paraquat has been researched along with Idiopathic Parkinson Disease in 162 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (1.23) | 18.7374 |
1990's | 1 (0.62) | 18.2507 |
2000's | 43 (26.54) | 29.6817 |
2010's | 72 (44.44) | 24.3611 |
2020's | 44 (27.16) | 2.80 |
Authors | Studies |
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Das, S; Mohamad Najib, NH; Teoh, SL; Yahaya, MF | 1 |
Ahmad, MH; Ali, M; Fatima, M; Mondal, AC; Rizvi, MA | 1 |
Kuter, KZ; Ossowska, K; Śmiałowska, M | 1 |
Arsac, JN; Baron, T; Dartiguelongue, M; Davoust, N; Mollereau, B; Sedru, M; Vulin, J | 1 |
Huang, M; Li, G; Shi, G; Tian, T; Wang, K; Zhang, B; Zhang, C | 1 |
Naidu, R; See, WZC; Tang, KS | 2 |
Huang, M; Tian, T; Wang, K; Wu, K; Yan, W; Zhang, B | 1 |
El-Saadi, MW; Grames, M; Huang, S; Keys, K; Knott, E; Li, H; Lu, XH; Ren, M; Tian, X; Yin, H | 1 |
Liu, CY; Wang, YL; Yang, HM; Zhang, XF; Zhou, YT | 1 |
Cui, M; Dong, Q; Feng, Y; Guo, M; Han, S; Hao, Y; Sun, J; Zhao, Y | 1 |
Chandrasekhar, M; Dey, A; Gopalakrishnan, AV; Iyer, M; Kesari, K; Narayanasamy, A; Sri Sabari, S; Vellingiri, B; Venkatesan, D | 1 |
Dai, L; Du, Z; Fang, Y; Jiang, H; Li, F; Li, H; Liu, C; Liu, Z; Meng, L; Tian, Y; Wang, Z; Xiong, M; Yan, Z; Yu, T; Yuan, X; Zhang, J; Zhang, Z | 1 |
Cheng, Y; Deng, P; Duan, W; Fu, G; He, H; Hong, H; Lin, X; Lu, Y; Mao, G; Pi, H; Tong, T; Wang, X; Xu, J; Xu, S; Xu, Y; Yang, L; Yu, Z; Zhang, J; Zhou, Z | 1 |
Agarwal, S; Chang, YM; Desai, TD; Ho, TJ; Huang, CY; Ju, DT; Kuo, WW; Liao, SC; Lin, YJ; Sun, JM; Yeh, YL | 1 |
Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G | 1 |
Chao, CC; Chen, JJ; Cheng, JJ; Chiou, CT; Hsu, TH; Huang, CL; Huang, NK; Lee, IJ; Lin, PY; Yang, YC; Yei, CE | 1 |
Chovsepian, A; Dening, Y; Dieterich, M; Dirscherl, P; Falkai, P; Giese, A; Giesert, F; Herms, J; Khairnar, A; Levin, J; Pan-Montojo, F; Ruf, V; Schmidt, F; Stievenard, A; Straßl, T; Weisenhorn, DV; Wurst, W | 1 |
Gao, J; Hawrysh, PJ; McQuibban, GA; Nodwell, J; Oh, A; Tan, S; Tompkins, TA | 1 |
Nuber, S; Selkoe, DJ | 1 |
Chang, R; Hou, L; Huang, R; Liu, J; Ruan, Z; Sun, F; Wang, Q; Wang, Y; Zhao, J | 1 |
Brown-Leung, JM; Cannon, JR; Chester, JA; Enkh-Amgalan, S; Nolan, RM; Syeda, T | 1 |
Ciesla, L; Conger, J; Maitra, U; Owens, MMM | 1 |
Ren, XY; Xu, YN; Zhang, XF; Zhou, YT | 1 |
Dorsey, ER; Ray, A | 1 |
Chandramohan, V; Chithra, Y; Dey, G; Ghose, V; Gowthami, N; Srinivas Bharath, MM; Vasudev, V | 1 |
Bernardino, L; Cristóvão, AC; Esteves, M; Ferreira, R; Lopes-Nunes, J; Santos, T; Saraiva, C; Vale, A | 1 |
Duan, W; Duan, Y; Fu, G; Li, Y; Liu, C; Liu, Y; Sun, Y; Tian, J; Xia, Z; Xu, S; Yang, Y; Yu, Q; Zhang, T; Zhou, J | 1 |
Cheng, B; Geng, L; Li, R; Lou, X; Lu, K; Song, W; Wang, L; Zhang, S | 1 |
de Camargo, JL; El Dib, R; Gomaa, H; Lopes, LC; Vaccari, C | 1 |
Dey, AB; Dey, S; Dwivedi, S; Goyal, V; Rai, N; Upadhyay, AD | 1 |
Alves, G; Beal, MF; Bernardino, L; Campos, FL; Cristóvão, AC; Esteves, M; Fonseca, BM; Guhathakurta, S; Je, G; Kim, YS; Queiroz, J; Salgado, AJ; Sousa, N; Yang, L; Yoon, KS | 1 |
Jimenez-Carrion, P; Jones, BC; Lu, L; Mulligan, MK; O'Callaghan, JP; Silva, I; Torres-Rojas, C; Williams, RW; Zhao, W; Zhuang, D | 1 |
Ambaryan, A; Danilenko, V; Marsova, M; Odorskaya, M; Pavlova, G; Poluektova, E; Revishchin, A | 1 |
Huang, M; Li, Y; Tian, T; Wang, K; Wang, Y; Yan, W; Yang, H | 1 |
Freeman, JL; Wasel, O | 1 |
Ming, F; Qin, L; Tan, J; Tan, X; Tang, J; Wang, C; Zhang, H | 1 |
Cluet, D; Davoust, N; Dufourd, E; Girard, V; Goubard, V; Mollereau, B; Nataf, S; Pays, L; Querenet, M; Seugnet, L | 1 |
Afiyatullov, SS; Chingizova, EA; Girich, EV; Menchinskaya, ES; Ngoc, NTD; Pislyagin, EA; Pivkin, MV; Popov, RS; Smetanina, OF; Trinh, PTH; Yurchenko, AN; Yurchenko, EA | 1 |
Chao, CY; Cheng, JJ; Chiou, CT; Huang, CL; Huang, HT; Huang, NK; Kuo, YH; Lee, IJ; Yang, YC | 1 |
Ayoub, K; Beauchamp, S; Derksen, A; Dwyer, Z; Farmer, K; Fortin, T; Hayley, S; Rudyk, C; Shail, P; Torres, C; Ventura, K | 1 |
Ciesla, L; Harding, T; Liang, Q; Maitra, U | 1 |
El-Dash, HA; Fathy, SM; Said, NI | 1 |
Chang, Y; Gao, G; Li, X; Li, Y; Shi, Z; Thirupathi, A; Xie, J; Yu, P; Zhang, J; Zuo, Y | 1 |
Weed, DL | 1 |
Fleming, SM | 1 |
Girish, TK; Joshi, CG; Narasingappa, RB; Ravi, SK; Vincent, B | 1 |
Attia, HN; Maklad, YA | 1 |
Chen, SC; Chen, WY; Cheng, YH; Chou, WC; How, CM; Hsieh, NH; Huang, CW; Liao, CM; Lin, YJ; Yang, YF; You, SH | 2 |
Connor, JR; Huang, X; Lamendella, R; Meadowcroft, MD; Nandar, W; Neely, EB; Nixon, AM; Purnell, CJ; Snyder, AM; Wright, J | 1 |
Andersen, JK; Campisi, J; Chinta, SJ; Demaria, M; Limbad, C; Madden, DT; McQuade, A; Rajagopalan, S; Rane, A; Woods, G; Zou, Y | 1 |
Bordelon, Y; Bronstein, JM; Cockburn, M; Paul, KC; Ritz, B; Sinsheimer, JS | 1 |
Scott, KM; Williams-Gray, CH | 1 |
Bastías-Candia, S; Inestrosa, NC; Zolezzi, JM | 1 |
Cheng, JJ; Chiou, CT; Huang, CL; Huang, HM; Huang, HT; Huang, NK; Lee, YC; Yang, JM; Yang, YC | 1 |
Campbell, JL; Clewell, HJ; Hinderliter, PM; Travis, KZ | 1 |
Morioka, H; Nishio, R; Takeda, A; Takeuchi, A; Tamano, H | 1 |
Hartley, RC; Murphy, MP; Oliveira, JMA; Pinho, BR; Reis, SD | 1 |
Chaiyakunapruk, N; Lohitnavy, M; Lohitnavy, O; Norman Scholfield, C; Reisfeld, B; Sruamsiri, R; Tangamornsuksan, W | 1 |
Amiri, S; Amram, O; Caballero, M; Denney, JT; Hystad, P; Monsivais, P | 1 |
Brandt, A; Joop, G; Vilcinskas, A | 1 |
Birman, S; Cassar, M; Hajji, K; Leprince, J; Masmoudi-Kouki, O; Mezghani, S; Mteyrek, A; Sun, J; Vaudry, D | 1 |
Furuhata, R; Komata, Y; Morioka, H; Nishio, R; Takeda, A; Tamano, H | 1 |
Aboutalebi, H; Bae, EJ; Di Monte, DA; Helwig, M; Lee, SJ; Musgrove, RE; Ulusoy, A | 1 |
Chang, RL; Chung, LC; Day, CH; Ho, TJ; Huang, CY; Ju, DT; Kuo, WW; Liao, PH; Sivalingam, K; Viswanadha, VP | 1 |
Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E | 1 |
Lenaers, G; Reynier, P; Thany, SH | 1 |
Langston, JW; Mak, SK; Schüle, B; Tetrud, JW; Tewari, D | 1 |
Kamel, F | 1 |
Akhtar, MW; Ambasudhan, R; Andreyev, AY; Chan, SF; Dolatabadi, N; Han, X; Jaenisch, R; Lee, B; Lipton, SA; Lopez, K; Masliah, E; Molokanova, E; Nagar, S; Nakamura, T; Nakanishi, N; Nutter, A; Okamoto, S; Parker, J; Ryan, SD; Shan, B; Soldner, F; Sunico, CR; Talantova, M; Yates, JR; Zhang, X; Zhang, Y | 1 |
Cardozo-Pelaez, F; Dalton, R; Gremaud, JN; Lacher, SE; Sherwin, CM; Skagen, K; Steed, E; Sugden, KD; Woodahl, EL | 1 |
Armstrong, SM; Moore, C; Willis, GL | 1 |
Borowy-Borowski, H; Cohen, J; Harrison, K; Keshan, C; Lanthier, P; Leahy, S; Lopatin, D; Miller, H; Muthukumaran, K; Pandey, S; Sandhu, JK; Sikorska, M; Weinstock, S | 1 |
Allen, JL; Conrad, K; Cory-Slechta, DA; Liu, X; Oberdörster, G; Weston, D | 1 |
Kachroo, A; Schwarzschild, MA | 1 |
Birman, S; Cassar, M; Coulom, H; Han, KA; Iché-Torres, M; Issa, AR; Petitgas, C; Riemensperger, T; Rival, T | 1 |
Achumi, B; Alone, DP; Phom, L; Yenisetti, SC | 1 |
Chaouhan, HS; Chowdhuri, DK; Mudiam, MKR; Patel, DK; Pragya, P; Ratnasekhar, C; Shukla, AK | 1 |
Bhudhikanok, GS; Blair, A; Chade, A; Comyns, K; Furlong, M; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Richards, M; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM | 1 |
Cappelletti, L; Dallemole, DR; Ellwanger, JH; Franke, SI; Gonçalves da Silva, M; Molz, P; Müller, TE; Pêgas Henriques, JA; Pereira dos Santos, A; Prá, D | 1 |
Morrison, BE; Stojkovska, I; Wagner, BM | 1 |
Corbett, J; Kadiiska, MB; Kumar, A; Leinisch, F; Mason, RP | 1 |
Aprigliano, S; Carresi, C; Isidoro, C; Janda, E; Lascala, A; Mollace, V; Morani, F; Musolino, V; Parafati, M; Russo, V; Savoia, C; Ziviani, E | 1 |
Akaike, A; Izumi, Y; Kume, T; Matsushima, S; Takada-Takatori, Y; Yamamoto, N; Yamamoto, T | 1 |
Beltramini, M; Bisaglia, M; Bubacco, L; Casella, L; Ferrari, E; Filograna, R; Godena, VK; Sanchez-Martinez, A; Whitworth, AJ | 1 |
Bardien, S; Engelbrecht, L; Kinnear, C; Loos, B; van der Merwe, C; van der Westhuizen, FH; van Dyk, HC | 1 |
Botham, PA; Breckenridge, CB; Cook, AR; Minnema, DJ; Sturgess, NC; Travis, KZ | 1 |
Thompson, MD; Zhang, XF | 1 |
Ackerson, LC; Cely, I; Chesselet, MF; De La Rosa, K; Gabby, L; Maidment, NT; McDowell, KA; Mortazavi, F; Mulligan, CK; Murphy, NP; Richter, F; Sioshansi, PC; Tsan, L | 1 |
Christian, PK; Guruprasad, BR; Kumar, A; Panchal, K; Tiwari, AK | 1 |
Che, Y; Hou, L; Liu, X; Sun, F; Wang, H; Wang, K; Wang, Q; Zhang, C; Zhao, X; Zhou, X | 1 |
Chen, P; Chen, Z; Li, A; Liang, LP; Lou, XC; Wang, SL; Wu, XK; Zhao, CJ | 1 |
Andersen, JK; Bredesen, DE; Chinta, SJ; Poksay, KS; Rane, A; Rao, RV | 1 |
Choi, WS; Kruse, SE; Palmiter, RD; Xia, Z | 1 |
Fuentes, JM; Gonzalez-Polo, RA; Moran, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G | 1 |
Andersen, JK; Oo, ML; Peng, J; Stevenson, FF | 1 |
Bronstein, J; Cockburn, M; Costello, S; Ritz, B; Zhang, X | 1 |
Cochemé, HM; Murphy, MP | 1 |
Gil, SJ; Kang, MJ; Koh, HC | 1 |
Bronstein, J; Cockburn, M; Costello, S; Farrer, MJ; Lincoln, SJ; Manthripragada, AD; Ritz, BR | 1 |
Barr, DB; Buckley, B; Montesano, MA; Richfield, EK; Thiruchelvam, M; Winnik, B | 1 |
Guzman-Martinez, C; Jimenez-Del-Rio, M; Velez-Pardo, C | 1 |
Ren, JP; Sun, XJ; Zhao, YW | 1 |
Berry, C; La Vecchia, C; Nicotera, P | 1 |
Cuervo, AM; Di Monte, DA; Mak, SK; Manning-Bog, AB; McCormack, AL | 1 |
Bravo-San Pedro, JM; Cuadrado, A; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Lastres-Becker, I; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G | 1 |
Gómez-Pastor, R; Lavara-Culebras, E; Matallana, E; Muñoz-Soriano, V; Paricio, N | 1 |
Bernard, LP; Guilford, FT; Zeevalk, GD | 1 |
Bronstein, J; Cockburn, M; Farrer, M; Gatto, NM; Manthripragada, AD; Rhodes, SL; Ritz, B | 1 |
Cannon, JR; Greenamyre, JT | 1 |
Jain, SK; Patel, DK; Singh, MP; Singhal, NK; Srivastava, G | 1 |
Andersen, JK; Oo, ML; Peng, J | 1 |
Akaike, A; Izumi, Y; Kume, T | 1 |
Bhudhikanok, GS; Blair, A; Cambi, F; Chade, AR; Comyns, K; Fernandez, HH; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Priestley, B; Richards, MB; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM | 1 |
Han, JS; Heo, JY; Kweon, GR; Kwon, HJ; Park, JH; Ryu, MJ; Seo, KS; Shim, JH; Shong, M; Son, JH | 1 |
Colosio, C; Moretto, A | 1 |
Go, YM; Hansen, JM; Jones, DP; Roede, JR | 1 |
Adami, HO; Cole, P; Mandel, JS | 1 |
Huang, C; Tong, J; Xia, XG; Zhou, H | 1 |
Tieu, K | 1 |
Carroll, CB; Hanemann, CO; Zajicek, JP; Zeissler, ML | 1 |
Armentero, MT; Blandini, F | 1 |
Beal, MF; Calingasan, NY; Elemento, O; Gollamudi, S; Johri, A; Yang, L | 1 |
Desplats, P; Fujita, M; Hashimoto, M; Kosberg, K; Mante, M; Masliah, E; Patel, P; Patrick, C; Rockenstein, E | 1 |
Bordelon, Y; Bronstein, J; Lee, PC; Ritz, B | 1 |
Costa, AC; Loh, SH; Martins, LM | 1 |
Cory-Slechta, DA; Di Monte, DA; Langston, JW; Manning-Bog, AB; McCormack, AL; Thiffault, C; Thiruchelvam, M | 1 |
Baggs, RB; Cory-Slechta, DA; Goodman, BM; Richfield, EK; Thiruchelvam, M | 1 |
Di Monte, DA | 1 |
Uversky, VN | 1 |
Buckley, B; Cory-Slechta, DA; Mirochnitchenko, O; Prokopenko, O; Richfield, EK; Thiruchelvam, M | 1 |
Andersen, JK; Doctrow, SR; Peng, J; Stevenson, FF | 1 |
Armstrong-Gold, CE; Bonini, NM; Heutink, P; Meulener, M; Pallanck, LJ; Rizzu, P; Wes, PD; Whitworth, AJ | 1 |
Barlow, BK; Cory-Slechta, DA; Richfield, EK; Thiruchelvam, M | 1 |
Finley, B; Li, AA; McIntosh, LJ; Mink, PJ; Teta, MJ | 1 |
Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B | 1 |
Tiffany-Castiglioni, E; Yang, W | 1 |
Chew, KC; Dawson, TM; Dawson, VL; Ho, MW; Ko, HS; Lim, KL; Lim, TM; Pletnikova, O; Soong, TW; Tay, SP; Thomas, B; Troncoso, J; Tsang, F; Wang, C | 1 |
Gupta, YK; Kumar, A; Patel, S; Singh, MP; Singh, V | 1 |
Fuentes, JM; García-Rubio, L; Gómez-Martín, A; González-Polo, RA; Morán, JM; Niso-Santano, M; Soler, G | 1 |
Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K | 1 |
Bastos, ML; Carmo, H; Carvalho, F; Dinis-Oliveira, RJ; Duarte, JA; Navarro, AS; Remião, F | 1 |
Bonini, NM; Ischiropoulos, H; Meulener, MC; Thompson, L; Thomson, L; Xu, K | 1 |
An, JJ; Cho, SW; Choi, HS; Choi, SY; Eum, WS; Kang, JH; Kang, TC; Kim, DW; Kim, SY; Kwon, HJ; Kwon, OS; Lee, SH; Park, J; Won, MH; Yoo, KY | 1 |
Callahan, LM; Federoff, HJ; Giuliano, RE; Henricksen, LA; Luo, Y; Prifti, L | 1 |
German, DC; Liang, CL; Luby-Phelps, K; Wang, TT | 1 |
Giasson, BI; Lee, VM; Leight, S; Norris, EH; Trojanowski, JQ; Uryu, K | 1 |
Chen, J; Kang, X; Li, H; Wang, B; Xu, Z | 1 |
Andersen, JK; Doctrow, SR; Peng, J; Peng, L; Stevenson, FF | 1 |
Miller, RL; Sun, AY; Sun, GY | 1 |
Di Monte, DA; Ethell, DW; Fei, Q; McCormack, AL | 1 |
Chen, P; Chen, Z; He, M; Li, A; Liang, L; Wang, S; Wu, X; Zhang, M; Zhao, C | 1 |
James-Kracke, M; Miller, RL; Sun, AY; Sun, GY | 1 |
Fukushima, T; Hojo, N; Isobe, A; Shiwaku, K; Tawara, T; Yamane, Y | 1 |
Le Couteur, DG; McLean, AJ; Rivory, LP; Yang, MC | 1 |
Fink, AL; Li, J; Uversky, VN | 1 |
Fariello, RG; Gerlach, M; Riederer, P; Sulzer, D; Tampellini, D; Zecca, L | 1 |
Hayashi, T; Kawakami, I; Nakamura, M; Tamura, M; Yumino, K | 1 |
Fukushima, T | 1 |
Borm, PJ; Van Vliet, C | 1 |
Larsson, BS; Lindquist, NG; Lydén-Sokolowski, A | 1 |
26 review(s) available for paraquat and Idiopathic Parkinson Disease
Article | Year |
---|---|
Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson's Disease Pathophysiology.
Topics: Apoptosis; Dopaminergic Neurons; Humans; Nerve Degeneration; Paraquat; Parkinson Disease; Substantia Nigra | 2022 |
Neurotoxicity of pesticides - A link to neurodegeneration.
Topics: Dopamine; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides | 2022 |
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium | 2022 |
Paraquat and Parkinson's Disease: The Molecular Crosstalk of Upstream Signal Transduction Pathways Leading to Apoptosis.
Topics: Apoptosis; Herbicides; Humans; Paraquat; Parkinson Disease; Signal Transduction | 2024 |
Paraquat and Parkinson's disease: a systematic review and meta-analysis of observational studies.
Topics: Adult; Herbicides; Humans; Paraquat; Parkinson Disease; Research Design; Time Factors | 2019 |
Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Knockdown Techniques; Neurotoxicity Syndromes; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Rotenone; Zebrafish; Zebrafish Proteins | 2020 |
Does paraquat cause Parkinson's disease? A review of reviews.
Topics: Animals; Herbicides; Humans; Meta-Analysis as Topic; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Risk Factors; Systematic Reviews as Topic | 2021 |
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
Topics: Environmental Exposure; Gene-Environment Interaction; Genetic Predisposition to Disease; Herbicides; Humans; Insecticides; Mutation; Paraquat; Parkinson Disease; Risk Factors; Rotenone | 2017 |
Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model.
Topics: Animals; Disease Models, Animal; Dopamine; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Substantia Nigra | 2019 |
Paraquat exposure and Parkinson's disease: A systematic review and meta-analysis.
Topics: Environmental Exposure; Humans; Occupational Exposure; Odds Ratio; Paraquat; Parkinson Disease; Risk Factors | 2019 |
Parkinson's disease and enhanced inflammatory response.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Inflammation; Lipopolysaccharides; Neurons; Oxidative Stress; Oxidopamine; Oxygen; Paraquat; Parkinson Disease; Ubiquitin-Protein Ligases | 2015 |
Paraquat and Parkinson's disease.
Topics: Animals; Apoptosis; Disease Models, Animal; Herbicides; Humans; Mice; Nerve Degeneration; Paraquat; Parkinson Disease; Risk Factors | 2010 |
Neurotoxic in vivo models of Parkinson's disease recent advances.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; MPTP Poisoning; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Sympatholytics; Uncoupling Agents | 2010 |
[Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity].
Topics: Animals; Cell Death; Dopamine; Glutamate-Cysteine Ligase; Glutathione; Humans; Neurons; NF-E2-Related Factor 2; Oxidation-Reduction; Paraquat; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Substantia Nigra | 2011 |
Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease.
Topics: Animals; Brain; Dieldrin; Dose-Response Relationship, Drug; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Pyrethrins; Risk Assessment; Risk Factors; Rotenone; Time Factors; Toxicity Tests | 2011 |
Paraquat and Parkinson's disease: an overview of the epidemiology and a review of two recent studies.
Topics: Case-Control Studies; Herbicides; Paraquat; Parkinson Disease; Pesticides | 2012 |
A guide to neurotoxic animal models of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Haplorhini; Lewy Bodies; Mice; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Substantia Nigra | 2011 |
Animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Sympatholytics | 2012 |
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
Topics: alpha-Synuclein; Animals; Corpus Striatum; Environmental Exposure; Herbicides; Humans; Insecticides; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurotoxins; Oncogene Proteins; Paraquat; Parkinson Disease; Protein Deglycase DJ-1; Risk Factors; Rotenone; Synucleins; Twin Studies as Topic | 2003 |
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
Topics: Animals; Disease Models, Animal; Fungicides, Industrial; Herbicides; Maneb; Nerve Degeneration; Neurotoxins; Paraquat; Parkinson Disease; Rotenone; Uncoupling Agents | 2004 |
Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease.
Topics: Animals; Case-Control Studies; Dieldrin; Disease Models, Animal; Fungicides, Industrial; Heptachlor; Humans; Maneb; Occupational Diseases; Occupational Exposure; Paraquat; Parkinson Disease; Permethrin; Pesticides; Pyridazines; Risk Factors | 2005 |
Neural repair strategies for Parkinson's disease: insights from primate models.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; Disease Models, Animal; Fungicides, Industrial; Glial Cell Line-Derived Neurotrophic Factor; Herbicides; Humans; Maneb; Nerve Degeneration; Oxidopamine; Paraquat; Parkinson Disease; Pesticides; Primates; Rotenone | 2006 |
Paraquat exposure as an etiological factor of Parkinson's disease.
Topics: Environmental Exposure; Herbicides; History, 19th Century; Humans; Paraquat; Parkinson Disease | 2006 |
Oxidative and inflammatory pathways in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone | 2009 |
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.
Topics: Aging; Animals; Cell Death; Chelating Agents; Cholesterol; Humans; Iron; Lipid Metabolism; Locus Coeruleus; Melanins; Paraquat; Parkinson Disease; Pesticides; Substantia Nigra; Toxins, Biological | 2001 |
[Elucidation of paraquat poisoning mechanism and development of the neuronal death model].
Topics: Animals; Chaperonin 60; Disease Models, Animal; Electron Transport Complex I; Herbicides; Humans; Lipid Peroxidation; Mitochondria; NADH, NADPH Oxidoreductases; Niacinamide; Paraquat; Parkinson Disease; Superoxides | 2002 |
136 other study(ies) available for paraquat and Idiopathic Parkinson Disease
Article | Year |
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The effects of metallothionein in paraquat-induced Parkinson disease model of zebrafish.
Topics: Animals; Brain Injuries; Dopamine; Dopaminergic Neurons; Humans; Metallothionein; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neuroprotective Agents; Paraquat; Parkinson Disease; Substantia Nigra; Zebrafish | 2023 |
Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Flavanones; Herbicides; Humans; Male; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Rats, Wistar; Substantia Nigra | 2021 |
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
Topics: alpha-Synuclein; Animals; Carrier Proteins; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Environmental Exposure; Herbicides; Inflammation; Lipopolysaccharides; Microglia; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Protective Agents; Rats; Substantia Nigra | 2022 |
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Herbicides; Male; Neurotoxins; Paraquat; Parkinson Disease | 2021 |
Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Taurine | 2022 |
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Topics: alpha-Synuclein; Autophagy; Beclin-1; HMGB1 Protein; Humans; Paraquat; Parkinson Disease | 2022 |
Tracing brain genotoxic stress in Parkinson's disease with a novel single-cell genetic sensor.
Topics: Animals; Brain; DNA Damage; Dopaminergic Neurons; Humans; Mice; Mice, Transgenic; Paraquat; Parkinson Disease | 2022 |
A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease.
Topics: Animals; Dopamine; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Paraquat; Parkinson Disease; Substantia Nigra | 2022 |
Role of OCT3 and DRP1 in the Transport of Paraquat in Astrocytes: A Mouse Study.
Topics: Animals; Astrocytes; Cations; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Dynamins; Mice; Neurotoxicity Syndromes; Octamer Transcription Factor-3; Paraquat; Parkinson Disease; RNA, Small Interfering; Substantia Nigra | 2022 |
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.
Topics: alpha-Synuclein; Animals; Environmental Pollutants; Fungicides, Industrial; Humans; Maneb; Metabolomics; Mice; Neuroblastoma; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Phenylalanine; Proteomics; Tryptophan | 2022 |
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.
Topics: alpha-Synuclein; Animals; Ceramides; Cytokines; Environmental Pollutants; Glycerides; Glycerophospholipids; Herbicides; Humans; Lipopolysaccharides; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Neurotoxins; Paraquat; Parkinson Disease; Parkinsonian Disorders; RNA, Messenger; Sphingolipids | 2022 |
Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Mice; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease | 2023 |
SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease.
Topics: Animals; Herbicides; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Paraquat; Parkinson Disease; Sirtuin 1 | 2022 |
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Mice; Paraquat; Parkinson Disease; Rotenone | 2022 |
PRKN/parkin-mediated mitophagy is induced by the probiotics
Topics: Animals; Autophagy; Drosophila; Lactococcus lactis; Mitophagy; Paraquat; Parkinson Disease; Protein Kinases; Saccharomyces boulardii; Ubiquitin-Protein Ligases | 2023 |
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.
Topics: alpha-Synuclein; Animals; Calpain; Humans; Mice; Paraquat; Parkinson Disease | 2023 |
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Dopaminergic Neurons; Inflammasomes; Integrins; Macrophage-1 Antigen; Macrophages; Maneb; Memory Disorders; Mice; Microglia; NADPH Oxidases; NLR Family, Pyrin Domain-Containing 3 Protein; Paraquat; Parkinson Disease | 2023 |
Paraquat exposure produces sex-dependent reduction in binge-like alcohol drinking in high alcohol-preferring mice.
Topics: Alcohol Drinking; Animals; Binge Drinking; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease | 2023 |
Predicting structural features of selected flavonoids responsible for neuroprotection in a Drosophila model of Parkinson's disease.
Topics: Animals; Antioxidants; Drosophila; Flavones; Flavonoids; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease | 2023 |
Inactivation of microglia dampens blood-brain barrier permeability and loss of dopaminergic neurons in paraquat-lesioned mice.
Topics: Animals; Blood-Brain Barrier; Dopaminergic Neurons; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Neuroinflammatory Diseases; Occludin; Paraquat; Parkinson Disease; Permeability | 2023 |
Paraquat, Parkinson's Disease, and Agnotology.
Topics: Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides | 2023 |
Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Dopaminergic Neurons; Electron Transport Complex I; Humans; Paraquat; Parkinson Disease; Proteomics; Rotenone | 2023 |
CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Paraquat; Parkinson Disease; Rats; Substantia Nigra; Transcription Factors | 2023 |
Upregulation of mitochondrial calcium uniporter contributes to paraquat-induced neuropathology linked to Parkinson's disease via imbalanced OPA1 processing.
Topics: Animals; Dopamine; Mice; MicroRNAs; Paraquat; Parkinson Disease; Up-Regulation | 2023 |
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice; Mice, Inbred C57BL; Neuroblastoma; Paraquat; Parkinson Disease | 2023 |
Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease.
Topics: Aged; AMP-Activated Protein Kinases; Biomarkers; Case-Control Studies; Cell Line; Endoplasmic Reticulum Stress; Female; Humans; Male; Medicine, Ayurvedic; Middle Aged; Neurons; Nuclear Proteins; Paraquat; Parkinson Disease; Phytotherapy; Plant Extracts; Syzygium | 2020 |
Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Paraquat; Parkinson Disease; Pars Compacta; Rats; Substantia Nigra | 2020 |
Systems Genetics and Systems Biology Analysis of Paraquat Neurotoxicity in BXD Recombinant Inbred Mice.
Topics: Animals; Brain; Herbicides; Iron; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Paraquat; Parkinson Disease; Substantia Nigra; Systems Biology | 2020 |
Protective effects of Lactobacillus fermentum U-21 against paraquat-induced oxidative stress in Caenorhabditis elegans and mouse models.
Topics: Animals; Antioxidants; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic Neurons; Escherichia coli; Lactobacillus; Limosilactobacillus fermentum; Longevity; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Paraquat; Parkinson Disease; Survival Rate | 2020 |
Knockdown of TLR4 Represses the Paraquat-Induced Neuroinflammation and Microglial M1 Polarization.
Topics: Animals; Cytokines; Gene Knockdown Techniques; Inflammation; Mice; Microglia; Nervous System Diseases; Paraquat; Parkinson Disease; Signal Transduction; Toll-Like Receptor 4; Transcription Factors | 2020 |
The
Topics: Adult; Apoptosis; Female; HeLa Cells; Humans; Lymphocytes; Male; Mitochondria; Mutant Proteins; Mutation; Paraquat; Parkinson Disease; Ubiquitin-Protein Ligases | 2020 |
Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity.
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Herbicides; Homeodomain Proteins; Lipid Droplets; Male; Neuroglia; Paraquat; Parkinson Disease; RNA-Binding Proteins | 2020 |
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of
Topics: Animals; Antiparkinson Agents; Aspergillus; Cell Line, Tumor; Cell Survival; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Penicillium; Reactive Oxygen Species; Rotenone; Secondary Metabolism; Structure-Activity Relationship; Vietnam | 2020 |
Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease.
Topics: Antiparkinson Agents; Apoptosis; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Neurons; Paraquat; Parkinson Disease; Phosphorylation; Protein Kinases; Ubiquitin; Ubiquitin-Protein Ligases | 2021 |
Characterizing the protracted neurobiological and neuroanatomical effects of paraquat in a murine model of Parkinson's disease.
Topics: Age Factors; Animals; Antigens, Surface; Brain; Caspase 1; Corticosterone; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Milk Proteins; NF-kappa B; Paraquat; Parkinson Disease; Pesticides; Protozoan Proteins; Wiskott-Aldrich Syndrome Protein Family | 2021 |
GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Environmental Pollutants; Female; Flavones; Herbicides; Male; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease | 2021 |
Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson's disease.
Topics: Animals; Apoptosis; Disease Models, Animal; Inflammation; Male; Mice; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Plant Extracts; Pomegranate; Seeds | 2021 |
Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.
Topics: Amino Acid Transport System y+; Animals; Autophagy; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Ferritins; Ferroptosis; Humans; Iron; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Nuclear Receptor Coactivators; Paraquat; Parkinson Disease; Reactive Oxygen Species | 2021 |
Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease.
Topics: Antiparkinson Agents; Apoptosis; Cell Line, Tumor; DNA Damage; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Paraquat; Parkinson Disease; Phenols; Plant Extracts; Plant Leaves; Reactive Oxygen Species; Senna Plant | 2018 |
Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals.
Topics: Animals; Disease Models, Animal; Levodopa; Male; Mice; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Protein Carbonylation; Ubiquinone | 2018 |
PBPK/PD assessment for Parkinson's disease risk posed by airborne pesticide paraquat exposure.
Topics: Aged; Aged, 80 and over; Air Pollutants; Environmental Exposure; Humans; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Prevalence; Risk Factors; Taiwan | 2018 |
HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.
Topics: Animals; Brain; Disease Models, Animal; Gastrointestinal Microbiome; Gene-Environment Interaction; Genetic Variation; Genotype; Hemochromatosis Protein; Herbicides; Mice; Mice, Transgenic; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Tyrosine 3-Monooxygenase | 2018 |
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.
Topics: Animals; Cellular Senescence; Humans; Mice; Neuropathology; Paraquat; Parkinson Disease; Risk Factors | 2018 |
NFE2L2, PPARGC1α, and pesticides and Parkinson's disease risk and progression.
Topics: Aged; Aged, 80 and over; Environmental Exposure; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Maneb; Middle Aged; NF-E2-Related Factor 2; Paraquat; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pesticides; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease.
Topics: Astrocytes; Cellular Senescence; Humans; Neuropathology; Paraquat; Parkinson Disease | 2018 |
LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; beta Catenin; Cell Line; Cell Line, Tumor; Cell Survival; Glycogen Synthase Kinase 3; Humans; Immunohistochemistry; Paraquat; Parkinson Disease; Pyrazines; Pyridines; Wnt Signaling Pathway | 2018 |
Response to "Letter to the editor re: Cheng YH, Chou WC, Yang YF, et al. Environ Sci Pollut Res (2018). https://doi.org/10.107/s11356-017-0875-4".
Topics: Humans; Paraquat; Parkinson Disease; Pesticides | 2018 |
Letter to the editor re: Cheng, YH., Chou, WC., Yang, YF. et al. Environ Sci Pollut Res (2017). https://doi.org/10.1007/s11356-017-0875-4.
Topics: Humans; Paraquat; Parkinson Disease; Pesticides | 2018 |
Blockade of Rapid Influx of Extracellular Zn
Topics: Animals; Behavior, Animal; Chelating Agents; Dopaminergic Neurons; Extracellular Space; Glutamic Acid; Male; Models, Biological; Movement Disorders; Nerve Degeneration; Paraquat; Parkinson Disease; Rats, Wistar; Reactive Oxygen Species; Substantia Nigra; Zinc | 2019 |
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.
Topics: Animals; Antioxidants; Brain; Humans; Huntingtin Protein; Huntington Disease; Mitochondria; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Phenotype; Protein Aggregation, Pathological; Reactive Oxygen Species; Rotenone; Superoxides; Tyrosine 3-Monooxygenase; Zebrafish | 2019 |
Estimated Residential Exposure to Agricultural Chemicals and Premature Mortality by Parkinson's Disease in Washington State.
Topics: Aged; Aged, 80 and over; Agrochemicals; Atrazine; Environmental Exposure; Female; Herbicides; Humans; Male; Mortality, Premature; Odds Ratio; Paraquat; Parkinson Disease; Pesticides; Spatial Analysis; Washington | 2018 |
Tribolium castaneum as a whole-animal screening system for the detection and characterization of neuroprotective substances.
Topics: Animals; Diet; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Neuroprotective Agents; Paraquat; Parkinson Disease; Tribolium | 2019 |
Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.
Topics: Animals; Central Nervous System; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila Proteins; Humans; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pituitary Adenylate Cyclase-Activating Polypeptide; Reactive Oxygen Species; Receptors, G-Protein-Coupled | 2019 |
Paraquat as an Environmental Risk Factor in Parkinson's Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn
Topics: Aging; Animals; Dopaminergic Neurons; Exocytosis; Extracellular Space; Glutamic Acid; Male; Paraquat; Parkinson Disease; Presynaptic Terminals; Rats, Wistar; Reactive Oxygen Species; Receptors, AMPA; Risk Factors; Substantia Nigra; Zinc | 2019 |
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.
Topics: alpha-Synuclein; Animals; Axons; Brain; Cell Nucleus; Disease Progression; Humans; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidants; Oxidative Stress; Oxygen; Paraquat; Parkinson Disease; Reactive Oxygen Species; Vagus Nerve | 2019 |
Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model.
Topics: Alkaloids; Apoptosis; Cell Line; Cell Survival; Humans; In Situ Nick-End Labeling; MAP Kinase Signaling System; Neuroprotective Agents; Paraquat; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptor, IGF Type 1; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic | 2013 |
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone | 2013 |
Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication.
Topics: Adenosine Triphosphate; Adult; alpha-Synuclein; Cells, Cultured; Electron Transport Complex I; Female; Fibroblasts; Gene Expression Regulation; Herbicides; Humans; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Diseases; Paraquat; Parkinson Disease; RNA, Messenger; RNA, Small Interfering; Skin | 2011 |
Epidemiology. Paths from pesticides to Parkinson's.
Topics: Amyotrophic Lateral Sclerosis; Animals; Dementia; Environmental Exposure; Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Risk Factors; Rotenone | 2013 |
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Topics: alpha-Synuclein; Gene-Environment Interaction; Humans; Induced Pluripotent Stem Cells; MEF2 Transcription Factors; Mitochondria; Mutation; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Nitrogen Species; Substantia Nigra; Transcription Factors; Transcription, Genetic | 2013 |
Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport; Brain; Capillary Permeability; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Fluorescent Dyes; Herbicides; Male; Membrane Transport Modulators; Mice; Mice, Knockout; Paraquat; Parkinson Disease; Recombinant Proteins; Rhodamine 123; Sus scrofa; Tissue Distribution | 2014 |
Parkinson's disease, lights and melanocytes: looking beyond the retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Female; Light; Male; Melanocytes; Motor Activity; Oxidopamine; Paraquat; Parkinson Disease; Rats; Rats, Sprague-Dawley; Retina; Rotenone | 2014 |
Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease.
Topics: Administration, Oral; Animals; Cell Survival; Feasibility Studies; Male; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; Rats; Rats, Long-Evans; Rifabutin; Solubility; Substantia Nigra; Treatment Outcome; Ubiquinone; Vitamins; Water | 2014 |
Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice.
Topics: Air Pollutants; Animals; Animals, Newborn; Cell Count; Corpus Striatum; Disease Models, Animal; Drug Combinations; Female; Fungicides, Industrial; Herbicides; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Nanoparticles; Paraquat; Parkinson Disease; Particulate Matter; Silicones; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.
Topics: Allopurinol; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Enzyme Inhibitors; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Paraquat; Parkinson Disease; Pesticides; Uric Acid | 2014 |
A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Topics: Age Factors; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drosophila melanogaster; Drosophila Proteins; Environmental Exposure; Female; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D1; Ryanodine Receptor Calcium Release Channel | 2015 |
Curcumin's neuroprotective efficacy in Drosophila model of idiopathic Parkinson's disease is phase specific: implication of its therapeutic effectiveness.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Curcumin; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Resistance; Humans; Longevity; Movement; Neuroprotective Agents; Paraquat; Parkinson Disease; Time Factors; Treatment Outcome | 2014 |
Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster.
Topics: Animals; Behavior, Animal; Brain; Drosophila melanogaster; Gas Chromatography-Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Motor Activity; Nerve Degeneration; Oxidative Stress; Paraquat; Parkinson Disease; Principal Component Analysis; Reproducibility of Results | 2016 |
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Female; Gloves, Protective; Habits; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure; Occupational Health; Paraquat; Parkinson Disease; Permethrin; Pesticides; Risk; Rotenone; Surveys and Questionnaires; Trifluralin; Workplace | 2015 |
Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease.
Topics: Animals; Comet Assay; Disease Models, Animal; DNA Damage; Hypokinesia; Male; Paraquat; Parkinson Disease; Rats; Rats, Wistar; Selenium | 2015 |
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Cyclic N-Oxides; Disease Models, Animal; Dopaminergic Neurons; Injections, Intraperitoneal; Male; Maneb; Mesencephalon; Mice, Inbred C57BL; Microglia; Models, Biological; NADPH Oxidases; Nitric Oxide Synthase Type II; Paraquat; Parkinson Disease; Peroxynitrous Acid; Spin Labels; Substantia Nigra; Tyrosine 3-Monooxygenase | 2016 |
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Astrocytes; Astrocytoma; Autophagy; Benzhydryl Compounds; Enzyme Inhibitors; Formamides; Mice; Microtubule-Associated Proteins; Neuroprotection; Neuroprotective Agents; Neurotoxins; NF-E2-Related Factor 2; Oxidative Stress; Paraquat; Parkinson Disease; Phagosomes; Quinone Reductases; Sequestosome-1 Protein; Signal Transduction; Vacuoles | 2015 |
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.
Topics: Animals; Antioxidant Response Elements; Catalase; Glutamate-Cysteine Ligase; Herbicides; NF-E2-Related Factor 2; Paraquat; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Signal Transduction | 2015 |
Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.
Topics: Animals; Biomimetic Materials; Cell Line, Tumor; Drosophila melanogaster; Humans; Manganese; Models, Biological; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Superoxide Dismutase | 2016 |
Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson's Disease from Mitochondrial Dysfunction and Cell Death.
Topics: Cell Death; Cell Fusion; Cell Line, Tumor; Cell Respiration; Cell Survival; Curcumin; Electron Transport; Gene Knockdown Techniques; Humans; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Oxygen Consumption; Paraquat; Parkinson Disease; Protein Kinases; RNA, Small Interfering | 2017 |
Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease.
Topics: Herbicides; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease | 2016 |
Response to: Neurotoxicity of paraquat and paraquat-induced Parkinson's disease.
Topics: Herbicides; Humans; Neurotoxicity Syndromes; Paraquat; Parkinson Disease | 2016 |
Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.
Topics: Aging; Animals; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Genetic Variation; Male; Maneb; Mice, Knockout; Mice, Mutant Strains; Paraquat; Parkinson Disease; Pars Compacta; Risk | 2017 |
Supplementation of Spirulina (Arthrospira platensis) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1β
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drosophila melanogaster; Herbicides; Locomotion; Longevity; Oxidation-Reduction; Paraquat; Parkinson Disease; Phycocyanin; Spirulina; Superoxide Dismutase | 2017 |
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation.
Topics: Acetophenones; Adrenergic Neurons; Animals; Disease Models, Animal; Enzyme Inhibitors; Locus Coeruleus; Male; Maneb; Mice; Mice, Inbred C57BL; Microglia; NADPH Oxidases; Nerve Degeneration; Neurotoxicity Syndromes; NF-kappa B; Paraquat; Parkinson Disease; Risk Factors | 2017 |
Catalytic metalloporphyrin protects against paraquat neurotoxicity in vivo.
Topics: Animals; Antioxidants; Antiparkinson Agents; Behavior, Animal; Catalysis; Corpus Striatum; Dopamine; Male; Malondialdehyde; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Paraquat; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2008 |
Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.
Topics: Animals; Apoptosis; Caspases; Catalytic Domain; Cell Line, Transformed; Cytoprotection; Dopamine; Endoplasmic Reticulum; Herbicides; Intramolecular Oxidoreductases; Molecular Chaperones; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Prostaglandin-E Synthases; Protein Folding; Rats; Stress, Physiological; Substantia Nigra | 2008 |
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
Topics: Animals; Apoptosis; Dopamine; Gene Deletion; Mice; Mice, Mutant Strains; NADH Dehydrogenase; Neurons; Paraquat; Parkinson Disease; Rotenone | 2008 |
Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways.
Topics: Apoptosis; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation; Herbicides; Humans; Neuroblastoma; Neurons; Paraquat; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity | 2008 |
Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation.
Topics: Biomimetics; Cell Death; Cell Differentiation; Dopamine; Environmental Exposure; Humans; Infant, Newborn; Iron; Microglia; Neurons; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Salicylates; Superoxide Dismutase | 2009 |
Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.
Topics: Adult; Aged; Aged, 80 and over; Agriculture; California; Case-Control Studies; Comorbidity; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Female; Humans; Male; Maneb; Middle Aged; Odds Ratio; Paraquat; Parkinson Disease; Pesticides; Population Surveillance; Smoking | 2009 |
Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.
Topics: Electron Spin Resonance Spectroscopy; Mitochondria; Oxidation-Reduction; Paraquat; Parkinson Disease; Superoxides | 2009 |
Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice.
Topics: Animals; Dopamine; Glutathione Disulfide; Herbicides; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Paraquat; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Dopamine transporter genetic variants and pesticides in Parkinson's disease.
Topics: Case-Control Studies; Dopamine Plasma Membrane Transport Proteins; Environmental Exposure; Environmental Pollutants; Female; Genetic Variation; Genotype; Humans; Male; Maneb; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Polymorphism, Single Nucleotide; Risk Factors | 2009 |
Quantification of Paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Agents; Estrogen Receptor alpha; Herbicides; Mice; Microwaves; Paraquat; Parkinson Disease; Piperidines; Pyrazoles; Solvents; Tandem Mass Spectrometry | 2009 |
The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat.
Topics: Animals; Antioxidants; Disease Models, Animal; Drosophila melanogaster; Female; Ferric Compounds; Flavonoids; Motor Activity; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Phenols; Polyphenols; Survival Rate | 2010 |
Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glutathione Peroxidase; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Paraquat; Parkinson Disease; RNA, Messenger; Substantia Nigra; Superoxide Dismutase | 2009 |
Lysosomal degradation of alpha-synuclein in vivo.
Topics: alpha-Synuclein; Animals; Autophagy; Disease Models, Animal; Herbicides; HSC70 Heat-Shock Proteins; Humans; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Mesencephalon; Mice; Mice, Transgenic; Neurons; Paraquat; Parkinson Disease | 2010 |
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Topics: Animals; Apoptosis; Cell Line; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Mice; Mice, Knockout; Neuroblastoma; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Paraquat; Parkinson Disease; RNA, Small Interfering; Sulfoxides; Thiocyanates; Thioredoxins; Vitamin E | 2010 |
Effects of pharmacological agents on the lifespan phenotype of Drosophila DJ-1beta mutants.
Topics: Animals; Antioxidants; Brain; Dopamine; Drosophila; Mutation; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Phenotype; Reactive Oxygen Species | 2010 |
Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Glutathione; Glycerol; Intracellular Space; Lecithins; Liposomes; Maneb; Mesencephalon; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; Pesticides; Rats; Rats, Sprague-Dawley | 2010 |
α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.
Topics: Age of Onset; Aged; alpha-Synuclein; California; Causality; Comorbidity; Educational Status; Environmental Exposure; Female; Fungicides, Industrial; Herbicides; Humans; Male; Maneb; Paraquat; Parkinson Disease; Risk Assessment; Rural Health; Smoking | 2010 |
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Topics: Animals; Blotting, Western; Cytochrome P-450 CYP2E1; Dopamine; Lipid Peroxidation; Male; Maneb; Melatonin; Mice; Paraquat; Parkinson Disease; Polymerase Chain Reaction; Silymarin; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2011 |
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.
Topics: Aging; alpha-Synuclein; Animals; Cell Line; Cells, Cultured; Disease Progression; Environmental Exposure; Humans; Iron; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Paraquat; Parkinson Disease; Rats; Risk Factors | 2010 |
Rotenone, paraquat, and Parkinson's disease.
Topics: Aged; Case-Control Studies; Female; Herbicides; Humans; Insecticides; Iowa; Male; Middle Aged; Mitochondria; North Carolina; Occupational Exposure; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Rotenone | 2011 |
DJ-1 mediates paraquat-induced dopaminergic neuronal cell death.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Dopamine; Flow Cytometry; Mice; Mice, Knockout; Microscopy, Fluorescence; Mitochondria; Neurons; Oncogene Proteins; Oxidative Stress; Paraquat; Parkinson Disease; Peroxiredoxins; Poly(ADP-ribose) Polymerases; Protein Deglycase DJ-1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxides | 2011 |
Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.
Topics: Cell Line; Dopamine; Glutathione; Humans; Maneb; Neurons; Neurotoxicity Syndromes; Neurotoxins; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Peroxiredoxins; Pesticides; Reactive Oxygen Species; Thioredoxins; Transcription Factors | 2011 |
Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; DNA Primers; Dopamine; Dopaminergic Neurons; Environmental Exposure; Gene Silencing; Histological Techniques; Mice; Mice, Transgenic; Microdialysis; Paraquat; Parkinson Disease; Polymerase Chain Reaction; Protein Kinases; RNA Interference | 2011 |
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Dronabinol; Herbicides; Humans; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Receptor, Cannabinoid, CB1; Tumor Cells, Cultured; Up-Regulation | 2012 |
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
Topics: Animals; Corpus Striatum; Gene Expression Profiling; Gene Regulatory Networks; Humans; Male; Maneb; Mesencephalon; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Pyridazines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcriptome | 2012 |
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Disease Models, Animal; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Humans; Immunohistochemistry; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Maneb; Mice; Mice, Transgenic; Neurogenesis; Paraquat; Parkinson Disease; Pesticides; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Transcription, Genetic | 2012 |
Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.
Topics: Aged; Aged, 80 and over; Brain Injuries; Case-Control Studies; Chi-Square Distribution; Environmental Exposure; Female; Humans; Male; Middle Aged; Paraquat; Parkinson Disease; Pesticides; Risk Factors | 2012 |
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Dopamine; Drosophila; Drosophila Proteins; Herbicides; HSP90 Heat-Shock Proteins; Mitochondria; Mutation; Oxidative Stress; Paraquat; Parkinson Disease; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; TNF Receptor-Associated Factor 1; Ubiquitin-Protein Ligases | 2013 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environmental Exposure; gamma-Aminobutyric Acid; Gliosis; Herbicides; Homovanillic Acid; Humans; Injections, Intraperitoneal; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Parkinsonian Disorders; Risk Factors; Substantia Nigra; Tyrosine 3-Monooxygenase | 2002 |
Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Fungicides, Industrial; Herbicides; Homovanillic Acid; Immunohistochemistry; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Paraquat; Parkinson Disease; Phenotype; Serotonin; Tyrosine 3-Monooxygenase | 2002 |
[WITHDRAWN] Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
Topics: Animals; Apoptosis; bcl-X Protein; Blotting, Western; Body Weight; Cerebral Cortex; Corpus Striatum; Dopamine; Fungicides, Industrial; Glutathione Peroxidase; Herbicides; Hydrogen Peroxide; Immunohistochemistry; Lipid Metabolism; Lipid Peroxidation; Maneb; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Serotonin; Signal Transduction; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase | 2005 |
Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease.
Topics: Animals; Antioxidants; Blotting, Western; Catalase; Cells, Cultured; Dopamine; Immunohistochemistry; Male; Manganese; Manganese Compounds; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Chemical; Neurons; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase; Time Factors | 2005 |
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Blotting, Western; Cluster Analysis; Computational Biology; Crosses, Genetic; Drosophila; Drosophila Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Phylogeny; Protein Deglycase DJ-1; Rotenone; Sequence Alignment; Survival Analysis | 2005 |
Developmental pesticide models of the Parkinson disease phenotype.
Topics: Age Factors; Animals; Animals, Newborn; Dopamine; Drug Synergism; Female; Fungicides, Industrial; Herbicides; Male; Maneb; Mice; Mice, Inbred C57BL; Models, Biological; Motor Activity; Paraquat; Parkinson Disease; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Substantia Nigra | 2005 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis.
Topics: Dopamine Plasma Membrane Transport Proteins; Glutathione; Glutathione Transferase; Herbicides; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Reactive Oxygen Species; Receptors, Dopamine; Tumor Cells, Cultured | 2005 |
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide Donors; Nitroso Compounds; Paraquat; Parkinson Disease; Proteasome Endopeptidase Complex; Reference Values; Rotenone; Solubility; Stress, Physiological; Ubiquitin-Protein Ligases | 2005 |
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration.
Topics: Analysis of Variance; Animals; Catalase; Corpus Striatum; Cytochrome P-450 CYP2E1; Disease Models, Animal; Gene Expression; Glutathione Transferase; Herbicides; Lipid Peroxidation; Male; Maneb; Mice; Paraquat; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors | 2006 |
Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.
Topics: Animals; Cell Line; Cell Survival; Herbicides; Paraquat; Parkinson Disease; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats | 2006 |
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.
Topics: Aging; Animals; Animals, Genetically Modified; Cysteine; DNA Mutational Analysis; Drosophila melanogaster; Drosophila Proteins; Herbicides; Humans; Mice; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidative Stress; Paraquat; Parkinson Disease; Protein Deglycase DJ-1 | 2006 |
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.
Topics: alpha-Synuclein; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Dopamine Agents; Enzyme Stability; Gene Expression; HSP70 Heat-Shock Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Recombinant Fusion Proteins; Serine Endopeptidases; Superoxide Dismutase | 2006 |
VIP is a transcriptional target of Nurr1 in dopaminergic cells.
Topics: Animals; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Dopamine; Down-Regulation; Gene Expression Regulation, Developmental; Herbicides; Mesencephalon; Mice; Mice, Knockout; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Paraquat; Parkinson Disease; Promoter Regions, Genetic; Regulatory Elements, Transcriptional; RNA, Messenger; Substantia Nigra; Transcription Factors; Transcriptional Activation; Vasoactive Intestinal Peptide | 2007 |
Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.
Topics: Animals; Cell Size; Dendrites; Dopamine; Dopamine Plasma Membrane Transport Proteins; Herbicides; Immunohistochemistry; Male; Mesencephalon; Mice; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Neurons; Paraquat; Parkinson Disease; Pyridinium Compounds; Rotenone; Substantia Nigra; Uncoupling Agents | 2007 |
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
Topics: alpha-Synuclein; Animals; Brain; Drug Synergism; Environmental Exposure; Fungicides, Industrial; Humans; Inclusion Bodies; Maneb; Mice; Mice, Transgenic; Mitochondria; Mutation, Missense; Paraquat; Parkinson Disease | 2007 |
Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Survival; DNA Fragmentation; Ginkgo biloba; Herbicides; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Paraquat; Parkinson Disease; PC12 Cells; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Rats; Tyrosine 3-Monooxygenase | 2007 |
Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.
Topics: Aging; Animals; Cell Line; Cells, Cultured; Drug Synergism; Environmental Exposure; Herbicides; Iron; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Organometallic Compounds; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase | 2007 |
Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase.
Topics: Animals; Brain; Cell Line; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Herbicides; Mice; Microglia; NADPH Oxidases; Nerve Degeneration; Neurotoxins; Oxidative Stress; Paraquat; Parkinson Disease; Phosphoproteins; Protein Kinase C-delta; Protein Transport; Reactive Oxygen Species; Signal Transduction | 2007 |
Paraquat neurotoxicity is mediated by a Bak-dependent mechanism.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspase 3; Cell Survival; Cycloheximide; Gene Expression Regulation; Herbicides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Paraquat; Parkinson Disease; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2 | 2008 |
Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells.
Topics: Animals; Apoptosis; Caspase 3; Catalase; Cell Line; Cell Nucleus; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Reactive Oxygen Species; Superoxide Dismutase | 2008 |
Radical formation site of cerebral complex I and Parkinson's disease.
Topics: Animals; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hydroxyl Radical; Lipid Peroxidation; Mitochondria; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Paraquat; Parkinson Disease; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 1995 |
Hepatic disposition of neurotoxins and pesticides.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biological Transport; DDT; Hepatocytes; Humans; Liver; Malathion; Male; Neurotoxins; Paraquat; Parkinson Disease; Perfusion; Pesticides; Rats; Rats, Wistar; Tissue Distribution | 2000 |
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.
Topics: alpha-Synuclein; Circular Dichroism; Dieldrin; Ditiocarb; Nerve Tissue Proteins; Paraquat; Parkinson Disease; Pesticides; Protein Binding; Protein Conformation; Protein Folding; Rotenone; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins | 2001 |
Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes.
Topics: Animals; Brain; Catalysis; Diquat; Dose-Response Relationship, Drug; Free Radicals; Herbicides; Hydrogen Peroxide; Lipid Peroxidation; Microsomes; Oxygen; Paraquat; Parkinson Disease; Phospholipids; Rats; Thiobarbituric Acid Reactive Substances; Time Factors | 2002 |
Susceptibility in Parkinson's disease. 'Of mice and men'.
Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Free Radicals; Humans; Mice; Models, Biological; Oxygen; Paraquat; Parkinson Disease | 1988 |
Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: accumulation in neuromelanin.
Topics: Animals; Autoradiography; Diquat; Injections, Intraperitoneal; Melanins; Mice; Mice, Inbred C57BL; Models, Biological; Paraquat; Parkinson Disease; Pyridinium Compounds; Rana temporaria; Tissue Distribution | 1988 |