Page last updated: 2024-08-21

paraquat and Idiopathic Parkinson Disease

paraquat has been researched along with Idiopathic Parkinson Disease in 162 studies

Research

Studies (162)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.23)18.7374
1990's1 (0.62)18.2507
2000's43 (26.54)29.6817
2010's72 (44.44)24.3611
2020's44 (27.16)2.80

Authors

AuthorsStudies
Das, S; Mohamad Najib, NH; Teoh, SL; Yahaya, MF1
Ahmad, MH; Ali, M; Fatima, M; Mondal, AC; Rizvi, MA1
Kuter, KZ; Ossowska, K; Śmiałowska, M1
Arsac, JN; Baron, T; Dartiguelongue, M; Davoust, N; Mollereau, B; Sedru, M; Vulin, J1
Huang, M; Li, G; Shi, G; Tian, T; Wang, K; Zhang, B; Zhang, C1
Naidu, R; See, WZC; Tang, KS2
Huang, M; Tian, T; Wang, K; Wu, K; Yan, W; Zhang, B1
El-Saadi, MW; Grames, M; Huang, S; Keys, K; Knott, E; Li, H; Lu, XH; Ren, M; Tian, X; Yin, H1
Liu, CY; Wang, YL; Yang, HM; Zhang, XF; Zhou, YT1
Cui, M; Dong, Q; Feng, Y; Guo, M; Han, S; Hao, Y; Sun, J; Zhao, Y1
Chandrasekhar, M; Dey, A; Gopalakrishnan, AV; Iyer, M; Kesari, K; Narayanasamy, A; Sri Sabari, S; Vellingiri, B; Venkatesan, D1
Dai, L; Du, Z; Fang, Y; Jiang, H; Li, F; Li, H; Liu, C; Liu, Z; Meng, L; Tian, Y; Wang, Z; Xiong, M; Yan, Z; Yu, T; Yuan, X; Zhang, J; Zhang, Z1
Cheng, Y; Deng, P; Duan, W; Fu, G; He, H; Hong, H; Lin, X; Lu, Y; Mao, G; Pi, H; Tong, T; Wang, X; Xu, J; Xu, S; Xu, Y; Yang, L; Yu, Z; Zhang, J; Zhou, Z1
Agarwal, S; Chang, YM; Desai, TD; Ho, TJ; Huang, CY; Ju, DT; Kuo, WW; Liao, SC; Lin, YJ; Sun, JM; Yeh, YL1
Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G1
Chao, CC; Chen, JJ; Cheng, JJ; Chiou, CT; Hsu, TH; Huang, CL; Huang, NK; Lee, IJ; Lin, PY; Yang, YC; Yei, CE1
Chovsepian, A; Dening, Y; Dieterich, M; Dirscherl, P; Falkai, P; Giese, A; Giesert, F; Herms, J; Khairnar, A; Levin, J; Pan-Montojo, F; Ruf, V; Schmidt, F; Stievenard, A; Straßl, T; Weisenhorn, DV; Wurst, W1
Gao, J; Hawrysh, PJ; McQuibban, GA; Nodwell, J; Oh, A; Tan, S; Tompkins, TA1
Nuber, S; Selkoe, DJ1
Chang, R; Hou, L; Huang, R; Liu, J; Ruan, Z; Sun, F; Wang, Q; Wang, Y; Zhao, J1
Brown-Leung, JM; Cannon, JR; Chester, JA; Enkh-Amgalan, S; Nolan, RM; Syeda, T1
Ciesla, L; Conger, J; Maitra, U; Owens, MMM1
Ren, XY; Xu, YN; Zhang, XF; Zhou, YT1
Dorsey, ER; Ray, A1
Chandramohan, V; Chithra, Y; Dey, G; Ghose, V; Gowthami, N; Srinivas Bharath, MM; Vasudev, V1
Bernardino, L; Cristóvão, AC; Esteves, M; Ferreira, R; Lopes-Nunes, J; Santos, T; Saraiva, C; Vale, A1
Duan, W; Duan, Y; Fu, G; Li, Y; Liu, C; Liu, Y; Sun, Y; Tian, J; Xia, Z; Xu, S; Yang, Y; Yu, Q; Zhang, T; Zhou, J1
Cheng, B; Geng, L; Li, R; Lou, X; Lu, K; Song, W; Wang, L; Zhang, S1
de Camargo, JL; El Dib, R; Gomaa, H; Lopes, LC; Vaccari, C1
Dey, AB; Dey, S; Dwivedi, S; Goyal, V; Rai, N; Upadhyay, AD1
Alves, G; Beal, MF; Bernardino, L; Campos, FL; Cristóvão, AC; Esteves, M; Fonseca, BM; Guhathakurta, S; Je, G; Kim, YS; Queiroz, J; Salgado, AJ; Sousa, N; Yang, L; Yoon, KS1
Jimenez-Carrion, P; Jones, BC; Lu, L; Mulligan, MK; O'Callaghan, JP; Silva, I; Torres-Rojas, C; Williams, RW; Zhao, W; Zhuang, D1
Ambaryan, A; Danilenko, V; Marsova, M; Odorskaya, M; Pavlova, G; Poluektova, E; Revishchin, A1
Huang, M; Li, Y; Tian, T; Wang, K; Wang, Y; Yan, W; Yang, H1
Freeman, JL; Wasel, O1
Ming, F; Qin, L; Tan, J; Tan, X; Tang, J; Wang, C; Zhang, H1
Cluet, D; Davoust, N; Dufourd, E; Girard, V; Goubard, V; Mollereau, B; Nataf, S; Pays, L; Querenet, M; Seugnet, L1
Afiyatullov, SS; Chingizova, EA; Girich, EV; Menchinskaya, ES; Ngoc, NTD; Pislyagin, EA; Pivkin, MV; Popov, RS; Smetanina, OF; Trinh, PTH; Yurchenko, AN; Yurchenko, EA1
Chao, CY; Cheng, JJ; Chiou, CT; Huang, CL; Huang, HT; Huang, NK; Kuo, YH; Lee, IJ; Yang, YC1
Ayoub, K; Beauchamp, S; Derksen, A; Dwyer, Z; Farmer, K; Fortin, T; Hayley, S; Rudyk, C; Shail, P; Torres, C; Ventura, K1
Ciesla, L; Harding, T; Liang, Q; Maitra, U1
El-Dash, HA; Fathy, SM; Said, NI1
Chang, Y; Gao, G; Li, X; Li, Y; Shi, Z; Thirupathi, A; Xie, J; Yu, P; Zhang, J; Zuo, Y1
Weed, DL1
Fleming, SM1
Girish, TK; Joshi, CG; Narasingappa, RB; Ravi, SK; Vincent, B1
Attia, HN; Maklad, YA1
Chen, SC; Chen, WY; Cheng, YH; Chou, WC; How, CM; Hsieh, NH; Huang, CW; Liao, CM; Lin, YJ; Yang, YF; You, SH2
Connor, JR; Huang, X; Lamendella, R; Meadowcroft, MD; Nandar, W; Neely, EB; Nixon, AM; Purnell, CJ; Snyder, AM; Wright, J1
Andersen, JK; Campisi, J; Chinta, SJ; Demaria, M; Limbad, C; Madden, DT; McQuade, A; Rajagopalan, S; Rane, A; Woods, G; Zou, Y1
Bordelon, Y; Bronstein, JM; Cockburn, M; Paul, KC; Ritz, B; Sinsheimer, JS1
Scott, KM; Williams-Gray, CH1
Bastías-Candia, S; Inestrosa, NC; Zolezzi, JM1
Cheng, JJ; Chiou, CT; Huang, CL; Huang, HM; Huang, HT; Huang, NK; Lee, YC; Yang, JM; Yang, YC1
Campbell, JL; Clewell, HJ; Hinderliter, PM; Travis, KZ1
Morioka, H; Nishio, R; Takeda, A; Takeuchi, A; Tamano, H1
Hartley, RC; Murphy, MP; Oliveira, JMA; Pinho, BR; Reis, SD1
Chaiyakunapruk, N; Lohitnavy, M; Lohitnavy, O; Norman Scholfield, C; Reisfeld, B; Sruamsiri, R; Tangamornsuksan, W1
Amiri, S; Amram, O; Caballero, M; Denney, JT; Hystad, P; Monsivais, P1
Brandt, A; Joop, G; Vilcinskas, A1
Birman, S; Cassar, M; Hajji, K; Leprince, J; Masmoudi-Kouki, O; Mezghani, S; Mteyrek, A; Sun, J; Vaudry, D1
Furuhata, R; Komata, Y; Morioka, H; Nishio, R; Takeda, A; Tamano, H1
Aboutalebi, H; Bae, EJ; Di Monte, DA; Helwig, M; Lee, SJ; Musgrove, RE; Ulusoy, A1
Chang, RL; Chung, LC; Day, CH; Ho, TJ; Huang, CY; Ju, DT; Kuo, WW; Liao, PH; Sivalingam, K; Viswanadha, VP1
Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E1
Lenaers, G; Reynier, P; Thany, SH1
Langston, JW; Mak, SK; Schüle, B; Tetrud, JW; Tewari, D1
Kamel, F1
Akhtar, MW; Ambasudhan, R; Andreyev, AY; Chan, SF; Dolatabadi, N; Han, X; Jaenisch, R; Lee, B; Lipton, SA; Lopez, K; Masliah, E; Molokanova, E; Nagar, S; Nakamura, T; Nakanishi, N; Nutter, A; Okamoto, S; Parker, J; Ryan, SD; Shan, B; Soldner, F; Sunico, CR; Talantova, M; Yates, JR; Zhang, X; Zhang, Y1
Cardozo-Pelaez, F; Dalton, R; Gremaud, JN; Lacher, SE; Sherwin, CM; Skagen, K; Steed, E; Sugden, KD; Woodahl, EL1
Armstrong, SM; Moore, C; Willis, GL1
Borowy-Borowski, H; Cohen, J; Harrison, K; Keshan, C; Lanthier, P; Leahy, S; Lopatin, D; Miller, H; Muthukumaran, K; Pandey, S; Sandhu, JK; Sikorska, M; Weinstock, S1
Allen, JL; Conrad, K; Cory-Slechta, DA; Liu, X; Oberdörster, G; Weston, D1
Kachroo, A; Schwarzschild, MA1
Birman, S; Cassar, M; Coulom, H; Han, KA; Iché-Torres, M; Issa, AR; Petitgas, C; Riemensperger, T; Rival, T1
Achumi, B; Alone, DP; Phom, L; Yenisetti, SC1
Chaouhan, HS; Chowdhuri, DK; Mudiam, MKR; Patel, DK; Pragya, P; Ratnasekhar, C; Shukla, AK1
Bhudhikanok, GS; Blair, A; Chade, A; Comyns, K; Furlong, M; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Richards, M; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM1
Cappelletti, L; Dallemole, DR; Ellwanger, JH; Franke, SI; Gonçalves da Silva, M; Molz, P; Müller, TE; Pêgas Henriques, JA; Pereira dos Santos, A; Prá, D1
Morrison, BE; Stojkovska, I; Wagner, BM1
Corbett, J; Kadiiska, MB; Kumar, A; Leinisch, F; Mason, RP1
Aprigliano, S; Carresi, C; Isidoro, C; Janda, E; Lascala, A; Mollace, V; Morani, F; Musolino, V; Parafati, M; Russo, V; Savoia, C; Ziviani, E1
Akaike, A; Izumi, Y; Kume, T; Matsushima, S; Takada-Takatori, Y; Yamamoto, N; Yamamoto, T1
Beltramini, M; Bisaglia, M; Bubacco, L; Casella, L; Ferrari, E; Filograna, R; Godena, VK; Sanchez-Martinez, A; Whitworth, AJ1
Bardien, S; Engelbrecht, L; Kinnear, C; Loos, B; van der Merwe, C; van der Westhuizen, FH; van Dyk, HC1
Botham, PA; Breckenridge, CB; Cook, AR; Minnema, DJ; Sturgess, NC; Travis, KZ1
Thompson, MD; Zhang, XF1
Ackerson, LC; Cely, I; Chesselet, MF; De La Rosa, K; Gabby, L; Maidment, NT; McDowell, KA; Mortazavi, F; Mulligan, CK; Murphy, NP; Richter, F; Sioshansi, PC; Tsan, L1
Christian, PK; Guruprasad, BR; Kumar, A; Panchal, K; Tiwari, AK1
Che, Y; Hou, L; Liu, X; Sun, F; Wang, H; Wang, K; Wang, Q; Zhang, C; Zhao, X; Zhou, X1
Chen, P; Chen, Z; Li, A; Liang, LP; Lou, XC; Wang, SL; Wu, XK; Zhao, CJ1
Andersen, JK; Bredesen, DE; Chinta, SJ; Poksay, KS; Rane, A; Rao, RV1
Choi, WS; Kruse, SE; Palmiter, RD; Xia, Z1
Fuentes, JM; Gonzalez-Polo, RA; Moran, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G1
Andersen, JK; Oo, ML; Peng, J; Stevenson, FF1
Bronstein, J; Cockburn, M; Costello, S; Ritz, B; Zhang, X1
Cochemé, HM; Murphy, MP1
Gil, SJ; Kang, MJ; Koh, HC1
Bronstein, J; Cockburn, M; Costello, S; Farrer, MJ; Lincoln, SJ; Manthripragada, AD; Ritz, BR1
Barr, DB; Buckley, B; Montesano, MA; Richfield, EK; Thiruchelvam, M; Winnik, B1
Guzman-Martinez, C; Jimenez-Del-Rio, M; Velez-Pardo, C1
Ren, JP; Sun, XJ; Zhao, YW1
Berry, C; La Vecchia, C; Nicotera, P1
Cuervo, AM; Di Monte, DA; Mak, SK; Manning-Bog, AB; McCormack, AL1
Bravo-San Pedro, JM; Cuadrado, A; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Lastres-Becker, I; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G1
Gómez-Pastor, R; Lavara-Culebras, E; Matallana, E; Muñoz-Soriano, V; Paricio, N1
Bernard, LP; Guilford, FT; Zeevalk, GD1
Bronstein, J; Cockburn, M; Farrer, M; Gatto, NM; Manthripragada, AD; Rhodes, SL; Ritz, B1
Cannon, JR; Greenamyre, JT1
Jain, SK; Patel, DK; Singh, MP; Singhal, NK; Srivastava, G1
Andersen, JK; Oo, ML; Peng, J1
Akaike, A; Izumi, Y; Kume, T1
Bhudhikanok, GS; Blair, A; Cambi, F; Chade, AR; Comyns, K; Fernandez, HH; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Priestley, B; Richards, MB; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM1
Han, JS; Heo, JY; Kweon, GR; Kwon, HJ; Park, JH; Ryu, MJ; Seo, KS; Shim, JH; Shong, M; Son, JH1
Colosio, C; Moretto, A1
Go, YM; Hansen, JM; Jones, DP; Roede, JR1
Adami, HO; Cole, P; Mandel, JS1
Huang, C; Tong, J; Xia, XG; Zhou, H1
Tieu, K1
Carroll, CB; Hanemann, CO; Zajicek, JP; Zeissler, ML1
Armentero, MT; Blandini, F1
Beal, MF; Calingasan, NY; Elemento, O; Gollamudi, S; Johri, A; Yang, L1
Desplats, P; Fujita, M; Hashimoto, M; Kosberg, K; Mante, M; Masliah, E; Patel, P; Patrick, C; Rockenstein, E1
Bordelon, Y; Bronstein, J; Lee, PC; Ritz, B1
Costa, AC; Loh, SH; Martins, LM1
Cory-Slechta, DA; Di Monte, DA; Langston, JW; Manning-Bog, AB; McCormack, AL; Thiffault, C; Thiruchelvam, M1
Baggs, RB; Cory-Slechta, DA; Goodman, BM; Richfield, EK; Thiruchelvam, M1
Di Monte, DA1
Uversky, VN1
Buckley, B; Cory-Slechta, DA; Mirochnitchenko, O; Prokopenko, O; Richfield, EK; Thiruchelvam, M1
Andersen, JK; Doctrow, SR; Peng, J; Stevenson, FF1
Armstrong-Gold, CE; Bonini, NM; Heutink, P; Meulener, M; Pallanck, LJ; Rizzu, P; Wes, PD; Whitworth, AJ1
Barlow, BK; Cory-Slechta, DA; Richfield, EK; Thiruchelvam, M1
Finley, B; Li, AA; McIntosh, LJ; Mink, PJ; Teta, MJ1
Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B1
Tiffany-Castiglioni, E; Yang, W1
Chew, KC; Dawson, TM; Dawson, VL; Ho, MW; Ko, HS; Lim, KL; Lim, TM; Pletnikova, O; Soong, TW; Tay, SP; Thomas, B; Troncoso, J; Tsang, F; Wang, C1
Gupta, YK; Kumar, A; Patel, S; Singh, MP; Singh, V1
Fuentes, JM; García-Rubio, L; Gómez-Martín, A; González-Polo, RA; Morán, JM; Niso-Santano, M; Soler, G1
Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K1
Bastos, ML; Carmo, H; Carvalho, F; Dinis-Oliveira, RJ; Duarte, JA; Navarro, AS; Remião, F1
Bonini, NM; Ischiropoulos, H; Meulener, MC; Thompson, L; Thomson, L; Xu, K1
An, JJ; Cho, SW; Choi, HS; Choi, SY; Eum, WS; Kang, JH; Kang, TC; Kim, DW; Kim, SY; Kwon, HJ; Kwon, OS; Lee, SH; Park, J; Won, MH; Yoo, KY1
Callahan, LM; Federoff, HJ; Giuliano, RE; Henricksen, LA; Luo, Y; Prifti, L1
German, DC; Liang, CL; Luby-Phelps, K; Wang, TT1
Giasson, BI; Lee, VM; Leight, S; Norris, EH; Trojanowski, JQ; Uryu, K1
Chen, J; Kang, X; Li, H; Wang, B; Xu, Z1
Andersen, JK; Doctrow, SR; Peng, J; Peng, L; Stevenson, FF1
Miller, RL; Sun, AY; Sun, GY1
Di Monte, DA; Ethell, DW; Fei, Q; McCormack, AL1
Chen, P; Chen, Z; He, M; Li, A; Liang, L; Wang, S; Wu, X; Zhang, M; Zhao, C1
James-Kracke, M; Miller, RL; Sun, AY; Sun, GY1
Fukushima, T; Hojo, N; Isobe, A; Shiwaku, K; Tawara, T; Yamane, Y1
Le Couteur, DG; McLean, AJ; Rivory, LP; Yang, MC1
Fink, AL; Li, J; Uversky, VN1
Fariello, RG; Gerlach, M; Riederer, P; Sulzer, D; Tampellini, D; Zecca, L1
Hayashi, T; Kawakami, I; Nakamura, M; Tamura, M; Yumino, K1
Fukushima, T1
Borm, PJ; Van Vliet, C1
Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A1

Reviews

26 review(s) available for paraquat and Idiopathic Parkinson Disease

ArticleYear
Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson's Disease Pathophysiology.
    Molecular neurobiology, 2022, Volume: 59, Issue:6

    Topics: Apoptosis; Dopaminergic Neurons; Humans; Nerve Degeneration; Paraquat; Parkinson Disease; Substantia Nigra

2022
Neurotoxicity of pesticides - A link to neurodegeneration.
    Ecotoxicology and environmental safety, 2022, Sep-15, Volume: 243

    Topics: Dopamine; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides

2022
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
    International journal of molecular sciences, 2022, Sep-16, Volume: 23, Issue:18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium

2022
Paraquat and Parkinson's Disease: The Molecular Crosstalk of Upstream Signal Transduction Pathways Leading to Apoptosis.
    Current neuropharmacology, 2024, Volume: 22, Issue:1

    Topics: Apoptosis; Herbicides; Humans; Paraquat; Parkinson Disease; Signal Transduction

2024
Paraquat and Parkinson's disease: a systematic review and meta-analysis of observational studies.
    Journal of toxicology and environmental health. Part B, Critical reviews, 2019, Volume: 22, Issue:5-6

    Topics: Adult; Herbicides; Humans; Paraquat; Parkinson Disease; Research Design; Time Factors

2019
Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration.
    International journal of molecular sciences, 2020, Aug-20, Volume: 21, Issue:17

    Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Knockdown Techniques; Neurotoxicity Syndromes; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Rotenone; Zebrafish; Zebrafish Proteins

2020
Does paraquat cause Parkinson's disease? A review of reviews.
    Neurotoxicology, 2021, Volume: 86

    Topics: Animals; Herbicides; Humans; Meta-Analysis as Topic; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Risk Factors; Systematic Reviews as Topic

2021
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
    Current environmental health reports, 2017, Volume: 4, Issue:2

    Topics: Environmental Exposure; Gene-Environment Interaction; Genetic Predisposition to Disease; Herbicides; Humans; Insecticides; Mutation; Paraquat; Parkinson Disease; Risk Factors; Rotenone

2017
Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model.
    Molecular neurobiology, 2019, Volume: 56, Issue:2

    Topics: Animals; Disease Models, Animal; Dopamine; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Substantia Nigra

2019
Paraquat exposure and Parkinson's disease: A systematic review and meta-analysis.
    Archives of environmental & occupational health, 2019, Volume: 74, Issue:5

    Topics: Environmental Exposure; Humans; Occupational Exposure; Odds Ratio; Paraquat; Parkinson Disease; Risk Factors

2019
Parkinson's disease and enhanced inflammatory response.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Inflammation; Lipopolysaccharides; Neurons; Oxidative Stress; Oxidopamine; Oxygen; Paraquat; Parkinson Disease; Ubiquitin-Protein Ligases

2015
Paraquat and Parkinson's disease.
    Cell death and differentiation, 2010, Volume: 17, Issue:7

    Topics: Animals; Apoptosis; Disease Models, Animal; Herbicides; Humans; Mice; Nerve Degeneration; Paraquat; Parkinson Disease; Risk Factors

2010
Neurotoxic in vivo models of Parkinson's disease recent advances.
    Progress in brain research, 2010, Volume: 184

    Topics: Animals; Disease Models, Animal; Dopamine; Humans; MPTP Poisoning; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Sympatholytics; Uncoupling Agents

2010
[Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:1

    Topics: Animals; Cell Death; Dopamine; Glutamate-Cysteine Ligase; Glutathione; Humans; Neurons; NF-E2-Related Factor 2; Oxidation-Reduction; Paraquat; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Substantia Nigra

2011
Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease.
    Neurotoxicology, 2011, Volume: 32, Issue:4

    Topics: Animals; Brain; Dieldrin; Dose-Response Relationship, Drug; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Pyrethrins; Risk Assessment; Risk Factors; Rotenone; Time Factors; Toxicity Tests

2011
Paraquat and Parkinson's disease: an overview of the epidemiology and a review of two recent studies.
    Regulatory toxicology and pharmacology : RTP, 2012, Volume: 62, Issue:2

    Topics: Case-Control Studies; Herbicides; Paraquat; Parkinson Disease; Pesticides

2012
A guide to neurotoxic animal models of Parkinson's disease.
    Cold Spring Harbor perspectives in medicine, 2011, Volume: 1, Issue:1

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Haplorhini; Lewy Bodies; Mice; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Substantia Nigra

2011
Animal models of Parkinson's disease.
    The FEBS journal, 2012, Volume: 279, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Sympatholytics

2012
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
    The Lancet. Neurology, 2003, Volume: 2, Issue:9

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Environmental Exposure; Herbicides; Humans; Insecticides; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurotoxins; Oncogene Proteins; Paraquat; Parkinson Disease; Protein Deglycase DJ-1; Risk Factors; Rotenone; Synucleins; Twin Studies as Topic

2003
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
    Cell and tissue research, 2004, Volume: 318, Issue:1

    Topics: Animals; Disease Models, Animal; Fungicides, Industrial; Herbicides; Maneb; Nerve Degeneration; Neurotoxins; Paraquat; Parkinson Disease; Rotenone; Uncoupling Agents

2004
Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease.
    Journal of occupational and environmental medicine, 2005, Volume: 47, Issue:10

    Topics: Animals; Case-Control Studies; Dieldrin; Disease Models, Animal; Fungicides, Industrial; Heptachlor; Humans; Maneb; Occupational Diseases; Occupational Exposure; Paraquat; Parkinson Disease; Permethrin; Pesticides; Pyridazines; Risk Factors

2005
Neural repair strategies for Parkinson's disease: insights from primate models.
    Cell transplantation, 2006, Volume: 15, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; Disease Models, Animal; Fungicides, Industrial; Glial Cell Line-Derived Neurotrophic Factor; Herbicides; Humans; Maneb; Nerve Degeneration; Oxidopamine; Paraquat; Parkinson Disease; Pesticides; Primates; Rotenone

2006
Paraquat exposure as an etiological factor of Parkinson's disease.
    Neurotoxicology, 2006, Volume: 27, Issue:6

    Topics: Environmental Exposure; Herbicides; History, 19th Century; Humans; Paraquat; Parkinson Disease

2006
Oxidative and inflammatory pathways in Parkinson's disease.
    Neurochemical research, 2009, Volume: 34, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone

2009
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.
    Molecular pathology : MP, 2001, Volume: 54, Issue:6

    Topics: Aging; Animals; Cell Death; Chelating Agents; Cholesterol; Humans; Iron; Lipid Metabolism; Locus Coeruleus; Melanins; Paraquat; Parkinson Disease; Pesticides; Substantia Nigra; Toxins, Biological

2001
[Elucidation of paraquat poisoning mechanism and development of the neuronal death model].
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 2002, Volume: 57, Issue:1

    Topics: Animals; Chaperonin 60; Disease Models, Animal; Electron Transport Complex I; Herbicides; Humans; Lipid Peroxidation; Mitochondria; NADH, NADPH Oxidoreductases; Niacinamide; Paraquat; Parkinson Disease; Superoxides

2002

Other Studies

136 other study(ies) available for paraquat and Idiopathic Parkinson Disease

ArticleYear
The effects of metallothionein in paraquat-induced Parkinson disease model of zebrafish.
    The International journal of neuroscience, 2023, Volume: 133, Issue:8

    Topics: Animals; Brain Injuries; Dopamine; Dopaminergic Neurons; Humans; Metallothionein; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Paraquat; Parkinson Disease; Substantia Nigra; Zebrafish

2023
Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease.
    Neuropharmacology, 2021, 12-15, Volume: 201

    Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Flavanones; Herbicides; Humans; Male; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Rats, Wistar; Substantia Nigra

2021
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
    Pharmacological reports : PR, 2022, Volume: 74, Issue:1

    Topics: alpha-Synuclein; Animals; Carrier Proteins; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Environmental Exposure; Herbicides; Inflammation; Lipopolysaccharides; Microglia; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Protective Agents; Rats; Substantia Nigra

2022
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in
    International journal of molecular sciences, 2021, Oct-27, Volume: 22, Issue:21

    Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Herbicides; Male; Neurotoxins; Paraquat; Parkinson Disease

2021
Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways.
    Amino acids, 2022, Volume: 54, Issue:1

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Taurine

2022
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
    Neurotoxicity research, 2022, Volume: 40, Issue:2

    Topics: alpha-Synuclein; Autophagy; Beclin-1; HMGB1 Protein; Humans; Paraquat; Parkinson Disease

2022
Tracing brain genotoxic stress in Parkinson's disease with a novel single-cell genetic sensor.
    Science advances, 2022, 04-15, Volume: 8, Issue:15

    Topics: Animals; Brain; DNA Damage; Dopaminergic Neurons; Humans; Mice; Mice, Transgenic; Paraquat; Parkinson Disease

2022
A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 164

    Topics: Animals; Dopamine; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Paraquat; Parkinson Disease; Substantia Nigra

2022
Role of OCT3 and DRP1 in the Transport of Paraquat in Astrocytes: A Mouse Study.
    Environmental health perspectives, 2022, Volume: 130, Issue:5

    Topics: Animals; Astrocytes; Cations; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Dynamins; Mice; Neurotoxicity Syndromes; Octamer Transcription Factor-3; Paraquat; Parkinson Disease; RNA, Small Interfering; Substantia Nigra

2022
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.
    Chemosphere, 2022, Volume: 308, Issue:Pt 2

    Topics: alpha-Synuclein; Animals; Environmental Pollutants; Fungicides, Industrial; Humans; Maneb; Metabolomics; Mice; Neuroblastoma; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Phenylalanine; Proteomics; Tryptophan

2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.
    Environment international, 2022, Volume: 169

    Topics: alpha-Synuclein; Animals; Ceramides; Cytokines; Environmental Pollutants; Glycerides; Glycerophospholipids; Herbicides; Humans; Lipopolysaccharides; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Neurotoxins; Paraquat; Parkinson Disease; Parkinsonian Disorders; RNA, Messenger; Sphingolipids

2022
Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model.
    Environmental toxicology, 2023, Volume: 38, Issue:1

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease

2023
SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease.
    Redox biology, 2022, Volume: 58

    Topics: Animals; Herbicides; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Paraquat; Parkinson Disease; Sirtuin 1

2022
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
    Scientific reports, 2022, 12-19, Volume: 12, Issue:1

    Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Mice; Paraquat; Parkinson Disease; Rotenone

2022
PRKN/parkin-mediated mitophagy is induced by the probiotics
    Autophagy, 2023, Volume: 19, Issue:7

    Topics: Animals; Autophagy; Drosophila; Lactococcus lactis; Mitophagy; Paraquat; Parkinson Disease; Protein Kinases; Saccharomyces boulardii; Ubiquitin-Protein Ligases

2023
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.
    The American journal of pathology, 2023, Volume: 193, Issue:5

    Topics: alpha-Synuclein; Animals; Calpain; Humans; Mice; Paraquat; Parkinson Disease

2023
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.
    Journal of neuroinflammation, 2023, Feb-18, Volume: 20, Issue:1

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Inflammasomes; Integrins; Macrophage-1 Antigen; Macrophages; Maneb; Memory Disorders; Mice; Microglia; NADPH Oxidases; NLR Family, Pyrin Domain-Containing 3 Protein; Paraquat; Parkinson Disease

2023
Paraquat exposure produces sex-dependent reduction in binge-like alcohol drinking in high alcohol-preferring mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 174

    Topics: Alcohol Drinking; Animals; Binge Drinking; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease

2023
Predicting structural features of selected flavonoids responsible for neuroprotection in a Drosophila model of Parkinson's disease.
    Neurotoxicology, 2023, Volume: 96

    Topics: Animals; Antioxidants; Drosophila; Flavones; Flavonoids; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease

2023
Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 174

    Topics: Animals; Blood-Brain Barrier; Dopaminergic Neurons; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Neuroinflammatory Diseases; Occludin; Paraquat; Parkinson Disease; Permeability

2023
Paraquat, Parkinson's Disease, and Agnotology.
    Movement disorders : official journal of the Movement Disorder Society, 2023, Volume: 38, Issue:6

    Topics: Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides

2023
Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.
    Neurochemical research, 2023, Volume: 48, Issue:8

    Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Dopaminergic Neurons; Electron Transport Complex I; Humans; Paraquat; Parkinson Disease; Proteomics; Rotenone

2023
CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival.
    Molecular neurobiology, 2023, Volume: 60, Issue:8

    Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Paraquat; Parkinson Disease; Rats; Substantia Nigra; Transcription Factors

2023
Upregulation of mitochondrial calcium uniporter contributes to paraquat-induced neuropathology linked to Parkinson's disease via imbalanced OPA1 processing.
    Journal of hazardous materials, 2023, 07-05, Volume: 453

    Topics: Animals; Dopamine; Mice; MicroRNAs; Paraquat; Parkinson Disease; Up-Regulation

2023
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease.
    Brain research bulletin, 2023, 10-01, Volume: 202

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Neuroblastoma; Paraquat; Parkinson Disease

2023
Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 03-09, Volume: 75, Issue:4

    Topics: Aged; AMP-Activated Protein Kinases; Biomarkers; Case-Control Studies; Cell Line; Endoplasmic Reticulum Stress; Female; Humans; Male; Medicine, Ayurvedic; Middle Aged; Neurons; Nuclear Proteins; Paraquat; Parkinson Disease; Phytotherapy; Plant Extracts; Syzygium

2020
Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm.
    The European journal of neuroscience, 2020, Volume: 52, Issue:4

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Paraquat; Parkinson Disease; Pars Compacta; Rats; Substantia Nigra

2020
Systems Genetics and Systems Biology Analysis of Paraquat Neurotoxicity in BXD Recombinant Inbred Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 07-01, Volume: 176, Issue:1

    Topics: Animals; Brain; Herbicides; Iron; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease; Substantia Nigra; Systems Biology

2020
Protective effects of Lactobacillus fermentum U-21 against paraquat-induced oxidative stress in Caenorhabditis elegans and mouse models.
    World journal of microbiology & biotechnology, 2020, Jul-06, Volume: 36, Issue:7

    Topics: Animals; Antioxidants; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic Neurons; Escherichia coli; Lactobacillus; Limosilactobacillus fermentum; Longevity; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Paraquat; Parkinson Disease; Survival Rate

2020
Knockdown of TLR4 Represses the Paraquat-Induced Neuroinflammation and Microglial M1 Polarization.
    Neurotoxicity research, 2020, Volume: 38, Issue:3

    Topics: Animals; Cytokines; Gene Knockdown Techniques; Inflammation; Mice; Microglia; Nervous System Diseases; Paraquat; Parkinson Disease; Signal Transduction; Toll-Like Receptor 4; Transcription Factors

2020
The
    BioMed research international, 2020, Volume: 2020

    Topics: Adult; Apoptosis; Female; HeLa Cells; Humans; Lymphocytes; Male; Mitochondria; Mutant Proteins; Mutation; Paraquat; Parkinson Disease; Ubiquitin-Protein Ligases

2020
Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity.
    Scientific reports, 2020, 11-18, Volume: 10, Issue:1

    Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Herbicides; Homeodomain Proteins; Lipid Droplets; Male; Neuroglia; Paraquat; Parkinson Disease; RNA-Binding Proteins

2020
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of
    Marine drugs, 2020, Nov-30, Volume: 18, Issue:12

    Topics: Animals; Antiparkinson Agents; Aspergillus; Cell Line, Tumor; Cell Survival; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Penicillium; Reactive Oxygen Species; Rotenone; Secondary Metabolism; Structure-Activity Relationship; Vietnam

2020
Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 134

    Topics: Antiparkinson Agents; Apoptosis; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Neurons; Paraquat; Parkinson Disease; Phosphorylation; Protein Kinases; Ubiquitin; Ubiquitin-Protein Ligases

2021
Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease.
    Neurobiology of aging, 2021, Volume: 100

    Topics: Age Factors; Animals; Antigens, Surface; Brain; Caspase 1; Corticosterone; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Milk Proteins; NF-kappa B; Paraquat; Parkinson Disease; Pesticides; Protozoan Proteins; Wiskott-Aldrich Syndrome Protein Family

2021
GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson's disease.
    Communications biology, 2021, 02-05, Volume: 4, Issue:1

    Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Environmental Pollutants; Female; Flavones; Herbicides; Male; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease

2021
Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson's disease.
    BMC complementary medicine and therapies, 2021, Apr-26, Volume: 21, Issue:1

    Topics: Animals; Apoptosis; Disease Models, Animal; Inflammation; Male; Mice; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Plant Extracts; Pomegranate; Seeds

2021
Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Amino Acid Transport System y+; Animals; Autophagy; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Ferritins; Ferroptosis; Humans; Iron; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Nuclear Receptor Coactivators; Paraquat; Parkinson Disease; Reactive Oxygen Species

2021
Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease.
    Natural product research, 2018, Volume: 32, Issue:12

    Topics: Antiparkinson Agents; Apoptosis; Cell Line, Tumor; DNA Damage; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Paraquat; Parkinson Disease; Phenols; Plant Extracts; Plant Leaves; Reactive Oxygen Species; Senna Plant

2018
Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals.
    Behavioural pharmacology, 2018, Volume: 29, Issue:1

    Topics: Animals; Disease Models, Animal; Levodopa; Male; Mice; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Protein Carbonylation; Ubiquinone

2018
PBPK/PD assessment for Parkinson's disease risk posed by airborne pesticide paraquat exposure.
    Environmental science and pollution research international, 2018, Volume: 25, Issue:6

    Topics: Aged; Aged, 80 and over; Air Pollutants; Environmental Exposure; Humans; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Prevalence; Risk Factors; Taiwan

2018
HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.
    Journal of neurochemistry, 2018, Volume: 145, Issue:4

    Topics: Animals; Brain; Disease Models, Animal; Gastrointestinal Microbiome; Gene-Environment Interaction; Genetic Variation; Genotype; Hemochromatosis Protein; Herbicides; Mice; Mice, Transgenic; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Tyrosine 3-Monooxygenase

2018
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.
    Cell reports, 2018, 01-23, Volume: 22, Issue:4

    Topics: Animals; Cellular Senescence; Humans; Mice; Neuropathology; Paraquat; Parkinson Disease; Risk Factors

2018
NFE2L2, PPARGC1α, and pesticides and Parkinson's disease risk and progression.
    Mechanisms of ageing and development, 2018, Volume: 173

    Topics: Aged; Aged, 80 and over; Environmental Exposure; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Maneb; Middle Aged; NF-E2-Related Factor 2; Paraquat; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pesticides; Polymorphism, Single Nucleotide; Risk Factors

2018
Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease.
    Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:5

    Topics: Astrocytes; Cellular Senescence; Humans; Neuropathology; Paraquat; Parkinson Disease

2018
LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway.
    Toxicology, 2018, 12-01, Volume: 410

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; beta Catenin; Cell Line; Cell Line, Tumor; Cell Survival; Glycogen Synthase Kinase 3; Humans; Immunohistochemistry; Paraquat; Parkinson Disease; Pyrazines; Pyridines; Wnt Signaling Pathway

2018
Response to "Letter to the editor re: Cheng YH, Chou WC, Yang YF, et al. Environ Sci Pollut Res (2018). https://doi.org/10.107/s11356-017-0875-4".
    Environmental science and pollution research international, 2018, Volume: 25, Issue:33

    Topics: Humans; Paraquat; Parkinson Disease; Pesticides

2018
Letter to the editor re: Cheng, YH., Chou, WC., Yang, YF. et al. Environ Sci Pollut Res (2017). https://doi.org/10.1007/s11356-017-0875-4.
    Environmental science and pollution research international, 2018, Volume: 25, Issue:33

    Topics: Humans; Paraquat; Parkinson Disease; Pesticides

2018
Blockade of Rapid Influx of Extracellular Zn
    Molecular neurobiology, 2019, Volume: 56, Issue:6

    Topics: Animals; Behavior, Animal; Chelating Agents; Dopaminergic Neurons; Extracellular Space; Glutamic Acid; Male; Models, Biological; Movement Disorders; Nerve Degeneration; Paraquat; Parkinson Disease; Rats, Wistar; Reactive Oxygen Species; Substantia Nigra; Zinc

2019
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.
    Free radical biology & medicine, 2019, Volume: 130

    Topics: Animals; Antioxidants; Brain; Humans; Huntingtin Protein; Huntington Disease; Mitochondria; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Phenotype; Protein Aggregation, Pathological; Reactive Oxygen Species; Rotenone; Superoxides; Tyrosine 3-Monooxygenase; Zebrafish

2019
Estimated Residential Exposure to Agricultural Chemicals and Premature Mortality by Parkinson's Disease in Washington State.
    International journal of environmental research and public health, 2018, 12-16, Volume: 15, Issue:12

    Topics: Aged; Aged, 80 and over; Agrochemicals; Atrazine; Environmental Exposure; Female; Herbicides; Humans; Male; Mortality, Premature; Odds Ratio; Paraquat; Parkinson Disease; Pesticides; Spatial Analysis; Washington

2018
Tribolium castaneum as a whole-animal screening system for the detection and characterization of neuroprotective substances.
    Archives of insect biochemistry and physiology, 2019, Volume: 100, Issue:3

    Topics: Animals; Diet; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Neuroprotective Agents; Paraquat; Parkinson Disease; Tribolium

2019
Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.
    Human molecular genetics, 2019, 06-01, Volume: 28, Issue:11

    Topics: Animals; Central Nervous System; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila Proteins; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Reactive Oxygen Species; Receptors, G-Protein-Coupled

2019
Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn
    Molecular neurobiology, 2019, Volume: 56, Issue:11

    Topics: Aging; Animals; Dopaminergic Neurons; Exocytosis; Extracellular Space; Glutamic Acid; Male; Paraquat; Parkinson Disease; Presynaptic Terminals; Rats, Wistar; Reactive Oxygen Species; Receptors, AMPA; Risk Factors; Substantia Nigra; Zinc

2019
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.
    The Journal of clinical investigation, 2019, 06-13, Volume: 129, Issue:9

    Topics: alpha-Synuclein; Animals; Axons; Brain; Cell Nucleus; Disease Progression; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidants; Oxidative Stress; Oxygen; Paraquat; Parkinson Disease; Reactive Oxygen Species; Vagus Nerve

2019
Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model.
    Nutrients, 2019, Jul-19, Volume: 11, Issue:7

    Topics: Alkaloids; Apoptosis; Cell Line; Cell Survival; Humans; In Situ Nick-End Labeling; MAP Kinase Signaling System; Neuroprotective Agents; Paraquat; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptor, IGF Type 1; Signal Transduction; Tumor Suppressor Protein p53

2019
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 133, Issue:2

    Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic

2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
    Medecine sciences : M/S, 2013, Volume: 29, Issue:3

    Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone

2013
Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication.
    Journal of Parkinson's disease, 2011, Volume: 1, Issue:2

    Topics: Adenosine Triphosphate; Adult; alpha-Synuclein; Cells, Cultured; Electron Transport Complex I; Female; Fibroblasts; Gene Expression Regulation; Herbicides; Humans; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Diseases; Paraquat; Parkinson Disease; RNA, Messenger; RNA, Small Interfering; Skin

2011
Epidemiology. Paths from pesticides to Parkinson's.
    Science (New York, N.Y.), 2013, Aug-16, Volume: 341, Issue:6147

    Topics: Amyotrophic Lateral Sclerosis; Animals; Dementia; Environmental Exposure; Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Risk Factors; Rotenone

2013
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
    Cell, 2013, Dec-05, Volume: 155, Issue:6

    Topics: alpha-Synuclein; Gene-Environment Interaction; Humans; Induced Pluripotent Stem Cells; MEF2 Transcription Factors; Mitochondria; Mutation; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Nitrogen Species; Substantia Nigra; Transcription Factors; Transcription, Genetic

2013
Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Brain; Capillary Permeability; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Fluorescent Dyes; Herbicides; Male; Membrane Transport Modulators; Mice; Mice, Knockout; Paraquat; Parkinson Disease; Recombinant Proteins; Rhodamine 123; Sus scrofa; Tissue Distribution

2014
Parkinson's disease, lights and melanocytes: looking beyond the retina.
    Scientific reports, 2014, Jan-29, Volume: 4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Female; Light; Male; Melanocytes; Motor Activity; Oxidopamine; Paraquat; Parkinson Disease; Rats; Rats, Sprague-Dawley; Retina; Rotenone

2014
Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease.
    BMC neuroscience, 2014, Jan-31, Volume: 15

    Topics: Administration, Oral; Animals; Cell Survival; Feasibility Studies; Male; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; Rats; Rats, Long-Evans; Rifabutin; Solubility; Substantia Nigra; Treatment Outcome; Ubiquinone; Vitamins; Water

2014
Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice.
    Neurotoxicology, 2014, Volume: 41

    Topics: Air Pollutants; Animals; Animals, Newborn; Cell Count; Corpus Striatum; Disease Models, Animal; Drug Combinations; Female; Fungicides, Industrial; Herbicides; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Nanoparticles; Paraquat; Parkinson Disease; Particulate Matter; Silicones; Substantia Nigra; Tyrosine 3-Monooxygenase

2014
Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.
    Brain research, 2014, May-14, Volume: 1563

    Topics: Allopurinol; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Enzyme Inhibitors; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Paraquat; Parkinson Disease; Pesticides; Uric Acid

2014
A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Human molecular genetics, 2015, Jan-01, Volume: 24, Issue:1

    Topics: Age Factors; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila melanogaster; Drosophila Proteins; Environmental Exposure; Female; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D1; Ryanodine Receptor Calcium Release Channel

2015
Curcumin's neuroprotective efficacy in Drosophila model of idiopathic Parkinson's disease is phase specific: implication of its therapeutic effectiveness.
    Rejuvenation research, 2014, Volume: 17, Issue:6

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Curcumin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Resistance; Humans; Longevity; Movement; Neuroprotective Agents; Paraquat; Parkinson Disease; Time Factors; Treatment Outcome

2014
Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster.
    Molecular neurobiology, 2016, Volume: 53, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Drosophila melanogaster; Gas Chromatography-Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Motor Activity; Nerve Degeneration; Oxidative Stress; Paraquat; Parkinson Disease; Principal Component Analysis; Reproducibility of Results

2016
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
    Environment international, 2015, Volume: 75

    Topics: Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Female; Gloves, Protective; Habits; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure; Occupational Health; Paraquat; Parkinson Disease; Permethrin; Pesticides; Risk; Rotenone; Surveys and Questionnaires; Trifluralin; Workplace

2015
Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:2

    Topics: Animals; Comet Assay; Disease Models, Animal; DNA Damage; Hypokinesia; Male; Paraquat; Parkinson Disease; Rats; Rats, Wistar; Selenium

2015
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.
    Molecular neurobiology, 2016, Volume: 53, Issue:5

    Topics: alpha-Synuclein; Animals; Cyclic N-Oxides; Disease Models, Animal; Dopaminergic Neurons; Injections, Intraperitoneal; Male; Maneb; Mesencephalon; Mice, Inbred C57BL; Microglia; Models, Biological; NADPH Oxidases; Nitric Oxide Synthase Type II; Paraquat; Parkinson Disease; Peroxynitrous Acid; Spin Labels; Substantia Nigra; Tyrosine 3-Monooxygenase

2016
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.
    Autophagy, 2015, Volume: 11, Issue:7

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Astrocytes; Astrocytoma; Autophagy; Benzhydryl Compounds; Enzyme Inhibitors; Formamides; Mice; Microtubule-Associated Proteins; Neuroprotection; Neuroprotective Agents; Neurotoxins; NF-E2-Related Factor 2; Oxidative Stress; Paraquat; Parkinson Disease; Phagosomes; Quinone Reductases; Sequestosome-1 Protein; Signal Transduction; Vacuoles

2015
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.
    Journal of pharmacological sciences, 2015, Volume: 129, Issue:3

    Topics: Animals; Antioxidant Response Elements; Catalase; Glutamate-Cysteine Ligase; Herbicides; NF-E2-Related Factor 2; Paraquat; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Signal Transduction

2015
Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.
    The Journal of biological chemistry, 2016, Apr-22, Volume: 291, Issue:17

    Topics: Animals; Biomimetic Materials; Cell Line, Tumor; Drosophila melanogaster; Humans; Manganese; Models, Biological; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Superoxide Dismutase

2016
Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson's Disease from Mitochondrial Dysfunction and Cell Death.
    Molecular neurobiology, 2017, Volume: 54, Issue:4

    Topics: Cell Death; Cell Fusion; Cell Line, Tumor; Cell Respiration; Cell Survival; Curcumin; Electron Transport; Gene Knockdown Techniques; Humans; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Oxygen Consumption; Paraquat; Parkinson Disease; Protein Kinases; RNA, Small Interfering

2017
Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease.
    Laboratory investigation; a journal of technical methods and pathology, 2016, Volume: 96, Issue:9

    Topics: Herbicides; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease

2016
Response to: Neurotoxicity of paraquat and paraquat-induced Parkinson's disease.
    Laboratory investigation; a journal of technical methods and pathology, 2016, Volume: 96, Issue:9

    Topics: Herbicides; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease

2016
Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.
    Neurobiology of aging, 2017, Volume: 51

    Topics: Aging; Animals; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Genetic Variation; Male; Maneb; Mice, Knockout; Mice, Mutant Strains; Paraquat; Parkinson Disease; Pars Compacta; Risk

2017
Supplementation of Spirulina (Arthrospira platensis) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1β
    Journal of dietary supplements, 2017, Sep-03, Volume: 14, Issue:5

    Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drosophila melanogaster; Herbicides; Locomotion; Longevity; Oxidation-Reduction; Paraquat; Parkinson Disease; Phycocyanin; Spirulina; Superoxide Dismutase

2017
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation.
    Toxicology, 2017, 04-01, Volume: 380

    Topics: Acetophenones; Adrenergic Neurons; Animals; Disease Models, Animal; Enzyme Inhibitors; Locus Coeruleus; Male; Maneb; Mice; Mice, Inbred C57BL; Microglia; NADPH Oxidases; Nerve Degeneration; Neurotoxicity Syndromes; NF-kappa B; Paraquat; Parkinson Disease; Risk Factors

2017
Catalytic metalloporphyrin protects against paraquat neurotoxicity in vivo.
    Biomedical and environmental sciences : BES, 2008, Volume: 21, Issue:3

    Topics: Animals; Antioxidants; Antiparkinson Agents; Behavior, Animal; Catalysis; Corpus Striatum; Dopamine; Male; Malondialdehyde; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Paraquat; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase

2008
Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.
    Neuromolecular medicine, 2008, Volume: 10, Issue:4

    Topics: Animals; Apoptosis; Caspases; Catalytic Domain; Cell Line, Transformed; Cytoprotection; Dopamine; Endoplasmic Reticulum; Herbicides; Intramolecular Oxidoreductases; Molecular Chaperones; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Prostaglandin-E Synthases; Protein Folding; Rats; Stress, Physiological; Substantia Nigra

2008
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-30, Volume: 105, Issue:39

    Topics: Animals; Apoptosis; Dopamine; Gene Deletion; Mice; Mice, Mutant Strains; NADH Dehydrogenase; Neurons; Paraquat; Parkinson Disease; Rotenone

2008
Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways.
    Journal of toxicology and environmental health. Part A, 2008, Volume: 71, Issue:22

    Topics: Apoptosis; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation; Herbicides; Humans; Neuroblastoma; Neurons; Paraquat; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity

2008
Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation.
    Free radical biology & medicine, 2009, Jan-15, Volume: 46, Issue:2

    Topics: Biomimetics; Cell Death; Cell Differentiation; Dopamine; Environmental Exposure; Humans; Infant, Newborn; Iron; Microglia; Neurons; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Salicylates; Superoxide Dismutase

2009
Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.
    American journal of epidemiology, 2009, Apr-15, Volume: 169, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Agriculture; California; Case-Control Studies; Comorbidity; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Female; Humans; Male; Maneb; Middle Aged; Odds Ratio; Paraquat; Parkinson Disease; Pesticides; Population Surveillance; Smoking

2009
Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.
    Methods in enzymology, 2009, Volume: 456

    Topics: Electron Spin Resonance Spectroscopy; Mitochondria; Oxidation-Reduction; Paraquat; Parkinson Disease; Superoxides

2009
Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice.
    Toxicology letters, 2009, Jul-24, Volume: 188, Issue:2

    Topics: Animals; Dopamine; Glutathione Disulfide; Herbicides; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Paraquat; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase

2009
Dopamine transporter genetic variants and pesticides in Parkinson's disease.
    Environmental health perspectives, 2009, Volume: 117, Issue:6

    Topics: Case-Control Studies; Dopamine Plasma Membrane Transport Proteins; Environmental Exposure; Environmental Pollutants; Female; Genetic Variation; Genotype; Humans; Male; Maneb; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Polymorphism, Single Nucleotide; Risk Factors

2009
Quantification of Paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry.
    Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Agents; Estrogen Receptor alpha; Herbicides; Mice; Microwaves; Paraquat; Parkinson Disease; Piperidines; Pyrazoles; Solvents; Tandem Mass Spectrometry

2009
The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat.
    Neurochemical research, 2010, Volume: 35, Issue:2

    Topics: Animals; Antioxidants; Disease Models, Animal; Drosophila melanogaster; Female; Ferric Compounds; Flavonoids; Motor Activity; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Phenols; Polyphenols; Survival Rate

2010
Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice.
    Chinese medical journal, 2009, Oct-05, Volume: 122, Issue:19

    Topics: Administration, Oral; Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutathione Peroxidase; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Paraquat; Parkinson Disease; RNA, Messenger; Substantia Nigra; Superoxide Dismutase

2009
Lysosomal degradation of alpha-synuclein in vivo.
    The Journal of biological chemistry, 2010, Apr-30, Volume: 285, Issue:18

    Topics: alpha-Synuclein; Animals; Autophagy; Disease Models, Animal; Herbicides; HSC70 Heat-Shock Proteins; Humans; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Mesencephalon; Mice; Mice, Transgenic; Neurons; Paraquat; Parkinson Disease

2010
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
    Free radical biology & medicine, 2010, May-15, Volume: 48, Issue:10

    Topics: Animals; Apoptosis; Cell Line; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Mice; Mice, Knockout; Neuroblastoma; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Paraquat; Parkinson Disease; RNA, Small Interfering; Sulfoxides; Thiocyanates; Thioredoxins; Vitamin E

2010
Effects of pharmacological agents on the lifespan phenotype of Drosophila DJ-1beta mutants.
    Gene, 2010, Aug-15, Volume: 462, Issue:1-2

    Topics: Animals; Antioxidants; Brain; Dopamine; Drosophila; Mutation; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Phenotype; Reactive Oxygen Species

2010
Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.
    Neurochemical research, 2010, Volume: 35, Issue:10

    Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Glutathione; Glycerol; Intracellular Space; Lecithins; Liposomes; Maneb; Mesencephalon; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; Pesticides; Rats; Rats, Sprague-Dawley

2010
α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.
    Neuroepidemiology, 2010, Volume: 35, Issue:3

    Topics: Age of Onset; Aged; alpha-Synuclein; California; Causality; Comorbidity; Educational Status; Environmental Exposure; Female; Fungicides, Industrial; Herbicides; Humans; Male; Maneb; Paraquat; Parkinson Disease; Risk Assessment; Rural Health; Smoking

2010
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
    Journal of pineal research, 2011, Volume: 50, Issue:2

    Topics: Animals; Blotting, Western; Cytochrome P-450 CYP2E1; Dopamine; Lipid Peroxidation; Male; Maneb; Melatonin; Mice; Paraquat; Parkinson Disease; Polymerase Chain Reaction; Silymarin; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins

2011
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.
    Journal of neurochemistry, 2010, Volume: 115, Issue:6

    Topics: Aging; alpha-Synuclein; Animals; Cell Line; Cells, Cultured; Disease Progression; Environmental Exposure; Humans; Iron; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Paraquat; Parkinson Disease; Rats; Risk Factors

2010
Rotenone, paraquat, and Parkinson's disease.
    Environmental health perspectives, 2011, Volume: 119, Issue:6

    Topics: Aged; Case-Control Studies; Female; Herbicides; Humans; Insecticides; Iowa; Male; Middle Aged; Mitochondria; North Carolina; Occupational Exposure; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Rotenone

2011
DJ-1 mediates paraquat-induced dopaminergic neuronal cell death.
    Toxicology letters, 2011, Apr-25, Volume: 202, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Dopamine; Flow Cytometry; Mice; Mice, Knockout; Microscopy, Fluorescence; Mitochondria; Neurons; Oncogene Proteins; Oxidative Stress; Paraquat; Parkinson Disease; Peroxiredoxins; Poly(ADP-ribose) Polymerases; Protein Deglycase DJ-1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxides

2011
Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 121, Issue:2

    Topics: Cell Line; Dopamine; Glutathione; Humans; Maneb; Neurons; Neurotoxicity Syndromes; Neurotoxins; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Peroxiredoxins; Pesticides; Reactive Oxygen Species; Thioredoxins; Transcription Factors

2011
Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice.
    International journal of biological sciences, 2011, Volume: 7, Issue:8

    Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; DNA Primers; Dopamine; Dopaminergic Neurons; Environmental Exposure; Gene Silencing; Histological Techniques; Mice; Mice, Transgenic; Microdialysis; Paraquat; Parkinson Disease; Polymerase Chain Reaction; Protein Kinases; RNA Interference

2011
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
    Neuropathology and applied neurobiology, 2012, Volume: 38, Issue:6

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Dronabinol; Herbicides; Humans; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Receptor, Cannabinoid, CB1; Tumor Cells, Cultured; Up-Regulation

2012
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Animals; Corpus Striatum; Gene Expression Profiling; Gene Regulatory Networks; Humans; Male; Maneb; Mesencephalon; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Pyridazines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcriptome

2012
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
    Molecular neurodegeneration, 2012, Sep-28, Volume: 7

    Topics: alpha-Synuclein; Animals; Disease Models, Animal; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Humans; Immunohistochemistry; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Maneb; Mice; Mice, Transgenic; Neurogenesis; Paraquat; Parkinson Disease; Pesticides; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Transcription, Genetic

2012
Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.
    Neurology, 2012, Nov-13, Volume: 79, Issue:20

    Topics: Aged; Aged, 80 and over; Brain Injuries; Case-Control Studies; Chi-Square Distribution; Environmental Exposure; Female; Humans; Male; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Risk Factors

2012
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.
    Cell death & disease, 2013, Jan-17, Volume: 4

    Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine; Drosophila; Drosophila Proteins; Herbicides; HSP90 Heat-Shock Proteins; Mitochondria; Mutation; Oxidative Stress; Paraquat; Parkinson Disease; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; TNF Receptor-Associated Factor 1; Ubiquitin-Protein Ligases

2013
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
    Neurobiology of disease, 2002, Volume: 10, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environmental Exposure; gamma-Aminobutyric Acid; Gliosis; Herbicides; Homovanillic Acid; Humans; Injections, Intraperitoneal; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Risk Factors; Substantia Nigra; Tyrosine 3-Monooxygenase

2002
Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype.
    Neurotoxicology, 2002, Volume: 23, Issue:4-5

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Fungicides, Industrial; Herbicides; Homovanillic Acid; Immunohistochemistry; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Paraquat; Parkinson Disease; Phenotype; Serotonin; Tyrosine 3-Monooxygenase

2002
[WITHDRAWN] Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
    The Journal of biological chemistry, 2005, 06-10, Volume: 280, Issue:23

    Topics: Animals; Apoptosis; bcl-X Protein; Blotting, Western; Body Weight; Cerebral Cortex; Corpus Striatum; Dopamine; Fungicides, Industrial; Glutathione Peroxidase; Herbicides; Hydrogen Peroxide; Immunohistochemistry; Lipid Metabolism; Lipid Peroxidation; Maneb; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Serotonin; Signal Transduction; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase

2005
Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease.
    The Journal of biological chemistry, 2005, Aug-12, Volume: 280, Issue:32

    Topics: Animals; Antioxidants; Blotting, Western; Catalase; Cells, Cultured; Dopamine; Immunohistochemistry; Male; Manganese; Manganese Compounds; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Chemical; Neurons; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase; Time Factors

2005
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
    Current biology : CB, 2005, Sep-06, Volume: 15, Issue:17

    Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Blotting, Western; Cluster Analysis; Computational Biology; Crosses, Genetic; Drosophila; Drosophila Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Phylogeny; Protein Deglycase DJ-1; Rotenone; Sequence Alignment; Survival Analysis

2005
Developmental pesticide models of the Parkinson disease phenotype.
    Environmental health perspectives, 2005, Volume: 113, Issue:9

    Topics: Age Factors; Animals; Animals, Newborn; Dopamine; Drug Synergism; Female; Fungicides, Industrial; Herbicides; Male; Maneb; Mice; Mice, Inbred C57BL; Models, Biological; Motor Activity; Paraquat; Parkinson Disease; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Substantia Nigra

2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases

2005
The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis.
    Journal of toxicology and environmental health. Part A, 2005, Nov-26, Volume: 68, Issue:22

    Topics: Dopamine Plasma Membrane Transport Proteins; Glutathione; Glutathione Transferase; Herbicides; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Reactive Oxygen Species; Receptors, Dopamine; Tumor Cells, Cultured

2005
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
    Human molecular genetics, 2005, Dec-15, Volume: 14, Issue:24

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide Donors; Nitroso Compounds; Paraquat; Parkinson Disease; Proteasome Endopeptidase Complex; Reference Values; Rotenone; Solubility; Stress, Physiological; Ubiquitin-Protein Ligases

2005
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration.
    Brain research, 2006, Apr-07, Volume: 1081, Issue:1

    Topics: Analysis of Variance; Animals; Catalase; Corpus Striatum; Cytochrome P-450 CYP2E1; Disease Models, Animal; Gene Expression; Glutathione Transferase; Herbicides; Lipid Peroxidation; Male; Maneb; Mice; Paraquat; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors

2006
Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 92, Issue:2

    Topics: Animals; Cell Line; Cell Survival; Herbicides; Paraquat; Parkinson Disease; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats

2006
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Aug-15, Volume: 103, Issue:33

    Topics: Aging; Animals; Animals, Genetically Modified; Cysteine; DNA Mutational Analysis; Drosophila melanogaster; Drosophila Proteins; Herbicides; Humans; Mice; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidative Stress; Paraquat; Parkinson Disease; Protein Deglycase DJ-1

2006
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.
    Free radical biology & medicine, 2006, Oct-01, Volume: 41, Issue:7

    Topics: alpha-Synuclein; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Dopamine Agents; Enzyme Stability; Gene Expression; HSP70 Heat-Shock Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Recombinant Fusion Proteins; Serine Endopeptidases; Superoxide Dismutase

2006
VIP is a transcriptional target of Nurr1 in dopaminergic cells.
    Experimental neurology, 2007, Volume: 203, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Dopamine; Down-Regulation; Gene Expression Regulation, Developmental; Herbicides; Mesencephalon; Mice; Mice, Knockout; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Paraquat; Parkinson Disease; Promoter Regions, Genetic; Regulatory Elements, Transcriptional; RNA, Messenger; Substantia Nigra; Transcription Factors; Transcriptional Activation; Vasoactive Intestinal Peptide

2007
Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.
    Experimental neurology, 2007, Volume: 203, Issue:2

    Topics: Animals; Cell Size; Dendrites; Dopamine; Dopamine Plasma Membrane Transport Proteins; Herbicides; Immunohistochemistry; Male; Mesencephalon; Mice; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Neurons; Paraquat; Parkinson Disease; Pyridinium Compounds; Rotenone; Substantia Nigra; Uncoupling Agents

2007
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
    The American journal of pathology, 2007, Volume: 170, Issue:2

    Topics: alpha-Synuclein; Animals; Brain; Drug Synergism; Environmental Exposure; Fungicides, Industrial; Humans; Inclusion Bodies; Maneb; Mice; Mice, Transgenic; Mitochondria; Mutation, Missense; Paraquat; Parkinson Disease

2007
Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2007, Volume: 21, Issue:6

    Topics: Animals; Apoptosis; Caspase 3; Cell Survival; DNA Fragmentation; Ginkgo biloba; Herbicides; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; PC12 Cells; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Tyrosine 3-Monooxygenase

2007
Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Jun-27, Volume: 27, Issue:26

    Topics: Aging; Animals; Cell Line; Cells, Cultured; Drug Synergism; Environmental Exposure; Herbicides; Iron; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Organometallic Compounds; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase

2007
Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase.
    Brain research, 2007, Sep-05, Volume: 1167

    Topics: Animals; Brain; Cell Line; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Herbicides; Mice; Microglia; NADPH Oxidases; Nerve Degeneration; Neurotoxins; Oxidative Stress; Paraquat; Parkinson Disease; Phosphoproteins; Protein Kinase C-delta; Protein Transport; Reactive Oxygen Species; Signal Transduction

2007
Paraquat neurotoxicity is mediated by a Bak-dependent mechanism.
    The Journal of biological chemistry, 2008, Feb-08, Volume: 283, Issue:6

    Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspase 3; Cell Survival; Cycloheximide; Gene Expression Regulation; Herbicides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Paraquat; Parkinson Disease; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2

2008
Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells.
    Acta biochimica et biophysica Sinica, 2008, Volume: 40, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Catalase; Cell Line; Cell Nucleus; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Reactive Oxygen Species; Superoxide Dismutase

2008
Radical formation site of cerebral complex I and Parkinson's disease.
    Journal of neuroscience research, 1995, Oct-15, Volume: 42, Issue:3

    Topics: Animals; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hydroxyl Radical; Lipid Peroxidation; Mitochondria; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Paraquat; Parkinson Disease; Reactive Oxygen Species; Superoxide Dismutase; Superoxides

1995
Hepatic disposition of neurotoxins and pesticides.
    Pharmacology & toxicology, 2000, Volume: 87, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Transport; DDT; Hepatocytes; Humans; Liver; Malathion; Male; Neurotoxins; Paraquat; Parkinson Disease; Perfusion; Pesticides; Rats; Rats, Wistar; Tissue Distribution

2000
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.
    FEBS letters, 2001, Jul-06, Volume: 500, Issue:3

    Topics: alpha-Synuclein; Circular Dichroism; Dieldrin; Ditiocarb; Nerve Tissue Proteins; Paraquat; Parkinson Disease; Pesticides; Protein Binding; Protein Conformation; Protein Folding; Rotenone; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins

2001
Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes.
    Journal of biochemistry, 2002, Volume: 131, Issue:4

    Topics: Animals; Brain; Catalysis; Diquat; Dose-Response Relationship, Drug; Free Radicals; Herbicides; Hydrogen Peroxide; Lipid Peroxidation; Microsomes; Oxygen; Paraquat; Parkinson Disease; Phospholipids; Rats; Thiobarbituric Acid Reactive Substances; Time Factors

2002
Susceptibility in Parkinson's disease. 'Of mice and men'.
    Medical hypotheses, 1988, Volume: 27, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Free Radicals; Humans; Mice; Models, Biological; Oxygen; Paraquat; Parkinson Disease

1988
Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: accumulation in neuromelanin.
    Neuroscience letters, 1988, Oct-31, Volume: 93, Issue:1

    Topics: Animals; Autoradiography; Diquat; Injections, Intraperitoneal; Melanins; Mice; Mice, Inbred C57BL; Models, Biological; Paraquat; Parkinson Disease; Pyridinium Compounds; Rana temporaria; Tissue Distribution

1988