Page last updated: 2024-11-02

papaverine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

papaverine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 1 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Research Excerpts

ExcerptRelevanceReference
"Papaverine is a benzylisoquinoline alkaloid from the plant Papaver somniferum (Opium poppy)."1.62Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia. ( Ashok, C; Coumar, MS; Dyavaiah, M; Parcha, PK; Rajasekaran, B; Sarvagalla, S; Sudharshan, SJ, 2021)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Parcha, PK1
Sarvagalla, S1
Ashok, C1
Sudharshan, SJ1
Dyavaiah, M1
Coumar, MS1
Rajasekaran, B1

Other Studies

1 other study available for papaverine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

ArticleYear
Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:2

    Topics: Allosteric Site; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Cell Line, Tu

2021
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