papaverine has been researched along with Long QT Syndrome in 4 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intracoronary papaverine (PAP) is the most potent vasodilator used for the achievement of maximal hyperemia." | 4.02 | Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement. ( Anai, R; Araki, M; Inoue, K; Kataoka, M; Miura, T; Naka, Y; Okabe, H; Setoyama, K; Sonoda, S, 2021) |
| "Occasional premature beats were observed in 2 patients (4." | 1.29 | QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine. ( Asahi, S; Inoue, T; Morooka, S; Takabatake, Y; Takayanagi, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inoue, K | 1 |
| Sonoda, S | 1 |
| Naka, Y | 1 |
| Okabe, H | 1 |
| Setoyama, K | 1 |
| Miura, T | 1 |
| Anai, R | 1 |
| Araki, M | 1 |
| Kataoka, M | 1 |
| Yang, Y | 2 |
| Liang, B | 1 |
| Liu, J | 1 |
| Li, J | 1 |
| Grunnet, M | 1 |
| Olesen, SP | 1 |
| Rasmussen, HB | 1 |
| Ellinor, PT | 1 |
| Gao, L | 1 |
| Lin, X | 1 |
| Li, L | 1 |
| Wang, L | 1 |
| Xiao, J | 1 |
| Liu, Y | 2 |
| Zhang, S | 1 |
| Liang, D | 1 |
| Peng, L | 1 |
| Jespersen, T | 1 |
| Chen, YH | 1 |
| Inoue, T | 1 |
| Asahi, S | 1 |
| Takayanagi, K | 1 |
| Morooka, S | 1 |
| Takabatake, Y | 1 |
| Kern, MJ | 1 |
| Deligonul, U | 1 |
| Serota, H | 1 |
| Gudipati, C | 1 |
| Buckingham, T | 1 |
4 other studies available for papaverine and Long QT Syndrome
| Article | Year |
|---|---|
Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Control Studies; Coronary Angiography; Coronary | 2021 |
Identification of a Kir3.4 mutation in congenital long QT syndrome.
Topics: Adolescent; Adult; Aged; Aminophylline; Atropine; Chromosome Mapping; Drug Combinations; Female; G P | 2010 |
QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine.
Topics: Adult; Aged; Blood Flow Velocity; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; Coronary Ci | 1994 |
Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Flow Velocity; Coronary Vessels; Female; Hemodynamics; Huma | 1990 |