papaverine has been researched along with Ventricular Fibrillation in 11 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 9.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 5.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| " All compounds were evaluated for their ability to protect against chloroform-induced ventricular fibrillation in mice." | 3.65 | Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives. ( Neumeyer, JL; Perianayagam, C; Ruchirawat, S, 1977) |
| "Papaverine has been reported to increase the risk of ventricular arrhythmia (VA)." | 1.48 | Evaluation of the risk factors for ventricular arrhythmias secondary to QT prolongation induced by papaverine injection during coronary flow reserve studies using a 4 Fr angio-catheter. ( Kaneko, S; Mitamura, Y; Murai, H; Okabe, Y; Otowa, K; Takamura, M; Usui, S, 2018) |
| "Papaverine was injected into the bypass (0." | 1.28 | Global and regional ventricular function following intracoronary application of papaverine. ( Blasini, R; Haas, F; Heimisch, W; Mendler, N; Schad, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neumeyer, JL | 1 |
| Perianayagam, C | 1 |
| Ruchirawat, S | 1 |
| Okabe, Y | 1 |
| Otowa, K | 1 |
| Mitamura, Y | 1 |
| Murai, H | 1 |
| Usui, S | 1 |
| Kaneko, S | 1 |
| Takamura, M | 1 |
| Goto, M | 1 |
| Sato, M | 1 |
| Kitazawa, H | 1 |
| Takahashi, M | 1 |
| Fuse, K | 1 |
| Saito, A | 1 |
| Okabe, M | 1 |
| Aizawa, Y | 1 |
| MELVILLE, KI | 2 |
| SZEKERES, L | 1 |
| LENARD, G | 1 |
| DE JONGH, DK | 1 |
| VAN PROOSDIJ-HARTZEMA, EG | 1 |
| Schroeder, JS | 1 |
| Schad, H | 1 |
| Heimisch, W | 1 |
| Haas, F | 1 |
| Blasini, R | 1 |
| Mendler, N | 1 |
| Slogoff, S | 1 |
| Keats, AS | 1 |
| Cooley, DA | 1 |
| Reul, GJ | 1 |
| Frazier, OH | 1 |
| Ott, DA | 1 |
| Duncan, JM | 1 |
| Livesay, JJ | 1 |
| Lawson, JW | 1 |
2 trials available for papaverine and Ventricular Fibrillation
| Article | Year |
|---|---|
Newer antiarrhythmic agents for patients with coronary artery disease.
Topics: Acebutolol; Adult; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; | 1978 |
Addition of papaverine to cardioplegia does not reduce myocardial necrosis.
Topics: Clinical Trials as Topic; Constriction; Coronary Artery Bypass; Creatine Kinase; Double-Blind Method | 1986 |
9 other studies available for papaverine and Ventricular Fibrillation
| Article | Year |
|---|---|
Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chloroform; Dogs; Female; Isoquinolines; Mice | 1977 |
Evaluation of the risk factors for ventricular arrhythmias secondary to QT prolongation induced by papaverine injection during coronary flow reserve studies using a 4 Fr angio-catheter.
Topics: Aged; Cardiac Catheters; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Electrocardiogra | 2018 |
Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation.
Topics: Coronary Stenosis; Coronary Vessels; Electrocardiography; Female; Fractional Flow Reserve, Myocardia | 2014 |
The anti-fibrillation action of papaverine and its value in cardiac resuscitation after chloroform-adrenaline ventricular fibrillation in dogs.
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Chloroform; Dogs | 1948 |
The anti-fibrillation action of papaverine and its value in cardiac resuscitation after chloroform-adrenaline ventricular fibrillation.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Chloroform; Epinephrine; | 1948 |
[Change in the fibrillation threshold of auricular and ventricular musculature of isolated mammalian heart after cooling and after administration of various pharmacological agents].
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Heart; Heart Con | 1960 |
Studies on the action of papaverine and perparine on cardiac fibrillation.
Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Heart Conduction System; | 1952 |
Global and regional ventricular function following intracoronary application of papaverine.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; | 1991 |
Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Chloroform; Diphenhydramine; Electrocardiography; Female; | 1968 |