papaverine has been researched along with Subarachnoid Hemorrhage in 101 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intra-arterial infusion of papaverine was used clinically as a vasodilator for spastic arteries after subarachnoid hemorrhage, since in vitro experiment demonstrated that papaverine is one of the most potent vasodilators of human cerebral arteries following subarachnoid hemorrhage." | 9.07 | Intra-arterial papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Hashimoto, N; Kazekawa, K; Tsukahara, T; Yoshimura, S, 1994) |
| "Cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that has become refractory to maximal medical management can be treated with selective intra-arterial papaverine infusions." | 8.82 | Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK, 2005) |
| "IA papaverine-induced seizures are infrequently reported." | 8.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| "Eighty patients with subarachnoid hemorrhage and serious cerebral vasospasm underwent endovascular treatment using intra-arterial papaverine-hydrochloride (IAP) or transluminal balloon angioplasty (TBA)." | 7.88 | Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Gruber, A; Hosmann, A; Knosp, E; Rauscher, S; Wang, WT, 2018) |
| "Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage." | 7.72 | Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. ( DeArmond, SJ; Dillon, WP; Dowd, CF; Halbach, VV; Higashida, RT; Johnston, SC; Ko, NU; Lawton, MT; Setty, D; Smith, WS; Young, WL, 2004) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 7.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| "The purpose of this study was to test the hypothesis that balloon angioplasty is superior to papaverine infusion for the treatment of proximal anterior circulation arterial vasospasm following subarachnoid hemorrhage (SAH)." | 7.70 | Comparison of balloon angioplasty and papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Douville, CM; Elliott, JP; Eskridge, JM; Grady, MS; Lam, DJ; Le Roux, PD; Lewis, DH; Mayberg, MR; Newell, DW; Winn, HR, 1998) |
| "The clinical efficacy of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for treatment of vasospasm following subarachnoid hemorrhage was investigated." | 7.70 | Clinical evaluation of the effect of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Ishihara, S; Kaji, T; Katoh, H; Makita, K; Miyazawa, T; Nawashiro, H; Shima, K; Shimizu, A; Takiguchi, H; Tsuchiya, K; Umezawa, H, 1999) |
| "Complications associated with intraarterial papaverine infusion occurred in two patients treated for vasospasm due to subarachnoid hemorrhage (SAH)." | 7.70 | Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports. ( Hyodo, A; Kamezaki, T; Nagatomo, Y; Nose, T; Tsurushima, H, 2000) |
| "We describe two patients who had cerebral vasospasm after subarachnoid hemorrhage that was refractory to intraarterial injection of papaverine." | 7.69 | Intraarterial injection of amrinone for vasospasm induced by subarachnoid hemorrhage. ( Nakamura, S; Watanabe, H; Yoshida, K, 1997) |
| "Three patients presenting with subarachnoid hemorrhage due to aneurysmal rupture underwent cerebral blood flow (CBF) measurements before and after cisternal injection of papaverine hydrochloride." | 7.69 | Effect of cisternal papaverine on cerebral blood flow in patients with subarachnoid hemorrhage--three case reports. ( Iwakoshi, T; Kida, Y; Kitamura, R; Kobayashi, T; Maezawa, S; Niwa, M; Oyama, H; Tanaka, T; Yoshida, K, 1997) |
| "To evaluate the clinical effectiveness of PTA and/ or intra-arterial infusion of papaverine (PPV) for the treatment of symptomatic vasospasm after subarachnoid hemorrhage." | 7.69 | [Effectiveness of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for symptomatic vasospasm after subarachnoid hemorrhage]. ( Fujiwara, N; Honjo, Y; Nagao, S; Ohkawa, M; Takashima, H; Tanabe, M, 1997) |
| "Papaverine was effective in dilating narrowed arteries in most patients with symptomatic vasospasm caused by subarachnoid hemorrhage." | 7.69 | Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. ( Aldrich, EF; Clouston, JE; Numaguchi, Y; Simard, JM; Zitnay, KM; Zoarski, GH, 1995) |
| "This study examined the relationship between papaverine-sensitive and -insensitive components of vasospasm, arterial contractility and compliance, and time after subarachnoid hemorrhage (SAH) in dogs." | 7.69 | Papaverine-sensitive vasospasm and arterial contractility and compliance after subarachnoid hemorrhage in dogs. ( Johns, L; Macdonald, RL; Sima, B; Zhang, J, 1995) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 7.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "Angiographic improvement of cerebral vasospasm was observed in 80% of patients." | 5.56 | The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Engel, A; Gruber, A; Herta, J; Hosmann, A; Plöchl, W; Reinprecht, A; Wang, WT, 2020) |
| "Cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage is still a leading cause of morbidity and death." | 5.36 | Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report. ( Aytunur, CS; Baltaci, B; Basar, H; Gulhan, Y; Ozcan, A, 2010) |
| "Papaverine was infused into 32 arteries on 23 occasions." | 5.30 | Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Firlik, AD; Firlik, KS; Jungreis, CA; Kaufmann, AM; Yonas, H, 1999) |
| "The ruptured anterior communicating artery aneurysm was surgically obliterated the following day, and thereafter maximum hypervolemic and hypertensive therapies were used." | 5.29 | Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report. ( Clyde, BL; Firlik, AD; Kaufmann, AM; Spearman, MP; Yonas, H, 1996) |
| "Cerebral vasospasm that is caused by aneurysmal subarachnoid hemorrhage and that is refractory to maximal medical management can be treated with selective intraarterial papaverine infusions." | 5.11 | Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm. ( Couldwell, WT; Gottfried, ON; Kestle, JR; Liu, JK; MacDonald, JD; Madan, N; Rosenow, JM; Stevens, EA; Tenner, MS, 2004) |
| "It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage." | 5.09 | Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm. ( Bauhuf, C; Horn, P; Hubner, U; Ing, D; Munch, E; Poeckler-Schoeninger, C; Roth, H; Schmiedek, P; Thome, C; Vajkoczy, P, 2001) |
| "Thirty-one cases of cerebral vasospasm following subarachnoid hemorrhage were treated with intraarterial papaverine infusion." | 5.08 | [Endovascular treatment of cerebral vasospasm with intra-arterial papaverine infusion]. ( Imai, H; Itakura, T; Kinoshita, Y; Naka, D; Naka, Y; Nakai, E; Nakai, K; Nakamura, Y; Takehara, R; Terada, T, 1995) |
| "Intra-arterial infusion of papaverine was used clinically as a vasodilator for spastic arteries after subarachnoid hemorrhage, since in vitro experiment demonstrated that papaverine is one of the most potent vasodilators of human cerebral arteries following subarachnoid hemorrhage." | 5.07 | Intra-arterial papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Hashimoto, N; Kazekawa, K; Tsukahara, T; Yoshimura, S, 1994) |
| "Cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that has become refractory to maximal medical management can be treated with selective intra-arterial papaverine infusions." | 4.82 | Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK, 2005) |
| "IA papaverine-induced seizures are infrequently reported." | 4.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| "Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty." | 4.79 | Technical considerations on intra-arterial papaverine hydrochloride for cerebral vasospasm. ( Dion, JE; Jensen, ME; Mathis, JM, 1997) |
| "Eighty patients with subarachnoid hemorrhage and serious cerebral vasospasm underwent endovascular treatment using intra-arterial papaverine-hydrochloride (IAP) or transluminal balloon angioplasty (TBA)." | 3.88 | Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Gruber, A; Hosmann, A; Knosp, E; Rauscher, S; Wang, WT, 2018) |
| "Intra-arterial papaverine (IAP) is used to treat symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH)." | 3.73 | Intra-arterial papaverine used to treat cerebral vasospasm reduces brain oxygen. ( Hurst, RW; LeRoux, PD; Maloney-Wilensky, E; Spiotta, AM; Stiefel, MF; Udoetuk, JD; Weigele, JB, 2006) |
| "Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage." | 3.72 | Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. ( DeArmond, SJ; Dillon, WP; Dowd, CF; Halbach, VV; Higashida, RT; Johnston, SC; Ko, NU; Lawton, MT; Setty, D; Smith, WS; Young, WL, 2004) |
| "Selective intraarterial infusion of papaverine is used in the treatment of symptomatic cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage (SAH)." | 3.71 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage. ( Couldwell, WT; Liu, JK; Oestreich, HM; Tenner, MS, 2001) |
| "In 43 cases with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage treated by intraarterial infusion of papaverine (IAP), we studied cerebral hemodynamics by measuring cerebral circulation time (CCT) using digital subtraction angiogram." | 3.71 | Intraarterial infusion of papaverine and change of cerebral hemodynamics in symptomatic cerebral vasospasm. ( Kuwamura, K; Minami, H; Tamaki, N, 2001) |
| "Improvement in cerebral oxygenation as well as prevention of cerebral lactic acidosis can be successfully achieved after intraarterial infusion of papaverine." | 3.70 | Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm. ( Fandino, J; Kaku, Y; Schuknecht, B; Valavanis, A; Yonekawa, Y, 1998) |
| "Intraarterial papaverine infusions are performed to reverse cerebral arterial vasospasm resulting from subarachnoid hemorrhage, but such infusions may lead to increases in intracranial pressure (ICP)." | 3.70 | Intracranial pressure monitoring during intraarterial papaverine infusion for cerebral vasospasm. ( Angtuaco, EE; Cross, DT; Dacey, RG; Diringer, MN; Milburn, JM; Moran, CJ, 1998) |
| "The purpose of this study was to test the hypothesis that balloon angioplasty is superior to papaverine infusion for the treatment of proximal anterior circulation arterial vasospasm following subarachnoid hemorrhage (SAH)." | 3.70 | Comparison of balloon angioplasty and papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Douville, CM; Elliott, JP; Eskridge, JM; Grady, MS; Lam, DJ; Le Roux, PD; Lewis, DH; Mayberg, MR; Newell, DW; Winn, HR, 1998) |
| "The clinical efficacy of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for treatment of vasospasm following subarachnoid hemorrhage was investigated." | 3.70 | Clinical evaluation of the effect of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. ( Ishihara, S; Kaji, T; Katoh, H; Makita, K; Miyazawa, T; Nawashiro, H; Shima, K; Shimizu, A; Takiguchi, H; Tsuchiya, K; Umezawa, H, 1999) |
| "Complications associated with intraarterial papaverine infusion occurred in two patients treated for vasospasm due to subarachnoid hemorrhage (SAH)." | 3.70 | Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports. ( Hyodo, A; Kamezaki, T; Nagatomo, Y; Nose, T; Tsurushima, H, 2000) |
| "Three patients presenting with subarachnoid hemorrhage due to aneurysmal rupture underwent cerebral blood flow (CBF) measurements before and after cisternal injection of papaverine hydrochloride." | 3.69 | Effect of cisternal papaverine on cerebral blood flow in patients with subarachnoid hemorrhage--three case reports. ( Iwakoshi, T; Kida, Y; Kitamura, R; Kobayashi, T; Maezawa, S; Niwa, M; Oyama, H; Tanaka, T; Yoshida, K, 1997) |
| "Cerebral vasodilatation in response to aprikalim, an opener of ATP-sensitive K+ channels, is selectively augmented after subarachnoid hemorrhage (SAH)." | 3.69 | Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats. ( Faraci, FM; Heistad, DD; Sobey, CG, 1997) |
| "This study examined the relationship between papaverine-sensitive and -insensitive components of vasospasm, arterial contractility and compliance, and time after subarachnoid hemorrhage (SAH) in dogs." | 3.69 | Papaverine-sensitive vasospasm and arterial contractility and compliance after subarachnoid hemorrhage in dogs. ( Johns, L; Macdonald, RL; Sima, B; Zhang, J, 1995) |
| "Papaverine was effective in dilating narrowed arteries in most patients with symptomatic vasospasm caused by subarachnoid hemorrhage." | 3.69 | Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. ( Aldrich, EF; Clouston, JE; Numaguchi, Y; Simard, JM; Zitnay, KM; Zoarski, GH, 1995) |
| "To evaluate the clinical effectiveness of PTA and/ or intra-arterial infusion of papaverine (PPV) for the treatment of symptomatic vasospasm after subarachnoid hemorrhage." | 3.69 | [Effectiveness of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for symptomatic vasospasm after subarachnoid hemorrhage]. ( Fujiwara, N; Honjo, Y; Nagao, S; Ohkawa, M; Takashima, H; Tanabe, M, 1997) |
| "We describe two patients who had cerebral vasospasm after subarachnoid hemorrhage that was refractory to intraarterial injection of papaverine." | 3.69 | Intraarterial injection of amrinone for vasospasm induced by subarachnoid hemorrhage. ( Nakamura, S; Watanabe, H; Yoshida, K, 1997) |
| "This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride." | 3.68 | Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. ( Kaku, Y; Kazekawa, K; Tsukahara, T; Yonekawa, Y, 1992) |
| "We examined the efficacy of slow-release, and prolonged diffusion silicone pellets mixed with papaverine hydrochloride in the treatment of cerebral vasospasms following subarachnoid hemorrhage." | 3.67 | [Sustained-release pellet of vasodilators--basic experiment]. ( Arimitsu, T; Mori, K; Oda, Y; Okumura, T, 1984) |
| "Vasospasm as a complication of subarachnoid hemorrhage is a major concern in clinical practice." | 2.70 | Efficacy of controlled-release papaverine pellets in preventing symptomatic cerebral vasospasm. ( Cagli, S; Dalbasti, T; Karabiyikoglu, M; Oktar, N; Ozdamar, N, 2001) |
| "Cerebral vasospasm is a significant cause of morbidity and mortality in patients who have sustained a subarachnoid hemorrhage from aneurysm rupture." | 2.43 | Endovascular treatment strategies for cerebral vasospasm. ( Batjer, HH; Bendok, BR; Miller, JW; Mindea, SA; Yang, BP, 2006) |
| "Treatment of acute aneurysmal subarachnoid hemorrhages consists of occluding the aneurysm to prevent rebleed, attempting to prevent vasospasm, and maintaining blood flow to the brain through vessels in vasospasm." | 2.43 | Endovascular management of a patient after SAH. ( Chang, S; Murphy, K; Srinivas, A, 2005) |
| "For survivors of aneurysmal subarachnoid hemorrhage, cerebral vasospasm significantly contributes to its morbidity and mortality by causing delayed ischemic neurological deficit." | 2.40 | Neuroradiologic diagnosis and treatment of vasospasm. ( Elliott, JP; Eskridge, JM; Song, JK, 1997) |
| "Angiographic improvement of cerebral vasospasm was observed in 80% of patients." | 1.56 | The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm. ( Bavinzski, G; Dodier, P; Engel, A; Gruber, A; Herta, J; Hosmann, A; Plöchl, W; Reinprecht, A; Wang, WT, 2020) |
| "Cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage is still a leading cause of morbidity and death." | 1.36 | Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report. ( Aytunur, CS; Baltaci, B; Basar, H; Gulhan, Y; Ozcan, A, 2010) |
| "After the treatment of cerebral vasospasm in a SAH patient by intra-arterial administration of papaverine into the left posterior cerebral artery, severe mesencephalic extravasation of blood and contrast media was detected." | 1.35 | Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note. ( Baráth, K; Keller, E; Platz, J; Valavanis, A, 2008) |
| "In patients with subarachnoid hemorrhage, unpredictable response patterns to PPV were observed with "rebound" vasoconstriction suggesting increased contractility of the microcirculation." | 1.35 | Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery. ( Albrecht, KW; Bouma, GJ; Muizelaar, JP; Pennings, FA; Schuurman, PR, 2009) |
| "The best strategy for treatment of subarachnoid hemorrhage due to ruptured cerebral aneurysm is obliteration of the aneurysm as soon as possible." | 1.32 | Combined endovascular treatment for both intracranial aneurysm and symptomatic vasospasm. ( Duckwiler, GR; Gobin, YP; Martin, NA; Murayama, Y; Patel, AB; Song, JK; Tateshima, S; Uda, K; Viñuela, F, 2003) |
| "Patients who developed cerebral vasospasm and underwent cerebral arteriographic, transcranial Doppler ultrasonographic, and cerebral blood flow (CBF) studies before and after endovascular therapy for cerebral arterial spasm (vasospasm) were included in this study." | 1.31 | Multimodal quantitation of the effects of endovascular therapy for vasospasm on cerebral blood flow, transcranial doppler ultrasonographic velocities, and cerebral artery diameters. ( Afari, A; Glenn, TC; Gonzalez, NR; Guthrie, D; Lee, JH; Martin, NA; Oskouian, RJ; Viñuela, F, 2002) |
| "Incidence of cerebral vasospasm on angiograms among the two groups was analysed." | 1.31 | Magnesium: a useful adjunct in the prevention of cerebral vasospasm following aneurysmal subarachnoid haemorrhage. ( Chia, RY; Hughes, RS; Morgan, MK, 2002) |
| "Papaverine was administrated selectively via the vertebral artery on day 2, and serial angiography was performed for up to 2 hours." | 1.31 | Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits. ( Asari, S; Date, I; Nakajima, M; Ninomiya, Y; Ohmoto, T; Takahashi, K, 2001) |
| "Papaverine was infused into 32 arteries on 23 occasions." | 1.30 | Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Firlik, AD; Firlik, KS; Jungreis, CA; Kaufmann, AM; Yonas, H, 1999) |
| "Ninety nine patients with ruptured cerebral aneurysms, who survived more than one week and were treated in Wakayama City in 1994, were studied." | 1.30 | The effect of endovascular therapy for cerebral arterial spasm, its limitation and pitfalls. ( Hyotani, G; Itakura, T; Kido, T; Kinoshita, Y; Kuriyama, T; Naka, Y; Nakai, K; Terada, T; Tsuura, M; Yokote, H, 1997) |
| "The ruptured anterior communicating artery aneurysm was surgically obliterated the following day, and thereafter maximum hypervolemic and hypertensive therapies were used." | 1.29 | Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report. ( Clyde, BL; Firlik, AD; Kaufmann, AM; Spearman, MP; Yonas, H, 1996) |
| "The study focused on patients with aneurysmal subarachnoid hemorrhage who developed clinical signs and symptoms of vasospasm, which was documented by cerebral angiography." | 1.29 | Intracranial pressure changes induced during papaverine infusion for treatment of vasospasm. ( Eskridge, JM; Grady, MS; McAuliffe, W; Newell, DW; Townsend, M; Winn, HR, 1995) |
| "Phentolamine, that is an adrenergic blocking agent, relieved the early spam remarkably, but it was less effective on the late spam." | 1.25 | [Experimental Subarachnoid hemmorrhage in dogs--effect of various drugs and sympathectomy on cerebral arterial spasm (author's transl)]. ( Noda, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (12.87) | 18.7374 |
| 1990's | 40 (39.60) | 18.2507 |
| 2000's | 39 (38.61) | 29.6817 |
| 2010's | 7 (6.93) | 24.3611 |
| 2020's | 2 (1.98) | 2.80 |
| Authors | Studies |
|---|---|
| Neumann, A | 1 |
| Weber, W | 1 |
| Küchler, J | 1 |
| Schacht, H | 1 |
| Jensen-Kondering, U | 1 |
| Berlis, A | 1 |
| Schramm, P | 1 |
| Hosmann, A | 2 |
| Wang, WT | 2 |
| Dodier, P | 2 |
| Bavinzski, G | 2 |
| Engel, A | 1 |
| Herta, J | 1 |
| Plöchl, W | 1 |
| Reinprecht, A | 1 |
| Gruber, A | 2 |
| Rauscher, S | 1 |
| Knosp, E | 1 |
| Kim, JH | 1 |
| Yi, HJ | 1 |
| Ko, Y | 1 |
| Kim, YS | 1 |
| Kim, DW | 1 |
| Kim, JM | 1 |
| Ding, D | 1 |
| Platz, J | 1 |
| Baráth, K | 1 |
| Keller, E | 2 |
| Valavanis, A | 2 |
| Pennings, FA | 1 |
| Albrecht, KW | 1 |
| Muizelaar, JP | 1 |
| Schuurman, PR | 1 |
| Bouma, GJ | 1 |
| Shimamura, N | 1 |
| Naraoka, M | 1 |
| Nakano, T | 1 |
| Ogasawara, Y | 1 |
| Takeda, T | 1 |
| Ohkuma, H | 1 |
| Singla, N | 1 |
| Mathuriya, SN | 1 |
| Mohindra, S | 1 |
| Umredkar, AA | 1 |
| Adhikari, S | 1 |
| Gupta, SK | 1 |
| Gupta, V | 1 |
| Baltaci, B | 1 |
| Basar, H | 1 |
| Ozcan, A | 1 |
| Gulhan, Y | 1 |
| Aytunur, CS | 1 |
| Pierot, L | 1 |
| Aggour, M | 1 |
| Moret, J | 1 |
| Chittiboina, P | 1 |
| Willet, O | 1 |
| Nanda, A | 2 |
| Guthikonda, B | 1 |
| Kerz, T | 1 |
| Boor, S | 1 |
| Beyer, C | 1 |
| Welschehold, S | 1 |
| Schuessler, A | 1 |
| Oertel, J | 1 |
| Oskouian, RJ | 1 |
| Martin, NA | 2 |
| Lee, JH | 1 |
| Glenn, TC | 1 |
| Guthrie, D | 1 |
| Gonzalez, NR | 1 |
| Afari, A | 1 |
| Viñuela, F | 2 |
| Koide, M | 1 |
| Nishizawa, S | 2 |
| Ohta, S | 1 |
| Yokoyama, T | 2 |
| Namba, H | 1 |
| Srinivasan, J | 1 |
| Eskridge, J | 1 |
| Grady, MS | 3 |
| Newell, DW | 5 |
| Winn, HR | 4 |
| Murayama, Y | 1 |
| Song, JK | 2 |
| Uda, K | 1 |
| Gobin, YP | 1 |
| Duckwiler, GR | 1 |
| Tateshima, S | 1 |
| Patel, AB | 1 |
| Liu, JK | 4 |
| Tenner, MS | 2 |
| Gottfried, ON | 1 |
| Stevens, EA | 1 |
| Rosenow, JM | 1 |
| Madan, N | 1 |
| MacDonald, JD | 1 |
| Kestle, JR | 1 |
| Couldwell, WT | 4 |
| Goto, Y | 1 |
| Yamagata, S | 1 |
| Smith, WS | 1 |
| Dowd, CF | 1 |
| Johnston, SC | 1 |
| Ko, NU | 1 |
| DeArmond, SJ | 1 |
| Dillon, WP | 1 |
| Setty, D | 1 |
| Lawton, MT | 1 |
| Young, WL | 2 |
| Higashida, RT | 1 |
| Halbach, VV | 1 |
| Scanlon, A | 1 |
| Hui, C | 1 |
| Lau, KP | 1 |
| Chang, S | 1 |
| Srinivas, A | 1 |
| Murphy, K | 1 |
| Stiefel, MF | 1 |
| Spiotta, AM | 1 |
| Udoetuk, JD | 1 |
| Maloney-Wilensky, E | 1 |
| Weigele, JB | 1 |
| Hurst, RW | 1 |
| LeRoux, PD | 1 |
| Madhusudan Reddy, KR | 1 |
| Umamaheswara Rao, GS | 1 |
| Sastry Kolluri, VR | 1 |
| Sayama, CM | 1 |
| Mindea, SA | 1 |
| Yang, BP | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for papaverine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angioplasty, Balloon; Critical Care; Endovascular Pro | 2010 |
Endovascular therapy for vasospasm.
Topics: Angioplasty; Brain; Cerebrovascular Circulation; Humans; Papaverine; Subarachnoid Hemorrhage; Vasodi | 2002 |
Aneurysmal subarachnoid haemorrhage--Part 2: Post-operative nursing management diagnosis, complications and treatment: a composite case study.
Topics: Angioplasty, Balloon; Brain Edema; Female; Humans; Hydrocephalus; Infusions, Intra-Arterial; Intracr | 2004 |
Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.
Topics: Brain; Cerebral Arteries; Cerebrovascular Circulation; Humans; Infusions, Intra-Arterial; Oxygen Con | 2005 |
Endovascular management of a patient after SAH.
Topics: Aneurysm, Ruptured; Aortic Dissection; Cerebral Hemorrhage; Clinical Trials as Topic; Embolization, | 2005 |
Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.
Topics: Angioplasty, Balloon; Combined Modality Therapy; Humans; Intracranial Aneurysm; Papaverine; Subarach | 2006 |
Endovascular treatment strategies for cerebral vasospasm.
Topics: Aneurysm, Ruptured; Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Time Factors; | 2006 |
[Pharmacological treatment of vasospasm in subarachnoid hemorrhage].
Topics: Antioxidants; Humans; Ischemic Attack, Transient; Lipid Peroxides; Male; Nicardipine; Nimodipine; Pa | 1996 |
Technical considerations on intra-arterial papaverine hydrochloride for cerebral vasospasm.
Topics: Angioplasty, Balloon; Cerebral Angiography; Combined Modality Therapy; Humans; Injections, Intra-Art | 1997 |
Neuroradiologic diagnosis and treatment of vasospasm.
Topics: Angioplasty, Balloon; Brain Ischemia; Combined Modality Therapy; Decision Making; Humans; Injections | 1997 |
Endovascular therapy for aneurysmal vasospasm.
Topics: Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Cerebral Angiography; Cerebrovascular | 1999 |
Endovascular treatment of cerebral vasospasm.
Topics: Angioplasty, Balloon; Animals; Combined Modality Therapy; Humans; Papaverine; Subarachnoid Hemorrhag | 2000 |
Intra-arterial papaverine-induced seizures: case report and review of the literature.
Topics: Adult; Angioplasty, Balloon; Carotid Artery, Internal; Female; Humans; Infusions, Intra-Arterial; Mi | 2001 |
Cerebral vasodilators.
Topics: Aged; Alcohols; Blood Pressure; Carbon Dioxide; Cerebral Arterial Diseases; Cerebrovascular Circulat | 1971 |
Current concepts in the etiology and treatment of vasospasm.
Topics: Animals; Brain Edema; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Disease | 1968 |
9 trials available for papaverine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Effectiveness of papaverine cisternal irrigation for cerebral vasospasm after aneurysmal subarachnoid hemorrhage and measurement of biomarkers.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Biomarkers; Cell Adhesion Molecule-1; Cell Adhes | 2014 |
Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Angiography; Cerebrovascular Circulation; Drug Admin | 2004 |
Effect of intraarterial papaverine and/or angioplasty on the cerebral veins in patients with vasospasm after subarachnoid hemorrhage due to ruptured intracranial aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty; Cerebral Angiography; Cerebral Vein | 2006 |
[Endovascular treatment of cerebral vasospasm with intra-arterial papaverine infusion].
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Female; Humans; Infusions, Intra-Arterial; Ischemic Att | 1995 |
Intra-arterial papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Cerebral Angiography; Cerebrovascular Circulation; Humans; Infusions, Intra-Arterial; Intracranial A | 1994 |
Efficacy of transluminal angioplasty for the management of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Angioplasty, Balloon; Combined Modality Therapy; Double-Blind Method; Female; Glasgow C | 2000 |
Aggressive management of aneurysmal subarachnoid haemorrhage based on a papaverine angioplasty protocol.
Topics: Angioplasty, Balloon; Cerebral Arteries; Humans; Intracranial Aneurysm; Papaverine; Recovery of Func | 2000 |
Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Electrodes, Implanted | 2001 |
Efficacy of controlled-release papaverine pellets in preventing symptomatic cerebral vasospasm.
Topics: Adult; Delayed-Action Preparations; Drug Implants; Female; Humans; Intracranial Aneurysm; Male; Midd | 2001 |
77 other studies available for papaverine and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Evaluation of DeGIR registry data on endovascular treatment of cerebral vasospasm in Germany 2018-2021: an overview of the current care situation.
Topics: Endovascular Procedures; Female; Humans; Male; Nimodipine; Papaverine; Retrospective Studies; Routin | 2023 |
The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm.
Topics: Adult; Brain; Cerebrovascular Circulation; Endovascular Procedures; Female; Humans; Injections, Intr | 2020 |
Intra-Arterial Papaverine-Hydrochloride and Transluminal Balloon Angioplasty for Neurointerventional Management of Delayed-Onset Post-Aneurysmal Subarachnoid Hemorrhage Vasospasm.
Topics: Adult; Angiography; Angioplasty, Balloon; Brain Infarction; Female; Follow-Up Studies; Humans; Injec | 2018 |
Delayed morbidity and mortality in aneurysmal subarachnoid hemorrhage patients: effect of attenuating cerebral vasospasm.
Topics: Female; Fibrinolytic Agents; Humans; Male; Papaverine; Subarachnoid Hemorrhage; Vasospasm, Intracran | 2015 |
Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note.
Topics: Aged; Blood-Brain Barrier; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; In | 2008 |
Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery.
Topics: Adult; Aged; Arterioles; Cerebral Arteries; Cerebrovascular Circulation; Female; Humans; Male; Micro | 2009 |
[Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Anesthesia, Local; Embolizat | 2008 |
Severe hypotension with intracisternal application of papaverine after clipping of an intracranial aneurysm.
Topics: Acute Kidney Injury; Carotid Artery Diseases; Cerebral Angiography; Cisterna Magna; Fatal Outcome; H | 2009 |
Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report.
Topics: Bradycardia; Cisterna Magna; Fatal Outcome; Glasgow Coma Scale; Heart Arrest; Hemodynamics; Humans; | 2010 |
Transient oculomotor nerve palsy after topical administration of intracisternal papaverine.
Topics: Humans; Infusions, Intraventricular; Middle Aged; Oculomotor Nerve Diseases; Papaverine; Subarachnoi | 2011 |
Effect of intraarterial papaverine or nimodipine on vessel diameter in patients with cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain Ischemia; Capillaries; Carotid Artery, I | 2012 |
Multimodal quantitation of the effects of endovascular therapy for vasospasm on cerebral blood flow, transcranial doppler ultrasonographic velocities, and cerebral artery diameters.
Topics: Adult; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Brain; Cerebral Angiography; C | 2002 |
Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase.
Topics: Animals; Basilar Artery; Cerebral Angiography; Dogs; Drug Resistance; Female; Genistein; Isometric C | 2002 |
Combined endovascular treatment for both intracranial aneurysm and symptomatic vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty, Balloon; Cerebral Angiography; Comb | 2003 |
[Differences in outcome in patients with poor grade subarachnoid hemorrhage (WFNS grade IV and V): according to the perioperative management against vasospasm].
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Female; Glasgow Coma Scale; Humans; Male; Midd | 2004 |
Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Topics: Aged; Brain; Chlorobutanol; Female; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; M | 2004 |
Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage.
Topics: Adult; Aged; Blood Pressure; Cerebral Angiography; Female; Heart Rate; Humans; Infusions, Intra-Arte | 2005 |
Intra-arterial papaverine used to treat cerebral vasospasm reduces brain oxygen.
Topics: Blood Pressure; Body Temperature; Brain; Cerebral Angiography; Humans; Injections, Intra-Arterial; I | 2006 |
Profound hypotension after intracisternal papaverine.
Topics: Cisterna Magna; Hemodynamics; Humans; Injections; Male; Middle Aged; Papaverine; Subarachnoid Hemorr | 2006 |
Contralateral pupillary dilatation after intracisternal papaverine instillation.
Topics: Craniotomy; Diagnosis, Differential; Disease Progression; Functional Laterality; Humans; Intracrania | 2007 |
Stellate ganglion block as alternative to intrathecal papaverine in relieving vasospasm due to subarachnoid hemorrhage.
Topics: Adult; Female; Humans; Injections, Spinal; Male; Middle Aged; Nerve Block; Papaverine; Stellate Gang | 2007 |
[Endovascular treatment of vasospasm following subarachnoid aneurysmal haemorrhage].
Topics: Calcium Channel Blockers; Humans; Intracranial Aneurysm; Nicardipine; Nimodipine; Nitroprusside; Pap | 2007 |
Prostacyclin and thromboxane in cerebral vasospasm: effects of prostacyclin on experimentally-induced cerebral vasospasm.
Topics: Animals; Arachidonic Acids; Basilar Artery; Blood Pressure; Cats; Cerebrovascular Circulation; Epopr | 1984 |
Erythrocyte extracts enhance neurogenic vasoconstriction of dog cerebral arteries in vitro.
Topics: Animals; Cerebral Arteries; Dogs; Electric Stimulation; Erythrocytes; Female; In Vitro Techniques; I | 1984 |
[Sustained-release pellet of vasodilators--basic experiment].
Topics: Delayed-Action Preparations; Diltiazem; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; N | 1984 |
Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a "two-hemorrhage" canine model.
Topics: Aminophylline; Animals; Disease Models, Animal; Dog Diseases; Dogs; Ischemic Attack, Transient; Papa | 1983 |
Treatment of severe localized cerebral vasospasm following recurrent hemorrhage from middle cerebral artery aneurysm--case report.
Topics: Brain; Cerebral Angiography; Cerebral Arteries; Female; Humans; Intracranial Aneurysm; Ischemic Atta | 1993 |
Intracranial pressure changes induced during papaverine infusion for treatment of vasospasm.
Topics: Adult; Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Pressure; Female; Glasgow Coma Scale; H | 1995 |
Severe thrombocytopenia following intraarterial papaverine administration for treatment of vasospasm.
Topics: Aged; Antibodies; Blood Platelets; Cerebral Angiography; Humans; Infusions, Intra-Arterial; Intracra | 1995 |
Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion.
Topics: Brain; Brain Injuries; Carotid Artery, Internal; Cerebral Angiography; Humans; Infusions, Intra-Arte | 1995 |
Elevated transcranial Doppler ultrasound velocities following therapeutic arterial dilation.
Topics: Adult; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Carotid Artery Diseases; Cereb | 1995 |
Transient neurologic events associated with intraarterial papaverine infusion for subarachnoid hemorrhage-induced vasospasm.
Topics: Cerebral Angiography; Female; Humans; Infusions, Intra-Arterial; Intracranial Aneurysm; Ischemic Att | 1994 |
Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Basilar Artery; Blindness; Carotid Artery, Internal; Cerebral Angio | 1995 |
Papaverine-induced mydriasis.
Topics: Adult; Aged; Carotid Artery, Internal; Female; Humans; Infusions, Intra-Arterial; Ischemic Attack, T | 1994 |
Transient severe brain stem depression during intraarterial papaverine infusion for cerebral vasospasm.
Topics: Apnea; Basilar Artery; Brain Stem; Female; Humans; Infusions, Intra-Arterial; Intracranial Aneurysm; | 1994 |
The role of active smooth-muscle contraction in the occurrence of chronic vasospasm in the canine two-hemorrhage model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dogs; Female; Ischemic Attac | 1994 |
Papaverine-sensitive vasospasm and arterial contractility and compliance after subarachnoid hemorrhage in dogs.
Topics: Animals; Basilar Artery; Cerebral Angiography; Compliance; Dogs; Ischemic Attack, Transient; Papaver | 1995 |
Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report.
Topics: Cerebral Angiography; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Magnetic Resonance | 1996 |
Intra-arterial infusion of papaverine combined with intravenous administration of high-dose nicardipine for cerebral vasospasm.
Topics: Adult; Aged; Aneurysm, Ruptured; Calcium Channel Blockers; Cerebral Angiography; Dose-Response Relat | 1995 |
Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats.
Topics: Animals; ATP-Binding Cassette Transporters; Basilar Artery; Hypertension; Ion Channel Gating; KATP C | 1997 |
Effect of cisternal papaverine on cerebral blood flow in patients with subarachnoid hemorrhage--three case reports.
Topics: Adult; Aged; Cerebrovascular Circulation; Female; Humans; Injections, Spinal; Male; Middle Aged; Pap | 1997 |
Intraarterial injection of amrinone for vasospasm induced by subarachnoid hemorrhage.
Topics: Adult; Amrinone; Aneurysm, Ruptured; Brain; Cerebral Angiography; Female; Humans; Image Processing, | 1997 |
The effect of endovascular therapy for cerebral arterial spasm, its limitation and pitfalls.
Topics: Adult; Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Cerebral Angiography; Disability Evaluation; | 1997 |
Subarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries.
Topics: Animals; Brain; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cyclic GMP; Injecti | 1997 |
[Effectiveness of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for symptomatic vasospasm after subarachnoid hemorrhage].
Topics: Adult; Aged; Angioplasty, Balloon; Female; Humans; Infusions, Intra-Arterial; Ischemic Attack, Trans | 1997 |
Effectiveness of intra-arterially infused papaverine solutions of various concentrations for the treatment of cerebral vasospasm.
Topics: Adult; Aged; Carotid Artery, Internal; Cerebral Angiography; Dose-Response Relationship, Drug; Femal | 1997 |
Repeat intra-arterial papaverine for recurrent cerebral vasospasm after subarachnoid haemorrhage.
Topics: Adult; Aged; Cerebral Angiography; Female; Humans; Injections, Intra-Arterial; Ischemic Attack, Tran | 1997 |
Does papaverine cause endothelial injury in clinically relevant doses?
Topics: Animals; Brain; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Infusions, Intra-Ar | 1997 |
Comparison of balloon angioplasty and papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Angioplasty, Balloon; Blood Flow Velocity; Cerebral Angiography; Cerebrovascular Circul | 1998 |
Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm.
Topics: Acidosis, Lactic; Adult; Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Pressure; Blood Volum | 1998 |
Intracranial pressure monitoring during intraarterial papaverine infusion for cerebral vasospasm.
Topics: Age Factors; Drug Administration Schedule; Glasgow Coma Scale; Humans; Infusion Pumps; Infusions, In | 1998 |
Effects of intra-arterial papaverine on the chronic period of cerebral arterial vasospasm in rats.
Topics: Animals; Cerebral Arteries; Infusions, Intra-Arterial; Ischemic Attack, Transient; Male; Papaverine; | 1998 |
Intra-arterial papaverine for the treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Blood Flow Velocity; Cerebral Angiography; Cerebrovascular Circulation; Female; Humans; | 1999 |
Clinical evaluation of the effect of percutaneous transluminal angioplasty and intra-arterial papaverine infusion for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Angioplasty, Balloon; Evaluation Studies as Topic; Female; Humans; Infusions, Intra-Arterial; Intrac | 1999 |
[A case of symptomatic traumatic cerebral vasospasm associated with hyponatremia].
Topics: Aged; Craniocerebral Trauma; Disease Progression; Female; Humans; Hyponatremia; Papaverine; Sodium; | 1999 |
Papaverine and vasospasm.
Topics: Angioplasty, Balloon; Humans; Infusions, Intra-Arterial; Papaverine; Subarachnoid Hemorrhage; Treatm | 2000 |
Complications associated with intraarterial administration of papaverine for vasospasm following subarachnoid hemorrhage--two case reports.
Topics: Adult; Carotid Arteries; Cerebral Angiography; Craniotomy; Dose-Response Relationship, Drug; Fatal O | 2000 |
Effects of aging on cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Topics: Age Factors; Aging; Animals; Basilar Artery; Blood Pressure; Cerebral Angiography; Infusions, Intra- | 2001 |
Bedside monitoring of cerebral blood flow in patients with subarachnoid hemorrhage.
Topics: Adult; Aged; Blood Pressure; Blood Volume; Brain; Cerebrovascular Circulation; Female; Hemodilution; | 2001 |
Current indications and results of cerebral angioplasty.
Topics: Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Ag | 2001 |
Effect of intra-arterial infusion of papaverine hydrochloride on brain tissue oxygen pressure in the management of severe vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Brain; Humans; Injections, Intra-Arterial; Intracranial Aneurysm; Oxygen; Papaverine; Partial Pressu | 2001 |
Mechanical and pharmacologic treatment of vasospasm.
Topics: Angioplasty, Balloon; Humans; Papaverine; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Ag | 2001 |
Intraarterial infusion of papaverine and change of cerebral hemodynamics in symptomatic cerebral vasospasm.
Topics: Adult; Aged; Aged, 80 and over; Angiography; Blood Flow Velocity; Brain; Female; Hemodynamics; Human | 2001 |
Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage.
Topics: Adult; Brain Ischemia; Female; Humans; Infusions, Intra-Arterial; Male; Papaverine; Stroke; Subarach | 2001 |
Magnesium: a useful adjunct in the prevention of cerebral vasospasm following aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Cerebral Angiography; Female; Humans; Injections, Intra-Arterial; Injections, Intraveno | 2002 |
Some considerations on cerebral vasospasm.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Cats; Cerebral Arteries; Cerebral He | 1975 |
Experimental cerebral vasospasm. Part 2: effects of vasoactive drugs and sympathectomy on early and late spasm.
Topics: Animals; Circle of Willis; Disease Models, Animal; Dogs; Ischemic Attack, Transient; Isoxsuprine; Me | 1975 |
[Experimental Subarachnoid hemmorrhage in dogs--effect of various drugs and sympathectomy on cerebral arterial spasm (author's transl)].
Topics: Animals; Autonomic Agents; Cerebral Arteries; Dogs; Ischemic Attack, Transient; Isoxsuprine; Methyse | 1975 |
Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty, Balloon; Female; Humans; Infusions, | 1992 |
Longitudinal in vivo and in vitro time-course study of chronic cerebrovasospasm in the rabbit basilar artery.
Topics: Acetylcholine; Animals; Basilar Artery; Chronic Disease; Dose-Response Relationship, Drug; In Vitro | 1991 |
Two indices of functional damage of the artery wall parallel the time course of irreversible narrowing in experimental vasospasm in the rabbit.
Topics: Animals; Basilar Artery; Endothelium, Vascular; Ischemic Attack, Transient; Kinetics; Muscle Contrac | 1991 |
Pharmacologic irreversible narrowing in chronic cerebrovasospasm in rabbits is associated with functional damage.
Topics: Acetylcholine; Animals; Basilar Artery; Cimetidine; Epinephrine; Histamine; In Vitro Techniques; Isc | 1990 |
Pharmacological reversibility of experimental cerebral vasospasm.
Topics: Adenosine; Animals; Basilar Artery; Ischemic Attack, Transient; Male; Microscopy, Electron; Nitropru | 1990 |
The role of endothelin in the pathogenesis of vasospasm following subarachnoid haemorrhage.
Topics: Angiography; Animals; Basilar Artery; Dogs; Endothelins; Female; Injections; Ischemic Attack, Transi | 1989 |
[Efficacy of intracisternal papaverine on symptomatic vasospasm].
Topics: Cerebral Angiography; Cerebral Hemorrhage; Cisterna Magna; Humans; Injections; Intracranial Aneurysm | 1986 |
Observations on the effects of intrathecal papaverine in experimental vasospasm.
Topics: Animals; Basilar Artery; Cerebral Angiography; Disease Models, Animal; Haplorhini; Injections, Spina | 1973 |
Regional cerebral blood flow studies in subarachnoid hemorrhage.
Topics: Blood Flow Velocity; Blood Pressure; Cerebral Angiography; Cerebrovascular Circulation; Humans; Hydr | 1972 |