papaverine has been researched along with Myocardial Ischemia in 10 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 7.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "Fifty-six patients with atypical chest pain were randomly assigned to two groups: 25 patients were treated with the ACE inhibitor enalapril (ACE inhibitor group), and 31 were not treated with ACE inhibitors (non-ACE inhibitor group)." | 5.09 | Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors. ( Horie, H; Kinoshita, M; Matsumoto, T; Minai, K; Ohira, N; Takashima, H; Yokohama, H, 2001) |
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 3.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance." | 1.32 | Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. ( Fukudome, T; Hamasaki, S; Ishida, S; Kataoka, T; Minagoe, S; Mizoguchi, E; Ninomiya, Y; Okui, H; Otsuji, Y; Saihara, K; Shinsato, T; Tei, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakayama, M | 1 |
| Tanaka, N | 1 |
| Yamashita, J | 1 |
| Iwasaki, K | 1 |
| Krüger, D | 1 |
| ElMokhtari, NE | 1 |
| Wieckhorst, A | 1 |
| Simon-Herrmann, G | 1 |
| Simon, R | 1 |
| Gori, T | 1 |
| Fineschi, M | 1 |
| Shamloul, R | 1 |
| Ghanem, HM | 1 |
| Salem, A | 1 |
| Elnashaar, A | 1 |
| Elnaggar, W | 1 |
| Darwish, H | 1 |
| Mousa, AA | 1 |
| Kataoka, T | 1 |
| Hamasaki, S | 1 |
| Ishida, S | 1 |
| Saihara, K | 1 |
| Okui, H | 1 |
| Fukudome, T | 1 |
| Shinsato, T | 1 |
| Mizoguchi, E | 1 |
| Ninomiya, Y | 1 |
| Otsuji, Y | 1 |
| Minagoe, S | 1 |
| Tei, C | 1 |
| Morioka, T | 1 |
| Kitakaze, M | 1 |
| Minamino, T | 1 |
| Takashima, S | 1 |
| Node, K | 1 |
| Okazaki, Y | 1 |
| Sato, H | 1 |
| Shinozaki, Y | 1 |
| Chujo, M | 1 |
| Mori, H | 1 |
| Zeiher, AM | 1 |
| Krause, T | 1 |
| Schächinger, V | 1 |
| Minners, J | 1 |
| Moser, E | 1 |
| Schlack, W | 1 |
| Uebing, A | 1 |
| Schäfer, M | 1 |
| Bier, F | 1 |
| Grunert, S | 1 |
| Ebel, D | 1 |
| Piper, HM | 1 |
| Thämer, V | 1 |
| Rossen, JD | 1 |
| Nahser, PJ | 1 |
| Oskarsson, H | 1 |
| Brown, RE | 1 |
| Winniford, MD | 1 |
| Minai, K | 1 |
| Matsumoto, T | 1 |
| Horie, H | 1 |
| Ohira, N | 1 |
| Takashima, H | 1 |
| Yokohama, H | 1 |
| Kinoshita, M | 1 |
1 review available for papaverine and Myocardial Ischemia
| Article | Year |
|---|---|
Two coronary "orphan" diseases in search of clinical consideration: coronary syndromes x and y.
Topics: Acute Coronary Syndrome; Adult; Aged; Angina Pectoris; Chest Pain; Coronary Angiography; Electrocard | 2012 |
1 trial available for papaverine and Myocardial Ischemia
| Article | Year |
|---|---|
Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors.
Topics: Acetylcholine; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; | 2001 |
8 other studies available for papaverine and Myocardial Ischemia
| Article | Year |
|---|---|
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine.
Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Dose-Response Relationship, Drug; E | 2020 |
Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms.
Topics: Aged; Blood Flow Velocity; Case-Control Studies; Coronary Aneurysm; Coronary Angiography; Coronary C | 2010 |
Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction.
Topics: Adrenergic alpha-Antagonists; Adult; Coronary Disease; Echocardiography, Stress; Humans; Impotence, | 2004 |
Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy.
Topics: Acetylcholine; Aged; Blood Flow Velocity; Cardiac Volume; Coronary Angiography; Coronary Artery Dise | 2004 |
Downward shift of coronary pressure-flow relationship following a brief period of ischemia in dogs.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Dogs; Myocardial Contraction; Myocardial I | 1995 |
Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.
Topics: Acetylcholine; Aged; Coronary Angiography; Coronary Circulation; Coronary Vessels; Exercise; Exercis | 1995 |
Intracoronary SIN-1C during reperfusion reduces infarct size in dog.
Topics: Acetonitriles; Animals; Coronary Circulation; Dogs; Electrocardiography; Female; Infusions, Intraven | 1995 |
Does pharmacologic coronary flow reserve reflect vasodilator responsiveness to increased myocardial demand in humans?
Topics: Adenosine; Adrenergic beta-Agonists; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; C | 1996 |