papaverine and Intermittent Claudication
papaverine has been researched along with Intermittent Claudication in 19 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The effect of ethaverine hydrochloride on exercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-controlled study conducted at three sites." | 9.06 | Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. ( Chubb, JM; Hogan, L; Michie, DD; Phillips, RE; Trainor, FS; Zellner, SR, 1986) |
"The effect of ethaverine hydrochloride on exercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-controlled study conducted at three sites." | 5.06 | Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. ( Chubb, JM; Hogan, L; Michie, DD; Phillips, RE; Trainor, FS; Zellner, SR, 1986) |
" During angiography, the p-FFR was measured using a pressure guidewire after administration of papaverine to induce hyperemia." | 3.80 | Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index. ( Ebisawa, S; Hioki, H; Ikeda, U; Izawa, A; Koyama, J; Miura, T; Miyashita, Y; Motoki, H; Tomita, T, 2014) |
Research
Studies (19)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (89.47) | 18.7374 |
1990's | 1 (5.26) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (5.26) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Hioki, H | 1 |
Miyashita, Y | 1 |
Miura, T | 1 |
Ebisawa, S | 1 |
Motoki, H | 1 |
Izawa, A | 1 |
Tomita, T | 1 |
Koyama, J | 1 |
Ikeda, U | 1 |
BETTS, TW | 1 |
STEIN, ID | 1 |
Lambert, J | 1 |
Lambert, PJ | 1 |
Sonnenfeld, T | 1 |
Cronestrand, R | 1 |
Seino, Y | 1 |
Rose, HB | 1 |
Kanazawa, M | 1 |
Vyden, JK | 1 |
Wall, FJ | 1 |
Murie, JA | 1 |
Quin, RO | 2 |
Forrest, H | 1 |
Sheldon, CD | 1 |
Schwartz, LB | 1 |
Purut, CM | 1 |
Craig, DM | 1 |
Smith, PK | 1 |
Moawad, J | 1 |
McCann, RL | 1 |
Emanuel, MB | 1 |
Evans, DH | 2 |
Bell, PR | 2 |
Baker, AR | 1 |
Macpherson, DS | 1 |
Trainor, FS | 1 |
Phillips, RE | 1 |
Michie, DD | 1 |
Zellner, SR | 1 |
Hogan, L | 1 |
Chubb, JM | 1 |
Bliss, BP | 1 |
Skagseth, E | 1 |
Hall, KV | 1 |
Stern, FH | 2 |
Barner, HB | 2 |
Kaiser, GC | 2 |
Willman, VL | 2 |
Hanlon, CR | 2 |
Tibbs, EE | 1 |
Reviews
1 review available for papaverine and Intermittent Claudication
Article | Year |
---|---|
Pressure studies in arterial surgery.
Topics: Blood Pressure; Blood Pressure Determination; Hemodynamics; Humans; Intermittent Claudication; Ische | 1987 |
Trials
4 trials available for papaverine and Intermittent Claudication
Article | Year |
---|---|
Double-blind study of papaverine hydrochloride on the efficacy in the treatment of intermittent claudication.
Topics: Aged; Blood Pressure; Brachial Artery; Clinical Trials as Topic; Doppler Effect; Double-Blind Method | 1983 |
Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication.
Topics: Ankle; Blood Pressure; Brachial Artery; Clinical Trials as Topic; Double-Blind Method; Exercise Test | 1986 |
Leg cramps in geriatric diabetics with peripheral vascular ischemia: treatment.
Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Diabetic Angiopathies; Female; Humans; | 1966 |
Further evaluation of papaverine for peripheral vascular ischemia.
Topics: Aged; Clinical Trials as Topic; Diabetes Complications; Female; Humans; Intermittent Claudication; I | 1967 |
Other Studies
14 other studies available for papaverine and Intermittent Claudication
Article | Year |
---|---|
Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index.
Topics: Aged; Ankle Brachial Index; Arterial Pressure; Constriction, Pathologic; Exercise Test; Feasibility | 2014 |
Intra-arterial therapy in occlusive vascular disease.
Topics: Cardiovascular Diseases; Humans; Intermittent Claudication; Papaverine; Peripheral Vascular Diseases | 1954 |
A MEDICAL APPRAISAL OF THERAPY FOR OCCLUSIVE ARTERIAL DISEASE.
Topics: Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Vessel Prosthesis; Blood Vessel Prosthesis I | 1964 |
Untoward hemodynamic effects of intra-arterial injections of vasodilator drugs on the muscle circulation in the dog hind limb with experimental arterial occlusion.
Topics: Acetylcholine; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Dogs; Histamine; Inj | 1967 |
Pharmacological vasodilation during reconstructive vascular surgery.
Topics: Aged; Blood Flow Velocity; Ethanolamines; Female; Femoral Artery; Humans; Injections, Intra-Arterial | 1980 |
Pressure contour analysis in the assessment of arterial stenosis.
Topics: Adult; Aged; Arterial Occlusive Diseases; Blood Pressure; Blood Pressure Determination; Female; Femo | 1983 |
Measurement of vascular input impedance in infrainguinal vein grafts.
Topics: Aged; Angiography; Arteriovenous Shunt, Surgical; Female; Follow-Up Studies; Graft Occlusion, Vascul | 1997 |
Specific calcium antagonists in the treatment of peripheral vascular disease.
Topics: Arterial Occlusive Diseases; Arteriosclerosis; Biological Transport; Blood Viscosity; Calcium; Cell | 1979 |
Proceedings: The haemodynamic effect of papaverine in peripheral arterial disease.
Topics: Blood Flow Velocity; Blood Pressure; Dose-Response Relationship, Drug; Hemodynamics; Humans; Intermi | 1976 |
Pressure, flow and peripheral resistance measurements during surgery for femoro-popliteal occlusion (preliminary observations on 21 limbs).
Topics: Aged; Angiography; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Blood Flow Velocity; | 1973 |
In situ vein bypass. Experiences with new vein valve strippers.
Topics: Adult; Aged; Ampicillin; Anticoagulants; Arteriovenous Shunt, Surgical; Dextrans; Female; Femoral Ve | 1973 |
Clinical documentation of hemodynamics of the disappearing pulse.
Topics: Aged; Angiography; Blood Flow Velocity; Blood Pressure; Female; Gangrene; Hemodynamics; Humans; Inte | 1968 |
Intermittent claudication with pedal pulses.
Topics: Adult; Aged; Angiography; Aortic Coarctation; Aortic Diseases; Aortography; Arteries; Arterioscleros | 1968 |
Sustained release papaverine in peripheral ischemia: report of 21 ambulatory cases with oscillometric studies.
Topics: Adult; Aged; Arteriosclerosis; Delayed-Action Preparations; Female; Humans; Intermittent Claudicatio | 1969 |