papaverine has been researched along with Melanoma in 4 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Excerpt | Relevance | Reference |
---|---|---|
"Sodium butyrate and cyclic AMP-stimulating agents (prostaglandin E1, papaverine, theophylline, and RO20-1724) caused reductions in the cell number (primarily due to reduction in cell division) when added individually to human melanoma cells in culture." | 3.66 | Effect of sodium butyrate in combination with prostaglandin E1 and inhibitors of cyclic nucleotide phosphodiesterase on human amelanotic melanoma cells in culture. ( Prasad, KN; Sakamoto, A, 1978) |
"Melphalan dose was corrected for ideal body weight (IBW) in 42% (n = 68) of procedures." | 1.35 | A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. ( Andtbacka, RH; Beasley, GM; Caudle, A; Delman, KA; Grobmyer, SR; Hochwald, SN; Kane, JM; McMahon, NS; Mosca, PJ; Noyes, RD; Padussis, J; Petersen, RP; Pruitt, SK; Ross, MI; Seigler, H; Tyler, DS; Zager, JS, 2009) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (50.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Beasley, GM | 2 |
Caudle, A | 1 |
Petersen, RP | 1 |
McMahon, NS | 1 |
Padussis, J | 1 |
Mosca, PJ | 2 |
Zager, JS | 2 |
Hochwald, SN | 2 |
Grobmyer, SR | 2 |
Delman, KA | 2 |
Andtbacka, RH | 2 |
Noyes, RD | 2 |
Kane, JM | 2 |
Seigler, H | 1 |
Pruitt, SK | 1 |
Ross, MI | 2 |
Tyler, DS | 2 |
Santillan, AA | 1 |
Prasad, KN | 1 |
Sakamoto, A | 1 |
Helson, L | 1 |
Lai, K | 1 |
Young, CW | 1 |
4 other studies available for papaverine and Melanoma
Article | Year |
---|---|
A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Chem | 2009 |
Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Pe | 2009 |
Effect of sodium butyrate in combination with prostaglandin E1 and inhibitors of cyclic nucleotide phosphodiesterase on human amelanotic melanoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Butyrates; Cell | 1978 |
Papaverine-induced changes in cultured human melanoma cells.
Topics: Bucladesine; Butyrates; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Humans; Mela | 1974 |