papaverine has been researched along with Sepsis in 4 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate the effect of papaverine on RAGE associated NF-κB pathway by determining the level of soluble RAGE (sRAGE) and HMGB1, and to support this hypothesis by evaluating inflammatory biochemical, oxidative stress markers, Hounsfield unit (HU) value in computed tomography (CT), and histo-pathological results." | 8.31 | Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology. ( Elgörmüş, ÇS; Erbaş, O; Gür, SG; Özkul, B; Sever, İH; Yiğittürk, G, 2023) |
| "Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate the effect of papaverine on RAGE associated NF-κB pathway by determining the level of soluble RAGE (sRAGE) and HMGB1, and to support this hypothesis by evaluating inflammatory biochemical, oxidative stress markers, Hounsfield unit (HU) value in computed tomography (CT), and histo-pathological results." | 4.31 | Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology. ( Elgörmüş, ÇS; Erbaş, O; Gür, SG; Özkul, B; Sever, İH; Yiğittürk, G, 2023) |
| "Papaverine was found to directly inhibit HMGB1/RAGE interaction." | 1.51 | Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses. ( Abe, H; Abe, T; Inada, M; Inoue, S; Nakajima, S; Ogawa, N; Oyama, T; Sato, A; Shibasaki, H; Suzuki, Y; Takasawa, R; Tamada, K; Tanuma, S; Watanabe, N; Yokomizo, T; Yoshimori, A, 2019) |
| "The patient also suffered from septicemia caused by Enterococcus faecium." | 1.42 | Non-occlusive mesenteric ischemia after splenic metastasectomy for small-cell lung cancer. ( Fukuda, N; Honda, Y; Kawamoto, H; Mimura, H; Monobe, Y; Naomoto, Y; Nishino, K; Ochi, N; Takigawa, N; Yamagishi, T; Yamane, H; Yoshida, K, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Özkul, B | 1 |
| Sever, İH | 1 |
| Yiğittürk, G | 1 |
| Elgörmüş, ÇS | 1 |
| Gür, SG | 1 |
| Erbaş, O | 1 |
| Tamada, K | 1 |
| Nakajima, S | 1 |
| Ogawa, N | 1 |
| Inada, M | 1 |
| Shibasaki, H | 1 |
| Sato, A | 1 |
| Takasawa, R | 1 |
| Yoshimori, A | 1 |
| Suzuki, Y | 1 |
| Watanabe, N | 1 |
| Oyama, T | 1 |
| Abe, H | 1 |
| Inoue, S | 1 |
| Abe, T | 1 |
| Yokomizo, T | 1 |
| Tanuma, S | 1 |
| Yamane, H | 1 |
| Fukuda, N | 1 |
| Nishino, K | 1 |
| Yoshida, K | 1 |
| Ochi, N | 1 |
| Yamagishi, T | 1 |
| Honda, Y | 1 |
| Kawamoto, H | 1 |
| Monobe, Y | 1 |
| Mimura, H | 1 |
| Naomoto, Y | 1 |
| Takigawa, N | 1 |
| McCALL, ML | 1 |
| FINCH, V | 1 |
| TAYLOR, HW | 1 |
4 other studies available for papaverine and Sepsis
| Article | Year |
|---|---|
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology.
Topics: Acute Lung Injury; Animals; C-Reactive Protein; HMGB1 Protein; Lactic Acid; Papaverine; Radiology; R | 2023 |
Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.
Topics: Animals; Anti-Inflammatory Agents; Female; HMGB1 Protein; Inflammation; Interleukin-6; Mice; Mice, I | 2019 |
Non-occlusive mesenteric ischemia after splenic metastasectomy for small-cell lung cancer.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Asian People; Fatal Outcome; Humans; Japan; Lung Neopla | 2015 |
The cerebral effects of papaverine hydrochloride in toxemia of pregnancy.
Topics: Brain; Female; Humans; Papaverine; Pre-Eclampsia; Pregnancy; Sepsis; Toxemia | 1951 |