papaverine has been researched along with Substance-Related Disorders in 7 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The naltrexone stimulus-generalization curve and dose-response curve for loss of body weight were shifted to the left by IBMX and Ro 20-1724, which produce quasi-withdrawal, but not by papaverine, which does not." | 1.28 | Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats. ( Holtzman, SG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lajtai, A | 1 |
| Mayer, M | 1 |
| Lakatos, Á | 1 |
| Porpáczy, Z | 1 |
| Miseta, A | 1 |
| Seetohul, LN | 1 |
| Maskell, PD | 1 |
| De Paoli, G | 1 |
| Pounder, DJ | 1 |
| Holtzman, SG | 1 |
| Davis, VE | 2 |
| Najjar, FB | 1 |
| Bridi, G | 1 |
| Rizk, G | 1 |
| Halushka, PV | 1 |
| Hoffmann, PC | 1 |
| Walsh, MJ | 1 |
7 other studies available for papaverine and Substance-Related Disorders
| Article | Year |
|---|---|
Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse?
Topics: Adolescent; Adult; Alprazolam; Amides; Drug Combinations; Humans; Male; Papaverine; Quaternary Ammon | 2016 |
Biomarkers for illicit heroin: a previously unrecognized origin of papaverine.
Topics: Atracurium; Biomarkers; Diagnostic Errors; False Positive Reactions; Forensic Toxicology; Heroin; Hu | 2013 |
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; D | 1989 |
Neuroamine-derived alkaloids: a possible common denominator in alcoholism and related drug dependencies.
Topics: Adolescent; Adult; Aged; Alcoholism; Aldehyde Oxidoreductases; Alkaloids; Biogenic Amines; Brain; Do | 1973 |
Management of micro-emboli of the digital arteries.
Topics: Adult; Angiography; Arteries; Catheterization; Dextrans; Dextroamphetamine; Embolism; Fingers; Hepar | 1974 |
Alcohol addiction and tetrahydropapaveroline.
Topics: Alcoholism; Animals; Brain; Carbon Isotopes; Codeine; Dextropropoxyphene; Dopamine; Guinea Pigs; Hum | 1970 |
Alcohol addiction and tetrahydropapaveroline.
Topics: Alcoholism; Aldehydes; Animals; Brain Stem; Carbon Isotopes; Cerebral Cortex; Disulfiram; Dopamine; | 1970 |