papaverine has been researched along with Spasm in 47 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
Excerpt | Relevance | Reference |
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"This study is planned bringing about a new choice for the prophylaxis of RA spasm which is topical iloprost and compares its efficacy with papaverine and diltiazem." | 9.12 | An alternative agent for radial arterial graft spasm: application of topical iloprost. ( Besogul, Y; Ikizler, M; Karakaya, A; Ozdemir, C; Sirmagul, B, 2007) |
"Fifty-eight patients were randomized into three groups to compare papaverine's ability to prevent spasm and to treat established spasm." | 9.11 | Papaverine delivery to the internal mammary artery pedicle effectively treats spasm. ( Crawford, FA; Crumbley, AJ; Girard, DS; Kratz, JM; Sutton, JP; Williams, TH; Zellner, JL, 2004) |
"In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 7.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
"We recommend topical use of papaverine at 37 degrees C to relieve intraoperative spasm of the internal thoracic artery." | 7.69 | Effect of normothermic papaverine to relieve intraoperative spasm of the internal thoracic artery. ( Bilgen, F; Coruh, T; Ozler, A; Serbetçioğlu, A; Tarhan, IA; Yapici, MF, 1996) |
"Papaverine was topically applied on the renal arteries resulting in vasodilation and reperfusion of the kidney." | 6.58 | Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy. ( Cadeddu, JA; Sorokin, I; Stevens, SL, 2018) |
"This study is planned bringing about a new choice for the prophylaxis of RA spasm which is topical iloprost and compares its efficacy with papaverine and diltiazem." | 5.12 | An alternative agent for radial arterial graft spasm: application of topical iloprost. ( Besogul, Y; Ikizler, M; Karakaya, A; Ozdemir, C; Sirmagul, B, 2007) |
"Fifty-eight patients were randomized into three groups to compare papaverine's ability to prevent spasm and to treat established spasm." | 5.11 | Papaverine delivery to the internal mammary artery pedicle effectively treats spasm. ( Crawford, FA; Crumbley, AJ; Girard, DS; Kratz, JM; Sutton, JP; Williams, TH; Zellner, JL, 2004) |
"In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 3.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
"We recommend topical use of papaverine at 37 degrees C to relieve intraoperative spasm of the internal thoracic artery." | 3.69 | Effect of normothermic papaverine to relieve intraoperative spasm of the internal thoracic artery. ( Bilgen, F; Coruh, T; Ozler, A; Serbetçioğlu, A; Tarhan, IA; Yapici, MF, 1996) |
"Spasm and endothelial injury during harvesting of saphenous vein grafts can be prevented by a protocol that involves perivenous infiltration with 37 degrees C papaverine hydrochloride solution prior to skin incision, initial distention of the vein with the same warm papaverine solution, storage of the distended vein graft in a cold papaverine solution, and maintenance of the vein in the distended state throughout the operative procedure." | 3.67 | A clinical technique for prevention of spasm and preservation of endothelium in saphenous vein grafts. ( Haudenschild, CC; LoGerfo, FW; Quist, WC, 1984) |
" Methods of harvesting generally cause spasm of the vein and it has been shown that preventing the spasm by applying papaverine improves long-term patency." | 3.66 | Early changes in venous arterial autografts: a scanning electron microscope study. ( Belbeck, LW; Gunstensen, J; Julian, J; Richardson, M; Shand, JE, 1983) |
"Papaverine was topically applied on the renal arteries resulting in vasodilation and reperfusion of the kidney." | 2.58 | Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy. ( Cadeddu, JA; Sorokin, I; Stevens, SL, 2018) |
" Thus, the present investigation revealed the phytochemical constituents and explored the detailed pharmacodynamic basis for the curative use of G." | 1.72 | The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the ( Ahmad, W; Amir, M; Ansari, MN; Rehman, NU, 2022) |
"Papaverine has been used to prevent graft spasm, but its effect is short-lived." | 1.35 | Prevention of arterial graft spasm by botulinum toxin: an in-vitro experiment. ( Imaizumi, M; Iwata, H; Murakami, E; Takemura, H, 2009) |
"Vasospasm is known to be present during most microvascular procedures." | 1.27 | Experimental vasospasm. ( Seaber, AV, 1987) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 31 (65.96) | 18.7374 |
1990's | 5 (10.64) | 18.2507 |
2000's | 8 (17.02) | 29.6817 |
2010's | 2 (4.26) | 24.3611 |
2020's | 1 (2.13) | 2.80 |
Authors | Studies |
---|---|
Rehman, NU | 1 |
Ansari, MN | 1 |
Ahmad, W | 1 |
Amir, M | 1 |
Sorokin, I | 1 |
Stevens, SL | 1 |
Cadeddu, JA | 1 |
Sciahbasi, A | 1 |
Cuono, A | 1 |
Marrangoni, A | 1 |
Rigattieri, S | 1 |
Yoshizaki, T | 1 |
Tabuchi, N | 1 |
Toyama, M | 1 |
Murakami, E | 1 |
Iwata, H | 1 |
Imaizumi, M | 1 |
Takemura, H | 1 |
Conant, AR | 1 |
Shackcloth, MJ | 1 |
Oo, AY | 1 |
Chester, MR | 1 |
Simpson, AW | 1 |
Dihmis, WC | 1 |
DAHLBOM, R | 1 |
EDLUND, T | 1 |
EKSTRAND, T | 1 |
LOHI, A | 1 |
ABBEY, P | 1 |
AMOROSO, EC | 2 |
CONNOLLY, JE | 2 |
HADFIELD, GJ | 2 |
KINMONTH, JB | 2 |
LEE, RH | 2 |
HARLACHER, A | 1 |
ARRIGONI-MARTELLI, E | 1 |
KRAMER, M | 1 |
SHEVCHENKO, AI | 1 |
ELLIS, PP | 1 |
LENDE, RA | 1 |
MARKLAND, C | 1 |
BYRNE-QUINN, E | 1 |
MAYERHOFER, E | 1 |
Girard, DS | 1 |
Sutton, JP | 1 |
Williams, TH | 1 |
Crumbley, AJ | 1 |
Zellner, JL | 1 |
Kratz, JM | 1 |
Crawford, FA | 1 |
Sanders, LH | 1 |
Newman, MA | 1 |
Ozdemir, C | 1 |
Ikizler, M | 1 |
Besogul, Y | 1 |
Karakaya, A | 1 |
Sirmagul, B | 1 |
LoGerfo, FW | 1 |
Haudenschild, CC | 1 |
Quist, WC | 1 |
De Maeyer, P | 1 |
Oosterlinck, W | 1 |
De Sy, W | 1 |
Shand, JE | 1 |
Richardson, M | 1 |
Belbeck, LW | 1 |
Julian, J | 1 |
Gunstensen, J | 1 |
Feikes, HL | 1 |
Roberts, AJ | 1 |
Samson, RH | 1 |
Gupta, SK | 1 |
Scher, LA | 1 |
Veith, FJ | 1 |
Bilgen, F | 1 |
Yapici, MF | 1 |
Serbetçioğlu, A | 1 |
Tarhan, IA | 1 |
Coruh, T | 1 |
Ozler, A | 1 |
Erdinc, M | 1 |
Ocal, A | 1 |
Arquilla, B | 1 |
Gupta, R | 1 |
Gernshiemer, J | 1 |
Fischer, M | 1 |
Harrison, WE | 1 |
Mellor, AJ | 1 |
Clark, J | 1 |
Singer, DR | 1 |
Reuse-Blom, S | 1 |
Gabrielian, ES | 1 |
Akopov, SE | 1 |
Ghazarian, AV | 1 |
Hartsock, LA | 1 |
Seaber, AV | 2 |
Urbaniak, JR | 1 |
Valentine, RJ | 1 |
Whelan, TV | 1 |
Meyers, HF | 1 |
Sardo, P | 1 |
Cepich, MS | 1 |
Giulini, SM | 1 |
Zaritsky, A | 1 |
Pollak, S | 1 |
Frideman, P | 1 |
Swarts, Y | 1 |
Maitai, CK | 1 |
Njoroge, DK | 1 |
Munenge, RW | 1 |
Agosti, A | 1 |
Mantovani, P | 1 |
Mori, L | 1 |
Göthlin, J | 1 |
Olin, T | 1 |
Dreikorn, K | 1 |
Beduhn, D | 1 |
Fournier, AM | 1 |
Mourou, M | 1 |
Chiousse, E | 1 |
László, G | 1 |
Kareva, GF | 1 |
Kapp, J | 1 |
Mahaley, MS | 1 |
Odom, GL | 1 |
Filipowski, P | 1 |
Somorjai, K | 1 |
Hahn, F | 1 |
Teschendorf, HJ | 1 |
Kretzschmar, R | 1 |
Gossow, U | 1 |
Glanzmann, C | 1 |
Upson, JF | 1 |
Harrod, DB | 1 |
Tanaka, T | 1 |
Smyth, EH | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention[NCT02832115] | Phase 4 | 100 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Change in Radial artery cross sectional area in mm^2 - Before application of topical nitroglycerine / placebo (Pre dilation) vs Prior to arterial puncture after application of topical nitroglycerine / placebo (Post-dilation) (NCT02832115)
Timeframe: Application of nitroglycerine / placebo until prior to arterial puncture. Approximate 60 to 120 minutes
Intervention | mm^2 (Mean) |
---|---|
Study | 2.5 |
Control | -0.2 |
Need to abort procedure or convert to transfemoral access (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | Participants (Count of Participants) |
---|---|
Study | 0 |
Control | 4 |
Patient discomfort or pain during procedure measured using Visual analog scale 0-10, 0 being no discomfort or pain (best) and 10 being worst discomfort or pain (worst) (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | score on a scale (Mean) |
---|---|
Study | 0.792 |
Control | 0.875 |
"Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more. Radial artery spasm score is sum of:~Intraprocedural pain in the forearm aggravated by movement of the catheter/sheath - Absent :0; Present:1~Difficulty in manipulating the catheter- Absence :0; Present:1~Difficulty with sheath removal: Absent: 0; Present:1~Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail- No:0; Yes:1" (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
Intervention | Participants (Count of Participants) |
---|---|
Study | 8 |
Control | 15 |
Radial pulse at end of procedure 0- 4+, 0 indicating no palpable pulse (worst); 1 + indicating a faint, but detectable pulse; 2 + suggesting a slightly more diminished pulse than normal; 3 + is a normal pulse; and 4 + indicating a bounding pulse (best). (NCT02832115)
Timeframe: At the end of transradial cardiac catheterization after sheath removal
Intervention | score on a scale (Mean) |
---|---|
Study | 2.208333333 |
Control | 2.166666667 |
1 review available for papaverine and Spasm
Article | Year |
---|---|
Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy.
Topics: Adult; Humans; Intraoperative Complications; Ischemia; Kidney; Kidney Diseases; Male; Nephrectomy; P | 2018 |
3 trials available for papaverine and Spasm
Article | Year |
---|---|
Papaverine delivery to the internal mammary artery pedicle effectively treats spasm.
Topics: Arterial Occlusive Diseases; Female; Humans; Injections; Internal Mammary-Coronary Artery Anastomosi | 2004 |
An alternative agent for radial arterial graft spasm: application of topical iloprost.
Topics: Administration, Topical; Aged; Arterial Occlusive Diseases; Coronary Artery Bypass; Diltiazem; Dose- | 2007 |
[Study of the effectivenss of Halidor on surgical patients].
Topics: Cholelithiasis; Clinical Trials as Topic; Cycloheptanes; Fumarates; Humans; Kidney Calculi; Morphine | 1968 |
43 other studies available for papaverine and Spasm
Article | Year |
---|---|
The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the
Topics: Animals; Antidiarrheals; Diarrhea; Fruit; Gas Chromatography-Mass Spectrometry; Grewia; Jejunum; Mic | 2022 |
Papaverine use for radial artery sheath entrapment.
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Papaverine; Percutaneous Coronary Interv | 2019 |
Verapamil and nitroglycerin improves the patency rate of radial artery grafts.
Topics: Administration, Topical; Aged; Coronary Artery Bypass; Drug Combinations; Female; Graft Occlusion, V | 2008 |
Prevention of arterial graft spasm by botulinum toxin: an in-vitro experiment.
Topics: Animals; Aorta, Abdominal; Aortic Diseases; Botulinum Toxins; Cardiovascular Agents; Dose-Response R | 2009 |
Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators.
Topics: Adrenergic alpha-Agonists; Aged; Angiotensin II; Coronary Artery Bypass; Diltiazem; Dose-Response Re | 2003 |
The activity of 10-amino-acylphenothiazines, basically substituted derivatives of phenothiazine-10-carboxylic acid, atropine, papaverine and some other spasmolytic drugs against barium- and acetylcholine-induced spasms of guinea-pig and rat ileum.
Topics: Acetylcholine; Animals; Atropine; Barium; Carboxylic Acids; Guinea Pigs; Ileum; Muscle Relaxants, Ce | 1953 |
Use of papaverine in traumatic arterial spasm after supracondylar fracture of humerus.
Topics: Fractures, Bone; Humans; Humeral Fractures; Humerus; Papaverine; Spasm | 1955 |
Traumatic arterial spasm; its relief in man and in monkeys.
Topics: Animals; Arteries; Disease; Haplorhini; Humans; Male; Papaverine; Spasm; Vascular Diseases | 1956 |
Traumatic arterial spasm; its relief in man and in monkeys.
Topics: Animals; Arteries; Disease; Haplorhini; Humans; Male; Papaverine; Spasm; Vascular Diseases | 1956 |
Traumatic arterial spasm; its relief in man and in monkeys.
Topics: Animals; Arteries; Disease; Haplorhini; Humans; Male; Papaverine; Spasm; Vascular Diseases | 1956 |
Traumatic arterial spasm; its relief in man and in monkeys.
Topics: Animals; Arteries; Disease; Haplorhini; Humans; Male; Papaverine; Spasm; Vascular Diseases | 1956 |
[Postoperative use of the spasmolytic parinokhellin in thoracic surgery].
Topics: Humans; Khellin; Papaverine; Parasympatholytics; Postoperative Period; Spasm; Thoracic Surgery; Thor | 1957 |
[Comparative studies of spasmolytic activity in vitro and in vivo].
Topics: Atropine; In Vitro Techniques; Muscle Relaxants, Central; Papaverine; Parasympatholytics; Scopolamin | 1958 |
[The effect of various pharmacological substances on the response of smooth muscle to direct electrical stimulation].
Topics: Anticonvulsants; Atropine; Diphenhydramine; Diphenylacetic Acids; Electric Stimulation; Epinephrine; | 1962 |
INDUCED SPASM IN THE RETINAL ARTERIOLES OF CATS. II. INFLUENCES OF PHYSICAL FACTORS AND DRUGS.
Topics: Arterioles; Caffeine; Cats; Epinephrine; Histamine; Neostigmine; Niacinamide; Norepinephrine; Papave | 1964 |
RENAL ARTERY SPASM.
Topics: Animals; Histology; Kidney; Papaverine; Procaine; Rabbits; Renal Artery; Research; Spasm; Vascular D | 1964 |
PROLONGED ARTERIOSPASM AFTER OVERDOSE OF ORAL ERGOTAMINE TARTRATE IN MIGRAINE.
Topics: Anticoagulants; Arteries; Ergotamine; Humans; Migraine Disorders; Papaverine; Poisoning; Spasm; Toxi | 1964 |
[36 years' experience with the use of papaverine in the treatment of pyloric spasm in younger infants and in the newborn].
Topics: Humans; Infant; Infant, Newborn; Papaverine; Pylorus; Spasm | 1951 |
Intractable postoperative internal thoracic artery spasm managed with angiographic intraluminal papaverine.
Topics: Aged; Aged, 80 and over; Female; Humans; Injections, Intra-Arterial; Internal Mammary-Coronary Arter | 2005 |
A clinical technique for prevention of spasm and preservation of endothelium in saphenous vein grafts.
Topics: Blood Vessel Prosthesis; Humans; Microscopy, Electron, Scanning; Papaverine; Saphenous Vein; Spasm; | 1984 |
Prevention of vasospasms during extensive renal surgery. An experimental study in rats.
Topics: Animals; Kidney; Male; Mannitol; Papaverine; Perfusion; Phenoxybenzamine; Preoperative Care; Rats; R | 1981 |
Early changes in venous arterial autografts: a scanning electron microscope study.
Topics: Animals; Arteries; Dogs; Endothelium; Female; Male; Microscopy, Electron, Scanning; Papaverine; Spas | 1983 |
Harvesting and protection of the saphenous vein associated with early delivery of blood cardioplegia in coronary artery bypass graft surgery.
Topics: Constriction; Coronary Artery Bypass; Heart Arrest, Induced; Humans; Myocardial Revascularization; P | 1982 |
Arterial spasm complicating distal vascular bypass procedures.
Topics: Aged; Arteries; Female; Humans; Leg; Male; Middle Aged; Papaverine; Postoperative Complications; Rad | 1982 |
Effect of normothermic papaverine to relieve intraoperative spasm of the internal thoracic artery.
Topics: Administration, Topical; Adult; Aged; Blood Flow Velocity; Coronary Artery Bypass; Female; Humans; I | 1996 |
Internal thoracic artery spasm and normothermic papaverine.
Topics: Coronary Artery Bypass; Humans; Hypothermia; Mammary Arteries; Papaverine; Spasm; Vasoconstriction; | 1997 |
Acute arterial spasm in an extremity caused by inadvertent intra-arterial injection successfully treated in the emergency department.
Topics: Adult; Alcohol Withdrawal Delirium; Angiography; Anti-Anxiety Agents; Arm; Brachial Artery; Chlordia | 2000 |
Vasodilator pre-treatment of human radial arteries; comparison of effects of phenoxybenzamine vs papaverine on norepinephrine-induced contraction in vitro.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Papaverine; P | 2001 |
Action of papaverine on serum-induced spasms in cerebral arterioles.
Topics: Animals; Arterioles; Blood; Cerebrovascular Circulation; Papaverine; Rabbits; Spasm; Time Factors; V | 1979 |
Cerebral-artery spasm in vitro.
Topics: Arteriosclerosis; Cerebral Arteries; Dinoprost; Humans; In Vitro Techniques; Muscle Contraction; Nif | 1990 |
Inhibition of epinephrine-induced vasospasm with adrenoreceptor blockade in the rat cremaster muscle.
Topics: Animals; Arteries; Epinephrine; Male; Muscles; Papaverine; Phentolamine; Rats; Receptors, Adrenergic | 1991 |
Nonocclusive mesenteric ischemia in renal patients: recognition and prevention of intestinal gangrene.
Topics: Aged; Humans; Infarction; Intestines; Ischemia; Kidney Failure, Chronic; Male; Mesenteric Arteries; | 1990 |
Experimental vasospasm.
Topics: Animals; Electromagnetic Phenomena; Lidocaine; Microsurgery; Muscles; Papaverine; Parasympatholytics | 1987 |
[Diagnostic and therapeutic role of angiography in acute vascular insufficiency of the superior mesenteric artery].
Topics: Aged; Embolism; Female; Humans; Injections, Intra-Arterial; Male; Mesenteric Arteries; Mesenteric Va | 1988 |
[Reactive vasospasm in the newborn treated by papaverine infusion].
Topics: Catheterization; Humans; Infant, Low Birth Weight; Infant, Newborn; Infusions, Intra-Arterial; Ische | 1987 |
A comparative study of two antispasmodic products: Buscopan and NO-Spa.
Topics: Animals; Butylscopolammonium Bromide; Disease Models, Animal; Guinea Pigs; Ileal Diseases; Papaverin | 1985 |
Action of caerulein and related substances on the sphincter of Oddi.
Topics: Ampulla of Vater; Animals; Bile Ducts; Cattle; Cholecystokinin; Depression, Chemical; Drug Antagonis | 1971 |
Traumatic arterial spasm. An angiographic study in rabbits.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Anesthesia, Conduction; Anesthetics, Local; | 1970 |
[Treatment of renal vasospasm in shock (author's transl)].
Topics: Angiography; Animals; Cadaver; Dogs; Humans; Kidney; Kidney Transplantation; Papaverine; Phenoxybenz | 1973 |
[Nafditrofuryl and carotid spasms].
Topics: Carotid Artery Diseases; Cerebral Angiography; Child; Diagnosis, Differential; Ethylamines; Furans; | 1972 |
[The effect of pharmacologic agents coronary circulation in experimental spasms of heart vessels].
Topics: Animals; Blood Circulation; Cats; Coronary Vessels; Methods; Morphine; Nitroglycerin; Papaverine; Ph | 1963 |
Experimental evaluation of potential spasmolytic drugs.
Topics: Animals; Cats; Choline; Isosorbide Dinitrate; Magnesium Sulfate; Papaverine; Parasympatholytics; Pho | 1970 |
[The antiallergic activity of tritoqualine].
Topics: Anaphylaxis; Animals; Asthma; Barium; Benzofurans; Gastric Juice; Guinea Pigs; Heart; Histamine; Ile | 1970 |
The influence of spasm on small arterial anastomoses.
Topics: Animals; Arteries; Brachial Artery; Dogs; Femoral Artery; Papaverine; Spasm; Sympathectomy | 1968 |
[Experimental study on cerebral angiospasm, with special reference to the intracranial vertebro-basilar system].
Topics: Acetylcholine; Animals; Basilar Artery; Cats; Cerebral Angiography; Mesenteric Arteries; Papaverine; | 1968 |
Major arterial injury in closed fracture of the neck of the humerus. Report of a case.
Topics: Aged; Amputation, Surgical; Arm; Axillary Artery; Brachial Artery; Female; Forearm; Gangrene; Humans | 1969 |