papaverine has been researched along with Substance Withdrawal Syndrome in 6 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine treatment (1 x 10(-7) - 5 x 10(-7) - 1 x 10(-6) M) before or after the opioid agonists was able of both preventing and reversing the naloxone-induced contracture after exposure to mu (morphine and DAGO) or k (U50-488H) opiate agonists in a concentration-dependent fascion." | 1.32 | The effect of papaverine on acute opiate withdrawal in guinea pig ileum. ( Capasso, A; Loizzo, A, 2003) |
| " The naltrexone stimulus-generalization curve and dose-response curve for loss of body weight were shifted to the left by IBMX and Ro 20-1724, which produce quasi-withdrawal, but not by papaverine, which does not." | 1.28 | Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats. ( Holtzman, SG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Capasso, A | 1 |
| Loizzo, A | 1 |
| Sandler, M | 1 |
| Glover, V | 1 |
| Armando, I | 1 |
| Clow, A | 1 |
| Myers, RD | 3 |
| Melchior, CL | 2 |
| Holtzman, SG | 1 |
6 other studies available for papaverine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
The effect of papaverine on acute opiate withdrawal in guinea pig ileum.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Dise | 2003 |
Pictet-Spengler condensation products, stress and alcoholism: some clinical overtones.
Topics: Alcoholism; Animals; Carbolines; Chemical Phenomena; Chemistry; Gas Chromatography-Mass Spectrometry | 1982 |
Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism.
Topics: Alcohol Drinking; Alcoholism; Alkaloids; Animals; Brain; Carbolines; Disease Models, Animal; Humans; | 1978 |
Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain.
Topics: Alcohol Drinking; Animals; Biogenic Amines; Brain Chemistry; Dose-Response Relationship, Drug; Human | 1977 |
Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat.
Topics: Alcohol Drinking; Animals; Choice Behavior; Dose-Response Relationship, Drug; Drinking Behavior; Eth | 1977 |
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; D | 1989 |