papaverine has been researched along with Parkinson Disease in 11 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pasha, MK | 1 |
| Sharma, RK | 1 |
| Rajput, AH | 1 |
| Gnanalingham, KK | 1 |
| Hunter, AJ | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Coscia, CJ | 1 |
| Burke, W | 1 |
| Jamroz, G | 1 |
| Lasala, JM | 1 |
| McFarlane, J | 1 |
| Mitchell, J | 1 |
| O'Toole, MM | 1 |
| Wilson, ML | 1 |
| Davis, VE | 1 |
| Cashaw, JL | 2 |
| McMurtrey, KD | 1 |
| Dougan, D | 1 |
| Wade, D | 1 |
| Mearrick, P | 1 |
| Duvoisin, RC | 1 |
| Posner, DM | 1 |
| Geraghty, CA | 1 |
| Montastruc, JL | 1 |
| Rascol, O | 1 |
| Belin, J | 1 |
| Ane, M | 1 |
| Rascol, A | 1 |
| Sandler, M | 1 |
| Hadjiev, D | 1 |
2 reviews available for papaverine and Parkinson Disease
| Article | Year |
|---|---|
Disposition of catecholamine-derived alkaloids in mammalian systems.
Topics: Alkaloids; Animals; Brain; Catecholamines; Ethanol; Humans; Liver; Papaverine; Parkinson Disease; Ra | 1975 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
1 trial available for papaverine and Parkinson Disease
| Article | Year |
|---|---|
Does papaverine interact with levodopa in Parkinson's disease?
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Female; Humans; Levodopa; Ma | 1987 |
8 other studies available for papaverine and Parkinson Disease
| Article | Year |
|---|---|
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
Selective dopamine antagonist pretreatment on the antiparkinsonian effects of benzazepine D1 dopamine agonists in rodent and primate models of Parkinson's disease--the differential effects of D1 dopamine antagonists in the primate.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Callithrix; Dopamine Agonists; Dopami | 1995 |
Occurrence of a new class of tetrahydroisoquinoline alkaloids in L-dopa-treated parkinsonian patients.
Topics: Animals; Biotransformation; Brain; Carbidopa; Catechols; Humans; Levodopa; Mice; Papaverine; Parkins | 1977 |
Effects of L-dopa metabolites at a dopamine receptor suggest a basis for 'on-off' effect in Parkinson's disease.
Topics: Animals; Dopamine; Dopamine Antagonists; Evoked Potentials; Intestinal Mucosa; Isoquinolines; Levodo | 1975 |
Antagonism of levodopa by papaverine.
Topics: Aged; Corpus Striatum; Fatigue; Female; Headache; Humans; Hyperhidrosis; Intracranial Arterioscleros | 1975 |
Letter: antagonism of levodopa by papaverine.
Topics: Aged; Female; Humans; Levodopa; Papaverine; Parkinson Disease | 1975 |
Method for the identification of tetrahydropapaveroline using the Pictet-Spengler condensation reaction and high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Elect | 1989 |
Some anomalies in the L-DOPA response: recent biochemical studies.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Models, Biological; Papave | 1974 |