Page last updated: 2024-11-02

papaverine and Pregnancy

papaverine has been researched along with Pregnancy in 96 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Papaverine exposure was associated with higher rate of preterm delivery (22."5.62Pregnancy outcomes following gestational exposure to papaverine: An observational comparative study. ( Barchel, D; Berkovitch, M; Berlin, M; Braun, A; Gilan, A; Gueta, I; Kohn, E; Loebstein, R; Markovits, N, 2021)
" For both normal pregnancy and pre-eclampsia, the response of pre-constricted arteries to the endothelium-dependent vasodilator, bradykinin, was minimal."3.71Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia. ( Baker, PN; Crocker, IP; Ong, SS; Warren, AY, 2002)
"In drotaverine group, there was a mean 15% reduction in the duration of the first stage of labor and a mean 19% reduction in the second stage."2.71Drotaverine hydrochloride for augmentation of labor. ( Goel, N; Jain, P; Saxena, A; Singh, KC, 2004)
"Papaverine exposure was associated with higher rate of preterm delivery (22."1.62Pregnancy outcomes following gestational exposure to papaverine: An observational comparative study. ( Barchel, D; Berkovitch, M; Berlin, M; Braun, A; Gilan, A; Gueta, I; Kohn, E; Loebstein, R; Markovits, N, 2021)
"Adenosine failed to inhibit hypoxanthine uptake."1.30Hypoxanthine uptake at the fetal side of human placenta proceeds through a nucleobase-preferring carrier and a non-saturable process. ( Acevedo, CG; Bravo, I; Ramírez, M; Rojas, S, 1997)
"Thus pregnancy is associated with a reduced intrinsic tone, possibly because of a reduction in an endothelial constrictor influence on the vascular smooth muscle in isolated rat renal interlobar arteries."1.30Intrinsic tone and passive mechanics of isolated renal arteries from virgin and late-pregnant rats. ( Conrad, KP; Gandley, RE; Griggs, KC; McLaughlin, MK, 1997)
"Since terbutaline treatment in premature labor has been shown to increase phosphodiesterase activity in the myometrium, the phosphodiesterase-inhibiting effect of theophylline and papaverine on myometrial preparations from pregnant women has been studied."1.27In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor? ( Andersson, RG; Berg, G; Rydén, G, 1983)
"Prevention of premature labor is of considerable interest in research and clinics."1.25The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs. ( Mosler, KH, 1975)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-199073 (76.04)18.7374
1990's3 (3.13)18.2507
2000's11 (11.46)29.6817
2010's3 (3.13)24.3611
2020's6 (6.25)2.80

Authors

AuthorsStudies
Domokos, D1
Fülöp, F1
Falkay, G1
Gáspár, R1
Rzymski, P1
Tomczyk, KM1
Wilczak, M1
Ikeotuonye, AC1
Umeora, OJ1
Nwafor, JI1
Ojumah, BO1
Ekwunife, IC1
Dimejesi, IB1
Luhach, K1
Kulkarni, GT1
Singh, VP1
Sharma, B2
Sharma, N1
Dhiman, N1
Golani, LK1
Gueta, I1
Braun, A1
Gilan, A1
Berlin, M1
Kohn, E1
Barchel, D1
Markovits, N1
Berkovitch, M1
Loebstein, R1
Ibis, E1
Hayme, S1
Baysal, E1
Gul, N1
Ozkavukcu, S1
Ibrahim, MI1
Alzeeniny, HA1
Ellaithy, MI1
Salama, AH1
Abdellatif, MA1
Madhu, C1
Mahavarkar, S1
Bhave, S1
Tömösközi, Z1
Finance, O1
Arányi, P1
Ong, SS1
Crocker, IP2
Warren, AY2
Baker, PN2
HECKSCHER, S1
RIEGER, H1
TEN BERGE, B1
VAN ASSEN, FJ1
BAYER, R1
CIUCHTA, HP1
GAUTIERI, RF2
DOMANY, S1
CSEFFALVAY, T1
MORANMIRANDA, F1
GONNELLA, GC1
TOKUDA, G1
INOUE, S1
SOLLA, E1
URANGAIMAZ, FA2
TONNELIER, E1
KLAUER, D1
CHEKERDEMIAN, M1
MARZETTI, L1
BENAGIANO, G1
KOCHSIEK, K1
SCHELER, F1
SANDBERG, F1
INGELMAN-SUNDBERG, A1
LINDGREN L RYDEN, G1
Singh, KC1
Jain, P1
Goel, N1
Saxena, A1
McCALL, ML2
FINCH, V1
TAYLOR, HW2
FINCH, TV1
TIMONEN, S1
SCHRODERUS, KA1
Hammer, ES1
Cipolla, MJ1
Jain, V2
Lim, M1
Longo, M1
Fisk, NM1
Gupta, B1
Nellore, V1
Mittal, S1
Roy, A1
Patra, KK1
Mukhopadhyay, S1
Guha, S1
Mosler, KH5
Zimmer, F1
Castell, R1
Ewald, P1
Büttner, P1
Howard, JM1
Krantz, KE2
Wilde, CJ1
Kuhn, NJ1
Berg, G2
Andersson, RG2
Rydén, G2
Pańczyk, T4
Zrubek, H4
Oleszczuk, J5
Sawulicka-Oleszczuk, H4
Lopucki, M1
Wesołowska-Przystupa, A1
Chamley, WA1
Parkington, HC1
O'Shea, KS1
Bednarek, W1
Weiss, GK1
Dail, WG1
Ratner, A1
Matsumoto, K1
Akimoto, A1
Shibata, K1
Obata, T1
Tsuda, T1
Tsuboshima, M1
Dabek, W1
Otani, T1
Kai, S1
Narushima, M1
Ramírez, M1
Acevedo, CG1
Rojas, S1
Bravo, I1
Gandley, RE1
Griggs, KC1
Conrad, KP1
McLaughlin, MK1
Vedernikov, YP1
Syal, AS1
Okawa, T1
Saade, GR1
Garfield, RE1
Sokal, D1
Hieu, DT1
Weiner, DH1
Vinh, DQ1
Huu Vach, T1
Hanenberg, R1
Sharma, JB1
Pundir, P1
Kumar, A1
Murthy, NS1
Wareing, M1
Taggart, MJ1
Jameson, D1
Buckle, P1
Berić, BM1
Kupresanin, M1
Loizzi, RF1
de Pont, JJ1
Bonting, SL1
Hussa, RO1
Story, MT1
Pattillo, RA1
Kemp, RG1
Ferre, F1
Breuiller, M1
de Pariente, D1
Cedard, L1
Linka, F2
Hruczkowski, L1
Hodgson, BJ2
Parnham, MJ1
Carol, W1
Osa, T1
Maruta, K1
Servin, AL1
Jacquot, C1
Lussiana, JP1
Viel, C1
Marshall, JM4
Kroeger, EA2
Dornhöfer, W1
Ehrhart, J1
Ward, CO1
Marmo, E1
Annunziata, A1
Urban, J1
Czekanowski, R1
Lemke, H1
Oettel, M1
Chemnitius, KH1
Osman, OH1
Ismail, M1
el-Asmar, MF1
Ibrahim, SA1
Coceani, F1
Olley, PM1
Hashimoto, H1
Unemoto, T1
Hayashi, M1
Daniel, EE1
Ash, JF1
Spooner, BS1
Wessells, NK1
Ifrim, M1
Sálájan, V1
Kawahara, Y1
Yamada, S1
Götz, HG1
Diamond, J2
Ferrero, A1
Marzullo, C1
Salmoiraghi, ML1
Erny, R1
Kaern, T1
Schäffer, B1
Sharley, CB1
Dutta, D1
Bhargava, KC1
Chakravarti, RN1
Dhall, SR1
Eliason, BC1
Posner, HS1
Thomsen, K1
Schniewind, H1
Schultze-Mosgau, H1
Krämer, M1
Born, H1
Amon, K1
Amon, I1
Chervinskiĭ, AA1
Kondranin, GV1
Malyshev, IuV1
Polianskiĭ, GN1
Langanke, D1
Keller, J1
Chiara, A1
Maggioni, G1
Hensleigh, PA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of IV PAPAVERINE 80 mg Prior to Catheter Balloon Insertion on Bishop Score and Pain, Double Blinded Randomized Placebo Controlled Trial[NCT05759364]128 participants (Anticipated)Interventional2023-05-15Recruiting
Use of Antispasmodic Drotaverine to Shorten the Length of Labor in Nulliparous Women[NCT01639027]Phase 2/Phase 3352 participants (Actual)Interventional2012-05-31Completed
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for papaverine and Pregnancy

ArticleYear
[Clinical pharmacology in obstetrics: regulation of the uterus].
    Medizinische Klinik, 1975, May-02, Volume: 70, Issue:18

    Topics: Adrenergic beta-Agonists; Aspirin; Ergotamine; Female; Humans; Indomethacin; Methylergonovine; Obste

1975
Tocolytic therapy in obstetrics.
    Journal of perinatal medicine, 1974, Volume: 2, Issue:1

    Topics: Adrenergic beta-Agonists; Cyclic AMP; Ethanol; Female; Hemorrhage; Humans; Monitoring, Physiologic;

1974
[Obstetric drugs. 16].
    Pharmazeutische Praxis, 1967, Volume: 9

    Topics: Analgesics; Ergot Alkaloids; Female; Humans; Labor, Induced; Meperidine; Meprobamate; Muscles; Oxyto

1967

Trials

7 trials available for papaverine and Pregnancy

ArticleYear
Drotaverine to shorten the duration of labour in primigravidas: a randomised, double-blind, placebo-controlled trial.
    African health sciences, 2022, Volume: 22, Issue:3

    Topics: Double-Blind Method; Female; Humans; Infant, Newborn; Labor Pain; Labor, Obstetric; Oxytocin; Papave

2022
Drotaverine to improve progression of labor among nulliparous women.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014, Volume: 124, Issue:2

    Topics: Adult; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Labor Pain; Labor Stage, First; P

2014
Drotaverine to improve progression of labor among nulliparous women.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014, Volume: 124, Issue:2

    Topics: Adult; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Labor Pain; Labor Stage, First; P

2014
Drotaverine to improve progression of labor among nulliparous women.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014, Volume: 124, Issue:2

    Topics: Adult; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Labor Pain; Labor Stage, First; P

2014
Drotaverine to improve progression of labor among nulliparous women.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014, Volume: 124, Issue:2

    Topics: Adult; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Labor Pain; Labor Stage, First; P

2014
A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour.
    Archives of gynecology and obstetrics, 2010, Volume: 282, Issue:1

    Topics: Adult; Cervical Ripening; Cervix Uteri; Female; Humans; Injections, Intramuscular; Labor Stage, Firs

2010
Drotaverine hydrochloride for augmentation of labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2004, Volume: 84, Issue:1

    Topics: Adult; Analgesia, Obstetrical; Analgesics; Cervix Uteri; Double-Blind Method; Female; Humans; Labor

2004
Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2008, Volume: 100, Issue:3

    Topics: Adult; Butylscopolammonium Bromide; Female; Humans; Labor, Obstetric; Papaverine; Parasympatholytics

2008
Study of drotaverine on first stage of labour and pregnancy outcome.
    Journal of the Indian Medical Association, 2007, Volume: 105, Issue:8

    Topics: Drug-Related Side Effects and Adverse Reactions; Female; Humans; Labor Onset; Labor Stage, First; La

2007
Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2001, Volume: 74, Issue:3

    Topics: Cervix Uteri; Female; Humans; Labor, Obstetric; Papaverine; Parasympatholytics; Pregnancy; Quaternar

2001

Other Studies

86 other studies available for papaverine and Pregnancy

ArticleYear
Effects of newly synthetized isoquinoline derivatives on rat uterine contractility and ROCK II activity.
    Bioorganic & medicinal chemistry letters, 2018, 02-01, Volume: 28, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Isoquinolines; Molecular Structure; Pregnancy; Pr

2018
The Influence of Oral Drotaverine Administration on Materno-Fetal Circulation during the Second and Third Trimester of Pregnancy.
    Medicina (Kaunas, Lithuania), 2022, Feb-03, Volume: 58, Issue:2

    Topics: Administration, Oral; Female; Humans; Infant, Newborn; Papaverine; Pregnancy; Pregnancy Trimester, S

2022
Attenuation of neurobehavioural abnormalities by papaverine in prenatal valproic acid rat model of ASD.
    European journal of pharmacology, 2021, Jan-05, Volume: 890

    Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Dose-Response Relationship, Drug; Doublecortin P

2021
Papaverine ameliorates prenatal alcohol-induced experimental attention deficit hyperactivity disorder by regulating neuronal function, inflammation, and oxidative stress.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2021, Volume: 81, Issue:1

    Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cell Survival; Cy

2021
Pregnancy outcomes following gestational exposure to papaverine: An observational comparative study.
    British journal of clinical pharmacology, 2021, Volume: 87, Issue:10

    Topics: Cesarean Section; Female; Gestational Age; Humans; Papaverine; Pregnancy; Pregnancy Outcome; Prematu

2021
Efficacy and safety of papaverine as an in vitro motility enhancer on human spermatozoa.
    Journal of assisted reproduction and genetics, 2021, Volume: 38, Issue:6

    Topics: Acrosome Reaction; Animals; Asthenozoospermia; Cryopreservation; Female; Fertilization in Vitro; Hum

2021
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes.
    European journal of pharmacology, 2002, Aug-02, Volume: 449, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Calciu

2002
Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia.
    Hypertension in pregnancy, 2002, Volume: 21, Issue:3

    Topics: Adult; Analysis of Variance; Arteries; Bradykinin; Chorion; Endothelium, Vascular; Female; Humans; M

2002
Remarks and observation on obstetric analgesia.
    Acta medica Orientalia, 1953, Volume: 12, Issue:2

    Topics: Analgesia, Obstetrical; Female; Humans; Labor, Obstetric; Meperidine; Papaverine; Pregnancy; Work

1953
[Safe mitigation of labor pain by belladonna-exclud suppository].
    Die Medizinische, 1955, Aug-20, Issue:33-34

    Topics: Aminopyrine; Analgesia; Anesthesia; Anesthesia and Analgesia; Atropa belladonna; Barbiturates; Femal

1955
[Diabetes mellitus and pregnancy: labor induction with compositrin].
    Archiv fur Gynakologie, 1957, Volume: 189

    Topics: Cardiovascular Agents; Diabetes Mellitus; Ergot Alkaloids; Female; Humans; Labor, Induced; Labor, Ob

1957
[Testing labor-accelerating substances with an index of effectiveness].
    Medizinische Klinik, 1963, Jul-05, Volume: 58

    Topics: Anesthesia; Anesthesia, Obstetrical; Atropa belladonna; Female; Humans; Labor, Obstetric; Oxytocics;

1963
EFFECT OF CERTAIN DRUGS ON PERFUSED HUMAN PLACENTAS. II. VASODILATORS.
    Journal of pharmaceutical sciences, 1963, Volume: 52

    Topics: Female; Humans; Isoproterenol; Nitroglycerin; Papaverine; Perfusion; Pharmacology; Placenta; Pregnan

1963
[ON THE USE OF CONTINUOUS OXYTOCIN DROP INFUSION IN OBSTETRICS].
    Zentralblatt fur Gynakologie, 1963, Nov-02, Volume: 85

    Topics: Abortion, Induced; Abortion, Spontaneous; Abortion, Threatened; Female; Glucose; Humans; Obstetrics;

1963
[DIFFERENTIAL DIAGNOSIS OF NON-TRAUMATIC COMAS AND THEIR TREATMENT].
    Prensa medica argentina, 1963, Jul-26, Volume: 50

    Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Carbon Dioxide; Cerebrovascular

1963
[THE CERVIX UTERI AND DRUGS FROM THE OBSTETRICAL VIEWPOINT].
    [Sanfujinka chiryo] Obstetrical and gynecological therapy, 1964, Volume: 22

    Topics: Cardiovascular Agents; Cervix Uteri; Dihydroergotoxine; Ergot Alkaloids; Estriol; Female; Humans; Hy

1964
[OUR PRINCIPLES OF THERAPY IN MEDICATION IN LABOR (FURTHER OBSERVATIONS ON SERPASIL)].
    Minerva ginecologica, 1964, Mar-31, Volume: 16

    Topics: Ergonovine; Female; Humans; Labor, Obstetric; Papaverine; Pharmacology; Pregnancy; Quinine; Reserpin

1964
[THERAPEUTICS OF ARTERIAL HYPERTENSION IN PREGNANCY].
    Revista de la Asociacion Medica Argentina, 1964, Volume: 78

    Topics: Female; Guanethidine; Hibernation; Humans; Hydralazine; Hypertension; Hypothermia, Induced; Maternal

1964
[CLINICAL EVALUATION OF THE USE OF A DRUG WITH FIBRINOLYTIC ACTION IN THE THERAPY OF GESTOSIS IN THE THIRD TRIMESTER].
    La Clinica ostetrica e ginecologica, 1964, Volume: 66

    Topics: Antihypertensive Agents; Diuretics; Drug Therapy; Female; Humans; Niacin; Nicotinic Acids; Papaverin

1964
[Comparative experimental studies on drugs with peripheral vascular effects with special reference to a placental extract].
    Arzneimittel-Forschung, 1962, Volume: 12

    Topics: Acetylcholine; Female; Papaverine; Placenta; Placental Extracts; Pregnancy

1962
In vitro studies of the motility of the human uterus. VI. The effects of papaverine, atropine, pethidine, relaxin and spasmaverin on the spontaneous motility on different parts of the pregnant and non-pregnant uterus.
    The Journal of obstetrics and gynaecology of the British Empire, 1961, Volume: 68

    Topics: Atropine; Female; Humans; In Vitro Techniques; Meperidine; Muscle Relaxants, Central; Musculoskeleta

1961
The cerebral effects of papaverine hydrochloride in toxemia of pregnancy.
    American journal of obstetrics and gynecology, 1951, Volume: 61, Issue:2

    Topics: Brain; Female; Humans; Papaverine; Pre-Eclampsia; Pregnancy; Sepsis; Toxemia

1951
The cerebral effects of papaverine hydrochloride in toxemia of pregnancy.
    Transactions & studies of the College of Physicians of Philadelphia, 1951, Volume: 18, Issue:4

    Topics: Cerebral Arteries; Cerebral Veins; Female; Humans; Papaverine; Pre-Eclampsia; Pregnancy; Veins

1951
The effect of papaverin on the circulation of pre-eclamptic and eclamptic patients.
    Acta obstetricia et gynecologica Scandinavica, 1950, Volume: 29, Issue:4

    Topics: Eclampsia; Female; Humans; Papaverine; Pre-Eclampsia; Pregnancy

1950
Arterial wall hyperplasia is increased in placental compared with myoendometrial radial uterine arteries from late-pregnant rats.
    American journal of obstetrics and gynecology, 2005, Volume: 192, Issue:1

    Topics: Animals; Arteries; Case-Control Studies; Female; Hyperplasia; Muscle, Smooth, Vascular; Myometrium;

2005
Inhibitory effect of erythropoietin on contractility of human chorionic plate vessels.
    American journal of obstetrics and gynecology, 2006, Volume: 194, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arteries; Chorion; Enzyme

2006
Tocolysis.
    Bibliotheca gynaecologica, 1966, Volume: 42

    Topics: Animals; Chlordiazepoxide; Diazepam; Female; Guinea Pigs; Humans; In Vitro Techniques; Muscle Contra

1966
[Significance of the enlargement of the pregnant rat uterus in wall tension, elasticity and function of the myometrium].
    Archiv fur Gynakologie, 1966, Volume: 203, Issue:3

    Topics: Animals; Elasticity; Female; Muscle Contraction; Papaverine; Pregnancy; Pregnancy, Animal; Rats; Ute

1966
Transfer and use of glucose in the human placenta during in vitro perfusion and the associated effects of oxytocin and papaverine.
    American journal of obstetrics and gynecology, 1967, Jun-15, Volume: 98, Issue:4

    Topics: Biological Transport; Blood Glucose; Dialysis; Erythrocytes; Female; Glucose; Humans; In Vitro Techn

1967
Lactose synthesis and the utilisation of glucose by rat mammary acini.
    The International journal of biochemistry, 1981, Volume: 13, Issue:3

    Topics: Animals; Bucladesine; Cyclic AMP; Female; Glucose; Intracellular Fluid; Lactation; Lactose; Mammary

1981
In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor?
    American journal of obstetrics and gynecology, 1983, Apr-01, Volume: 145, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Drug Interactions; Female; Humans; Muscle Relaxation; My

1983
[Metabolism of triglycerides of the placenta during extraorganic circulation].
    Zentralblatt fur Gynakologie, 1984, Volume: 106, Issue:20

    Topics: Energy Metabolism; Female; Humans; Maternal-Fetal Exchange; Metaproterenol; Papaverine; Perfusion; P

1984
Relaxin inhibits the plateau component of the action potential in the circular myometrium of the rat.
    The Journal of physiology, 1984, Volume: 353

    Topics: Action Potentials; Animals; Calcium; Dinoprost; Female; In Vitro Techniques; Isoproterenol; Membrane

1984
Calcium and neural tube closure defects: an in vitro study.
    Birth defects original article series, 1982, Volume: 18, Issue:3 Pt A

    Topics: Animals; Calcimycin; Calcium; Central Nervous System; Female; Mice; Neural Tube Defects; Papaverine;

1982
[Energetic metabolism of the placenta and vascular blood flow as criteria for the choice of drugs in risk pregnancy--results of our investigations].
    Zentralblatt fur Gynakologie, 1983, Volume: 105, Issue:1

    Topics: Female; Humans; Metaproterenol; Papaverine; Placenta; Pregnancy; Pressure; Risk; Vascular Resistance

1983
Evidence for direct neural control of ovarian steroidogenesis in rats.
    Journal of reproduction and fertility, 1982, Volume: 65, Issue:2

    Topics: Animals; Diestrus; Electric Stimulation; Female; Ovary; Papaverine; Phentolamine; Pregnancy; Progest

1982
[Effects of 16,16-dimethyl-trans-delta 2-PGE1 methyl ester (ONO-802) on uterine motility (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 78, Issue:4

    Topics: Alprostadil; Animals; Cricetinae; Dose-Response Relationship, Drug; Female; Papaverine; Pregnancy; P

1981
[Metabolic capacity of human placenta with regard to carbohydrate metabolism under the effect of orciprenaline and papaverine under experimental conditions].
    Ginekologia polska, 1980, Volume: 51, Issue:2

    Topics: Female; Humans; In Vitro Techniques; Lactates; Metaproterenol; Oxidation-Reduction; Papaverine; Perf

1980
[Effect of orciprenaline and papaverine on glucose ultilization in the placenta, perfused in vitro].
    Ginekologia polska, 1980, Volume: 51, Issue:4

    Topics: Dose-Response Relationship, Drug; Female; Glucose; Humans; In Vitro Techniques; Metaproterenol; Papa

1980
Ejaculation obtained by intracavernous papaverine in a cervical spinal cord injury patient resulting in pregnancy and childbirth. Case report.
    Paraplegia, 1994, Volume: 32, Issue:3

    Topics: Adult; Ejaculation; Electric Stimulation; Female; Humans; Injections; Male; Papaverine; Penis; Pregn

1994
Hypoxanthine uptake at the fetal side of human placenta proceeds through a nucleobase-preferring carrier and a non-saturable process.
    Placenta, 1997, Volume: 18, Issue:4

    Topics: Adenine; Adenosine; Biological Transport; Blood Flow Velocity; Female; Fetus; Guanine; Humans; Hypox

1997
Intrinsic tone and passive mechanics of isolated renal arteries from virgin and late-pregnant rats.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Animals; Endothelium, Vascular; Female; In Vitro Techniques; Muscle Tonus; Muscle, Smooth, Vascular;

1997
The role of cyclic nucleotides in the spontaneous contractility and responsiveness to nitric oxide of the rat uterus at midgestation and term.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Female; Guanylate Cyclase;

2000
Long-term follow-up after quinacrine sterilization in Vietnam. Part I: interim efficacy analysis.
    Fertility and sterility, 2000, Volume: 74, Issue:6

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Cohort Studies; Delayed-Action Preparatio

2000
Characterization of small arteries isolated from the human placental chorionic plate.
    Placenta, 2002, Volume: 23, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arteries; Chorionic Villi

2002
A comparison of anti-inflammatory and other compounds on the spontaneously contracting pregnant rat uterus.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Chlorpromazine; Desipramine; Diazepam; Female; In Vitro Technique

1977
[Legal abortion during the first trimester of pregnancy at the University Hospital for Women in Novi Sad (1960-1975)].
    Zentralblatt fur Gynakologie, 1977, Volume: 99, Issue:6

    Topics: Abortion, Therapeutic; Atropine; Female; Hospitals, University; Humans; Muscle Relaxation; Papaverin

1977
Inhibition by cyclic AMP of lactose production in lactating guinea pig mammary gland slices.
    Biochimica et biophysica acta, 1975, May-05, Volume: 392, Issue:1

    Topics: Animals; Bucladesine; Colchicine; Cyclic AMP; Cytochalasin B; Dose-Response Relationship, Drug; Epin

1975
Effect of cyclic 3':5'-AMP derivatives prostaglandins and related agents on human chorionic gonadotropin secretion in human malignant trophoblast in culture.
    In vitro, 1977, Volume: 13, Issue:7

    Topics: Adenine; Adenylyl Cyclases; Bucladesine; Cell Line; Chorionic Gonadotropin; Cyclic AMP; Female; Fluo

1977
[3'5'-Cyclic AMP phosphodiesterase activity in the internal and external layers of human myometrium at the end of pregnancy].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Jul-04, Volume: 285, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Caffeine; Female; Humans; Imidazoles; Indomethacin; Kinetics; M

1977
The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Drug Therapy, Combina

1975
[Effect of orciprenaline and papaverine on the pressure during the perfusion of the human placenta in experimental conditions].
    Ginekologia polska, 1978, Volume: 49, Issue:6

    Topics: Female; Humans; Metaproterenol; Papaverine; Placenta; Pregnancy; Pressure

1978
Effect of isoproterenol on uptake of calcium-45 by pregnant human and rat myometrium.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 14, Issue:1

    Topics: Animals; Calcium; Calcium Radioisotopes; Female; Humans; In Vitro Techniques; Isoproterenol; Lithium

1976
The effect of metyrapone on uterine prostaglandin output and smooth muscle activity.
    European journal of pharmacology, 1976, Volume: 40, Issue:2

    Topics: Animals; Female; Ileum; In Vitro Techniques; Isoproterenol; Metyrapone; Muscle, Smooth; Papaverine;

1976
[Obstetrical emergencies, concerning the mother].
    Zeitschrift fur arztliche Fortbildung, 1975, Apr-15, Volume: 69, Issue:8

    Topics: Acute Kidney Injury; Blood Coagulation Disorders; Calcium; Embolism, Amniotic Fluid; Emergencies; Fe

1975
The mechanical response of rat myometrium to adenosine triphosphate in Ca-free solution.
    The Japanese journal of physiology, 1987, Volume: 37, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Female; In Vitro Techniques; Papaverine; Potas

1987
Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 290, Issue:2

    Topics: Female; Humans; In Vitro Techniques; Muscle Relaxation; Myometrium; Papaverine; Phosphodiesterase In

1987
Metabolism of 6,7-dimethoxy 4-(p-chlorobenzyl)-isoquinoline. I. Single-dose pharmacokinetics in the rat and mouse.
    Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:7

    Topics: Animals; Autoradiography; Biotransformation; Blood Vessels; Female; Kinetics; Liver; Male; Mice; Pap

1985
Adrenergic influences on uterine smooth muscle.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1973, Mar-15, Volume: 265, Issue:867

    Topics: Animals; Butyrates; Calcium; Chlorides; Cyclic AMP; Female; In Vitro Techniques; Isoproterenol; Lant

1973
Beta-adrenergic effects on rat myometrium: mechanisms of membrane hyperpolarization.
    The American journal of physiology, 1973, Volume: 225, Issue:6

    Topics: Adrenergic beta-Agonists; Aminophylline; Animals; Calcium; Cell Membrane; Cell Membrane Permeability

1973
Effect of certain drugs on perfused human placenta. 8. Angiotensin-II antagonists.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:2

    Topics: Acetates; Angiotensin II; Atropine; Blood Pressure Determination; Cobalt; Cocaine; Cyproheptadine; D

1968
[Pharmacodynamic properties of 1-(2'-piperidine-ethyl)-4,4-bis-(para-methoxy-phenyl)-2,5-imidazolidinedione-chlorhydrate (I. 255). Studies of the effect on musculature of intestine gallbladder, uterus, bladder and trachea in vitro].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Barium; Cats; Chlorides; Colon; Depression, Chemical; Duodenum; Fe

1970
Effect of blockade of adrenergic alpha-receptors on the activity of preparations stimulating and inhibiting the contraction of the rat uterus.
    Polish medical journal, 1970, Volume: 9, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Epinephrine; Female; Norepinephrine; Oxytocics

1970
[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHROM. 2. Toxicologic findings].
    Archiv fur experimentelle Veterinarmedizin, 1974, Volume: 28, Issue:5

    Topics: Acute Disease; Administration, Oral; Animals; Atropine; Body Weight; Chlorpromazine; Chronic Disease

1974
Effect on the rat uterus of the venom from the scorpion Leiurus quinquestriatus.
    Toxicon : official journal of the International Society on Toxinology, 1972, Volume: 10, Issue:4

    Topics: Animals; Atropine; Chlorpheniramine; Cocaine; Diphenhydramine; Estrus; Female; Hexamethonium Compoun

1972
The response of the ductus arteriosus to prostaglandins.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:3

    Topics: Anaerobiosis; Animals; Dose-Response Relationship, Drug; Ductus Arteriosus; Female; In Vitro Techniq

1973
Inhibitory action of spermine on the contractions of rat uterus.
    The American journal of physiology, 1973, Volume: 225, Issue:3

    Topics: Animals; Calcium; Electrophysiology; Female; Muscle Contraction; Muscle, Smooth; Papaverine; Pregnan

1973
Studies concerning the source of calcium for contraction of rat myometrium.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:12

    Topics: Acetylcholine; Action Potentials; Animals; Calcium; Calcium Radioisotopes; Carbon Radioisotopes; Chl

1973
Effects of papaverine and calcium-free medium on salivary gland morphogenesis.
    Developmental biology, 1973, Volume: 33, Issue:2

    Topics: Animals; Calcium; Culture Media; Epithelial Cells; Epithelium; Female; In Vitro Techniques; Mice; Mi

1973
[Correlation between pregnancy complications and congenital malformations in the newborn infant].
    Acta Universitatis Carolinae. Medica. Monographia, 1973, Volume: 56

    Topics: Abnormalities, Drug-Induced; Carbohydrate Metabolism; Congenital Abnormalities; Drug-Related Side Ef

1973
[Pharmacological studies on the vascular system of the human placenta].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:2

    Topics: Acetylcholine; Atropine; Blood Vessels; Caffeine; Carbon Dioxide; Ephedrine; Epinephrine; Ergotamine

1974
Smooth muscle relaxants: dissociation between resting membrane potential and resting tension in rat myometrium.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 168, Issue:1

    Topics: Animals; Catecholamines; Epinephrine; Female; In Vitro Techniques; Isoproterenol; Membrane Potential

1969
A comparison of the effects of various smooth muscle relaxants on the electrical and mechanical activity of rat uterus.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 168, Issue:1

    Topics: Action Potentials; Animals; Calcium; Cell Membrane; Electricity; Epinephrine; Female; In Vitro Techn

1969
[Intensive therapy of gestoses. Our experience in the years 1969-1971].
    Annali di ostetricia, ginecologia, medicina perinatale, 1971, Volume: 92, Issue:12

    Topics: Betamethasone; Brain Edema; Diazepam; Ergoloid Mesylates; Female; Furosemide; Humans; Mannitol; Papa

1971
[Effects of uterine contraction on the fetus].
    Marseille medical, 1972, Volume: 109, Issue:1

    Topics: Anesthesia, Obstetrical; Female; Fetal Diseases; Fetal Heart; Fetus; Humans; Labor, Obstetric; Metap

1972
Effectiveness of induction of labor by intraveneous oxytocin.
    Acta obstetricia et gynecologica Scandinavica. Supplement, 1971, Volume: 9

    Topics: Birth Weight; Cesarean Section; Delivery, Obstetric; Female; Gestational Age; Humans; Infant, Newbor

1971
The value of physiotherapy in obstetrics.
    The Medical journal of Australia, 1970, Jun-06, Volume: 1, Issue:23

    Topics: Acetaminophen; Anesthesia, Obstetrical; Anesthetics, Local; Aspirin; Codeine; Conditioning, Psycholo

1970
Therapeutic studies in experimental amniotic fluid embolism in rabbits.
    American journal of obstetrics and gynecology, 1970, Apr-15, Volume: 106, Issue:8

    Topics: Anaphylaxis; Animals; Atropine; Bronchial Spasm; Disease Models, Animal; Electrocardiography; Emboli

1970
Reduced passage of carbon-14-dieldrin to the fetal rat by phenobarbital but not by eight other drugs or dieldrin.
    American journal of obstetrics and gynecology, 1971, Aug-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Ammonium Chloride; Animals; Aspirin; Bicarbonates; Brain; Brain Chemistry; Car

1971
[Effect and passage of vasoactive drugs in the in vitro perfused placenta of guinea pigs].
    Archiv fur Gynakologie, 1967, Volume: 204, Issue:1

    Topics: Amides; Animals; Dextrans; Epinephrine; Female; Glucose; Guinea Pigs; Indoles; Lysergic Acid Diethyl

1967
[Experimental studies of a new spasmoanalgetic on the rat uterus and 1st clinical experience in obstetrics].
    Zentralblatt fur Gynakologie, 1968, Aug-17, Volume: 90, Issue:33

    Topics: Acetates; Adult; Animals; Female; Humans; In Vitro Techniques; Injections, Intravenous; Labor, Obste

1968
[Use of mannitol and vasodilators for preventing and treating acute renal insufficiency].
    Klinicheskaia meditsina, 1968, Volume: 46, Issue:11

    Topics: Abortion, Septic; Acute Kidney Injury; Aminophylline; Female; Humans; Mannitol; Papaverine; Poisonin

1968
[Problems of labor pain inhibition by pharmacological agents].
    Medizinische Klinik, 1969, Jan-24, Volume: 64, Issue:4

    Topics: Bronchodilator Agents; Chlordiazepoxide; Diazepam; Female; Halothane; Humans; Infant Mortality; Isop

1969
[Effect of papaquine on the course of labor and puerperium in comparison with dolcontral and spasmonal].
    Zeitschrift fur arztliche Fortbildung, 1965, Sep-15, Volume: 59, Issue:18

    Topics: Analgesics; Brain Injuries; Dystocia; Female; Humans; Infant Mortality; Infant, Newborn; Obstetric L

1965
[On medico-surgical induction of labor. Clinical study of 310 cases].
    Annali di ostetricia e ginecologia, 1965, Volume: 87, Issue:4

    Topics: Adult; Castor Oil; Ergonovine; Female; Humans; Labor, Induced; Papaverine; Pregnancy; Quinine

1965
Extracorporeal perfusion of the human placenta. I. Placental transfer of ascorbic acid.
    American journal of obstetrics and gynecology, 1966, Sep-01, Volume: 96, Issue:1

    Topics: Ascorbic Acid; Female; Humans; In Vitro Techniques; Oxytocin; Papaverine; Perfusion; Placenta; Pregn

1966