papaverine has been researched along with Myocardial Infarction in 35 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 9.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| "In order to evaluate coronary flow response to 2 different vasodilators, nicorandil and papaverine, in patients with myocardial infarction, we measured coronary flow reserve using a Doppler guide wire in infarct-related and non infarct-related arteries." | 7.70 | [Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine]. ( Gen, H; Himura, Y; Hirozane, T; Iga, K; Inoko, M; Izumi, C; Kitaguchi, S; Kondo, H; Konishi, T; Tamura, T, 2000) |
| "3 mg Atropinmethylnitrat, without phenobarbital) was given in a dosis of 3 and 6 tablets in patients with acute myocardial infarction." | 7.65 | [The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Löhner, J, 1976) |
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 5.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| "This study sought to elucidate serial changes in microvascular integrity during papaverine-induced hyperemia in the risk area for myocardial infarction." | 3.71 | Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography. ( Fujiwara, H; Hayashi, Y; Imazu, M; Okimoto, T; Otsuka, M; Sakuma, T; Sumii, K, 2001) |
| "We investigated the usefulness of the intracoronary administration of nicorandil (NIC) compared with that of papaverine (PAP) in the evaluation of coronary flow reserve (CFR) in 17 patients, including 10 patients with old myocardial infarction and 7 patients with angina pectoris." | 3.70 | Estimation of coronary flow reserve by intracoronary administration of nicorandil: comparison with intracoronary administration of papaverine. ( Dohi, K; Fujimoto, S; Hashimoto, T; Inoue, F; Kawamoto, A; Uemura, S, 1998) |
| "In order to evaluate coronary flow response to 2 different vasodilators, nicorandil and papaverine, in patients with myocardial infarction, we measured coronary flow reserve using a Doppler guide wire in infarct-related and non infarct-related arteries." | 3.70 | [Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine]. ( Gen, H; Himura, Y; Hirozane, T; Iga, K; Inoko, M; Izumi, C; Kitaguchi, S; Kondo, H; Konishi, T; Tamura, T, 2000) |
| "The authors realized a retrospective clinical-statistical study about 121 cases of acute myocardial infarction (AMI), treated in the Department of general medicine with a pharmacological association of Lysine acetylsalicylate--Erythrityl tetranitrate--Papaverine hydrochloride, with the purpose of obtaining a vasodilatation on coronary arteries and a platelet antiaggregation, in the light of the new etiopathogenetic views about the prolonged coronary spasm and the platelet aggregation, in some cases of myocardial infarction with or without thrombosis." | 3.66 | [Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review]. ( Carile, L; Di Falco, C; Laquaglia, GA; Marchionni, F; Martone, P, 1982) |
| " All compounds were evaluated for their ability to protect against chloroform-induced ventricular fibrillation in mice." | 3.65 | Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives. ( Neumeyer, JL; Perianayagam, C; Ruchirawat, S, 1977) |
| "3 mg Atropinmethylnitrat, without phenobarbital) was given in a dosis of 3 and 6 tablets in patients with acute myocardial infarction." | 3.65 | [The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)]. ( Bussmann, WD; Kaltenbach, M; Löhner, J, 1976) |
| "The restenosis rate after recanalization of chronic totally occluded coronary arteries is high." | 1.29 | Restoration of coronary blood flow in severely narrowed and chronically occluded coronary arteries before and after angioplasty: implications regarding restenosis. ( Dubois-Randé, JL; Dupouy, P; Geschwind, HJ; Zelinsky, R, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (71.43) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neumeyer, JL | 1 |
| Perianayagam, C | 1 |
| Ruchirawat, S | 1 |
| Sun, Z | 1 |
| Tong, G | 1 |
| Kim, TH | 1 |
| Ma, N | 1 |
| Niu, G | 1 |
| Cao, F | 1 |
| Chen, X | 1 |
| HARRIS, AS | 1 |
| ESTANDIA, A | 1 |
| BISTENI, A | 1 |
| SMITH, HT | 1 |
| RIECKER, HH | 1 |
| STREIT, M | 1 |
| TAESCHLER, M | 1 |
| KALLENBERG, L | 1 |
| KOBAYASHI, T | 1 |
| TAKEUCHI, M | 1 |
| FAZEKAS, JF | 1 |
| ALMAN, RW | 1 |
| TICKTIN, HE | 1 |
| EHRMANTRAUT, WR | 1 |
| SAVARESE, CJ | 1 |
| LUSTOK, MJ | 1 |
| Carile, L | 1 |
| Laquaglia, GA | 1 |
| Martone, P | 1 |
| Marchionni, F | 1 |
| Di Falco, C | 1 |
| Schlack, W | 1 |
| Uebing, A | 1 |
| Schäfer, M | 1 |
| Bier, F | 1 |
| Grunert, S | 1 |
| Ebel, D | 1 |
| Piper, HM | 1 |
| Thämer, V | 1 |
| Suryapranata, H | 1 |
| Zijlstra, F | 1 |
| MacLeod, DC | 1 |
| van den Brand, M | 1 |
| de Feyter, PJ | 1 |
| Serruys, PW | 1 |
| Klauss, V | 1 |
| Meissner, O | 1 |
| Metz, J | 1 |
| Theisen, K | 1 |
| Mudra, H | 1 |
| Geschwind, HJ | 1 |
| Dupouy, P | 1 |
| Dubois-Randé, JL | 1 |
| Zelinsky, R | 1 |
| Ishihara, M | 1 |
| Sato, H | 1 |
| Tateishi, H | 1 |
| Kawagoe, T | 1 |
| Shimatani, Y | 1 |
| Kurisu, S | 1 |
| Sakai, K | 1 |
| Neumann, FJ | 1 |
| Blasini, R | 1 |
| Schmitt, C | 1 |
| Alt, E | 1 |
| Dirschinger, J | 1 |
| Gawaz, M | 1 |
| Kastrati, A | 1 |
| Schömig, A | 1 |
| Inoue, F | 1 |
| Hashimoto, T | 1 |
| Fujimoto, S | 1 |
| Uemura, S | 1 |
| Kawamoto, A | 1 |
| Dohi, K | 1 |
| Izumi, C | 1 |
| Kondo, H | 1 |
| Tamura, T | 1 |
| Inoko, M | 1 |
| Kitaguchi, S | 1 |
| Hirozane, T | 1 |
| Himura, Y | 1 |
| Iga, K | 1 |
| Gen, H | 1 |
| Konishi, T | 1 |
| Sakuma, T | 1 |
| Otsuka, M | 1 |
| Okimoto, T | 1 |
| Fujiwara, H | 1 |
| Sumii, K | 1 |
| Imazu, M | 1 |
| Hayashi, Y | 1 |
| Melloni, GF | 1 |
| Lureti, GF | 1 |
| Minoja, GM | 1 |
| Melloni, CF | 1 |
| Scarlatti, GF | 1 |
| Facchetti, M | 1 |
| Fassini, G | 1 |
| Schroeder, JS | 1 |
| Kipsidzen, N | 1 |
| Kikava, GM | 1 |
| Bussmann, WD | 1 |
| Löhner, J | 1 |
| Kaltenbach, M | 1 |
| Köhler, U | 1 |
| Cifaldi, S | 1 |
| Viglietto, A | 1 |
| Marone, G | 1 |
| Azzinnari, G | 1 |
| Colantuoni, A | 1 |
| Slogoff, S | 1 |
| Keats, AS | 1 |
| Cooley, DA | 1 |
| Reul, GJ | 1 |
| Frazier, OH | 1 |
| Ott, DA | 1 |
| Duncan, JM | 1 |
| Livesay, JJ | 1 |
| Severin, SE | 1 |
| Zoli, I | 1 |
| Baroncini, S | 1 |
| Cornia, GL | 1 |
| Donato, S | 1 |
| Minore, G | 1 |
| Pigini, G | 1 |
| Pretolani, E | 1 |
| Mikaeloff, P | 1 |
| Amiel, L | 1 |
| Delaye, J | 1 |
| Roques, JC | 1 |
| Age, C | 1 |
| Saint-Pierre, A | 1 |
| Dupont, JC | 1 |
| Eyraud, J | 1 |
| Sassard, M | 1 |
| Levin, AI | 1 |
| Vaĭnberg, AG | 1 |
| Votcal, BE | 1 |
| Lozinskij, LG | 1 |
| Monroe, RG | 2 |
| LaFarge, CG | 2 |
| Gamble, WJ | 2 |
| Kumar, AE | 2 |
| Manasek, FJ | 1 |
| Stark, J | 1 |
| Sanders, GL | 1 |
| Phornphutkul, C | 1 |
| Davis, M | 1 |
| Huttman, DH | 1 |
| Amadini, S | 1 |
| Bagnoli, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Value of Abciximab in Patients With AMI Undergoing PCI After High Dose Clopidogrel Pretreatment (BRAVE 3)[NCT00133250] | Phase 4 | 800 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for papaverine and Myocardial Infarction
| Article | Year |
|---|---|
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin | 1964 |
6 trials available for papaverine and Myocardial Infarction
| Article | Year |
|---|---|
[Contrast echocardiography in the evaluation of myocardial flow reserve].
Topics: Adult; Aged; Contrast Media; Coronary Circulation; Coronary Disease; Echocardiography; Female; Hemod | 1993 |
Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Blood Flow Velocity; Coronary Angiography; Female; Heparin; | 1998 |
Newer antiarrhythmic agents for patients with coronary artery disease.
Topics: Acebutolol; Adult; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; | 1978 |
[On the efficacy of carbocromen in the treatment of myocardial infarction (author's transl)].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chromonar; Clinical Trials as To | 1976 |
Addition of papaverine to cardioplegia does not reduce myocardial necrosis.
Topics: Clinical Trials as Topic; Constriction; Coronary Artery Bypass; Creatine Kinase; Double-Blind Method | 1986 |
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; | 1970 |
28 other studies available for papaverine and Myocardial Infarction
| Article | Year |
|---|---|
Isoquinolines. 5. Synthesis and antiarrhythmic activity of benzylisoquinoline derivatives.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chloroform; Dogs; Female; Isoquinolines; Mice | 1977 |
PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction.
Topics: Aminophylline; Animals; Atropine; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2015 |
Effects of papaverine upon ectopic ventricular tachycardia produced by myocardial infarction.
Topics: Myocardial Infarction; Papaverine; Tachycardia; Tachycardia, Ventricular; Ventricular Premature Comp | 1953 |
Standard management of myocardial infarctions.
Topics: Anticoagulants; Disease Management; Myocardial Infarction; Papaverine | 1955 |
[Pharmacodynamic studies on experimental cardiac infarcts in rats].
Topics: Animals; Electrocardiography; Myocardial Infarction; Nitrites; Papaverine; Rats | 1957 |
[On the follow-up treatment of heart infarct with Myocardon].
Topics: Aminophylline; Atropine; Drug Combinations; Follow-Up Studies; Humans; Myocardial Infarction; Nitrog | 1963 |
[REHABILITATION IN HEART DISEASE].
Topics: Acenocoumarol; Dipyridamole; Electrocardiography; Geriatrics; Heart Defects, Congenital; Heart Disea | 1963 |
Papaverine suppositories in myocardial infarction.
Topics: Cardiovascular Diseases; Coronary Disease; Humans; Myocardial Infarction; Papaverine; Suppositories | 1952 |
[Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review].
Topics: Adult; Aged; Aspirin; Coronary Vessels; Erythrityl Tetranitrate; Female; Heart Failure; Humans; Lysi | 1982 |
Intracoronary SIN-1C during reperfusion reduces infarct size in dog.
Topics: Acetonitriles; Animals; Coronary Circulation; Dogs; Electrocardiography; Female; Infusions, Intraven | 1995 |
Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction.
Topics: Angiography, Digital Subtraction; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Cir | 1994 |
Restoration of coronary blood flow in severely narrowed and chronically occluded coronary arteries before and after angioplasty: implications regarding restenosis.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Blood Flow Velocity; Blood Pressure; Cardiac Output; Ch | 1994 |
Attenuation of the no-reflow phenomenon after coronary angioplasty for acute myocardial infarction with intracoronary papaverine.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Circulation; Female; Hea | 1996 |
Estimation of coronary flow reserve by intracoronary administration of nicorandil: comparison with intracoronary administration of papaverine.
Topics: Angina Pectoris; Coronary Angiography; Coronary Circulation; Coronary Vessels; Electrocardiography; | 1998 |
[Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine].
Topics: Angioplasty, Balloon, Coronary; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial | 2000 |
Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Contrast Media; Coronary Circulation; Echoc | 2001 |
[Comparative statistical study of the treatment of myocardial infarct with anticoagulants and anti-aggregants].
Topics: Aged; Anticoagulants; Dicumarol; Dipyridamole; Drug Evaluation; Female; Heparin; Humans; Male; Middl | 1977 |
[The effect of nitroglycerin in patients with acute myocardial infarction. IV. Myocardon in patients with and without left ventricular failure (author's transl)].
Topics: Acute Disease; Adult; Aged; Atropine; Blood Pressure; Cardiac Output; Drug Combinations; Female; Hea | 1976 |
[Prevention of myocardial infarct by general practitioner].
Topics: Cardiac Glycosides; Family Practice; Humans; Iontophoresis; Magnesium; Myocardial Infarction; Papave | 1975 |
[Hyperbaric oxygen and coronary dilator agents in experimental necrosis of the myocardium in rats].
Topics: Animals; Dipyridamole; Hyperbaric Oxygenation; Myocardial Infarction; Necrosis; Papaverine; Rats; Va | 1975 |
[Basic directions in the study of the biochemistry of the myocardium].
Topics: Adaptation, Physiological; Animals; Camphor; Cardiac Glycosides; Cardiomegaly; Cardiovascular Diseas | 1967 |
[Therapeutic possibilities in coronary disease].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Arteriosclerosis; Cardiomegaly; Coronary Disease | 1973 |
[Venous aortocoronary bypass. Hemodynamic and morphological study].
Topics: Angina Pectoris; Blood Pressure Determination; Catheterization; Coronary Artery Bypass; Extracorpore | 1974 |
[Action of nitroglycerin and intravenous injections of papaverine on the contractile function of the heart in patients with coronary circulatory disorders].
Topics: Adult; Aged; Coronary Disease; Female; Heart; Humans; Hypertension; Injections, Intravenous; Male; M | 1969 |
Left ventricular performance and coronary flow after coronary embolization with plastic microspheres.
Topics: Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Disease Models, Animal; Dog | 1971 |
The Anrep effect reconsidered.
Topics: Adenosine Triphosphate; Aminophylline; Animals; Blood Flow Velocity; Blood Pressure; Catheterization | 1972 |
[Aspirin in the treatment of myocardial infarct].
Topics: Aspirin; Bicarbonates; Blood Coagulation; Blood Sedimentation; Gastrointestinal Diseases; Hematuria; | 1971 |
[Clinical studies with a new anticoronaritis preparation].
Topics: Arteriosclerosis; Arteritis; Coronary Disease; Electrocardiography; Humans; Myocardial Infarction; P | 1969 |