papaverine has been researched along with Idiopathic Parkinson Disease in 11 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pasha, MK | 1 |
| Sharma, RK | 1 |
| Rajput, AH | 1 |
| Gnanalingham, KK | 1 |
| Hunter, AJ | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Coscia, CJ | 1 |
| Burke, W | 1 |
| Jamroz, G | 1 |
| Lasala, JM | 1 |
| McFarlane, J | 1 |
| Mitchell, J | 1 |
| O'Toole, MM | 1 |
| Wilson, ML | 1 |
| Davis, VE | 1 |
| Cashaw, JL | 2 |
| McMurtrey, KD | 1 |
| Dougan, D | 1 |
| Wade, D | 1 |
| Mearrick, P | 1 |
| Duvoisin, RC | 1 |
| Posner, DM | 1 |
| Geraghty, CA | 1 |
| Montastruc, JL | 1 |
| Rascol, O | 1 |
| Belin, J | 1 |
| Ane, M | 1 |
| Rascol, A | 1 |
| Sandler, M | 1 |
| Hadjiev, D | 1 |
2 reviews available for papaverine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Disposition of catecholamine-derived alkaloids in mammalian systems.
Topics: Alkaloids; Animals; Brain; Catecholamines; Ethanol; Humans; Liver; Papaverine; Parkinson Disease; Ra | 1975 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
1 trial available for papaverine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Does papaverine interact with levodopa in Parkinson's disease?
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Female; Humans; Levodopa; Ma | 1987 |
8 other studies available for papaverine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
Selective dopamine antagonist pretreatment on the antiparkinsonian effects of benzazepine D1 dopamine agonists in rodent and primate models of Parkinson's disease--the differential effects of D1 dopamine antagonists in the primate.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Callithrix; Dopamine Agonists; Dopami | 1995 |
Occurrence of a new class of tetrahydroisoquinoline alkaloids in L-dopa-treated parkinsonian patients.
Topics: Animals; Biotransformation; Brain; Carbidopa; Catechols; Humans; Levodopa; Mice; Papaverine; Parkins | 1977 |
Effects of L-dopa metabolites at a dopamine receptor suggest a basis for 'on-off' effect in Parkinson's disease.
Topics: Animals; Dopamine; Dopamine Antagonists; Evoked Potentials; Intestinal Mucosa; Isoquinolines; Levodo | 1975 |
Antagonism of levodopa by papaverine.
Topics: Aged; Corpus Striatum; Fatigue; Female; Headache; Humans; Hyperhidrosis; Intracranial Arterioscleros | 1975 |
Letter: antagonism of levodopa by papaverine.
Topics: Aged; Female; Humans; Levodopa; Papaverine; Parkinson Disease | 1975 |
Method for the identification of tetrahydropapaveroline using the Pictet-Spengler condensation reaction and high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Elect | 1989 |
Some anomalies in the L-DOPA response: recent biochemical studies.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Models, Biological; Papave | 1974 |