papaverine has been researched along with Malignant Melanoma in 4 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium butyrate and cyclic AMP-stimulating agents (prostaglandin E1, papaverine, theophylline, and RO20-1724) caused reductions in the cell number (primarily due to reduction in cell division) when added individually to human melanoma cells in culture." | 3.66 | Effect of sodium butyrate in combination with prostaglandin E1 and inhibitors of cyclic nucleotide phosphodiesterase on human amelanotic melanoma cells in culture. ( Prasad, KN; Sakamoto, A, 1978) |
| "Melphalan dose was corrected for ideal body weight (IBW) in 42% (n = 68) of procedures." | 1.35 | A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. ( Andtbacka, RH; Beasley, GM; Caudle, A; Delman, KA; Grobmyer, SR; Hochwald, SN; Kane, JM; McMahon, NS; Mosca, PJ; Noyes, RD; Padussis, J; Petersen, RP; Pruitt, SK; Ross, MI; Seigler, H; Tyler, DS; Zager, JS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beasley, GM | 2 |
| Caudle, A | 1 |
| Petersen, RP | 1 |
| McMahon, NS | 1 |
| Padussis, J | 1 |
| Mosca, PJ | 2 |
| Zager, JS | 2 |
| Hochwald, SN | 2 |
| Grobmyer, SR | 2 |
| Delman, KA | 2 |
| Andtbacka, RH | 2 |
| Noyes, RD | 2 |
| Kane, JM | 2 |
| Seigler, H | 1 |
| Pruitt, SK | 1 |
| Ross, MI | 2 |
| Tyler, DS | 2 |
| Santillan, AA | 1 |
| Prasad, KN | 1 |
| Sakamoto, A | 1 |
| Helson, L | 1 |
| Lai, K | 1 |
| Young, CW | 1 |
4 other studies available for papaverine and Malignant Melanoma
| Article | Year |
|---|---|
A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Chem | 2009 |
Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Pe | 2009 |
Effect of sodium butyrate in combination with prostaglandin E1 and inhibitors of cyclic nucleotide phosphodiesterase on human amelanotic melanoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Butyrates; Cell | 1978 |
Papaverine-induced changes in cultured human melanoma cells.
Topics: Bucladesine; Butyrates; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Humans; Mela | 1974 |