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papaverine and Scleroderma, Systemic

papaverine has been researched along with Scleroderma, Systemic in 2 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kristensen, JK2
Henriksen, O2

Other Studies

2 other studies available for papaverine and Scleroderma, Systemic

ArticleYear
Decreased blood flow in a papaverine-induced passive vascular bed in sclerodermal skin.
    Acta dermato-venereologica, 1979, Volume: 59, Issue:2

    Topics: Adult; Aged; Female; Humans; Injections, Intradermal; Male; Middle Aged; Papaverine; Radioisotope Di

1979
Distensibiltiy of the papaverine-induced passive vascular bed in dermis of generalized scleroderma.
    The Journal of investigative dermatology, 1979, Volume: 72, Issue:5

    Topics: Adult; Aged; Blood Vessels; Elasticity; Female; Humans; Male; Middle Aged; Muscle, Smooth; Papaverin

1979