Page last updated: 2024-11-02

papaverine and Thrombosis

papaverine has been researched along with Thrombosis in 41 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.

Research Excerpts

Excerpt	Relevance	Reference
"Papaverine was given by intramuscular injection to all patients at a dosage of 90 mg/day postoperatively."	1.46	Antithrombotic Therapies in Digit Replantation with Papaverine Administration: A Prospective, Observational Study. ( Zheng, X; Zhu, H; Zhu, X, 2017)
" This action carried over to ex vivo situation following intraduodenal dosing as demonstrated in rabbits."	1.27	Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939). ( Nakamizo, N; Shuto, K; Yamada, K, 1983)
"Papaverine was most effective followed by EP 092, Phentolamine was less effective, showing the minor importance of alpha-receptor stimulation in this model."	1.27	Local measurements of thrombus induced vasoconstriction in vivo. ( Herrmann, KS; Kreuzer, H, 1988)

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (80.49)	18.7374
1990's	5 (12.20)	18.2507
2000's	1 (2.44)	29.6817
2010's	2 (4.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Huang, TL	1
Mayence, A	1
Vanden Eynde, JJ	1
Zhu, H	1
Zhu, X	1
Zheng, X	1
GABARRA, MS	1
TURPINI, R	1
CIPOLLI, PL	1
BARELLO, P	1
SANABRIA, J	1
Yamada, K	1
Shuto, K	1
Nakamizo, N	1
Boley, SJ	2
Pirk, J	1
Ruzbarský, V	1
König, J	1
Krajícek, M	1
Pavel, P	1
Firt, P	1
Finelli, DA	1
Pallan, TM	1
Wulkan, IA	2
Abadir, AR	2
Flores, L	2
Chaudhry, MR	2
Gintautas, J	2
D'Amore, MJ	1
Borge, MA	1
Messersmith, RN	1
Johnson, BL	1
Bandyk, DF	1
Back, MR	1
Avino, AJ	1
Roth, SM	1
Zatevakhin, II	1
Koshkin, VM	2
Shestakov, VA	1
Il'in, SG	1
Adil'khanov, SG	2
Antonova, NIu	1
Robinson, HB	1
Williams, GM	1
Swartz, WM	1
Brink, RR	1
Buncke, HJ	1
Pallan, T	1
Hashmat, AI	1
Abrahams, J	1
Fani, K	1
Nostrand, I	1
Abildgaard, U	1
Amtorp, O	1
Agerskov, K	1
Sjøntoft, E	1
Christensen, NJ	1
Henriksen, O	1
Sardo, P	1
Cepich, MS	1
Giulini, SM	1
Herrmann, KS	1
Kreuzer, H	1
Markwardt, F	2
Breddin, K	2
Diederen, W	1
Kadatz, R	1
Barthel, W	1
Glusa, E	1
Hoffman, A	1
Sandmann, W	1
Kremer, K	1
Kovacicek, S	1
Bollinger, A	1
Padmanabhan, J	1
Krovetz, LJ	1
Varghese, PJ	2
Izukawa, T	2
Mellits, ED	1
Rowe, RD	2
Sprayregen, S	1
Veith, FJ	1
Siegelman, SS	1
Bernhard, VM	1
Grondin, CM	1
Castonguay, YR	1
Lepage, G	1
Meere, C	1
Grondin, P	1
Bounameaux, Y	1
Bosniak, MA	1
Hardy, MA	1
Quint, J	1
Ghossein, NA	1
Scharrer, I	1
Schepping, M	1
Arnoux, M	1
Rioux, G	1
Zürn, H	1
Anderson, J	1
Allert, J	1
Förster, C	1
Kusztos, D	1
Vidovszky, T	1
Perlick, E	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pilot-Study to Evaluate the Clinical Significance of the Fluorescence Videoangiography With Indocyanine-Green in Patients With PAD, Rutherford Classification II-V, and Relation to Common Diagnostics.[NCT00876668]				25 participants (Anticipated)	Observational	2007-06-30	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for papaverine and Thrombosis

Article	Year
Some non-conventional biomolecular targets for diamidines. A short survey. Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7 Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myot	2014
An aggressive roentgenologic and surgical approach to acute mesenteric ischemia. Surgery annual, 1973, Volume: 5 Topics: Angiography; Blood Flow Velocity; Blood Pressure; Embolism; Humans; Infusions, Parenteral; Intestine	1973

Trials

1 trial available for papaverine and Thrombosis

Article	Year
Effect of topical papaverine in preventing thrombosis following arteriotomies. A double-blind study in infants and children. The Journal of pediatrics, 1972, Volume: 81, Issue:4 Topics: Arteries; Cardiac Catheterization; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant	1972

Other Studies

38 other studies available for papaverine and Thrombosis

Article	Year
Antithrombotic Therapies in Digit Replantation with Papaverine Administration: A Prospective, Observational Study. Plastic and reconstructive surgery, 2017, Volume: 140, Issue:4 Topics: Adolescent; Adult; Amputation, Traumatic; Female; Finger Injuries; Follow-Up Studies; Humans; Inject	2017
[Thrombosis and embolism]. Revista paulista de medicina, 1953, Volume: 42, Issue:3 Topics: Embolism; Heparin; Humans; Papaverine; Pulmonary Embolism; Thrombosis	1953
[Cerebral infarct: new pathogenetic and therapeutic concepts in the light of 419 cases]. Giornale di gerontologia, 1961, Volume: 9 Topics: Anticoagulants; Cerebral Hemorrhage; Cerebral Infarction; Humans; Intracranial Embolism; Intracrania	1961
[BILATERAL THROMBOSIS OF THE INTERNAL CAROTID ARTERIES. APROPOS OF 5 PERSONAL CASES]. Acta neurologica et psychiatrica Belgica, 1964, Volume: 64 Topics: Arteriosclerosis; Arteritis; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Angiograp	1964
Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939). Thrombosis research, 1983, Jan-15, Volume: 29, Issue:2 Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzamides; Collagen;	1983
Early diagnosis of acute mesenteric ischemia. Hospital practice (Office ed.), 1981, Volume: 16, Issue:8 Topics: Acute Disease; Constriction, Pathologic; Embolism; Gangrene; Humans; Intestines; Ischemia; Mesenteri	1981
The effect of antiaggregating drugs on the patency of grafts in the arterial system. World journal of surgery, 1980, Volume: 4, Issue:5 Topics: Animals; Anticoagulants; Aorta, Abdominal; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Dogs; Erg	1980
Was heparin the culprit? Radiology, 1993, Volume: 189, Issue:2 Topics: Animals; Brachial Artery; Chemical Precipitation; Dogs; Drug Interactions; Heparin; Humans; Iopamido	1993
Incompatibility of Isovue 370 and papaverine in peripheral arteriography. Radiology, 1993, Volume: 187, Issue:1 Topics: Angiography; Arm; Brachial Artery; Drug Interactions; Female; Humans; Iopamidol; Middle Aged; Papave	1993
Limb-threatening lower extremity ischemia successfully treated with intra-arterial infusion--case reports. Angiology, 1999, Volume: 50, Issue:3 Topics: Adult; Caffeine; Central Nervous System Stimulants; Drug Combinations; Ergotamine; Female; Follow-Up	1999
Intraoperative duplex monitoring of infrainguinal vein bypass procedures. Journal of vascular surgery, 2000, Volume: 31, Issue:4 Topics: Anastomosis, Surgical; Arteries; Blood Flow Velocity; Constriction, Pathologic; Female; Fibrinolytic	2000
Treatment of acute central-retinal-artery occlusion. Lancet (London, England), 1978, Nov-25, Volume: 2, Issue:8100 Topics: Acute Disease; Fibrinolytic Agents; Heparin; Humans; Injections, Intra-Arterial; Ischemia; Orbit; Pa	1978
[Effect of papaverine and trental on hemostasis and rheologic properties of blood in acute arterial obstruction]. Problemy gematologii i perelivaniia krovi, 1979, Volume: 24, Issue:12 Topics: Acute Disease; Blood Viscosity; Hemostasis; Humans; Papaverine; Pentoxifylline; Theobromine; Thrombo	1979
[Peripheral macro-and microcirculatory changes in acute arterial obstruction with papaverine and trental administration]. Vestnik khirurgii imeni I. I. Grekova, 1979, Volume: 123, Issue:12 Topics: Acute Disease; Arterial Occlusive Diseases; Blood Circulation; Drug Evaluation; Embolism; Hemodynami	1979
Reduction of early occlusions in the high risk peripheral saphenous vein graft. Annals of surgery, 1976, Volume: 184, Issue:2 Topics: Angiography; Arterial Occlusive Diseases; Catheterization; Heparin; Humans; Leg; Monitoring, Physiol	1976
Prevention of thrombosis in arterial and venous microanastomoses by using topical agents. Plastic and reconstructive surgery, 1976, Volume: 58, Issue:4 Topics: Administration, Topical; Animals; Arteries; Foot; Isotonic Solutions; Lidocaine; Magnesium Sulfate;	1976
Radiologic contrast material and a vasodilator can produce arterial thrombosis. Proceedings of the Western Pharmacology Society, 1991, Volume: 34 Topics: Arm; Brachial Artery; Contrast Media; Drug Incompatibility; Female; Humans; Iopamidol; Middle Aged;	1991
A lethal complication of papaverine-induced priapism. The Journal of urology, 1991, Volume: 145, Issue:1 Topics: Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Multiple Sclerosis; Papaverine; Penis;	1991
Renal vascular adjustments to partial renal venous obstruction in dog kidney. Circulation research, 1987, Volume: 61, Issue:2 Topics: Angiotensin II; Animals; Dogs; Female; Hemodynamics; Kidney; Male; Papaverine; Receptors, Adrenergic	1987
[Diagnostic and therapeutic role of angiography in acute vascular insufficiency of the superior mesenteric artery]. La Radiologia medica, 1988, Volume: 75, Issue:4 Topics: Aged; Embolism; Female; Humans; Injections, Intra-Arterial; Male; Mesenteric Arteries; Mesenteric Va	1988
Local measurements of thrombus induced vasoconstriction in vivo. Thrombosis research, 1988, Jun-15, Volume: 50, Issue:6 Topics: Animals; Blood Pressure; Cricetinae; Mesocricetus; Microcirculation; Papaverine; Phentolamine; Prost	1988
[The effect of drugs on platelet function]. Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4 Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents; Blood Platelets; Cell Membrane Permeability;	1969
[The inhibition of thrombocyte aggregation in vitro and in vivo]. Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4 Topics: Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Blood Platelets; Dipyridamole; Fatty Acids, Es	1969
Local oxygen tension and blood flow in the normal and chronic ischemic myocardium in the anesthetized dog. Advances in experimental medicine and biology, 1973, Volume: 39 Topics: Anesthesia, Intravenous; Animals; Chloralose; Collateral Circulation; Constriction; Coronary Circula	1973
[Studies on the influence of papaverine on reactions of the blood platelets]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1967, Volume: 257, Issue:4 Topics: Adenine Nucleotides; Amines; Blood Coagulation; Blood Platelets; Humans; Nucleosides; Papaverine; Th	1967
[Intraoperative control of the function of the femoro-popliteal saphenous bypass. Results of electromagnetic current measurements]. VASA. Zeitschrift fur Gefasskrankheiten, 1974, Volume: 3, Issue:4 Topics: Blood Flow Velocity; Electromagnetic Phenomena; Femoral Artery; Humans; Papaverine; Popliteal Artery	1974
[Internal therapy of peripheral arterial blood circulation disorders]. Schweizerische medizinische Wochenschrift, 1970, May-02, Volume: 100, Issue:18 Topics: Adenosine Triphosphate; Aged; Angiotensin II; Anti-Bacterial Agents; Blood Pressure; Chlorpromazine;	1970
Intraoperative monitoring of femorotibial bypass grafts. The Surgical clinics of North America, 1974, Volume: 54, Issue:1 Topics: Animals; Arterial Occlusive Diseases; Arteries; Blood Flow Velocity; Blood Pressure; Cattle; Diabete	1974
Aortocoronary bypass grafts. Early postoperative angiographic evaluation and reexploration for stenosis or thrombosis of the vein graft. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 103, Issue:5 Topics: Aorta, Thoracic; Aortic Valve Stenosis; Blood Flow Velocity; Blood Vessel Prosthesis; Coronary Angio	1971
[Pharmacodynamic prevention of thrombosis]. Revue medicale de Liege, 1971, Oct-01, Volume: 26, Issue:19 Topics: Adenosine Diphosphate; Amitriptyline; Anticoagulants; Aspirin; Collagen; Dipyridamole; Guanethidine;	1971
Demonstration of the effect of irradiation on canine bowel using in vivo photographic magnification angiography. Radiology, 1969, Volume: 93, Issue:6 Topics: Angiography; Animals; Dogs; Intestines; Papaverine; Photography; Radiation Injuries, Experimental; T	1969
[Prevention of thrombosis using aspirin? nfluence of acetylsalicylic acid on thrombocyte aggregation in vitro and in vivo]. Klinische Wochenschrift, 1969, Dec-15, Volume: 47, Issue:24 Topics: Aspirin; Blood Coagulation Tests; Blood Platelets; Dipyridamole; Female; Humans; Middle Aged; Papave	1969
[The treatment of acute retinal arterial obliterations with thromboclasis]. Bulletin des societes d'ophtalmologie de France, 1969, Volume: 69, Issue:2 Topics: Aged; Female; Heparin; Humans; Male; Middle Aged; Papaverine; Procaine; Retinal Vessels; Temporal Ar	1969
[Effect of flavonoids and tocopherol on thrombocyte function]. Das Deutsche Gesundheitswesen, 1970, Jul-10, Volume: 25, Issue:28 Topics: Blood Platelets; Flavonoids; Humans; Papaverine; Plants, Medicinal; Platelet Adhesiveness; Thrombosi	1970
[Effect of bencyclane in obliterative arterial diseases]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:10 Topics: Aged; Arteriosclerosis Obliterans; Blood Circulation; Cerebrovascular Disorders; Cycloheptanes; Diab	1970
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:10 Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female;	1970
Topical papaverine in arteriotomies in infants and children: effect on incidence of thrombosis. The Journal of pediatrics, 1968, Volume: 72, Issue:6 Topics: Adolescent; Arteries; Cardiac Catheterization; Child; Child, Preschool; Humans; Infant; Infant, Newb	1968
[Thrombophilia in early and late sclerosis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Feb-01, Volume: 23, Issue:3 Topics: Age Factors; Anticoagulants; Arteries; Arteriosclerosis; Dipyridamole; Humans; Lipid Metabolism; Nuc	1968