papaverine has been researched along with Vasospasm, Intracranial in 75 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that has become refractory to maximal medical management can be treated with selective intra-arterial papaverine infusions." | 8.82 | Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK, 2005) |
| "Microcatheter-guided intra-arterial (IA) papaverine infusion in conjunction with balloon angioplasty is an available therapy for patients with symptomatic vasospasm after subarachnoid hemorrhage (SAH) that is refractory to hypertensive, hypervolemic therapy." | 8.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| "Eighty patients with subarachnoid hemorrhage and serious cerebral vasospasm underwent endovascular treatment using intra-arterial papaverine-hydrochloride (IAP) or transluminal balloon angioplasty (TBA)." | 7.88 | Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Gruber, A; Hosmann, A; Knosp, E; Rauscher, S; Wang, WT, 2018) |
| "This small study suggests that intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after mechanical thrombectomy in acute ischemic stroke is effective and safe." | 7.81 | Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke. ( Al Shameri, RA; Baltsavias, G; Luft, A; Valavanis, A; Yella, S, 2015) |
| "Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage." | 7.72 | Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. ( DeArmond, SJ; Dillon, WP; Dowd, CF; Halbach, VV; Higashida, RT; Johnston, SC; Ko, NU; Lawton, MT; Setty, D; Smith, WS; Young, WL, 2004) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 7.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| "Complications associated with intraarterial papaverine infusion occurred in two patients treated for vasospasm due to subarachnoid hemorrhage (SAH)." | 7.70 | Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports. ( Hyodo, A; Kamezaki, T; Nagatomo, Y; Nose, T; Tsurushima, H, 2000) |
| "Angiographic improvement of cerebral vasospasm was observed in 80% of patients." | 5.56 | The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Engel, A; Gruber, A; Herta, J; Hosmann, A; Plöchl, W; Reinprecht, A; Wang, WT, 2020) |
| "Here, we describe a case of anterior communicating artery aneurysm with hydrocephalus." | 5.33 | Haemodynamic changes after intracisternal papaverine instillation during intracranial aneurysmal surgery. ( Dash, HH; Prabhakar, H; Rath, GP; Suri, A, 2006) |
| "Cerebral vasospasm that is caused by aneurysmal subarachnoid hemorrhage and that is refractory to maximal medical management can be treated with selective intraarterial papaverine infusions." | 5.11 | Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm. ( Couldwell, WT; Gottfried, ON; Kestle, JR; Liu, JK; MacDonald, JD; Madan, N; Rosenow, JM; Stevens, EA; Tenner, MS, 2004) |
| "It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage." | 5.09 | Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm. ( Bauhuf, C; Horn, P; Hubner, U; Ing, D; Munch, E; Poeckler-Schoeninger, C; Roth, H; Schmiedek, P; Thome, C; Vajkoczy, P, 2001) |
| "Cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that has become refractory to maximal medical management can be treated with selective intra-arterial papaverine infusions." | 4.82 | Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK, 2005) |
| "Microcatheter-guided intra-arterial (IA) papaverine infusion in conjunction with balloon angioplasty is an available therapy for patients with symptomatic vasospasm after subarachnoid hemorrhage (SAH) that is refractory to hypertensive, hypervolemic therapy." | 4.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| "Eighty patients with subarachnoid hemorrhage and serious cerebral vasospasm underwent endovascular treatment using intra-arterial papaverine-hydrochloride (IAP) or transluminal balloon angioplasty (TBA)." | 3.88 | Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Gruber, A; Hosmann, A; Knosp, E; Rauscher, S; Wang, WT, 2018) |
| "This small study suggests that intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after mechanical thrombectomy in acute ischemic stroke is effective and safe." | 3.81 | Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke. ( Al Shameri, RA; Baltsavias, G; Luft, A; Valavanis, A; Yella, S, 2015) |
| "Intra-arterial papaverine (IAP) is used to treat symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH)." | 3.73 | Intra-arterial papaverine used to treat cerebral vasospasm reduces brain oxygen. ( Hurst, RW; LeRoux, PD; Maloney-Wilensky, E; Spiotta, AM; Stiefel, MF; Udoetuk, JD; Weigele, JB, 2006) |
| "Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage." | 3.72 | Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. ( DeArmond, SJ; Dillon, WP; Dowd, CF; Halbach, VV; Higashida, RT; Johnston, SC; Ko, NU; Lawton, MT; Setty, D; Smith, WS; Young, WL, 2004) |
| "In 43 cases with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage treated by intraarterial infusion of papaverine (IAP), we studied cerebral hemodynamics by measuring cerebral circulation time (CCT) using digital subtraction angiogram." | 3.71 | Intraarterial infusion of papaverine and change of cerebral hemodynamics in symptomatic cerebral vasospasm. ( Kuwamura, K; Minami, H; Tamaki, N, 2001) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 3.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| "Complications associated with intraarterial papaverine infusion occurred in two patients treated for vasospasm due to subarachnoid hemorrhage (SAH)." | 3.70 | Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports. ( Hyodo, A; Kamezaki, T; Nagatomo, Y; Nose, T; Tsurushima, H, 2000) |
| "Vasospasm as a complication of subarachnoid hemorrhage is a major concern in clinical practice." | 2.70 | Efficacy of controlled-release papaverine pellets in preventing symptomatic cerebral vasospasm. ( Cagli, S; Dalbasti, T; Karabiyikoglu, M; Oktar, N; Ozdamar, N, 2001) |
| "We critically reviewed current literature on the adverse effects of iPPV in aneurysmal surgery with a focus on oculomotor nerve involvement." | 2.58 | Prolonged Intracisternal Papaverine Toxicity: Index Case Description and Proposed Mechanism of Action. ( Alambyan, V; Kohen, M; Manjila, S; Ostergard, T; Pace, J; Ramos-Estebanez, C; Zhou, X, 2018) |
| "Symptomatic cerebral vasospasm is also a strong predictor of poor clinical outcome and has thus drawn a great deal of interest from cerebrovascular surgeons." | 2.43 | Endovascular treatment strategies for cerebral vasospasm. ( Batjer, HH; Bendok, BR; Miller, JW; Mindea, SA; Yang, BP, 2006) |
| "Treatment of acute aneurysmal subarachnoid hemorrhages consists of occluding the aneurysm to prevent rebleed, attempting to prevent vasospasm, and maintaining blood flow to the brain through vessels in vasospasm." | 2.43 | Endovascular management of a patient after SAH. ( Chang, S; Murphy, K; Srinivas, A, 2005) |
| "Cerebral vasospasm is still one of the leading causes of morbidity and mortality from subarachnoid hemorrhage." | 2.43 | Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine. ( Hoh, BL; Ogilvy, CS, 2005) |
| "Angiographic improvement of cerebral vasospasm was observed in 80% of patients." | 1.56 | The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Engel, A; Gruber, A; Herta, J; Hosmann, A; Plöchl, W; Reinprecht, A; Wang, WT, 2020) |
| " The complete disappearance of BAEP waveforms with a consistent temporal delay suggests a possible adverse effect on the proximal eighth nerve." | 1.35 | Adverse effects of topical papaverine on auditory nerve function. ( Asher, AL; Chadwick, GM; Pollard, RJ; Van Der Veer, CA, 2008) |
| "In patients with subarachnoid hemorrhage, unpredictable response patterns to PPV were observed with "rebound" vasoconstriction suggesting increased contractility of the microcirculation." | 1.35 | Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery. ( Albrecht, KW; Bouma, GJ; Muizelaar, JP; Pennings, FA; Schuurman, PR, 2009) |
| "After the treatment of cerebral vasospasm in a SAH patient by intra-arterial administration of papaverine into the left posterior cerebral artery, severe mesencephalic extravasation of blood and contrast media was detected." | 1.35 | Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note. ( Baráth, K; Keller, E; Platz, J; Valavanis, A, 2008) |
| "Here, we describe a case of anterior communicating artery aneurysm with hydrocephalus." | 1.33 | Haemodynamic changes after intracisternal papaverine instillation during intracranial aneurysmal surgery. ( Dash, HH; Prabhakar, H; Rath, GP; Suri, A, 2006) |
| "The best strategy for treatment of subarachnoid hemorrhage due to ruptured cerebral aneurysm is obliteration of the aneurysm as soon as possible." | 1.32 | Combined endovascular treatment for both intracranial aneurysm and symptomatic vasospasm. ( Duckwiler, GR; Gobin, YP; Martin, NA; Murayama, Y; Patel, AB; Song, JK; Tateshima, S; Uda, K; Viñuela, F, 2003) |
| "A 50-year-old patient suffering from cerebral vasospasm after subarachnoid hemorrhage before and after superselective papaverine infusion was examined." | 1.31 | Estimation of cerebral oxygenation and hemodynamics in cerebral vasospasm using indocyaningreen dye dilution and near infrared spectroscopy: a case report. ( Keller, E; Martin, M; Wolf, M; Yonekawa, Y, 2001) |
| "Papaverine was administrated selectively via the vertebral artery on day 2, and serial angiography was performed for up to 2 hours." | 1.31 | Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits. ( Asari, S; Date, I; Nakajima, M; Ninomiya, Y; Ohmoto, T; Takahashi, K, 2001) |
| "A rabbit model of acute cerebral vasospasm induced by autologous blood injected into the basilar and prepontine cistern was used." | 1.31 | The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm. ( Liu, HM; Tu, YK, 2002) |
| "Patients who developed cerebral vasospasm and underwent cerebral arteriographic, transcranial Doppler ultrasonographic, and cerebral blood flow (CBF) studies before and after endovascular therapy for cerebral arterial spasm (vasospasm) were included in this study." | 1.31 | Multimodal quantitation of the effects of endovascular therapy for vasospasm on cerebral blood flow, transcranial doppler ultrasonographic velocities, and cerebral artery diameters. ( Afari, A; Glenn, TC; Gonzalez, NR; Guthrie, D; Lee, JH; Martin, NA; Oskouian, RJ; Viñuela, F, 2002) |
| "Incidence of cerebral vasospasm on angiograms among the two groups was analysed." | 1.31 | Magnesium: a useful adjunct in the prevention of cerebral vasospasm following aneurysmal subarachnoid haemorrhage. ( Chia, RY; Hughes, RS; Morgan, MK, 2002) |
| "It is difficult to treat ruptured aneurysms with symptomatic vasospasm." | 1.30 | [Endovascular surgery for untreated ruptured aneurysm with symptomatic vasospasm]. ( Akiyama, Y; Hayashi, N; Higashi, T; Kikuchi, H; Kokuzawa, J; Manaka, H; Morizane, A; Nagata, I; Nakahara, I; Namura, S; Nishizaki, J; Sakai, H; Sakai, N; Takahashi, J; Yanamoto, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.67) | 18.7374 |
| 1990's | 2 (2.67) | 18.2507 |
| 2000's | 56 (74.67) | 29.6817 |
| 2010's | 13 (17.33) | 24.3611 |
| 2020's | 2 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Neumann, A | 1 |
| Weber, W | 1 |
| Küchler, J | 1 |
| Schacht, H | 1 |
| Jensen-Kondering, U | 1 |
| Berlis, A | 1 |
| Schramm, P | 1 |
| Hosmann, A | 2 |
| Wang, WT | 2 |
| Dodier, P | 2 |
| Bavinzski, G | 2 |
| Engel, A | 1 |
| Herta, J | 1 |
| Plöchl, W | 1 |
| Reinprecht, A | 1 |
| Gruber, A | 2 |
| Zhou, X | 1 |
| Alambyan, V | 1 |
| Ostergard, T | 1 |
| Pace, J | 1 |
| Kohen, M | 1 |
| Manjila, S | 1 |
| Ramos-Estebanez, C | 1 |
| Rauscher, S | 1 |
| Knosp, E | 1 |
| Kim, JH | 1 |
| Yi, HJ | 1 |
| Ko, Y | 1 |
| Kim, YS | 1 |
| Kim, DW | 1 |
| Kim, JM | 1 |
| Praeger, AJ | 1 |
| Lewis, PM | 1 |
| Hwang, PY | 1 |
| Ding, D | 1 |
| Baltsavias, G | 1 |
| Yella, S | 1 |
| Al Shameri, RA | 1 |
| Luft, A | 1 |
| Valavanis, A | 2 |
| Zygourakis, CC | 1 |
| Vasudeva, V | 1 |
| Lai, PM | 1 |
| Kim, AH | 1 |
| Wang, H | 1 |
| Du, R | 1 |
| Chadwick, GM | 1 |
| Asher, AL | 1 |
| Van Der Veer, CA | 1 |
| Pollard, RJ | 1 |
| Platz, J | 1 |
| Baráth, K | 1 |
| Keller, E | 3 |
| Pennings, FA | 1 |
| Albrecht, KW | 1 |
| Muizelaar, JP | 1 |
| Schuurman, PR | 1 |
| Bouma, GJ | 1 |
| RUSSEK, HI | 1 |
| ZOHMAN, BL | 1 |
| Singla, N | 1 |
| Mathuriya, SN | 1 |
| Mohindra, S | 1 |
| Umredkar, AA | 1 |
| Adhikari, S | 1 |
| Gupta, SK | 1 |
| Gupta, V | 1 |
| Pierot, L | 1 |
| Aggour, M | 1 |
| Moret, J | 1 |
| Chittiboina, P | 1 |
| Willet, O | 1 |
| Nanda, A | 2 |
| Guthikonda, B | 1 |
| Menon, G | 1 |
| Baldawa, SS | 1 |
| Nair, S | 1 |
| Kerz, T | 1 |
| Boor, S | 1 |
| Beyer, C | 1 |
| Welschehold, S | 1 |
| Schuessler, A | 1 |
| Oertel, J | 1 |
| Li, QY | 1 |
| Xu, WL | 1 |
| Zhang, Y | 1 |
| Lu, PS | 1 |
| Yuan, ZC | 1 |
| Zhan, LP | 1 |
| Wang, P | 1 |
| Lu, XY | 1 |
| Cheng, B | 1 |
| Chowdhury, FH | 1 |
| Haque, MR | 1 |
| Oskouian, RJ | 1 |
| Martin, NA | 2 |
| Lee, JH | 1 |
| Glenn, TC | 1 |
| Guthrie, D | 1 |
| Gonzalez, NR | 1 |
| Afari, A | 1 |
| Viñuela, F | 2 |
| Liu, HM | 1 |
| Tu, YK | 1 |
| Koide, M | 1 |
| Nishizawa, S | 1 |
| Ohta, S | 1 |
| Yokoyama, T | 1 |
| Namba, H | 1 |
| Srinivasan, J | 1 |
| Eskridge, J | 1 |
| Grady, MS | 1 |
| Newell, DW | 2 |
| Winn, HR | 1 |
| Murayama, Y | 1 |
| Song, JK | 1 |
| Uda, K | 1 |
| Gobin, YP | 1 |
| Duckwiler, GR | 1 |
| Tateshima, S | 1 |
| Patel, AB | 1 |
| Cairns, CJ | 1 |
| Finfer, SR | 1 |
| Harrington, TJ | 1 |
| Cook, R | 1 |
| DESCUNS, P | 1 |
| GARRE, H | 1 |
| ENJALBERT, JM | 1 |
| Morawski, K | 1 |
| Telischi, FF | 1 |
| Merchant, F | 1 |
| Namyslowski, G | 1 |
| Lisowska, G | 1 |
| Lonsbury-Martin, BL | 1 |
| Liu, JK | 4 |
| Tenner, MS | 2 |
| Gottfried, ON | 1 |
| Stevens, EA | 1 |
| Rosenow, JM | 1 |
| Madan, N | 1 |
| MacDonald, JD | 1 |
| Kestle, JR | 1 |
| Couldwell, WT | 4 |
| Goto, Y | 1 |
| Yamagata, S | 1 |
| Smith, WS | 1 |
| Dowd, CF | 1 |
| Johnston, SC | 1 |
| Ko, NU | 1 |
| DeArmond, SJ | 1 |
| Dillon, WP | 1 |
| Setty, D | 1 |
| Lawton, MT | 1 |
| Young, WL | 1 |
| Higashida, RT | 1 |
| Halbach, VV | 1 |
| Scanlon, A | 1 |
| Kiran, S | 1 |
| Agrawal, D | 2 |
| Hoh, BL | 1 |
| Ogilvy, CS | 1 |
| Hui, C | 1 |
| Lau, KP | 1 |
| Chang, S | 1 |
| Srinivas, A | 1 |
| Murphy, K | 1 |
| Stiefel, MF | 1 |
| Spiotta, AM | 1 |
| Udoetuk, JD | 1 |
| Maloney-Wilensky, E | 1 |
| Weigele, JB | 1 |
| Hurst, RW | 1 |
| LeRoux, PD | 1 |
| Madhusudan Reddy, KR | 1 |
| Umamaheswara Rao, GS | 1 |
| Sastry Kolluri, VR | 1 |
| Rath, GP | 2 |
| Prabhakar, H | 2 |
| Dash, HH | 2 |
| Suri, A | 1 |
| Sayama, CM | 1 |
| Mindea, SA | 1 |
| Yang, BP | 1 |
| Bendok, BR | 1 |
| Miller, JW | 1 |
| Batjer, HH | 1 |
| Elsayed, AA | 1 |
| Moran, CJ | 1 |
| Cross, DT | 1 |
| Derdeyn, CP | 1 |
| Pilgram, TK | 1 |
| Milburn, JM | 1 |
| Dacey, RG | 1 |
| Diringer, MN | 1 |
| Pritz, MB | 1 |
| Jain, V | 1 |
| Bithal, PK | 1 |
| Sasaki, T | 1 |
| Kasuya, H | 2 |
| Munakata, R | 1 |
| Ichikawa, T | 1 |
| Kodama, N | 1 |
| Abdennour, L | 1 |
| Lejean, L | 1 |
| Bonneville, F | 1 |
| Boch, AL | 1 |
| Puybasset, L | 1 |
| Morizane, A | 1 |
| Nakahara, I | 1 |
| Sakai, N | 1 |
| Yanamoto, H | 1 |
| Akiyama, Y | 1 |
| Sakai, H | 1 |
| Higashi, T | 1 |
| Namura, S | 1 |
| Takahashi, J | 1 |
| Nishizaki, J | 1 |
| Kokuzawa, J | 1 |
| Manaka, H | 1 |
| Hayashi, N | 1 |
| Nagata, I | 1 |
| Kikuchi, H | 1 |
| Ishizaki, T | 1 |
| Momota, H | 1 |
| Kuwahara, K | 1 |
| Tanooka, A | 1 |
| Morimoto, S | 1 |
| Polin, RS | 1 |
| Coenen, VA | 1 |
| Hansen, CA | 1 |
| Shin, P | 1 |
| Baskaya, MK | 1 |
| Kassell, NF | 1 |
| Tsurushima, H | 2 |
| Hyodo, A | 2 |
| Yoshii, Y | 1 |
| Kamezaki, T | 1 |
| Nagatomo, Y | 1 |
| Nose, T | 1 |
| Smith, TP | 1 |
| Enterline, DS | 1 |
| Uské, A | 1 |
| Ezura, M | 1 |
| Takahashi, A | 1 |
| Morgan, MK | 2 |
| Jonker, B | 1 |
| Finfer, S | 1 |
| Harrington, T | 1 |
| Dorsch, NW | 1 |
| Iseda, T | 1 |
| Nakano, S | 1 |
| Yoneyama, T | 1 |
| Ikeda, T | 1 |
| Moriyama, T | 1 |
| Sameshima, T | 1 |
| Goya, T | 1 |
| Wakisaka, S | 1 |
| Wolf, M | 1 |
| Martin, M | 1 |
| Yonekawa, Y | 2 |
| Vajkoczy, P | 1 |
| Horn, P | 1 |
| Bauhuf, C | 1 |
| Munch, E | 1 |
| Hubner, U | 1 |
| Ing, D | 1 |
| Thome, C | 1 |
| Poeckler-Schoeninger, C | 1 |
| Roth, H | 1 |
| Schmiedek, P | 1 |
| Wanke, I | 1 |
| Dörfler, A | 1 |
| Dietrich, U | 1 |
| Aalders, T | 1 |
| Forsting, M | 1 |
| Nakajima, M | 2 |
| Date, I | 2 |
| Takahashi, K | 2 |
| Ninomiya, Y | 2 |
| Asari, S | 2 |
| Ohmoto, T | 2 |
| Dalbasti, T | 1 |
| Karabiyikoglu, M | 1 |
| Ozdamar, N | 1 |
| Oktar, N | 1 |
| Cagli, S | 1 |
| Ono, S | 1 |
| Satoh, M | 1 |
| Iseda, K | 1 |
| Manabe, H | 1 |
| Ohkuma, H | 1 |
| Ogane, K | 1 |
| Tanaka, M | 1 |
| Suzuki, S | 1 |
| Hegner, T | 1 |
| Krayenbühl, N | 1 |
| Hefti, M | 1 |
| Eskridge, JM | 1 |
| Aaslid, R | 1 |
| Reisch, R | 1 |
| Filippi, R | 1 |
| Böcher-Schwarz, H | 1 |
| Mauer, D | 1 |
| Ringel, K | 1 |
| Stoeter, P | 1 |
| Perneczky, A | 1 |
| Carhuapoma, JR | 1 |
| Qureshi, AI | 1 |
| Tamargo, RJ | 1 |
| Mathis, JM | 1 |
| Hanley, DF | 1 |
| Minami, H | 1 |
| Kuwamura, K | 1 |
| Tamaki, N | 1 |
| Oestreich, HM | 1 |
| Coşkun, E | 1 |
| Chia, RY | 1 |
| Hughes, RS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for papaverine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Prolonged Intracisternal Papaverine Toxicity: Index Case Description and Proposed Mechanism of Action.
Topics: Female; Humans; Intracranial Aneurysm; Middle Aged; Papaverine; Vasodilator Agents; Vasospasm, Intra | 2018 |
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angioplasty, Balloon; Critical Care; Endovascular Pro | 2010 |
Endovascular therapy for vasospasm.
Topics: Angioplasty; Brain; Cerebrovascular Circulation; Humans; Papaverine; Subarachnoid Hemorrhage; Vasodi | 2002 |
Aneurysmal subarachnoid haemorrhage--Part 2: Post-operative nursing management diagnosis, complications and treatment: a composite case study.
Topics: Angioplasty, Balloon; Brain Edema; Female; Humans; Hydrocephalus; Infusions, Intra-Arterial; Intracr | 2004 |
Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine.
Topics: Angioplasty, Balloon; Humans; Injections, Intra-Arterial; Nicardipine; Papaverine; Vasodilator Agent | 2005 |
Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.
Topics: Brain; Cerebral Arteries; Cerebrovascular Circulation; Humans; Infusions, Intra-Arterial; Oxygen Con | 2005 |
Endovascular management of a patient after SAH.
Topics: Aneurysm, Ruptured; Aortic Dissection; Cerebral Hemorrhage; Clinical Trials as Topic; Embolization, | 2005 |
Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.
Topics: Angioplasty, Balloon; Combined Modality Therapy; Humans; Intracranial Aneurysm; Papaverine; Subarach | 2006 |
Endovascular treatment strategies for cerebral vasospasm.
Topics: Aneurysm, Ruptured; Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Time Factors; | 2006 |
[Medical therapy for cerebral vasospasm].
Topics: Calcium Channel Blockers; Humans; Papaverine; Urokinase-Type Plasminogen Activator; Vasospasm, Intra | 2006 |
Endovascular treatment of cerebral vasospasm.
Topics: Angioplasty, Balloon; Animals; Combined Modality Therapy; Humans; Papaverine; Subarachnoid Hemorrhag | 2000 |
[Neuroradiologic treatment of cerebral vasospasm].
Topics: Angioplasty; Humans; Papaverine; Radiography; Vasodilator Agents; Vasospasm, Intracranial | 2000 |
[Endovascular treatment for cerebral vasospasm].
Topics: Angioplasty, Balloon; Female; Humans; Male; Middle Aged; Papaverine; Vasodilator Agents; Vasospasm, | 2000 |
Intra-arterial papaverine-induced seizures: case report and review of the literature.
Topics: Adult; Angioplasty, Balloon; Carotid Artery, Internal; Female; Humans; Infusions, Intra-Arterial; Mi | 2001 |
7 trials available for papaverine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Effectiveness of papaverine cisternal irrigation for cerebral vasospasm after aneurysmal subarachnoid hemorrhage and measurement of biomarkers.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Biomarkers; Cell Adhesion Molecule-1; Cell Adhes | 2014 |
Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Angiography; Cerebrovascular Circulation; Drug Admin | 2004 |
Effect of intraarterial papaverine and/or angioplasty on the cerebral veins in patients with vasospasm after subarachnoid hemorrhage due to ruptured intracranial aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty; Cerebral Angiography; Cerebral Vein | 2006 |
Efficacy of transluminal angioplasty for the management of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Angioplasty, Balloon; Combined Modality Therapy; Double-Blind Method; Female; Glasgow C | 2000 |
Aggressive management of aneurysmal subarachnoid haemorrhage based on a papaverine angioplasty protocol.
Topics: Angioplasty, Balloon; Cerebral Arteries; Humans; Intracranial Aneurysm; Papaverine; Recovery of Func | 2000 |
Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Electrodes, Implanted | 2001 |
Efficacy of controlled-release papaverine pellets in preventing symptomatic cerebral vasospasm.
Topics: Adult; Delayed-Action Preparations; Drug Implants; Female; Humans; Intracranial Aneurysm; Male; Midd | 2001 |
54 other studies available for papaverine and Vasospasm, Intracranial
| Article | Year |
|---|---|
Evaluation of DeGIR registry data on endovascular treatment of cerebral vasospasm in Germany 2018-2021: an overview of the current care situation.
Topics: Endovascular Procedures; Female; Humans; Male; Nimodipine; Papaverine; Retrospective Studies; Routin | 2023 |
The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm.
Topics: Adult; Brain; Cerebrovascular Circulation; Endovascular Procedures; Female; Humans; Injections, Intr | 2020 |
Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm.
Topics: Adult; Angiography; Angioplasty, Balloon; Brain Infarction; Female; Follow-Up Studies; Humans; Injec | 2018 |
Topical papaverine as rescue therapy for vasospasm complicated by unsecured aneurysm.
Topics: Administration, Topical; Female; Humans; Intracranial Aneurysm; Middle Aged; Papaverine; Vasospasm, | 2014 |
Delayed morbidity and mortality in aneurysmal subarachnoid hemorrhage patients: effect of attenuating cerebral vasospasm.
Topics: Female; Fibrinolytic Agents; Humans; Male; Papaverine; Subarachnoid Hemorrhage; Vasospasm, Intracran | 2015 |
Intra-arterial administration of papaverine during mechanical thrombectomy for acute ischemic stroke.
Topics: Aged; Brain Ischemia; Combined Modality Therapy; Female; Fibrinolytic Agents; Humans; Infusions, Int | 2015 |
Transient pupillary dilation following local papaverine application in intracranial aneurysm surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Cerebral Artery; Craniotomy; Female; Functional | 2015 |
Adverse effects of topical papaverine on auditory nerve function.
Topics: Administration, Topical; Afferent Pathways; Aged; Aged, 80 and over; Basilar Artery; Cochlear Nerve; | 2008 |
Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note.
Topics: Aged; Blood-Brain Barrier; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; In | 2008 |
Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery.
Topics: Adult; Aged; Arterioles; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Male; Micro | 2009 |
Papaverine in cerebral angiospasm (vascular encephalopathy).
Topics: Brain Diseases; Humans; Papaverine; Vasospasm, Intracranial | 1948 |
Severe hypotension with intracisternal application of papaverine after clipping of an intracranial aneurysm.
Topics: Acute Kidney Injury; Carotid Artery Diseases; Cerebral Angiography; Cisterna Magna; Fatal Outcome; H | 2009 |
Transient oculomotor nerve palsy after topical administration of intracisternal papaverine.
Topics: Humans; Infusions, Intraventricular; Middle Aged; Oculomotor Nerve Diseases; Papaverine; Subarachnoi | 2011 |
Transient oculomotor nerve palsy after topical administration of intracisternal papaverine.
Topics: Administration, Topical; Aneurysm, Ruptured; Cisterna Magna; Dose-Response Relationship, Drug; Human | 2011 |
Effect of intraarterial papaverine or nimodipine on vessel diameter in patients with cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain Ischemia; Capillaries; Carotid Artery, I | 2012 |
Intravascular infusion of lidocaine: a novel way to relieve sudden internal carotid artery occlusion in embolization of intracranial aneurysms.
Topics: Aged; Carotid Artery, Internal; Carotid Stenosis; Embolization, Therapeutic; Female; Humans; Infusio | 2012 |
Severe hypotension, cardiac arrest, and death after intracisternal instillation of papaverine during anterior communicating artery aneurysm clipping. A case report.
Topics: Fatal Outcome; Female; Heart Arrest; Humans; Hypotension; Instillation, Drug; Intracranial Aneurysm; | 2013 |
Multimodal quantitation of the effects of endovascular therapy for vasospasm on cerebral blood flow, transcranial doppler ultrasonographic velocities, and cerebral artery diameters.
Topics: Adult; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Brain; Cerebral Angiography; C | 2002 |
The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm.
Topics: Acute Disease; Animals; Catheterization; Cerebral Angiography; Cisterna Magna; Image Processing, Com | 2002 |
Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase.
Topics: Animals; Basilar Artery; Cerebral Angiography; Dogs; Drug Resistance; Female; Genistein; Isometric C | 2002 |
Combined endovascular treatment for both intracranial aneurysm and symptomatic vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty, Balloon; Cerebral Angiography; Comb | 2003 |
Papaverine angioplasty to treat cerebral vasospasm following traumatic subarachnoid haemorrhage.
Topics: Adult; Angioplasty, Balloon; Craniocerebral Trauma; Humans; Male; Papaverine; Radiography; Subarachn | 2003 |
[Carotid injection of papaverine in cerebrovascular spasms].
Topics: Brain; Cardiovascular System; Humans; Injections; Papaverine; Vasospasm, Intracranial | 1957 |
Preventing internal auditory artery vasospasm using topical papaverine: an animal study.
Topics: Administration, Topical; Animals; Cerebellopontine Angle; Cochlea; Disease Models, Animal; Laser-Dop | 2003 |
[Differences in outcome in patients with poor grade subarachnoid hemorrhage (WFNS grade IV and V): according to the perioperative management against vasospasm].
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Female; Glasgow Coma Scale; Humans; Male; Midd | 2004 |
Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Topics: Aged; Brain; Chlorobutanol; Female; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; M | 2004 |
Papaverine and vasospasm.
Topics: Carotid Arteries; Drug Administration Schedule; Glasgow Coma Scale; Humans; Injections, Intra-Arteri | 2005 |
Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage.
Topics: Adult; Aged; Blood Pressure; Cerebral Angiography; Female; Heart Rate; Humans; Infusions, Intra-Arte | 2005 |
Intra-arterial papaverine used to treat cerebral vasospasm reduces brain oxygen.
Topics: Blood Pressure; Body Temperature; Brain; Cerebral Angiography; Humans; Injections, Intra-Arterial; I | 2006 |
Profound hypotension after intracisternal papaverine.
Topics: Cisterna Magna; Hemodynamics; Humans; Injections; Male; Middle Aged; Papaverine; Subarachnoid Hemorr | 2006 |
Haemodynamic changes after intracisternal papaverine instillation during intracranial aneurysmal surgery.
Topics: Administration, Topical; Bradycardia; Humans; Hypotension; Intracranial Aneurysm; Intraoperative Com | 2006 |
Contralateral pupillary dilatation after intracisternal papaverine instillation.
Topics: Craniotomy; Diagnosis, Differential; Disease Progression; Functional Laterality; Humans; Intracrania | 2007 |
Stellate ganglion block as alternative to intrathecal papaverine in relieving vasospasm due to subarachnoid hemorrhage.
Topics: Adult; Female; Humans; Injections, Spinal; Male; Middle Aged; Nerve Block; Papaverine; Stellate Gang | 2007 |
[Endovascular treatment of vasospasm following subarachnoid aneurysmal haemorrhage].
Topics: Calcium Channel Blockers; Humans; Intracranial Aneurysm; Nicardipine; Nimodipine; Nitroprusside; Pap | 2007 |
[Endovascular surgery for untreated ruptured aneurysm with symptomatic vasospasm].
Topics: Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Embolization, Therapeutic; Female; Humans; Intracran | 1999 |
[A case of symptomatic traumatic cerebral vasospasm associated with hyponatremia].
Topics: Aged; Craniocerebral Trauma; Disease Progression; Female; Humans; Hyponatremia; Papaverine; Sodium; | 1999 |
Papaverine and vasospasm.
Topics: Angioplasty, Balloon; Humans; Infusions, Intra-Arterial; Papaverine; Subarachnoid Hemorrhage; Treatm | 2000 |
Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports.
Topics: Adult; Carotid Arteries; Cerebral Angiography; Craniotomy; Dose-Response Relationship, Drug; Fatal O | 2000 |
Angiographic cerebral circulation time before and after endovascular therapy for symptomatic vasospasm.
Topics: Adult; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Cerebral Angiography; Cerebrovasc | 2000 |
Estimation of cerebral oxygenation and hemodynamics in cerebral vasospasm using indocyaningreen dye dilution and near infrared spectroscopy: a case report.
Topics: Brain Chemistry; Cerebrovascular Circulation; Coloring Agents; Dye Dilution Technique; Female; Hemod | 2001 |
Combined endovascular therapy of ruptured aneurysms and cerebral vasospasm.
Topics: Adult; Aneurysm, Ruptured; Carotid Arteries; Cerebral Angiography; Combined Modality Therapy; Emboli | 2000 |
Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Topics: Age Factors; Aging; Animals; Basilar Artery; Blood Pressure; Cerebral Angiography; Infusions, Intra- | 2001 |
Comparison of cerebral vasospasm between young and old animals: preliminary report.
Topics: Aging; Animals; Basilar Artery; Cerebral Angiography; Male; Papaverine; Rabbits; Time Factors; Vasod | 2001 |
Assessment of cerebral microcirculatory changes during cerebral vasospasm by analyzing cerebral circulation time on DSA images.
Topics: Aged; Angiography, Digital Subtraction; Cerebral Angiography; Cerebrovascular Circulation; Humans; I | 2001 |
Bedside monitoring of cerebral blood flow in patients with subarachnoid hemorrhage.
Topics: Adult; Aged; Blood Pressure; Blood Volume; Brain; Cerebrovascular Circulation; Female; Hemodilution; | 2001 |
Current indications and results of cerebral angioplasty.
Topics: Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Ag | 2001 |
Effect of intra-arterial infusion of papaverine hydrochloride on brain tissue oxygen pressure in the management of severe vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Brain; Humans; Injections, Intra-Arterial; Intracranial Aneurysm; Oxygen; Papaverine; Partial Pressu | 2001 |
Mechanical and pharmacologic treatment of vasospasm.
Topics: Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Ag | 2001 |
Intraarterial infusion of papaverine and change of cerebral hemodynamics in symptomatic cerebral vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Blood Flow Velocity; Brain; Female; Hemodynamics; Human | 2001 |
Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage.
Topics: Adult; Brain Ischemia; Female; Humans; Infusions, Intra-Arterial; Male; Papaverine; Stroke; Subarach | 2001 |
Statistical techniques and vasospasm.
Topics: Data Interpretation, Statistical; Delayed-Action Preparations; Drug Implants; Humans; Papaverine; Va | 2002 |
Vasospasm.
Topics: Delayed-Action Preparations; Drug Implants; Humans; Papaverine; Patient Selection; Vasospasm, Intrac | 2002 |
Papaverine and vasospasm.
Topics: Clinical Trials as Topic; Humans; Papaverine; Vasodilator Agents; Vasospasm, Intracranial | 2002 |
Magnesium: a useful adjunct in the prevention of cerebral vasospasm following aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Cerebral Angiography; Female; Humans; Injections, Intra-Arterial; Injections, Intraveno | 2002 |