papaverine has been researched along with Seizures in 15 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "IA papaverine-induced seizures are infrequently reported." | 8.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| " The effects of papaverine, an adenosine uptake inhibitor, were tested against theophylline-induced seizures." | 7.67 | Proconvulsant effect of papaverine on theophylline-induced seizures in rats. ( Ramzan, I, 1989) |
| "IA papaverine-induced seizures are infrequently reported." | 4.81 | Intra-arterial papaverine-induced seizures: case report and review of the literature. ( Carhuapoma, JR; Hanley, DF; Mathis, JM; Qureshi, AI; Tamargo, RJ, 2001) |
| " The effects on amygdala-triggered seizures of papaverine, adenosine, 2-chloroadenosine, and the adenosine antagonists, isobutylmethylxanthine and caffeine, were also investigated at seizure threshold." | 3.67 | Adenosine modulation of amygdala kindling. ( Dragunow, M; Goddard, GV, 1984) |
| " The effects of papaverine, an adenosine uptake inhibitor, were tested against theophylline-induced seizures." | 3.67 | Proconvulsant effect of papaverine on theophylline-induced seizures in rats. ( Ramzan, I, 1989) |
| "Papaverine is a vasodilator agent that is an opium alkaloid." | 1.48 | Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats. ( Cokluk, C; Him, A; Kocacan, SE; Kuruoglu, E; Marangoz, AH; Marangoz, C, 2018) |
| "Changes of hippocampal EEF seizure activity elicited by electrical stimulation of the hippocampus or penicillin injection into the hippocampus were investigated under the effect of locally applied drugs influencing the cAMP level in the brain." | 1.26 | Effects of drugs influencing the cAMP level on hippocampal seizure activity. ( Hartmann, G; Lissák, K; Ludvig, N; Varga, A, 1981) |
| "Papaverine in low doses was ineffective, but in higher doses lowered PSAT; it antagonized the effect of GAMA, elevating the threshold." | 1.26 | [Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam]. ( Georgiev, V, 1978) |
| "Paperine slightly lowers the convulsive-seizure reactivity only in pentylenetetrazol convulsions." | 1.26 | Experimental study of the effects of imidazol, papaverine and histamine on convulsive-seizure reactivity. ( Atanassova-Shopova, S; Lazarova, M; Roussinov, KS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marangoz, AH | 1 |
| Kocacan, SE | 1 |
| Him, A | 1 |
| Kuruoglu, E | 1 |
| Cokluk, C | 1 |
| Marangoz, C | 1 |
| YERASIMIDES, TG | 1 |
| MARGOLIS, G | 1 |
| PONTON, HJ | 1 |
| MERCIER, J | 1 |
| Scanlon, A | 1 |
| Ludvig, N | 1 |
| Varga, A | 1 |
| Hartmann, G | 1 |
| Lissák, K | 1 |
| Dragunow, M | 2 |
| Goddard, GV | 1 |
| Marques, EP | 1 |
| Gil, F | 1 |
| Proen"ca, P | 1 |
| Monsanto, P | 1 |
| Oliveira, MF | 1 |
| Castanheira, A | 1 |
| Vieira, DN | 1 |
| Carhuapoma, JR | 1 |
| Qureshi, AI | 1 |
| Tamargo, RJ | 1 |
| Mathis, JM | 1 |
| Hanley, DF | 1 |
| Georgiev, V | 1 |
| Roussinov, KS | 1 |
| Lazarova, M | 1 |
| Atanassova-Shopova, S | 1 |
| Ramzan, I | 1 |
| Babbini, M | 1 |
| Torrielli, MV | 1 |
| Suchowsky, GK | 1 |
| Pegrassi, L | 1 |
| Bonsignori, A | 1 |
| Bertazzoli, C | 1 |
| Chieli, T | 1 |
| Meyer, JS | 1 |
| Gotoh, F | 1 |
2 reviews available for papaverine and Seizures
| Article | Year |
|---|---|
Aneurysmal subarachnoid haemorrhage--Part 2: Post-operative nursing management diagnosis, complications and treatment: a composite case study.
Topics: Angioplasty, Balloon; Brain Edema; Female; Humans; Hydrocephalus; Infusions, Intra-Arterial; Intracr | 2004 |
Intra-arterial papaverine-induced seizures: case report and review of the literature.
Topics: Adult; Angioplasty, Balloon; Carotid Artery, Internal; Female; Humans; Infusions, Intra-Arterial; Mi | 2001 |
13 other studies available for papaverine and Seizures
| Article | Year |
|---|---|
Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats.
Topics: Animals; Convulsants; Epilepsy; Female; Papaverine; Penicillins; Rats; Rats, Wistar; Seizures; Vasod | 2018 |
PROPHYLAXIS OF EXPERIMENTAL CONTRAST MEDIUM INJURY TO THE SPINAL CORD BY VASODEPRESSOR DRUGS.
Topics: Acetrizoic Acid; Angiography; Blood Circulation; Blood Pressure; Blood Pressure Determination; Contr | 1963 |
[Effect on audiogenic seizure of white rat of some natural or synthetic alkaloids derived from opium: morphine, dihydro-oxycodeinone, papaverine].
Topics: Alkaloids; Animals; Epilepsy; Epilepsy, Reflex; Morphine; Opium; Papaverine; Rats; Seizures | 1950 |
Effects of drugs influencing the cAMP level on hippocampal seizure activity.
Topics: Animals; Bucladesine; Cyclic AMP; Electric Stimulation; Electroencephalography; Hippocampus; Histami | 1981 |
Adenosine modulation of amygdala kindling.
Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Amygdala; Animals; Caffeine; Differential Threshold; Ki | 1984 |
Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports.
Topics: Acids; Fatal Outcome; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Papav | 2000 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Amino | 1978 |
Experimental study of the effects of imidazol, papaverine and histamine on convulsive-seizure reactivity.
Topics: Animals; Electric Stimulation; Histamine; Imidazoles; Male; Mice; Papaverine; Pentylenetetrazole; Ra | 1976 |
Proconvulsant effect of papaverine on theophylline-induced seizures in rats.
Topics: Animals; Behavior, Animal; Convulsants; Male; Papaverine; Rats; Rats, Inbred Strains; Seizures; Theo | 1989 |
Time-dependent effects of papaverine on electrically induced seizures in rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Hippocampus; Kindling, Neurologic; Male; Papaverine; | 1987 |
Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination.
Topics: Animals; Azepines; Benzene Derivatives; Diphenylacetic Acids; Drug Synergism; Female; Gallbladder; G | 1972 |
Some pharmacological properties of 4H-3-methylcarboxamide 1,3-benzoxazine-2-one (FI 6654).
Topics: Acetylcholine; Animals; Antidepressive Agents; Arousal; Atropine; Barium; Duodenum; Electroencephalo | 1969 |
Continuous recording of cerebral metabolism, internal jugular flow and EEG in man.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aged; Aminophylline; Apnea; Blood Flow Velocity; Brain; Ca | 1964 |