papaverine has been researched along with Reperfusion Injury in 11 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 7.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| "The mechanism of the papaverine (PV) for the treatment of cerebral ischemia remains unclear." | 3.96 | Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury. ( Gu, H; Guan, S; Liu, J; Liu, Q; Qi, YF; Wang, Z; Wei, PL; Zhang, YY, 2020) |
| "This study was undertaken in order to assess the role of purely circulation-related effects upon free-radical-mediated reperfusion injury in the liver by comparing the respective effects of the oxygen free-radical scavenger superoxide dismutase (SOD) and the vasodilative action of papaverine in an ischemia/reperfusion model of the liver." | 3.68 | Role of the hepatovasculature in free radical mediated reperfusion damage of the liver. ( Isselhard, W; Minor, T, 1993) |
| "In the Han:SPRD rat model of autosomal dominant polycystic kidney disease (ADPKD), gene transfer occurred into the vasculature, some epithelial cysts and interstitial cells." | 1.29 | In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. ( Cowley, BD; Nicolson, AG; Rosen, S; Sukhatme, VP; Zhu, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, S | 1 |
| Liu, Q | 1 |
| Gu, H | 1 |
| Zhang, YY | 1 |
| Wei, PL | 1 |
| Qi, YF | 1 |
| Liu, J | 1 |
| Wang, Z | 1 |
| Mastantuono, T | 1 |
| Starita, N | 1 |
| Sapio, D | 1 |
| D'Avanzo, SA | 1 |
| Di Maro, M | 1 |
| Muscariello, E | 1 |
| Paterni, M | 1 |
| Colantuoni, A | 1 |
| Lapi, D | 1 |
| Ersoy, YE | 1 |
| Ayan, F | 1 |
| Himmetoglu, S | 1 |
| Grace, PA | 1 |
| Da Costa, M | 1 |
| Qureshi, A | 1 |
| Sheehan, S | 1 |
| Burke, P | 1 |
| Bouchier-Hayes, D | 1 |
| Andrews, FJ | 1 |
| Malcontenti-Wilson, C | 1 |
| O'Brien, PE | 1 |
| Minor, T | 1 |
| Isselhard, W | 1 |
| Zhu, G | 1 |
| Nicolson, AG | 1 |
| Cowley, BD | 1 |
| Rosen, S | 1 |
| Sukhatme, VP | 1 |
| Bishop, MJ | 1 |
| Kowalski, TF | 1 |
| Guidotti, SM | 1 |
| Harlan, JM | 1 |
| Horgan, MJ | 1 |
| Ge, M | 1 |
| Gu, J | 1 |
| Rothlein, R | 1 |
| Malik, AB | 1 |
| Chazouillères, O | 1 |
| Ballet, F | 1 |
| Chrétien, Y | 1 |
| Marteau, P | 1 |
| Rey, C | 1 |
| Maillard, D | 1 |
| Poupon, R | 1 |
| Chaudry, IH | 1 |
1 review available for papaverine and Reperfusion Injury
| Article | Year |
|---|---|
ATP-MgCl2 and liver blood flow following shock and ischemia.
Topics: Adenosine Triphosphate; Animals; Dopamine; Ischemia; Ligation; Liver Circulation; Magnesium; Magnesi | 1989 |
10 other studies available for papaverine and Reperfusion Injury
| Article | Year |
|---|---|
Pluripotent anti-inflammatory immunomodulatory effects of papaverine against cerebral ischemic-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expressio | 2020 |
The Effects of Vaccinium myrtillus Extract on Hamster Pial Microcirculation during Hypoperfusion-Reperfusion Injury.
Topics: Acetylcholine; Animals; Anthocyanins; Arterioles; Capillary Permeability; Cell Adhesion; Cerebrovasc | 2016 |
Trace element levels in ischemia-reperfusion injury after left colonic anastomosis in rats and effects of papaverine and pentoxiphylline on vascular endothelial growth factor in anastomosis healing.
Topics: Animals; Colon; Female; Papaverine; Pentoxifylline; Rats; Rats, Wistar; Reperfusion Injury; Trace El | 2011 |
An aggressive approach to acute superior mesenteric arterial ischemia.
Topics: Aged; Embolism; Heparin; Humans; Intestines; Intraoperative Care; Male; Mesenteric Artery, Superior; | 1993 |
Protection against gastric ischemia-reperfusion injury by nitric oxide generators.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Cell Movement; Gastric Mucosa; Male; Neutrophils; | 1994 |
Role of the hepatovasculature in free radical mediated reperfusion damage of the liver.
Topics: Adenosine Triphosphate; Animals; Free Radicals; In Vitro Techniques; Liver; Liver Circulation; Liver | 1993 |
In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys.
Topics: Adenoviridae; Animals; beta-Galactosidase; Cold Temperature; Disease Models, Animal; Dopamine; Gene | 1996 |
Antibody against neutrophil adhesion improves reperfusion and limits alveolar infiltrate following unilateral pulmonary artery occlusion.
Topics: Animals; Antibodies, Monoclonal; Arterial Occlusive Diseases; Cell Adhesion; Constriction; Neutrophi | 1992 |
Role of ICAM-1 in neutrophil-mediated lung vascular injury after occlusion and reperfusion.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Capillaries; Cell Adhesion Molecules; Endothelium, Va | 1991 |
Protective effect of vasodilators on liver function after long hypothermic preservation: a study in the isolated perfused rat liver.
Topics: Animals; Bile; Hemodynamics; In Vitro Techniques; Liver; Liver Circulation; Liver Transplantation; M | 1989 |