papaverine has been researched along with Mitochondrial Diseases in 1 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Papaverine and zolpidem were recently shown to be protective of bioenergetic loss in cell models of optic neuropathy." | 1.46 | Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. ( Cortopassi, GA; Datta, S; McMackin, MZ; Yu, AK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, AK | 1 |
| Datta, S | 1 |
| McMackin, MZ | 1 |
| Cortopassi, GA | 1 |
1 other study available for papaverine and Mitochondrial Diseases
| Article | Year |
|---|---|
Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules.
Topics: Animals; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex I; Glaucoma, Open-An | 2017 |