papaverine has been researched along with Optic Nerve Diseases in 1 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Optic Nerve Diseases: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine and zolpidem were recently shown to be protective of bioenergetic loss in cell models of optic neuropathy." | 1.46 | Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. ( Cortopassi, GA; Datta, S; McMackin, MZ; Yu, AK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, AK | 1 |
| Datta, S | 1 |
| McMackin, MZ | 1 |
| Cortopassi, GA | 1 |
1 other study available for papaverine and Optic Nerve Diseases
| Article | Year |
|---|---|
Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules.
Topics: Animals; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex I; Glaucoma, Open-An | 2017 |