papaverine has been researched along with Neuroblastoma in 33 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of microwave induced hyperthermia, papaverine, and chemotherapy were evaluated in transplanted CI300 murine neuroblastoma." | 7.66 | Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma. ( Grosfeld, JL; Weber, TR; West, KW, 1980) |
| "The effect of papaverine on transplantable C1300 murine neuroblastoma model was evaluated." | 7.66 | A study of the effect of papaverine in neuroblastoma using the experimental C1300 murine system. ( Murphy, GP; Wajsman, Z; Williams, P, 1978) |
| "Mouse neuroblastoma cells in culture have been used as a model for the study of the mechanism by which activities of tyrosine hydroxylase (EC 1." | 7.65 | Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate. ( Prasad, KN; Waymire, JC; Weiner, N, 1972) |
| "The effects of microwave induced hyperthermia, papaverine, and chemotherapy were evaluated in transplanted CI300 murine neuroblastoma." | 3.66 | Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma. ( Grosfeld, JL; Weber, TR; West, KW, 1980) |
| "The effect of papaverine on transplantable C1300 murine neuroblastoma model was evaluated." | 3.66 | A study of the effect of papaverine in neuroblastoma using the experimental C1300 murine system. ( Murphy, GP; Wajsman, Z; Williams, P, 1978) |
| "When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine." | 3.66 | Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. ( Fibach, E; Ishii, DN; Weinstein, IB; Yamasaki, H, 1978) |
| "In developing a chemotherapeutic program for children with disseminated neuroblastoma, we established three human neuroblastoma lines in cell culture to study the effects of dibutyryl cyclic AMP, papaverine, 5-trifluoromethyl-2'-deoxyuridine, and cyclophosphamide on cell growth, biochemical behavior, and morphology." | 3.65 | A rationale for the treatment of metastatic neuroblastoma. ( Das, SK; Helson, C; Helson, L; Peterson, RF, 1976) |
| "The inhibitors of cyclic AMP phosphodiesterase (papaverine and 4-(-3-butoxy-4-methoxybenzyl)-2-imidazolidinone), serum-free medium, and x irradiation caused cell death and neurite formation in human neuroblastoma cells in culture (IMR-32), whereas theophylline was ineffective." | 3.65 | Role of cyclic AMP in differentiation of human neuroblastoma cells in culture. ( Kumar, S; Prasad, KN, 1975) |
| "Mouse neuroblastoma cells in culture have been used as a model for the study of the mechanism by which activities of tyrosine hydroxylase (EC 1." | 3.65 | Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate. ( Prasad, KN; Waymire, JC; Weiner, N, 1972) |
| " Two cases with either stage III or IV neuroblastoma, whose tumors had not been extirpated at the initial operation, were treated by intra-aortic PGE1 infusion combined with oral papaverine and conventional anti-malignant chemotherapy." | 1.27 | [Intra-aortic PGE1 infusion combined with anti-malignant chemotherapy in the treatment of advanced neuroblastoma]. ( Hayakawa, K; Inoue, S; Munakata, H; Nara, K; Ono, K; Sato, S; Takahashi, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Steinherz, PG | 1 |
| Rosen, G | 1 |
| Ghavimi, F | 1 |
| Wollner, N | 1 |
| Wang, Y | 1 |
| Miller, DR | 1 |
| Reynolds, CP | 1 |
| Perez-Polo, JR | 1 |
| Nakajima, F | 2 |
| Imashuku, S | 3 |
| Green, AA | 1 |
| Yoshikawa, Y | 1 |
| Yamanouchi, K | 1 |
| Nitschke, R | 1 |
| Cangir, A | 1 |
| Crist, W | 1 |
| Berry, DH | 1 |
| Tawa, A | 1 |
| Kawa, K | 1 |
| Shu, K | 1 |
| Ikeda, T | 1 |
| Yabuuchi, H | 1 |
| Okada, A | 1 |
| Sugano, T | 1 |
| Fujiwara, K | 1 |
| Todo, S | 2 |
| Ogita, S | 2 |
| Goto, Y | 1 |
| Anderson, DW | 1 |
| Crowle, AJ | 1 |
| West, KW | 1 |
| Weber, TR | 1 |
| Grosfeld, JL | 1 |
| Waymire, JC | 2 |
| Gilmer-Waymire, K | 1 |
| Boehme, RE | 1 |
| Glazer, RI | 1 |
| Schneider, FH | 3 |
| Weiss, B | 1 |
| Prasad, KN | 7 |
| Becker, G | 1 |
| Tripathy, K | 1 |
| Penit, J | 1 |
| Huot, J | 1 |
| Jard, S | 1 |
| Helson, L | 2 |
| Helson, C | 1 |
| Peterson, RF | 1 |
| Das, SK | 1 |
| Chang, JH | 1 |
| Lazo, JS | 1 |
| Ruddon, RW | 1 |
| Prashad, N | 1 |
| Rosenberg, RN | 1 |
| Kumar, S | 1 |
| Nandy, K | 1 |
| Baste, C | 1 |
| Wajsman, Z | 1 |
| Williams, P | 1 |
| Murphy, GP | 1 |
| Ishii, DN | 1 |
| Fibach, E | 1 |
| Yamasaki, H | 1 |
| Weinstein, IB | 1 |
| Esumi, N | 1 |
| Hashida, T | 1 |
| Tsunamoto, K | 1 |
| Tokiwa, K | 1 |
| Arizono, N | 1 |
| Takahashi, T | 1 |
| Munakata, H | 1 |
| Nara, K | 1 |
| Takahashi, K | 1 |
| Sato, S | 1 |
| Hayakawa, K | 1 |
| Inoue, S | 1 |
| Ono, K | 1 |
| Sheppard, JR | 1 |
| Hamprecht, B | 2 |
| Schultz, J | 2 |
| Weiner, N | 1 |
1 review available for papaverine and Neuroblastoma
| Article | Year |
|---|---|
Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase.
Topics: Adenylyl Cyclases; Animals; Astrocytoma; Brain; Cyclic AMP; Cyclic GMP; Enzyme Activation; Isoenzyme | 1975 |
1 trial available for papaverine and Neuroblastoma
| Article | Year |
|---|---|
Intensive chemotherapy for metastatic neuroblastoma: a Southwest Oncology Group study.
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combi | 1980 |
31 other studies available for papaverine and Neuroblastoma
| Article | Year |
|---|---|
Higher leukocyte nadirs with lithium carbonate after chemotherapy.
Topics: Adolescent; Adult; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Humans; Hydroxyure | 1980 |
Induction of neurite outgrowth in the IMR-32 human neuroblastoma cell line by nerve growth factor.
Topics: Animals; Axons; Bucladesine; Cell Differentiation; Cell Line; Culture Media; Glioma; Humans; Male; M | 1981 |
Characterization and activation of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in C1300 murine neuroblastoma clones growing in vivo.
Topics: Animals; Carrier Proteins; Clone Cells; Cyclic AMP; Cyclic AMP Receptor Protein; Enzyme Activation; | 1982 |
Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells.
Topics: Animals; Carcinoma; Cell Line; DNA Replication; Glioma; Humans; Kinetics; Measles virus; Mouth Neopl | 1984 |
[Maturation therapy for advanced neuroblastoma-therapeutic effects and problems].
Topics: Adrenal Gland Neoplasms; Cell Differentiation; Child, Preschool; Cyclophosphamide; Drug Therapy, Com | 1982 |
Intra-aortic prostaglandin E1 infusion in maturation of neuroblastoma.
Topics: Abdominal Neoplasms; Alprostadil; Aorta; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combina | 1982 |
Regression and differentiation of neuroblastoma tumors in mice treated with differentiating agents--prostaglandin E1 and a phosphodiesterase inhibitor, RO 20-1724.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Cell Differentiation; Drug The | 1982 |
Synergistic effect of hyperthermia, papaverine, and chemotherapy in murine neuroblastoma.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Hyperthermia, Induced; Male; Mice; Microwaves; Ne | 1980 |
Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Cell Line; Cyclic AMP; Dopamine beta-Hy | 1978 |
Effects of adenosine 3':5'-monophosphate and related agents on ribonucleic acid synthesis and morphological differentiation in mouse neuroblastoma cells in culture.
Topics: Acetylcholinesterase; Adenine; Animals; Bucladesine; Butyrates; Cell Differentiation; Cell Line; Cyc | 1975 |
Differences and similarities between guanosine 3',5'-cyclic monophosphate phosphodiesterase and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in neuroblastoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Buffer | 1975 |
Neuroblastoma cell adenylate cyclase: direct activation by adenosine and prostaglandins.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Adenylyl Cyclases; Cell Line; Cyclic GMP; D | 1976 |
A rationale for the treatment of metastatic neuroblastoma.
Topics: Antineoplastic Agents; Bucladesine; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combina | 1976 |
Differentiation of mouse neuroblastoma cells in vitro and in vivo induced by cyclic adenosine monophosphate (cAMP).
Topics: Adenosine Monophosphate; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic AMP; M | 1976 |
Neurite extension and malignancy of neuroblastoma cells after treatment with prostaglandin E1 and papaverine.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cyclic AMP; Cyclic GMP; Male; Mice; M | 1977 |
Induction of cyclic AMP-binding proteins by dibutyryl cyclic AMP in mouse neuroblastoma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Carrier Proteins; Cells, Cultured; Cyclic AMP; Cyc | 1978 |
Effect of sodium butyrate in combination with X-irradiation, chemotherapeutic and cyclic AMP stimulating agents on neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antineoplastic Agents; Butyrates; Cell Line | 1979 |
Role of cyclic AMP in differentiation of human neuroblastoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Bu | 1975 |
Further studies on the effects of centrophenoxine on lipofuscin pigment in neuroblastoma cells in culture: an electron microscopic study.
Topics: Aging; Animals; Cells, Cultured; Glycolates; Lipofuscin; Meclofenoxate; Mice; Neoplasms, Experimenta | 1978 |
A study of the effect of papaverine in neuroblastoma using the experimental C1300 murine system.
Topics: Animals; Drug Evaluation, Preclinical; Mice; Mice, Inbred A; Neoplasm Metastasis; Neoplasms, Experim | 1978 |
Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells.
Topics: Bromodeoxyuridine; Cell Differentiation; Cell Line; Diterpenes; Dose-Response Relationship, Drug; Ne | 1978 |
Effects of sodium butyrate on mouse neuroblastoma cells in culture.
Topics: Acetylcholinesterase; Animals; Butyrates; Cells, Cultured; Culture Media; Fatty Acids; Fibroblasts; | 1976 |
Chemotherapy of neuroblastoma.
Topics: Age Factors; Animals; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Dactinomycin | 1975 |
Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma.
Topics: Abdominal Neoplasms; Alprostadil; Animals; Blood Coagulation Factors; Cell Differentiation; Cell Div | 1985 |
Neuroblastoma: incomplete differentiation on the way to maturation or morphological alteration resembling maturity?
Topics: Alprostadil; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Humans; Neuroblas | 1988 |
[Intra-aortic PGE1 infusion combined with anti-malignant chemotherapy in the treatment of advanced neuroblastoma].
Topics: Administration, Oral; Adrenal Gland Neoplasms; Alprostadil; Antineoplastic Combined Chemotherapy Pro | 1985 |
Neuroblastoma clones: prostaglandin versus dibutyryl cyclic AMP, 8-benzylthio-cyclic AMP, phosphodiesterase inhibitors and x-rays.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Cells, Cultured; Cyclic AMP; Mice; Neuroblast | 1972 |
Inhibitors of cyclic-nucleotide phosphodiesterase induce morphological differentiation of mouse neuroblastoma cell culture.
Topics: Animals; Axons; Benzyl Compounds; Cell Count; Cell Differentiation; Cells, Cultured; Culture Media; | 1972 |
Stimulation by prostaglandin E1 of adenosine 3':5'-cyclic monophosphate formation in neuroblastoma cells in the presence of phosphodiesterase inhibitors.
Topics: Adenine; Animals; Carbon Isotopes; Cell Count; Clone Cells; Cyclic AMP; Mice; Mutation; Neuroblastom | 1973 |
Influence of noradrenalin, prostaglandin E1 and inhibitors of phosphodiesterase activity on levels of the cyclic adenosine 3':5'-monophosphate in somatic cell hybrids.
Topics: Animals; Bromodeoxyuridine; Carbon Radioisotopes; Clone Cells; Cyclic AMP; Drug Resistance; Glioma; | 1973 |
Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate.
Topics: Animals; Butyrates; Carbon Isotopes; Cell Differentiation; Clone Cells; Cyclic AMP; Kinetics; Method | 1972 |