papaverine has been researched along with Pruritus in 6 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine has been reported, largely on the basis of clinical experience, to reduce the severity of pruritus associated with atopic dermatitis." | 9.06 | Failure of papaverine to reduce pruritus in atopic dermatitis: a double-blind, placebo-controlled cross-over study. ( Berth-Jones, J; Graham-Brown, RA, 1990) |
| "Papaverine has been reported, largely on the basis of clinical experience, to reduce the severity of pruritus associated with atopic dermatitis." | 5.06 | Failure of papaverine to reduce pruritus in atopic dermatitis: a double-blind, placebo-controlled cross-over study. ( Berth-Jones, J; Graham-Brown, RA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| WIRTH, L | 1 |
| MACRIS, SG | 1 |
| SMITH, GM | 1 |
| BEECHER, HK | 1 |
| CORTI, RN | 1 |
| GUILLOT, CF | 1 |
| Berth-Jones, J | 1 |
| Graham-Brown, RA | 1 |
| Hoting, E | 1 |
| Reiss, J | 1 |
| Schulz, KH | 1 |
2 trials available for papaverine and Pruritus
| Article | Year |
|---|---|
Failure of papaverine to reduce pruritus in atopic dermatitis: a double-blind, placebo-controlled cross-over study.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dermatitis, Atopic; Double-Blind Method; Female; H | 1990 |
[Papaverin--effective in therapy of pruritus of atopic dermatitis?].
Topics: Administration, Oral; Dermatitis, Atopic; Dose-Response Relationship, Drug; Humans; Intradermal Test | 1990 |
4 other studies available for papaverine and Pruritus
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Antipruritic qualities of papaverine hydrochloride.
Topics: Antipruritics; Dermatitis, Contact; Humans; Papaverine; Pruritus | 1947 |
Comparison of the antipruritic effect of morphine and papaverine in experimental and pathological itch in man.
Topics: Antipruritics; Humans; Male; Morphine; Papaverine; Pruritus | 1958 |
Papaverine in the treatment of pruritus.
Topics: Papaverine; Pruritus | 1949 |