papaverine has been researched along with Muscle Relaxation in 153 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments were carried out in vitro on a new antispasmodic drug, 2-(diethylamino)-1-methylethyl-cis-1-hydroxy[bicyclohexyl] -2-carboxylate (rociverine), to elucidate further the mechanism of its smooth-muscle relaxation." | 7.67 | Mechanism of smooth muscle relaxation by rociverine. ( Brunori, P; D'Agostino, G; Grana, E; Santagostino Barbone, MG; Subissi, A; Zonta, F, 1984) |
| "The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine." | 7.67 | Iloprost maintains acetylcholine relaxations of isolated rabbit aortic strips submitted to hypoxia. ( Demirel, E; Türker, RK, 1988) |
| "Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 5.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
| "In vitro and in vivo studies were performed to determine the potential use of tamsulosin (TAM) versus phentolamine (PHE) for intracavernosal injection (ICI) therapy when mixed with papaverine (PAP) and/or prostagladin E1 (PGE1) or with vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction." | 3.70 | Comparison of the synergistic effects of tamsulosin versus phentolamine on penile erection: in vitro and in vivo studies. ( Kim, SC; Lee, MY; Lee, SK; Seo, KK; Song, ES, 1999) |
| "We aimed to compare the electrical activity of corpus cavernosum before and after intracavernous papaverine injection and to determine the blood lipid profile in vascular and non-vascular erectile dysfunction, and also to assess whether vascular pathology and abnormal blood lipid levels impair cavernosal smooth-muscle relaxation." | 3.69 | Electrical activity of corpus cavernosum in vasculogenic and non-vasculogenic erectile dysfunction. ( Atahan, O; Kayigil, O; Metin, A, 1997) |
| "To investigate the relaxant action of histamine on human corpus cavernosum in vitro and the erectile response caused by the intracavernous injection of histamine in patients with psychogenic impotence." | 3.69 | The role of histamine in human penile erection. ( Antunes, E; Cará, AM; De Nucci, G; Lopes-Martins, RA; Nahoum, CR, 1995) |
| " Aspirin, indomethacin, and ONO 3708, a PG receptor antagonist, markedly inhibited the hypoxia-induced contraction, whereas superoxide dismutase and OKY 046, a thromboxane (Tx) A2 synthesis inhibitor, were ineffective." | 3.68 | Comparison of hypoxia-induced contraction in human, monkey, and dog coronary arteries. ( Matsumoto, T; Toda, N; Yoshida, K, 1992) |
| "Experiments were carried out in vitro on a new antispasmodic drug, 2-(diethylamino)-1-methylethyl-cis-1-hydroxy[bicyclohexyl] -2-carboxylate (rociverine), to elucidate further the mechanism of its smooth-muscle relaxation." | 3.67 | Mechanism of smooth muscle relaxation by rociverine. ( Brunori, P; D'Agostino, G; Grana, E; Santagostino Barbone, MG; Subissi, A; Zonta, F, 1984) |
| "The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine." | 3.67 | Iloprost maintains acetylcholine relaxations of isolated rabbit aortic strips submitted to hypoxia. ( Demirel, E; Türker, RK, 1988) |
| "The mode of action of papaverine on smooth muscle relaxation was examined through analyzing its effects on caffeine-induced contraction of guinea pig taenia coli, which might be due to calcium ion mobilized from intracellular store sites." | 3.66 | Mechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli. ( Kubota, K; Sunagane, N; Uruno, T, 1982) |
| " For this reason we have examined these relationships on segments of the abdominal aorta, the carotid artery, and the tail artery of normotensive rats in vitro under the condition of strong smooth muscle activation induced by norepinephrine (NE), and during smooth muscle relaxation induced by papaverine (PAP)." | 3.66 | Mechanical properties of arteries. ( Bauer, RD; Busse, R; Schabert, A, 1982) |
| "Established and new treatments for erectile dysfunction whose effects are mediated via manipulation of the NO pathway are also described." | 2.41 | The role of nitric oxide in penile erection. ( Cartledge, J; Eardley, I; Minhas, S, 2001) |
| "Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 1.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
| " The here obtained pharmacodynamic profiles of the drugs suggest that both milrinone and theophylline may be considered as potent relaxing agents of the lower oesophageal sphincter." | 1.35 | Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Psarra, TA, 2009) |
| "It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract." | 1.34 | Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. ( Ali Onur, M; Eroglu, M; Kandirali, E; Metin, A; Semercioz, A; Sezgin, A, 2007) |
| "An association between chronic renal failure (CRF) and gastroesophageal reflux (GER) is well known." | 1.34 | Effect of chronic renal failure on foregut smooth muscle reactivity: an experimental study. ( Tugay, M; Utkan, T; Yazir, Y; Yildiz, F, 2007) |
| "Hypothyroidism has been reported to occur in 6% of impotent men." | 1.33 | Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits. ( Bagcivan, I; Kaya, K; Kilicarslan, H; Sarac, B; Yildirim, MK; Yildirim, S, 2006) |
| "Hypothyroidism has been reported to occur in 6% of impotent men." | 1.33 | Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits. ( Bagcivan, I; Kaya, T; Kilicarslan, H; Sarac, B; Yildirim, MK, 2006) |
| "Pretreatment with indomethacin abolished the endothelium-dependent attenuation of lemakalim-induced relaxation caused by etomidate." | 1.32 | Inhibitory effects of etomidate and ketamine on adenosine triphosphate-sensitive potassium channel relaxation in canine pulmonary artery. ( Murray, PA; Sohn, JT, 2003) |
| " We found a shift in the dose-response curve of only phosphodiesterase 5 inhibitors." | 1.32 | The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips. ( Bagcivan, I; Gokce, G; Kilicarslan, H; Sarac, B; Sarioglu, Y; Yildirim, S, 2003) |
| "Allergic rhinitis, also known as hay fever, rose fever or summer catarrh, is a major challenge to health professionals." | 1.32 | Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis. ( Amit, A; Bagchi, D; Bagchi, M; D'Souza, P; Pratibha, N; Saxena, VS; Stohs, SJ, 2003) |
| "Treatment with melatonin (EC(50) 4." | 1.32 | Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. ( Ayanğolu-Dülger, G; Paskaloglu, K; Sener, G, 2004) |
| "Papaverine did not increase both cAMP and cGMP contents in the uterus in the presence of H-65K+ or oxytocin." | 1.31 | Mechanism of relaxant response to papaverine on the smooth muscle of non-pregnant rat uterus. ( Gotoh, K; Nakajyo, S; Orita, S; Shimizu, K; Takahashi, M; Urakawa, N; Yoshihara, E, 2000) |
| "Tissue from men with all types of vasculogenic impotence also showed a decreased contractile response to alpha-adrenoceptor stimulation." | 1.29 | Corpus cavernosal relaxation in impotent men. ( King, P; Pickard, RS; Powell, PH; Zar, MA, 1994) |
| "When papaverine was washed out, a second application of 10(-4) M histamine also induced transient increases in [Ca2+]i and force." | 1.29 | Relationship between cytosolic calcium concentration and force in the papaverine-induced relaxation of medial strips of pig coronary artery. ( Aoki, H; Kanaide, H; Kobayashi, S; Nishimura, J, 1994) |
| "Circular muscle strips from achalasia patients contracted during field stimulation, an effect that was caused by muscarinic receptor activation." | 1.28 | Effects of postganglionic nerve stimulation in oesophageal achalasia: an in vitro study. ( Andersson, KE; Forman, A; Funch-Jensen, P; Raundahl, U; Tłottrup, A, 1990) |
| "Cromakalim was three to four times more potent than pinacidil." | 1.28 | K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit. ( Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F, 1990) |
| "We conclude that diabetic men with impotence have impairment in both the autonomic and the endothelium-dependent mechanisms that mediate the relaxation of the smooth muscle of the corpora cavernosa." | 1.28 | Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. ( Azadzoi, K; Cohen, RA; Goldstein, I; Krane, RJ; Saenz de Tejada, I, 1989) |
| "Histamine has a greater relaxant effect on mesenteric artery strips at 22 degrees than at 38 degrees, normally." | 1.27 | Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery. ( Christiansen, VJ; Horst, MA; Robinson, C, 1983) |
| "Since terbutaline treatment in premature labor has been shown to increase phosphodiesterase activity in the myometrium, the phosphodiesterase-inhibiting effect of theophylline and papaverine on myometrial preparations from pregnant women has been studied." | 1.27 | In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor? ( Andersson, RG; Berg, G; Rydén, G, 1983) |
| " The effects of these drugs on the basal tension, on dose-response curves for muscle contraction produced by histamine and on cAMP level were investigated in guinea pig trachea, together with their influence on the resting and histamine-evoked mechanical and membrane activities of dog trachea." | 1.27 | The effects of methylxanthines, ethymizol, ephedrine and papaverine on guinea pig and dog trachea. ( Bauer, V; Bilcíková, L; Kolena, J, 1987) |
| "Papaverine was shown to be the substance able to cause the biggest relaxation effect." | 1.27 | Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study. ( Barbanti, G; Beneforti, P; Lapini, A; Turini, D, 1988) |
| "The papaverine probe was further used to examine structural aspects of human colon papaverine binding sites." | 1.27 | Molecular properties of the papaverine binding sites identified in human colonic membranes with 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl) isoquinoline as probe. ( Christinaki, H; Servin, AL; Viel, C, 1988) |
| " Fusaric acid produced a shift to the right and down in the dose-response curves to all tested agonists, and antagonized acetylcholine and serotonin most effectively among these agonists." | 1.26 | Relaxation of isolated rabbit arteries by fusaric (5-butylpicolinic) acid. ( Asano, M; Hidaka, H, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (32.68) | 18.7374 |
| 1990's | 57 (37.25) | 18.2507 |
| 2000's | 40 (26.14) | 29.6817 |
| 2010's | 6 (3.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takase, Y | 1 |
| Saeki, T | 1 |
| Fujimoto, M | 1 |
| Saito, I | 1 |
| Patai, Z | 1 |
| Guttman, A | 1 |
| Mikus, EG | 1 |
| Baccari, MC | 1 |
| Bani, D | 1 |
| Calamai, F | 1 |
| Aydin, C | 1 |
| Bagcivan, I | 4 |
| Yildirim, S | 4 |
| Koyuncu, A | 1 |
| Topcu, O | 1 |
| Soylu, S | 1 |
| Ozer, H | 1 |
| Koutsoviti-Papadopoulou, M | 1 |
| Psarra, TA | 1 |
| Batzias, GC | 1 |
| Krönström, J | 1 |
| Karlsson, W | 1 |
| Johansson, BR | 1 |
| Holmgren, S | 1 |
| Mirkhani, H | 1 |
| Shafa, M | 1 |
| Khazraei, H | 1 |
| Ertan, AA | 1 |
| Beriat, NC | 1 |
| Gürpinar, A | 1 |
| Onur, MA | 1 |
| Cehreli, MC | 1 |
| Utkan, T | 5 |
| Sarioglu, Y | 6 |
| Yazir, Y | 3 |
| Belvisi, MG | 1 |
| Dale, N | 1 |
| Birrell, MA | 1 |
| Canning, BJ | 1 |
| Gocmez, SS | 1 |
| Komsuoglu-Celikyurt, I | 1 |
| Gacar, N | 1 |
| Karasu-Minareci, E | 1 |
| Kaya, Y | 1 |
| Belgin Yildirim, F | 1 |
| Kelicen, P | 1 |
| Pekiner, C | 1 |
| Uma, S | 3 |
| Noda, K | 1 |
| Takebe, M | 1 |
| Oka, M | 1 |
| Hirouchi, M | 1 |
| Ukai, Y | 1 |
| Toda, N | 5 |
| Sohn, JT | 1 |
| Murray, PA | 1 |
| Kilicarslan, H | 3 |
| Gokce, G | 1 |
| Sarac, B | 3 |
| Che, Y | 1 |
| Rand, MJ | 4 |
| Li, CG | 4 |
| Roffey, P | 1 |
| Thangathurai, D | 1 |
| Mikhail, M | 1 |
| Mogos, M | 1 |
| Riad, M | 1 |
| Stein, J | 1 |
| Karagiannis, J | 1 |
| Reid, JJ | 1 |
| Darby, I | 1 |
| Roche, P | 1 |
| Amit, A | 1 |
| Saxena, VS | 1 |
| Pratibha, N | 1 |
| D'Souza, P | 1 |
| Bagchi, M | 1 |
| Bagchi, D | 1 |
| Stohs, SJ | 1 |
| Kumcu, EK | 2 |
| Büyüknacar, HS | 1 |
| Kiroğlu, OE | 1 |
| Göçmen, C | 2 |
| Döndaş, N | 1 |
| Dikmen, A | 2 |
| Sivrikaya, A | 1 |
| Celik, OF | 1 |
| Sivrikaya, N | 1 |
| Ozgur, GK | 1 |
| Bozkurt, TE | 1 |
| Sahin-Erdemli, I | 1 |
| Paskaloglu, K | 1 |
| Sener, G | 1 |
| Ayanğolu-Dülger, G | 1 |
| Waseda, K | 1 |
| Takeuchi, T | 1 |
| Ohta, M | 1 |
| Okishio, Y | 1 |
| Fujita, A | 1 |
| Hata, F | 1 |
| Takewaki, T | 1 |
| Pescatori, ES | 2 |
| Morgia, G | 1 |
| Pirozzi-Farina, F | 1 |
| Farina, FP | 1 |
| Fujimoto, S | 1 |
| Mori, M | 1 |
| Tsushima, H | 1 |
| Kunimatsu, M | 1 |
| Yildirim, MK | 2 |
| Kaya, K | 1 |
| Liu, JQ | 1 |
| Yang, D | 1 |
| Folz, RJ | 1 |
| Kaya, T | 1 |
| Eroglu, M | 1 |
| Sezgin, A | 1 |
| Semercioz, A | 1 |
| Metin, A | 3 |
| Kandirali, E | 1 |
| Ali Onur, M | 1 |
| Huang, SC | 1 |
| Yildiz, F | 2 |
| Tugay, M | 1 |
| Ozkan, MH | 1 |
| Vural, IM | 1 |
| Moralioglu, S | 1 |
| Chen, X | 1 |
| Zhao, J | 1 |
| Gregersen, H | 1 |
| Sunagane, N | 7 |
| Fujihara, R | 1 |
| Uruno, T | 7 |
| Kubota, K | 7 |
| Dadkar, NK | 1 |
| Aroskar, VA | 1 |
| Dohadwalla, AN | 1 |
| Sakata, T | 1 |
| Schmidt, M | 1 |
| Imbs, JL | 1 |
| Giesen, EM | 1 |
| Schwartz, J | 1 |
| Robinson, C | 1 |
| Christiansen, VJ | 1 |
| Horst, MA | 1 |
| Berg, G | 2 |
| Andersson, RG | 2 |
| Rydén, G | 2 |
| D'Agostino, G | 2 |
| Zonta, F | 2 |
| Santagostino Barbone, MG | 1 |
| Grana, E | 2 |
| Brunori, P | 1 |
| Subissi, A | 1 |
| Lucchelli, A | 1 |
| Bauer, RD | 2 |
| Busse, R | 2 |
| Schabert, A | 2 |
| Sattler, T | 1 |
| Kimura, I | 2 |
| Kimura, M | 2 |
| Yoshimura, Y | 1 |
| Haraldsson, B | 1 |
| Nilsson, H | 1 |
| Folkow, B | 1 |
| Huddart, H | 1 |
| Saad, KH | 1 |
| Fujita, H | 1 |
| Usui, H | 1 |
| Kurahashi, K | 1 |
| Yoshikawa, M | 1 |
| Kitamura, Y | 1 |
| Okamura, T | 3 |
| Brosch, SF | 1 |
| Truss, MC | 1 |
| Uckert, S | 1 |
| Stief, CG | 2 |
| Schulz-Knappe, P | 2 |
| Hess, R | 1 |
| Forssmann, WG | 2 |
| Jonas, U | 2 |
| Hatake, K | 1 |
| Wakabayashi, I | 1 |
| Hishida, S | 1 |
| Pickard, RS | 1 |
| King, P | 1 |
| Zar, MA | 1 |
| Powell, PH | 1 |
| Cará, AM | 1 |
| Lopes-Martins, RA | 1 |
| Antunes, E | 1 |
| Nahoum, CR | 1 |
| De Nucci, G | 1 |
| Taher, A | 1 |
| Meyer, M | 1 |
| Truss, M | 1 |
| Kühberger, E | 1 |
| Groschner, K | 1 |
| Kukovetz, WR | 1 |
| Brunner, F | 1 |
| Martinez-Piñeiro, L | 1 |
| Trigo-Rocha, F | 1 |
| Hsu, GL | 1 |
| von Heyden, B | 1 |
| Lue, TF | 1 |
| Tanagho, EA | 1 |
| Aoki, H | 1 |
| Nishimura, J | 1 |
| Kobayashi, S | 2 |
| Kanaide, H | 1 |
| Naline, E | 3 |
| Candenas, ML | 2 |
| Palette, C | 1 |
| Moreau, J | 2 |
| Norte, M | 1 |
| Martin, JD | 1 |
| Pays, M | 1 |
| Advenier, C | 3 |
| Jovanović, A | 1 |
| Grbović, L | 1 |
| Tulić, I | 1 |
| Balcioglu, A | 1 |
| Kimblad, PO | 1 |
| Massa, G | 1 |
| Sjöberg, T | 1 |
| Steen, S | 1 |
| Matsumoto, T | 2 |
| Kinoshita, M | 1 |
| Burgaud, JL | 2 |
| Oudart, N | 2 |
| Rajanayagam, MA | 1 |
| Montuschi, P | 1 |
| Preziosi, P | 1 |
| Navarra, P | 1 |
| Lin, JS | 1 |
| Lin, YM | 1 |
| Jou, YC | 1 |
| Cheng, JT | 1 |
| Chuliá, S | 1 |
| Noguera, MA | 1 |
| Ivorra, MD | 1 |
| D'Ocón, MP | 2 |
| Perez-Vallina, JR | 1 |
| Revuelta, MP | 2 |
| Cantabrana, B | 2 |
| Hidalgo, A | 2 |
| Minamoto, Y | 1 |
| Nakamura, K | 1 |
| Toda, H | 1 |
| Miyawaki, I | 1 |
| Kitamura, R | 1 |
| Vinh, VH | 1 |
| Hatano, Y | 1 |
| Mori, K | 1 |
| Börjesson, L | 2 |
| Nordgren, S | 2 |
| Delbro, DS | 2 |
| Atahan, O | 1 |
| Kayigil, O | 2 |
| Segarra, G | 1 |
| Medina, P | 1 |
| Domenech, C | 1 |
| Martínez León, JB | 1 |
| Vila, JM | 1 |
| Aldasoro, M | 1 |
| Lluch, S | 1 |
| Delaey, C | 1 |
| Van de Voorde, J | 1 |
| Glasgow, I | 1 |
| Mattar, K | 1 |
| Krantis, A | 2 |
| Tanobe, Y | 1 |
| Fujioka, H | 1 |
| Ayajiki, K | 1 |
| Utkan, NZ | 1 |
| Kurnaz, F | 1 |
| Seçilmiş, A | 1 |
| Uçar, P | 1 |
| Baysal, F | 2 |
| Kim, SC | 1 |
| Seo, KK | 1 |
| Lee, SK | 1 |
| Song, ES | 1 |
| Lee, MY | 1 |
| Moncada Iribarren, I | 1 |
| Sáenz de Tejada, I | 4 |
| Frith, D | 1 |
| Gibson, A | 1 |
| Silingardi, V | 1 |
| Galeazzi, GM | 1 |
| Rigatelli, M | 1 |
| Ranzi, A | 1 |
| Artibani, W | 1 |
| Shimizu, K | 1 |
| Yoshihara, E | 1 |
| Takahashi, M | 1 |
| Gotoh, K | 1 |
| Orita, S | 1 |
| Urakawa, N | 1 |
| Nakajyo, S | 1 |
| Takagi, M | 1 |
| Mochida, H | 1 |
| Noto, T | 1 |
| Yano, K | 1 |
| Inoue, H | 1 |
| Ikeo, T | 1 |
| Kikkawa, K | 1 |
| Cartledge, J | 1 |
| Minhas, S | 1 |
| Eardley, I | 1 |
| Erden, F | 1 |
| Ozdemirci, S | 1 |
| Ulak, G | 1 |
| Gacar, MN | 1 |
| Yamashita, T | 1 |
| Kawashima, S | 1 |
| Ozaki, M | 1 |
| Namiki, M | 1 |
| Satomi-Kobayashi, S | 1 |
| Seno, T | 1 |
| Matsuda, Y | 1 |
| Inoue, N | 1 |
| Hirata, K | 1 |
| Akita, H | 1 |
| Umetani, K | 1 |
| Tanaka, E | 1 |
| Mori, H | 1 |
| Yokoyama, M | 1 |
| Lu, M | 1 |
| Battinelli, L | 1 |
| Daniele, C | 1 |
| Melchioni, C | 1 |
| Salvatore, G | 1 |
| Mazzanti, G | 1 |
| Verheggen, R | 1 |
| Bumann, K | 1 |
| Kaumann, AJ | 1 |
| Cohen, ML | 2 |
| Wiley, KS | 1 |
| Takayanagi, I | 3 |
| Yamashita, H | 3 |
| Manda, T | 1 |
| Takagi, K | 1 |
| Karasawa, A | 1 |
| Kasuya, Y | 3 |
| Bevan, JA | 1 |
| Berić, BM | 1 |
| Kupresanin, M | 1 |
| Landry, AS | 1 |
| Fredholm, BB | 1 |
| Brodin, K | 1 |
| Strandberg, K | 1 |
| Onder, S | 1 |
| Ozgül, M | 1 |
| Toygar, A | 1 |
| Ueda, S | 1 |
| Ikegami, K | 1 |
| Sakanashi, M | 1 |
| Yonemura, KI | 1 |
| Takayanagi, K | 1 |
| Taniyama, K | 1 |
| Maeda, M | 1 |
| Takahashi, N | 1 |
| Araki, H | 1 |
| Matsumoto, H | 1 |
| Galkin, AA | 1 |
| Timin, EN | 1 |
| Kuriyama, H | 1 |
| Ito, Y | 1 |
| Kitamura, K | 1 |
| Godfraind, T | 1 |
| Hidaka, H | 1 |
| Asano, M | 1 |
| Radomirov, R | 1 |
| Engler, MB | 1 |
| Javellaud, J | 1 |
| Azadzoi, KM | 2 |
| Kim, N | 1 |
| Brown, ML | 1 |
| Goldstein, I | 2 |
| Cohen, RA | 3 |
| Osthaus, LE | 1 |
| Galligan, JJ | 1 |
| Fonger, JD | 1 |
| Yang, XM | 1 |
| Haudenschild, CC | 1 |
| Shemin, RJ | 1 |
| Kimoto, Y | 2 |
| Kumazawa, J | 1 |
| Kessler, R | 1 |
| Constantinou, CE | 2 |
| Yoshida, K | 1 |
| Chang, KC | 1 |
| Lim, JK | 1 |
| Park, CW | 1 |
| Henrion, D | 1 |
| Chillon, JM | 1 |
| Hoffman, M | 1 |
| Capdeville-Atkinson, C | 1 |
| Atkinson, J | 1 |
| McKay, A | 1 |
| O'Rourke, ST | 1 |
| Vanhoutte, PM | 2 |
| Tsuru, H | 1 |
| Kohno, S | 1 |
| Matsubayashi, H | 1 |
| Shikada, K | 1 |
| Yamamoto, A | 1 |
| Tanaka, S | 1 |
| Zeitune, MG | 1 |
| Bazerque, PM | 1 |
| Morrison, KJ | 1 |
| Cortes, D | 1 |
| Bookstein, JJ | 1 |
| Vandeberg, J | 1 |
| Machado, T | 1 |
| Kobayashi, Y | 1 |
| Hattori, K | 1 |
| Tłottrup, A | 1 |
| Forman, A | 1 |
| Funch-Jensen, P | 1 |
| Raundahl, U | 1 |
| Andersson, KE | 2 |
| Hu, CY | 1 |
| Robinson, CP | 1 |
| Holmquist, F | 1 |
| Fovaeus, M | 1 |
| Hedlund, H | 1 |
| Nickols, GA | 2 |
| Metz, MA | 1 |
| Cline, WH | 1 |
| Türker, RK | 1 |
| Demirel, E | 1 |
| Lai, FM | 1 |
| Tanikella, T | 1 |
| Cervoni, P | 1 |
| Yeates, RA | 1 |
| Schmid, M | 1 |
| Leitold, M | 1 |
| Bilcíková, L | 1 |
| Bauer, V | 1 |
| Kolena, J | 1 |
| Tanabe, S | 1 |
| Ikeda, Y | 1 |
| Shiraki, Y | 1 |
| Sakai, K | 1 |
| Azadzoi, K | 1 |
| Krane, RJ | 1 |
| Ogawa, T | 1 |
| Costa, M | 1 |
| Furness, JB | 1 |
| Humphreys, CM | 1 |
| Whalley, ET | 1 |
| Amure, YO | 1 |
| Lye, RH | 1 |
| Barbanti, G | 1 |
| Beneforti, P | 1 |
| Lapini, A | 1 |
| Turini, D | 1 |
| Kawagoe, J | 1 |
| Servin, AL | 1 |
| Christinaki, H | 1 |
| Viel, C | 1 |
| Kobori, T | 1 |
| Fujiwara, S | 1 |
| Kassell, NF | 1 |
| Sasaki, T | 1 |
| Nakagomi, T | 1 |
| Lehman, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Medication Facilitated Ureteral Access Sheath Deployment During Ureteroscopy and Endoscopic-Guided Percutaneous Nephrolithotomy: A Randomized Double-Blind Placebo Controlled Trial of Tadalafil, Tamsulosin and Combination[NCT03229889] | Phase 4 | 220 participants (Anticipated) | Interventional | 2017-06-07 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for papaverine and Muscle Relaxation
| Article | Year |
|---|---|
Diagnosing erectile dysfunction: instruments for the study of smooth muscle relaxation.
Topics: Erectile Dysfunction; Hemodynamics; Humans; Male; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; P | 2005 |
Pharmacological treatment of erectile dysfunction.
Topics: Adrenergic alpha-Antagonists; Alprostadil; Apomorphine; Dopamine Agonists; Erectile Dysfunction; Hum | 1999 |
The role of nitric oxide in penile erection.
Topics: Animals; Arginine; Erectile Dysfunction; Genetic Therapy; Humans; Male; Muscle Relaxation; Muscle, S | 2001 |
1 trial available for papaverine and Muscle Relaxation
| Article | Year |
|---|---|
Audiovisual sexual stimulation by virtual glasses is effective in inducing complete cavernosal smooth muscle relaxation: a pharmacocavernosometric study.
Topics: Adult; Aged; Audiovisual Aids; Erectile Dysfunction; Eyeglasses; Humans; Male; Middle Aged; Muscle R | 2000 |
149 other studies available for papaverine and Muscle Relaxation
| Article | Year |
|---|---|
Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Chromones; Coronary Vessels; Cyclic GMP; Dinopr | 1993 |
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smoo | 2018 |
Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus.
Topics: Animals; Benzoxazoles; Carbachol; Cholinergic Agonists; Dimethylphenylpiperazinium Iodide; Electric | 2009 |
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs.
Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazine | 2009 |
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.
Topics: Animals; Bronchodilator Agents; Esophageal Sphincter, Lower; Female; Male; Milrinone; Muscle Relaxat | 2009 |
Involvement of contractile elements in control of bioluminescence in Northern krill, Meganyctiphanes norvegica (M. Sars).
Topics: Actin Cytoskeleton; Animals; Euphausiacea; Immunohistochemistry; Light; Luminescence; Muscle Relaxat | 2009 |
Comparison of the effects of levosimendan and papaverine on human internal mammary artery and saphenous vein.
Topics: Aged; Dose-Response Relationship, Drug; Female; Humans; Hydrazones; In Vitro Techniques; Male; Mamma | 2009 |
Vascular smooth muscle contraction/relaxation of rat carotid artery is not altered by bone grafting substitutes in vitro.
Topics: Animals; Biocompatible Materials; Bone Matrix; Bone Substitutes; Carotid Arteries; Ceramics; Dose-Re | 2010 |
Changes in the neurogenic and endothelium-dependent relaxant responses of rabbit corpus cavernosum smooth muscle after cavernous nerve neurotomy.
Topics: Animals; Carbachol; Electric Stimulation; Male; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Pa | 2010 |
Bronchodilator activity of bitter tastants in human tissue.
Topics: Animals; Bronchi; Bronchodilator Agents; Chloroquine; Dose-Response Relationship, Drug; Guinea Pigs; | 2011 |
Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Erectile Dysfunction; Ethanol; Male | 2012 |
The achilles heel in melatonin: asthma.
Topics: Acetylcholine; Animals; Asthma; Circadian Rhythm; Dose-Response Relationship, Drug; Injections, Intr | 2012 |
Omeprazole-induced relaxation in rat aorta is partly dependent on endothelium.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; In Vitr | 2002 |
Functional role of inhibitory and excitatory nerves in the porcine lower urinary tract.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Atropine; Cyclic GMP; Dose-Response Relationship, D | 2002 |
Inhibitory effects of etomidate and ketamine on adenosine triphosphate-sensitive potassium channel relaxation in canine pulmonary artery.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cro | 2003 |
The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips.
Topics: Amrinone; Animals; Body Weight; Calcium; Creatinine; Dose-Response Relationship, Drug; Electric Stim | 2003 |
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, D | 2003 |
Anesthesiologist's role in bowel relaxation for artificial bladder construction.
Topics: Anesthesia; Cystectomy; Digestive System Physiological Phenomena; Humans; Ileum; Muscle Relaxation; | 2003 |
Impaired nitric oxide function in the basilar artery of the obese Zucker rat.
Topics: Acetylcholine; Animals; Basilar Artery; Biogenic Amines; Calcimycin; Endothelium, Vascular; Female; | 2003 |
Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis.
Topics: Animals; Barium Compounds; Carbachol; Cetirizine; Chlorides; Dose-Response Relationship, Drug; Drug | 2003 |
Effects of melatonin on impaired neurogenic and endothelial relaxations by bacterial lipopolysaccharide in the mouse corpus cavernosum.
Topics: Acetylcholine; Animals; Electric Stimulation; Endothelium; Escherichia coli; In Vitro Techniques; Li | 2004 |
The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diclofenac; Enzyme Inhibitors; Female; Humans; Mal | 2003 |
Evaluation of the rat bladder-derived relaxant factor by coaxial bioassay system.
Topics: Acetylcholine; Animals; Biological Assay; Biological Factors; Bupivacaine; Dose-Response Relationshi | 2004 |
Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental | 2004 |
Participation of ATP in nonadrenergic, noncholinergic relaxation of longitudinal muscle of wistar rat jejunum.
Topics: Adenosine Phosphosulfate; Adenosine Triphosphate; Animals; Apamin; Atropine; Drug Administration Sch | 2005 |
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Apamin; Barium; Benzopyrans; Caffeine; Calcitonin Gene-Rela | 2006 |
Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits.
Topics: Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Electric Stimulation; Hypothyroidi | 2006 |
A novel bronchial ring bioassay for the evaluation of small airway smooth muscle function in mice.
Topics: Animals; Biological Assay; Boron Compounds; Bronchi; Bronchoconstrictor Agents; Calcium Channel Bloc | 2006 |
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits.
Topics: Animals; Carbachol; Cyclic GMP; Disease Models, Animal; Electric Stimulation; Hypothyroidism; Impote | 2006 |
Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Doxazosin; Epinephrine; Male; Muscle Contr | 2007 |
Protease-activated receptor-1 (PAR1) and PAR2 but not PAR4 mediate relaxations in lower esophageal sphincter.
Topics: Animals; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Guinea Pigs; In Vitro Techni | 2007 |
Effect of chronic renal failure on foregut smooth muscle reactivity: an experimental study.
Topics: Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug | 2007 |
Torsion/detorsion of the testis does not modify responses to nitric oxide in rat isolated penile bulb.
Topics: Animals; Electric Stimulation; Endothelium-Dependent Relaxing Factors; Erectile Dysfunction; Male; M | 2007 |
The villi contribute to the mechanics in the guinea pig small intestine.
Topics: Animals; Elasticity; Epithelial Cells; Guinea Pigs; Intestinal Mucosa; Jejunum; Male; Muscle Relaxat | 2008 |
Mechanism of relaxant action of papaverine IV. Roles of sodium ion and cyclic AMP.
Topics: Animals; Bucladesine; Chlorides; Colon; Cyclic AMP; Deoxycholic Acid; Guinea Pigs; Lithium; Lithium | 1984 |
Peripheral vascular smooth muscle relaxation in normotensive and hypertensive rats.
Topics: Adenosine; Animals; Desoxycorticosterone; Hypertension; Isoproterenol; Male; Mesenteric Arteries; Mu | 1980 |
Mechanism of relaxant action of papaverine. III. Comparison of sodium ion dependencies on the relaxant effects of papaverine, Aspaminol and benactyzine in guinea-pig taenia coli.
Topics: Animals; Benactyzine; Calcium; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Intestines; Muscle Cont | 1983 |
Vasodilator effects of dopaminomimetics in the perfused rat kidney.
Topics: Animals; Butaclamol; Dopamine; Drug Interactions; In Vitro Techniques; Male; Muscle Relaxation; Papa | 1982 |
Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery.
Topics: Animals; Cold Temperature; Dibenzylchlorethamine; Dimaprit; Drug Synergism; Histamine; Mesenteric Ar | 1983 |
Mechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli.
Topics: Animals; Bucladesine; Caffeine; Calcium; Colon; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Male; | 1982 |
In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor?
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Drug Interactions; Female; Humans; Muscle Relaxation; My | 1983 |
Mechanism of smooth muscle relaxation by rociverine.
Topics: Animals; Atropine; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Calcium; Cyclohexanecarboxylic | 1984 |
Actions and interactions of ergotamine and dihydroergocristine in rat aortic strips.
Topics: Animals; Aorta, Thoracic; Dihydroergotoxine; Drug Interactions; Ergotamine; In Vitro Techniques; Mal | 1981 |
Mechanism of relaxant action of papaverine. II. Differences between modes of relaxant effects of papaverine and amytal in guinea-pig taenia coli.
Topics: Amobarbital; Animals; Calcium; Calcium Radioisotopes; Guinea Pigs; In Vitro Techniques; Male; Muscle | 1983 |
Mechanical properties of arteries.
Topics: Animals; Aorta, Abdominal; Arteries; Biomechanical Phenomena; Carotid Arteries; Elasticity; Female; | 1982 |
Dependence of elastic and viscous properties of elastic arteries on circumferential wall stress at two different smooth muscle tones.
Topics: Animals; Arteries; Elasticity; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; M | 1981 |
Quantitization of Ca spike frequency in a single sucrose gap and mechanical relaxation induced by Ca antagonists, isoproterenol and papaverine.
Topics: Action Potentials; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isoproterenol; Ma | 1981 |
Structurally reduced distensibility of cardiovascular low-pressure' compartments in primary hypertension, as studied in spontaneously hypertensive rats (SHR).
Topics: Animals; Blood Pressure; Blood Volume; Cardiovascular Physiological Phenomena; Hindlimb; Hypertensio | 1981 |
Papaverine-induced inhibition of electrical and mechanical activity and calcium movements of rat ileal smooth muscle.
Topics: Animals; Calcium; Ileum; Muscle Relaxation; Muscle, Smooth; Neural Conduction; Papaverine; Rats | 1980 |
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Dinoprost; Dogs; Dose-Respons | 1995 |
Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arterioles; Atropine; Dogs; Electric Stimulation; End | 1994 |
Inhibition by ethacrynic acid of NO-mediated relaxations of the rat anococcygeus muscle.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cysteine; Drug Interactions; Electric Stimulation; Et | 1994 |
Porcine detrusor cyclic nucleotide phosphodiesterase isoenzymes: characterization and functional effects of various phosphodiesterase inhibitors in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calmodulin; Carba | 1995 |
Endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rat aorta.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Atropine; Biological Factor | 1995 |
Corpus cavernosal relaxation in impotent men.
Topics: Adult; Aged; Aged, 80 and over; Female; Guanethidine; Humans; Impotence, Vasculogenic; Male; Middle | 1994 |
The role of histamine in human penile erection.
Topics: Adult; Aged; Erectile Dysfunction; Histamine; Humans; In Vitro Techniques; Injections; Male; Middle | 1995 |
Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Calmodulin; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic | 1994 |
The role of myoendothelial cell contact in non-nitric oxide-, non-prostanoid-mediated endothelium-dependent relaxation of porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Biological Fa | 1994 |
Cyclic guanosine monophosphate mediates penile erection in the rat.
Topics: Alprostadil; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Dose-Response Relatio | 1993 |
Relationship between cytosolic calcium concentration and force in the papaverine-induced relaxation of medial strips of pig coronary artery.
Topics: Animals; Caffeine; Calcium; Coronary Vessels; Cytosol; Female; Fluorescent Dyes; Fura-2; Histamine; | 1994 |
Effects of okadaic acid on the human isolated bronchus.
Topics: Acetylcholine; Bronchi; Cadmium; Cadmium Compounds; Caffeine; Dose-Response Relationship, Drug; Ethe | 1994 |
Endothelium-dependent relaxation in response to acetylcholine in the human uterine artery.
Topics: Acetylcholine; Adult; Arteries; Dibenzylchlorethamine; Endothelium, Vascular; Female; Humans; In Vit | 1994 |
Absence of desensitization to the relaxant activity of streptozotocin in isosorbide dinitrate-tolerant rat aorta.
Topics: Animals; Aorta, Thoracic; Drug Tolerance; Guanylate Cyclase; In Vitro Techniques; Isosorbide Dinitra | 1993 |
Endothelium-dependent relaxation in pulmonary arteries after lung preservation and transplantation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blood Pr | 1993 |
Interactions of nitrovasodilators and atrial natriuretic peptide in isolated dog coronary arteries.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic | 1993 |
Bronchodilatation of guinea-pig perfused bronchioles induced by the H3-receptor for histamine: role of epithelium.
Topics: Acetylcholine; Animals; Anticonvulsants; Arginine; Bronchi; Bronchodilator Agents; Epithelium; Femal | 1993 |
Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Autonomic Nervous System; Endothelium, Vascular; Hydroxocob | 1993 |
Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Female; Gastric Fundus; Gastrointestinal Motility; Interl | 1993 |
Role of cyclic adenosine monophosphate in prostaglandin E1-induced penile erection in rabbits.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Cyclic AMP; Dose-Response Relationship | 1995 |
The effect of S-(+)-boldine on the alpha 1-adrenoceptor of the guinea-pig aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Apo | 1996 |
Effect of Rp diastereoisomer of adenosine 3',5' cyclic-monophosphothioate on the cAMP-dependent relaxation of smooth muscle.
Topics: Animals; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Inhibitors; Female; Histamine; Muscle Rela | 1997 |
Suppression of acetylcholine-induced relaxation by local anesthetics and vascular NO-cyclic GMP system.
Topics: Acetylcholine; Anesthetics, Local; Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; | 1997 |
DMPP causes relaxation of rat distal colon by a purinergic and a nitrergic mechanism.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Carbachol; Colon; Dimethylphenylpiperazinium Io | 1997 |
Electrical activity of corpus cavernosum in vasculogenic and non-vasculogenic erectile dysfunction.
Topics: Adult; Cholesterol; Electromyography; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Injecti | 1997 |
Neurogenic contraction and relaxation of human penile deep dorsal vein.
Topics: Acetylcholine; Adolescent; Adult; Aged; Electric Stimulation; Endothelium, Vascular; Humans; In Vitr | 1998 |
The effect of NO donors on bovine retinal small arteries and posterior ciliary arteries.
Topics: Animals; Cattle; Ciliary Arteries; Cyclic GMP; Dose-Response Relationship, Drug; Electromyography; M | 1998 |
Rat gastroduodenal motility in vivo: involvement of NO and ATP in spontaneous motor activity.
Topics: Adenosine Triphosphate; Animals; Arginine; Carbachol; Duodenum; Gastrointestinal Motility; Male; Mus | 1998 |
Mechanism of neurogenic relaxation and modification of the response by enteric substances in isolated dog colon.
Topics: Adenosine Triphosphate; Animals; Arginine; Atropine; Bradykinin; Colon; Dogs; Dose-Response Relation | 1998 |
Effects of chronic unilateral internal pudendal arterial occlusion on reactivity of isolated corpus cavernosum strips from rabbits.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Arteries; Carbachol; Chronic Disease; Dose-Response | 1999 |
K(+)-induced neurogenic relaxation of rat distal colon.
Topics: Animals; Apamin; Carbachol; Colon; Drug Interactions; Enzyme Inhibitors; Hexamethonium; In Vitro Tec | 1999 |
Restorative effects of zinc and selenium on nitrergic relaxations impaired by cadmium in the mouse corpus cavernosum.
Topics: Acetylcholine; Animals; Cadmium; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Relax | 2000 |
Comparison of the synergistic effects of tamsulosin versus phentolamine on penile erection: in vitro and in vivo studies.
Topics: Adrenergic alpha-Antagonists; Alprostadil; Animals; Blood Pressure; Dogs; Drug Synergism; Erectile D | 1999 |
Mechanisms involved in kaempferol-induced relaxation in rat uterine smooth muscle.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antimetabolites; Cyclic AMP; Cyclic AMP-Dependent Protein Kina | 2000 |
Sildenafil citrate on nitrergic transmission in anococcygeus muscles from the urogenital system of male and female mice.
Topics: Animals; Carbachol; Colforsin; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; | 2000 |
Mechanism of relaxant response to papaverine on the smooth muscle of non-pregnant rat uterus.
Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Female; Guinea Pigs; In Vitro Techniques; Muscle Relaxatio | 2000 |
Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Arginine; Cyclic Nucleotide Phosphodi | 2001 |
Chronic ethanol consumption impairs adrenoceptor- and purinoceptor-mediated relaxations of isolated rat detrusor smooth muscle.
Topics: Adenosine; Alcohol Drinking; Animals; Carbachol; Dose-Response Relationship, Drug; Ethanol; Isoprote | 2001 |
Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic mice using synchrotron radiation microangiography.
Topics: Angiography; Animals; Cattle; Enzyme Inhibitors; Hindlimb; In Vitro Techniques; Lipopolysaccharides; | 2001 |
Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations.
Topics: Acetylcholine; Animals; Barium Compounds; Bicyclic Monoterpenes; Bridged Bicyclo Compounds; Calcium | 2002 |
BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery: comparison with CGRP(8-37).
Topics: Adolescent; Adult; Aged; Calcitonin Gene-Related Peptide; Female; Humans; In Vitro Techniques; Male; | 2002 |
Relaxation degree: a new concept in erectile dysfunction.
Topics: Adult; Case-Control Studies; Electromyography; Erectile Dysfunction; Humans; Male; Muscle Relaxation | 2001 |
Specific enhancement of norepinephrine-induced contraction in rat veins after beta adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Drug Interactions; Electric Stimulation; In Vitro Techniques; | 1977 |
Calcium ions and relaxation of intestinal smooth muscle induced by papaverine and aspaminol.
Topics: Animals; Calcium; Colon; Guinea Pigs; Ileum; In Vitro Techniques; Ions; Male; Microsomes; Muscle Con | 1977 |
Relaxation of depolarized guinea pig taenia caecum induced by some antispasmodics.
Topics: Animals; Benactyzine; Bucladesine; Calcium; Cecum; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Iso | 1978 |
Nonspecific relaxation of intestinal smooth muscle induced by antispasmodics and movement of Calcium ions.
Topics: Animals; Benactyzine; Calcium; Colon; Histamine H1 Antagonists; In Vitro Techniques; Ions; Male; Mic | 1978 |
Transient responses of rabbit cerebral blood vessels to norepinephrine: correlation with intrinsic myogenic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Carotid Artery, Internal; Cerebral Arteries; | 1979 |
[Legal abortion during the first trimester of pregnancy at the University Hospital for Women in Novi Sad (1960-1975)].
Topics: Abortion, Therapeutic; Atropine; Female; Hospitals, University; Humans; Muscle Relaxation; Papaverin | 1977 |
The activation of cyclic 3',5'-adenosine monophosphate-dependent protein kinase on sarcoplasmic reticulum fractions of various smooth muscles and its related novel relaxants.
Topics: Animals; Cyclic AMP; Enzyme Activation; Guinea Pigs; Hydroxybenzoates; In Vitro Techniques; Muscle R | 1977 |
Cyclic AMP in the rat jugular vein: relationship to vascular relaxation.
Topics: Animals; Cyclic AMP; Isoproterenol; Jugular Veins; Male; Muscle Contraction; Muscle Relaxation; Musc | 1979 |
On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cyclic AMP; Cyclic GMP; Drug Interactions; | 1979 |
The effect of potassium on frog stomach muscle.
Topics: Animals; Anura; Biological Transport, Active; Muscle Contraction; Muscle Relaxation; Ouabain; Papave | 1979 |
Effects of prostaglandin E1 on isolated dog renal artery.
Topics: Animals; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoproteren | 1979 |
[Non-specific relaxation of the smooth muscle caused by drugs].
Topics: Animals; Benactyzine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smoo | 1977 |
Modification of the antispasmodic actions of isoproterenol and papaverine by removal of external Na in the isolated rat rectum.
Topics: Animals; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Sm | 1977 |
[Kinetics of guinea pig taenia coli smooth muscle relaxation. Effect of papaverine and polarization].
Topics: Animals; Calcium; Colon; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Ion Channels; Muscl | 1978 |
[Papaverine actions and mechanism of vascular muscle relaxation (author's transl)].
Topics: Aged; Animals; Calcium; Dogs; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Papaver | 1978 |
Alternative mechanisms for the potentiation of the relaxation evoked by isoprenaline in aortae from young and aged rats.
Topics: Aging; Animals; Aorta, Thoracic; Blood Vessels; Cinnarizine; Drug Synergism; Isoproterenol; Muscle C | 1979 |
Relaxation of isolated rabbit arteries by fusaric (5-butylpicolinic) acid.
Topics: Aminophylline; Angiotensin II; Animals; Arteries; Atropine; Calcium; Catecholamines; Female; Fusaric | 1976 |
Pharmacological effect on the average rates of development of the contractile and relaxation phases of the acetylcholine contractile effect in the smooth muscles of guinea-pig caecum.
Topics: Acetylcholine; Animals; Barium; Cecum; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; M | 1976 |
Vascular relaxation to omega-3 fatty acids: comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600.
Topics: Animals; Aorta, Thoracic; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Gallop | 1992 |
Bronchodilator action of an agonist for histamine H3-receptors in guinea pig perfused bronchioles and lung parenchymal strips.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstriction; Bronchodilator Agents; Dose-Response Relations | 1992 |
Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone.
Topics: Acetylcholine; Animals; Bradykinin; Cholic Acids; Cyclic GMP; Eicosanoids; Endothelium, Vascular; Gu | 1992 |
Antagonists of nitric oxide synthesis inhibit nerve-mediated relaxations of longitudinal muscle in guinea pig ileum.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Guinea Pigs; Ileum; Isoproterenol; Male; Muscle Relax | 1992 |
Impaired relaxation of the human mammary artery after temporary clamping.
Topics: Acetylcholine; Constriction; Endothelium, Vascular; Humans; In Vitro Techniques; Mammary Arteries; M | 1992 |
Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle.
Topics: Acetylcholine; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Endothelium, Vascular | 1992 |
Relaxation mechanisms of antispasmodics papaverine and thiphenamil on the human corpus cavernosum.
Topics: Diphenylacetic Acids; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Papaveri | 1992 |
Comparison of hypoxia-induced contraction in human, monkey, and dog coronary arteries.
Topics: Animals; Aspirin; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; Humans; Hypoxia; | 1992 |
Pharmacological evaluation of GS-389, a novel tetrahydroisoquinoline analog related to higenamine, on vascular smooth muscle.
Topics: Alkaloids; Animals; Aorta, Thoracic; Bicarbonates; Cardiotonic Agents; Drug Interactions; Egtazic Ac | 1992 |
Decrease in endothelium-dependent relaxation in the mesenteric arterial bed following vascular calcium overload produced by vitamin D3 and nicotine in rats.
Topics: Animals; Body Weight; Calcium; Carbachol; Cholecalciferol; Endothelium; Histamine; Male; Muscle Rela | 1991 |
The effects of ethylenediamine in the rat small intestine: a powerful relaxant of the muscularis.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cholinergic Antagonists; Ethylen | 1991 |
Celiprolol has no direct or indirect relaxing effects in isolated arteries and veins.
Topics: Adrenergic beta-Antagonists; Animals; Arteries; Celiprolol; Dinoprost; In Vitro Techniques; Isometri | 1990 |
Relaxation response of isolated canine veins to agents that act on the adenylate cyclase-cyclic AMP system: further investigation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cycli | 1990 |
Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; In Vitro Tec | 1991 |
Reserpine non-selectively inhibits rat uterus contraction in vitro.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; | 1991 |
Inhibition of airway smooth muscle tone by a phorbol ester in the guinea pig trachea: role of epithelium and receptor reserve of the contractile agent.
Topics: Acetylcholine; Animals; Drug Interactions; Epithelium; Guinea Pigs; Male; Muscle Contraction; Muscle | 1991 |
Effects of cularine and other isoquinoline alkaloids on guinea-pig trachea and human bronchus.
Topics: Adenosine; Alkaloids; Animals; Bronchi; Calcium; Guinea Pigs; Histamine; Humans; In Vitro Techniques | 1990 |
The cavernosal acetylcholine/papaverine response. A practical in vivo method for quantification of endothelium-dependent relaxation. Rationale and experimental validation.
Topics: Acetylcholine; Animals; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Papaverine; | 1990 |
Nitroarginine inhibits endothelium-derived relaxation.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Female; In Vitro Technique | 1990 |
Effects of postganglionic nerve stimulation in oesophageal achalasia: an in vitro study.
Topics: Adolescent; Adult; Aged; Atropine; Electric Stimulation; Esophageal Achalasia; Esophagogastric Junct | 1990 |
Lack of an effect of soman on norepinephrine-induced relaxations of porcine coronary arteries.
Topics: Animals; Arteries; Coronary Vessels; Guinea Pigs; In Vitro Techniques; Muscle Relaxation; Muscle, Sm | 1990 |
Effects of [1-desamino-8-D-arginine]vasopressin and papaverine on rabbit renal pelvis.
Topics: Animals; Deamino Arginine Vasopressin; In Vitro Techniques; Isometric Contraction; Kidney Pelvis; Ma | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscl | 1990 |
Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cattle; Colforsin; Cyclic | 1985 |
Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3',5'-monophosphate and relaxation of vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin | 1986 |
Iloprost maintains acetylcholine relaxations of isolated rabbit aortic strips submitted to hypoxia.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Epoprostenol; Hypoxia; Iloprost; Muscle Relaxation; M | 1988 |
Effect of gamma-aminobutyric acid (GABA) on vasodilation in resistance-sized arteries isolated from the monkey, rabbit, and rat.
Topics: Animals; Arteries; Bicuculline; Dinoprost; gamma-Aminobutyric Acid; In Vitro Techniques; Macaca fasc | 1988 |
Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase.
Topics: Animals; Aorta; Glutathione; Glutathione Transferase; In Vitro Techniques; Muscle Relaxation; Nitrog | 1989 |
The effects of methylxanthines, ethymizol, ephedrine and papaverine on guinea pig and dog trachea.
Topics: Animals; Bronchodilator Agents; Cyclic AMP; Dogs; Ephedrine; Etimizol; Female; Guinea Pigs; Histamin | 1987 |
Enhancement of adenosine-induced relaxant responses of the guinea-pig isolated taenia coli and aortae by a novel nootropic agent BY-1949: comparison with dipyridamole.
Topics: Adenosine; Animals; Aorta, Thoracic; Brain; Colon; Dibenzoxazepines; Dipyridamole; Drug Synergism; G | 1988 |
Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence.
Topics: Acetylcholine; Diabetes Complications; Diabetes Mellitus; Electric Stimulation; Endothelium, Vascula | 1989 |
Mechanism of relaxant action of papaverine. VI. Sodium ion dependence of its effect on 45Ca-efflux in guinea-pig taenia coli.
Topics: Animals; Bucladesine; Calcium; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; I | 1985 |
Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract.
Topics: Adenosine Diphosphate; Animals; Apamin; Bee Venoms; Colon; Digestive System; Dogs; Female; Ileum; In | 1986 |
Analysis of the mechanism of action of bradykinin on human basilar artery in vitro.
Topics: Acetylcholine; Basilar Artery; Bradykinin; Endothelium; Humans; In Vitro Techniques; Muscle Relaxati | 1987 |
Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study.
Topics: Adult; Aged; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; | 1988 |
Effects of sucrose- or Tris-substitution for Na+ on responses to D 600, papaverine and KCN in the K+-depolarized taenia coli of guinea pigs.
Topics: Animals; Colon; Cyanides; Gallopamil; Glucose; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxa | 1988 |
Molecular properties of the papaverine binding sites identified in human colonic membranes with 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl) isoquinoline as probe.
Topics: Affinity Labels; Animals; Binding, Competitive; Colon; Humans; In Vitro Techniques; Male; Muscle Rel | 1988 |
Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.
Topics: Female; Humans; In Vitro Techniques; Muscle Relaxation; Myometrium; Papaverine; Phosphodiesterase In | 1987 |
Mechanisms of spasmolytic action of bile salts in depolarized guinea-pig taenia coli.
Topics: Animals; Bile Acids and Salts; Calcium; Chenodeoxycholic Acid; Cholic Acids; Colon; Deoxycholic Acid | 1986 |
Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Basilar Artery; Endothelium; Hemoglobins; Male; Musc | 1986 |