U; Mann, SP; Racké, K; Sharman, DF, 1984)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199026 (68.42)18.7374
1990's8 (21.05)18.2507
2000's3 (7.89)29.6817
2010's1 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bar-Am, O1
Amit, T1
Youdim, MB1
Weinreb, O1
Kitahama, K1
Jouvet, A1
Fujimiya, M1
Nagatsu, I1
Arai, R1
Walker, RF1
Baker, PC1
Hoff, KM1
Goodrich, CA1
McNamara, MC1
Lawson, EE1
Holzbauer, M1
Racké, K1
Mann, SP1
Cooper, T1
Cohen, G1
Krause, U1
Sharman, DF1
Mirmiran, M1
van de Poll, NE1
Corner, MA1
van Oyen, HG1
Bour, HL1
Venero, JL2
Machado, A2
Cano, J2
Barber, AJ1
Yu, PH1
Boulton, AA1
Moura, D1
Vaz-da-Silva, MJ1
Azevedo, I1
Brandão, F1
Guimarães, S1
Nakano, M1
Mizuno, T1
Penit-Soria, J1
Durand, C1
Herve, D1
Besson, MJ1
Maruyama, W1
Naoi, M1
Kitani, K1
Minami, C1
Yamamoto, T1
Kanai, S1
Ivy, GO1
Carrillo, MC1
Dörner, G2
Breese, GR2
Mueller, RA2
Vogel, RA1
Nelson, DL1
Herbet, A1
Glowinski, J1
Hamon, M1
Edwards, DJ1
Venetti, MC1
Hinz, G1
Döcke, F1
Tönjes, R1
Corte, LD1
Callingham, BA2
Simpkins, JW1
Mueller, GP1
Huang, HH1
Meites, J1
Tissari, AH2
Raunu, EM1
Sprengeler, T1
Rakow, D1
Schulze, G1
Christ, W1
Rajaofetra, N1
Poulat, P1
Marlier, L1
Geffard, M1
Privat, A1
Tatton, WG1
Greenwood, CE1
Salo, PT1
Seniuk, NA1
Koulu, M1
Saavedra, JM1
Bjelogrlic, N1
Niwa, M1
Agren, H1
Linnoila, M1
Kalaria, RN1
Harik, SI1
Ricaurte, GA1
DeLanney, LE1
Finnegan, KT1
Irwin, I1
Langston, JW1
Eble, JP1
Goodrich, C1
Melby, JC1
Holbrook, M1
Griffing, GT1
Johnston, JO1
Cousin, KM2
Gerald, MC2
Uretsky, NJ2
Lyles, GA1
Horita, A2
Lowe, MC1

Reviews

4 reviews available for pargyline and Aging

ArticleYear
Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:2

    Topics: Aging; Animals; Brain; Humans; Mitochondria; Neuroprotective Agents; Pargyline; Propylamines

2016
[Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 116, Issue:6

    Topics: Aging; Animals; Apoptosis; Dopamine; Humans; Methyltransferases; Mitochondria; Neurotoxins; Pargylin

2000
Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
    Annals of the New York Academy of Sciences, 2002, Volume: 959

    Topics: Aging; Animals; Catalase; Free Radical Scavengers; Humans; Life Expectancy; Neuroprotective Agents;

2002
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
    Medical biology, 1975, Volume: 53, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami

1975

Other Studies

34 other studies available for pargyline and Aging

ArticleYear
5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:5-6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Cats; Decarboxylation; Drug Combinatio

2002
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
    Neurobiology of aging, 1982,Fall, Volume: 3, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi

1982
Changes in 5-HT and 5-HIAA stores in maturing mouse brain following MAO blockade with pargyline.
    General pharmacology, 1981, Volume: 12, Issue:6

    Topics: Aging; Animals; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Pargyline; Serotonin

1981
Biogenic amine turnover in newborn and adult rabbit brainstem nuclei after pargyline administration.
    Respiration physiology, 1984, Volume: 58, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Biogenic Amines; Brain Stem; Dopamine; Locus Coeruleus; Norepineph

1984
Regional differences in the effect of pargyline on dopamine concentrations in the rat hypophysis.
    Journal of neural transmission, 1984, Volume: 59, Issue:2

    Topics: Aging; Animals; Dopamine; Median Eminence; Microscopy, Fluorescence; Norepinephrine; Pargyline; Pitu

1984
Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat.
    Brain research, 1981, Jan-05, Volume: 204, Issue:1

    Topics: Aggression; Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Bra

1981
Effect of ageing on monoamine turnover in the prefrontal cortex of rats.
    Mechanisms of ageing and development, 1993, Dec-15, Volume: 72, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Biogenic Monoamines; Dopamine; Homovanillic Acid; Hy

1993
Chronic effects of monoamine oxidase-B inhibitors on the behaviour of aged mice.
    Life sciences, 1993, Volume: 53, Issue:9

    Topics: Aging; Animals; Behavior, Animal; Body Weight; Brain; Drinking; Isoenzymes; Locomotion; Male; Memory

1993
Release and disposition of 3H-noradrenaline in the saphenous vein of neonate and adult dogs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 347, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Dogs; Electric Stimulation; Female; Hydrocortisone; In Vitro Techn

1993
Age-related changes in the metabolism of neurotransmitters in rat striatum: a microdialysis study.
    Mechanisms of ageing and development, 1996, Feb-24, Volume: 86, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Corpus Striatum; Dopamine; Male; Microdialysis; Mono

1996
Morphological and biochemical adaptations to unilateral dopamine denervation of the neostriatum in newborn rats.
    Neuroscience, 1997, Volume: 77, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Basal Ganglia; Denervation; Dopami

1997
Hormone dependent differentiation, maturation and function of the brain and sexual behavior.
    Endokrinologie, 1977, Volume: 69, Issue:3

    Topics: Aging; Androgens; Animals; Brain; Cell Differentiation; Homosexuality; Humans; Luteinizing Hormone;

1977
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats.
    Annals of the New York Academy of Sciences, 1978, Jun-12, Volume: 305

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Central Nervous System Agents; Desipramin

1978
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal;

1978
[3H]Harmaline as a specific ligand of MAO A--II. Measurement of the turnover rates of MAO A during ontogenesis in the rat brain.
    Journal of neurochemistry, 1979, Volume: 32, Issue:6

    Topics: Aging; Alkaloids; Animals; Binding, Competitive; Brain; Female; Harmaline; Kinetics; Ligands; Male;

1979
Developmental aspects of rat heart monoamine oxidase.
    Biochemical pharmacology, 1979, Aug-01, Volume: 28, Issue:15

    Topics: Aging; Animals; Heart; Hot Temperature; In Vitro Techniques; Kinetics; Mitochondria, Heart; Monoamin

1979
Effects of psychotrophic drugs on brain differentiation in female rats.
    Endokrinologie, 1977, Volume: 70, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg

1977
The influence of age and adrenalectomy on rat heart monoamine oxidase.
    Biochemical pharmacology, 1977, Mar-01, Volume: 26, Issue:5

    Topics: Adrenalectomy; Aging; Animals; Body Weight; Heart; Kinetics; Male; Mathematics; Monoamine Oxidase; M

1977
Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion.
    Endocrinology, 1977, Volume: 100, Issue:6

    Topics: Aging; Animals; Brain; Catecholamines; Dopamine; Gonadotropins, Pituitary; Hydroxyindoleacetic Acid;

1977
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
    Journal of neurochemistry, 1975, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S

1975
Proceedings: Age dependent recovery of rat brain MAO activity after administration of a single dose of iproniazid and pargyline.
    Naunyn-Schmiedeberg's archives of pharmacology, 1975, Volume: 287 Suppl

    Topics: Aging; Animals; Brain; Half-Life; Iproniazid; Monoamine Oxidase; Pargyline; Rats

1975
Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study.
    Brain research. Developmental brain research, 1992, Jun-19, Volume: 67, Issue:2

    Topics: Aging; Animals; Embryonic and Fetal Development; Female; Gestational Age; Immunohistochemistry; Moto

1992
Transmitter synthesis increases in substantia nigra neurons of the aged mouse.
    Neuroscience letters, 1991, Oct-14, Volume: 131, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Axonal Transport; Corpus Striatum; Dihydroxyphenylal

1991
Age effects on monoamine turnover of the rat substantia nigra.
    Brain research, 1991, Aug-23, Volume: 557, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxyla

1991
Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats.
    Brain research, 1986, Aug-06, Volume: 379, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Hypertension; Hypothalamus; Kinetics;

1986
Differential postnatal development of monoamine oxidases A and B in the blood-brain barrier of the rat.
    Journal of neurochemistry, 1987, Volume: 49, Issue:5

    Topics: Aging; Animals; Benzylamines; Blood-Brain Barrier; Brain; Cerebral Cortex; Clorgyline; Microcirculat

1987
The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging.
    Brain research, 1988, Jan-12, Volume: 438, Issue:1-2

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Hydroxydopamines; Injections, Intraventricular; Male; Mic

1988
The maturational onset of the 5-HT mediated head twitch in mice.
    Physiology & behavior, 1987, Volume: 41, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Carbidopa; Female; Humans; Male; Mice; Motor Activity; Pargylin

1987
Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat.
    Hypertension (Dallas, Tex. : 1979), 1987, Volume: 10, Issue:5

    Topics: Aging; Androstenedione; Animals; Blood Pressure; Desoxycorticosterone; Hypertension; Male; Pargyline

1987
Effect of nialamide on the metabolism of dopamine injected into the nucleus accumbens of old rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Homovanillic Acid; Limbic System; Male; Mo

1986
Locomotor response of nialamide pretreated old rats to intraaccumbens dopamine.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:3

    Topics: Aging; Animals; Dopamine; Ergonovine; Injections; Male; Monoamine Oxidase; Motor Activity; Nialamide

1985
Proceedings: An effect of thyroid hormones upon monoamine oxidase activity.
    British journal of pharmacology, 1974, Volume: 51, Issue:1

    Topics: Aging; Animals; Half-Life; Hyperthyroidism; Hypothyroidism; Male; Monoamine Oxidase; Myocardium; Org

1974
On the extraneuronal nature of cardiac monoamine oxidase in the rat.
    Advances in biochemical psychopharmacology, 1972, Volume: 5

    Topics: Aging; Animals; Body Weight; Dopamine; Female; Heart; Heart Atria; Heart Septum; Heart Ventricles; H

1972
The influence of age on the recovery of cardiac monoamine oxidase after irreversible inhibition.
    Biochemical pharmacology, 1968, Volume: 17, Issue:10

    Topics: Aging; Animals; Brain; Depression, Chemical; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhib

1968