papaverine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
papaverine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 1 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Papaverine is a benzylisoquinoline alkaloid from the plant Papaver somniferum (Opium poppy)." | 1.62 | Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia. ( Ashok, C; Coumar, MS; Dyavaiah, M; Parcha, PK; Rajasekaran, B; Sarvagalla, S; Sudharshan, SJ, 2021) |
Research
Studies (1)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (100.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Parcha, PK | 1 |
Sarvagalla, S | 1 |
Ashok, C | 1 |
Sudharshan, SJ | 1 |
Dyavaiah, M | 1 |
Coumar, MS | 1 |
Rajasekaran, B | 1 |
Other Studies
1 other study available for papaverine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Article | Year |
---|---|
Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia.
Topics: Allosteric Site; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Cell Line, Tu | 2021 |