papaverine has been researched along with Neural Tube Defects in 3 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Shea, KS | 1 |
| Waterman, RE | 1 |
| Lee, H | 1 |
| Nagele, RG | 1 |
1 review available for papaverine and Neural Tube Defects
| Article | Year |
|---|---|
Scanning electron microscope studies of central nervous system development.
Topics: Animals; Cell Differentiation; Central Nervous System; Chick Embryo; Choroid Plexus; Cricetinae; Emb | 1979 |
2 other studies available for papaverine and Neural Tube Defects
| Article | Year |
|---|---|
Calcium and neural tube closure defects: an in vitro study.
Topics: Animals; Calcimycin; Calcium; Central Nervous System; Female; Mice; Neural Tube Defects; Papaverine; | 1982 |
Neural tube closure defects caused by papaverine in explanted early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Calcimycin; Chick Embryo; Microscopy, Electron; Microscopy, El | 1979 |