papaverine has been researched along with Paraplegia in 15 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to determine which vasoactive agent was more efficacious for erectile dysfunction (ED), intracavernosal papaverine or oral sildenafil, in paraplegic men within the first year after injury by using a penile color Doppler ultrasound as a quantitative imaging method and to determine the association between responses to these two vasoactive agents and factors such as neurological lesion level and lesion severity." | 7.77 | Efficacies of papaverine and sildenafil in the treatment of erectile dysfunction in early-stage paraplegic men. ( Comert, D; Gokkaya, NK; Gokkaya, S; Koseoglu, F; Yildiz, N, 2011) |
| "Papaverine was not associated with increased risk and may be superior to other conventionally used modalities." | 6.66 | Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta. ( Antunes, MD; Beven, EG; Cosgrove, DM; Furlan, AJ; Gottlieb, A; Grum, DF; Hinder, RA; Lytle, BW; Stewart, RW; Svensson, LG, 1988) |
| "The aim of the study was to determine which vasoactive agent was more efficacious for erectile dysfunction (ED), intracavernosal papaverine or oral sildenafil, in paraplegic men within the first year after injury by using a penile color Doppler ultrasound as a quantitative imaging method and to determine the association between responses to these two vasoactive agents and factors such as neurological lesion level and lesion severity." | 3.77 | Efficacies of papaverine and sildenafil in the treatment of erectile dysfunction in early-stage paraplegic men. ( Comert, D; Gokkaya, NK; Gokkaya, S; Koseoglu, F; Yildiz, N, 2011) |
| "Intracavernosal administration of papaverine or prostaglandin E1 for erectile impotence in paraplegics is being practised widely." | 3.69 | Management of pharmacologically induced prolonged penile erection with oral terbutaline in traumatic paraplegics. ( Krishnan, KR; Soni, BM; Vaidyanathan, S, 1994) |
| "We have previously described a technique for intrathecal administration of papaverine and cerebrospinal fluid drainage to prevent paraplegia after aortic surgery." | 3.68 | Appraisal of cerebrospinal fluid alterations during aortic surgery with intrathecal papaverine administration and cerebrospinal fluid drainage. ( Bednarski, M; Cosgrove, DM; Grum, DF; Loop, FD; Svensson, LG, 1990) |
| "Papaverine was not associated with increased risk and may be superior to other conventionally used modalities." | 2.66 | Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta. ( Antunes, MD; Beven, EG; Cosgrove, DM; Furlan, AJ; Gottlieb, A; Grum, DF; Hinder, RA; Lytle, BW; Stewart, RW; Svensson, LG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yildiz, N | 1 |
| Gokkaya, NK | 1 |
| Koseoglu, F | 1 |
| Gokkaya, S | 1 |
| Comert, D | 1 |
| Lima, B | 1 |
| Nowicki, ER | 1 |
| Blackstone, EH | 1 |
| Williams, SJ | 1 |
| Roselli, EE | 1 |
| Sabik, JF | 1 |
| Lytle, BW | 3 |
| Svensson, LG | 8 |
| Khan, SN | 1 |
| Stansby, G | 1 |
| Denys, P | 1 |
| Ben Smail, D | 1 |
| Even-Schneider, A | 1 |
| Chartier-Kastler, E | 1 |
| Soni, BM | 1 |
| Vaidyanathan, S | 1 |
| Krishnan, KR | 1 |
| Hess, KR | 1 |
| D'Agostino, RS | 1 |
| Entrup, MH | 1 |
| Hreib, K | 1 |
| Kimmel, WA | 1 |
| Nadolny, E | 1 |
| Shahian, DM | 1 |
| Sun, J | 1 |
| Hirsch, D | 1 |
| Svensson, G | 1 |
| Grum, DF | 4 |
| Bednarski, M | 1 |
| Cosgrove, DM | 3 |
| Loop, FD | 1 |
| Stewart, RW | 2 |
| Antunes, MD | 1 |
| Beven, EG | 2 |
| Furlan, AJ | 2 |
| Gottlieb, A | 1 |
| Hinder, RA | 2 |
| Gottlieb, AJ | 1 |
| Lewis, BS | 1 |
| Salgado, A | 1 |
| Von Ritter, CM | 1 |
| Groeneveld, HT | 1 |
| Rickards, ES | 1 |
| Hunter, SJ | 1 |
| Robinson, MF | 1 |
| Seifert, J | 2 |
| Lob, G | 2 |
| Stoephasius, E | 2 |
| Probst, J | 2 |
| Brendel, W | 2 |
4 reviews available for papaverine and Paraplegia
| Article | Year |
|---|---|
Cerebrospinal fluid drainage for thoracic and thoracoabdominal aortic aneurysm surgery.
Topics: Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cerebrospinal Fluid; Cerebrospinal Fluid Pres | 2012 |
[Genito-sexual dysfunction in patients with a medullary lesion].
Topics: Adult; Electric Stimulation Therapy; Erectile Dysfunction; Humans; Insemination, Artificial; Male; P | 2004 |
Paralysis after aortic surgery: in search of lost cord function.
Topics: Animals; Aorta; Aortic Aneurysm; Aortic Rupture; Cerebrospinal Fluid; Disease Models, Animal; Draina | 2005 |
Preliminary results and rationale for the use of intrathecal papaverine for the prevention of paraplegia after aortic surgery.
Topics: Adolescent; Adult; Aged; Aorta, Thoracic; Catheterization; Female; Humans; Injections, Spinal; Male; | 1988 |
2 trials available for papaverine and Paraplegia
| Article | Year |
|---|---|
Reduction of neurologic injury after high-risk thoracoabdominal aortic operation.
Topics: Adult; Aged; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cardiopulmonary Bypass; Cerebros | 1998 |
Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta.
Topics: Adult; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Clinical Trials as Topic; Constriction; H | 1988 |
9 other studies available for papaverine and Paraplegia
| Article | Year |
|---|---|
Efficacies of papaverine and sildenafil in the treatment of erectile dysfunction in early-stage paraplegic men.
Topics: Adult; Erectile Dysfunction; Humans; Male; Middle Aged; Papaverine; Paraplegia; Penis; Piperazines; | 2011 |
Spinal cord protective strategies during descending and thoracoabdominal aortic aneurysm repair in the modern era: the role of intrathecal papaverine.
Topics: Aged; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implantation; Chi-Square Distribution; Fema | 2012 |
Management of pharmacologically induced prolonged penile erection with oral terbutaline in traumatic paraplegics.
Topics: Administration, Oral; Adult; Alprostadil; Erectile Dysfunction; Humans; Male; Middle Aged; Papaverin | 1994 |
Spinal cord protection by papaverine and intrathecal cooling during aortic crossclamping.
Topics: Administration, Topical; Animals; Aorta, Thoracic; Cold Temperature; Disease Models, Animal; Intubat | 1998 |
Changes in cerebrospinal fluid pressure and spinal cord perfusion pressure prior to cross-clamping of the thoracic aorta in humans.
Topics: Anesthesia, Intravenous; Aorta, Thoracic; Blood Pressure; Central Venous Pressure; Cerebrospinal Flu | 1991 |
Appraisal of cerebrospinal fluid alterations during aortic surgery with intrathecal papaverine administration and cerebrospinal fluid drainage.
Topics: Aorta; Cerebrospinal Fluid; Cerebrospinal Fluid Pressure; Drainage; Female; Humans; Injections, Spin | 1990 |
Cross-clamping of the thoracic aorta. Influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol, and superoxide dismutase on spinal cord blood flow and paraplegia in baboons.
Topics: Allopurinol; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cinnarizine; Flunarizine; Hemodynam | 1986 |
Blood flow in muscles of paraplegic patients under various conditions measured by a double isotope technique.
Topics: Adolescent; Adult; Capillary Permeability; Chromium Isotopes; Edetic Acid; Female; Forearm; Humans; | 1972 |
[Possibilities of increasing the blood circulation in the muscle. Comparative studies in patients with paraplegic spinal injuries].
Topics: Blood Volume; Humans; Muscles; Papaverine; Paraplegia; Physical Therapy Modalities; Regional Blood F | 1974 |