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papaverine and Intermittent Claudication

papaverine has been researched along with Intermittent Claudication in 19 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.

Research Excerpts

ExcerptRelevanceReference
"The effect of ethaverine hydrochloride on exercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-controlled study conducted at three sites."9.06Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. ( Chubb, JM; Hogan, L; Michie, DD; Phillips, RE; Trainor, FS; Zellner, SR, 1986)
"The effect of ethaverine hydrochloride on exercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-controlled study conducted at three sites."5.06Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication. ( Chubb, JM; Hogan, L; Michie, DD; Phillips, RE; Trainor, FS; Zellner, SR, 1986)
" During angiography, the p-FFR was measured using a pressure guidewire after administration of papaverine to induce hyperemia."3.80Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index. ( Ebisawa, S; Hioki, H; Ikeda, U; Izawa, A; Koyama, J; Miura, T; Miyashita, Y; Motoki, H; Tomita, T, 2014)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199017 (89.47)18.7374
1990's1 (5.26)18.2507
2000's0 (0.00)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hioki, H1
Miyashita, Y1
Miura, T1
Ebisawa, S1
Motoki, H1
Izawa, A1
Tomita, T1
Koyama, J1
Ikeda, U1
BETTS, TW1
STEIN, ID1
Lambert, J1
Lambert, PJ1
Sonnenfeld, T1
Cronestrand, R1
Seino, Y1
Rose, HB1
Kanazawa, M1
Vyden, JK1
Wall, FJ1
Murie, JA1
Quin, RO2
Forrest, H1
Sheldon, CD1
Schwartz, LB1
Purut, CM1
Craig, DM1
Smith, PK1
Moawad, J1
McCann, RL1
Emanuel, MB1
Evans, DH2
Bell, PR2
Baker, AR1
Macpherson, DS1
Trainor, FS1
Phillips, RE1
Michie, DD1
Zellner, SR1
Hogan, L1
Chubb, JM1
Bliss, BP1
Skagseth, E1
Hall, KV1
Stern, FH2
Barner, HB2
Kaiser, GC2
Willman, VL2
Hanlon, CR2
Tibbs, EE1

Reviews

1 review available for papaverine and Intermittent Claudication

ArticleYear
Pressure studies in arterial surgery.
    European journal of vascular surgery, 1987, Volume: 1, Issue:4

    Topics: Blood Pressure; Blood Pressure Determination; Hemodynamics; Humans; Intermittent Claudication; Ische

1987

Trials

4 trials available for papaverine and Intermittent Claudication

ArticleYear
Double-blind study of papaverine hydrochloride on the efficacy in the treatment of intermittent claudication.
    Angiology, 1983, Volume: 34, Issue:4

    Topics: Aged; Blood Pressure; Brachial Artery; Clinical Trials as Topic; Doppler Effect; Double-Blind Method

1983
Effects of ethaverine hydrochloride on the walking tolerance of patients with intermittent claudication.
    Angiology, 1986, Volume: 37, Issue:5

    Topics: Ankle; Blood Pressure; Brachial Artery; Clinical Trials as Topic; Double-Blind Method; Exercise Test

1986
Leg cramps in geriatric diabetics with peripheral vascular ischemia: treatment.
    Journal of the American Geriatrics Society, 1966, Volume: 14, Issue:6

    Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Diabetic Angiopathies; Female; Humans;

1966
Further evaluation of papaverine for peripheral vascular ischemia.
    Journal of the American Geriatrics Society, 1967, Volume: 15, Issue:4

    Topics: Aged; Clinical Trials as Topic; Diabetes Complications; Female; Humans; Intermittent Claudication; I

1967

Other Studies

14 other studies available for papaverine and Intermittent Claudication

ArticleYear
Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2014, Volume: 21, Issue:5

    Topics: Aged; Ankle Brachial Index; Arterial Pressure; Constriction, Pathologic; Exercise Test; Feasibility

2014
Intra-arterial therapy in occlusive vascular disease.
    British medical journal, 1954, Jun-12, Volume: 1, Issue:4875

    Topics: Cardiovascular Diseases; Humans; Intermittent Claudication; Papaverine; Peripheral Vascular Diseases

1954
A MEDICAL APPRAISAL OF THERAPY FOR OCCLUSIVE ARTERIAL DISEASE.
    Angiology, 1964, Volume: 15

    Topics: Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Vessel Prosthesis; Blood Vessel Prosthesis I

1964
Untoward hemodynamic effects of intra-arterial injections of vasodilator drugs on the muscle circulation in the dog hind limb with experimental arterial occlusion.
    Angiology, 1967, Volume: 18, Issue:7

    Topics: Acetylcholine; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Dogs; Histamine; Inj

1967
Pharmacological vasodilation during reconstructive vascular surgery.
    Acta chirurgica Scandinavica, 1980, Volume: 146, Issue:1

    Topics: Aged; Blood Flow Velocity; Ethanolamines; Female; Femoral Artery; Humans; Injections, Intra-Arterial

1980
Pressure contour analysis in the assessment of arterial stenosis.
    Angiology, 1983, Volume: 34, Issue:7

    Topics: Adult; Aged; Arterial Occlusive Diseases; Blood Pressure; Blood Pressure Determination; Female; Femo

1983
Measurement of vascular input impedance in infrainguinal vein grafts.
    Annals of vascular surgery, 1997, Volume: 11, Issue:1

    Topics: Aged; Angiography; Arteriovenous Shunt, Surgical; Female; Follow-Up Studies; Graft Occlusion, Vascul

1997
Specific calcium antagonists in the treatment of peripheral vascular disease.
    Angiology, 1979, Volume: 30, Issue:7

    Topics: Arterial Occlusive Diseases; Arteriosclerosis; Biological Transport; Blood Viscosity; Calcium; Cell

1979
Proceedings: The haemodynamic effect of papaverine in peripheral arterial disease.
    The British journal of surgery, 1976, Volume: 63, Issue:8

    Topics: Blood Flow Velocity; Blood Pressure; Dose-Response Relationship, Drug; Hemodynamics; Humans; Intermi

1976
Pressure, flow and peripheral resistance measurements during surgery for femoro-popliteal occlusion (preliminary observations on 21 limbs).
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1973, Volume: 128

    Topics: Aged; Angiography; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Blood Flow Velocity;

1973
In situ vein bypass. Experiences with new vein valve strippers.
    Scandinavian journal of thoracic and cardiovascular surgery, 1973, Volume: 7, Issue:1

    Topics: Adult; Aged; Ampicillin; Anticoagulants; Arteriovenous Shunt, Surgical; Dextrans; Female; Femoral Ve

1973
Clinical documentation of hemodynamics of the disappearing pulse.
    Archives of surgery (Chicago, Ill. : 1960), 1968, Volume: 97, Issue:2

    Topics: Aged; Angiography; Blood Flow Velocity; Blood Pressure; Female; Gangrene; Hemodynamics; Humans; Inte

1968
Intermittent claudication with pedal pulses.
    JAMA, 1968, Jun-10, Volume: 204, Issue:11

    Topics: Adult; Aged; Angiography; Aortic Coarctation; Aortic Diseases; Aortography; Arteries; Arterioscleros

1968
Sustained release papaverine in peripheral ischemia: report of 21 ambulatory cases with oscillometric studies.
    Southern medical journal, 1969, Volume: 62, Issue:7

    Topics: Adult; Aged; Arteriosclerosis; Delayed-Action Preparations; Female; Humans; Intermittent Claudicatio

1969
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