papaverine has been researched along with Hypertension in 116 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 7.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| "The case of a patient with an anterior communicating artery aneurysm, who received intracisternal papaverine by instillation after aneurysm clipping, is reported." | 6.47 | Association of acute onset hypertension and tachycardia following intracisternal papaverine administration during intracranial aneurysm surgery: a case report and review of the literature. ( Agrawal, S; Sahu, S; Srivastava, VK, 2011) |
| "Coronary vasomotor responses to CPT and to maximal increase of blood flow induced by papaverine were studied in 10 untreated patients with essential hypertension, no other risk factors, and angiographically normal coronary arteries before and after intravenous ACE inhibition by perindoprilat." | 3.69 | Angiotensin-converting enzyme inhibition restores flow-dependent and cold pressor test-induced dilations in coronary arteries of hypertensive patients. ( Antony, I; Lerebours, G; Nitenberg, A, 1996) |
| "Cerebral vasodilatation in response to aprikalim, an opener of ATP-sensitive K+ channels, is selectively augmented after subarachnoid hemorrhage (SAH)." | 3.69 | Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats. ( Faraci, FM; Heistad, DD; Sobey, CG, 1997) |
| "Coronary arterial diameter, cross-sectional area and blood flow velocity were measured during coronary arteriography before and after intracoronary papaverine in 26 control subjects, 45 patients with significant coronary artery disease (> 50% luminal narrowing), 16 patients with syndrome X and 14 patients with hypertension and left ventricular hypertrophy (LVH)." | 3.69 | Abnormal coronary flow reserve in patients with angina pectoris and hypertensive left ventricular hypertrophy. ( Cai, X; Gong, L; Shen, W; Zhang, D; Zhang, X; Zheng, A, 1996) |
| "To examine the role played by angiotensin II (AII) in the development of prehypertensive vascular hypertrophy in the spontaneously hypertensive rat (SHR) and to determine whether normalization of prehypertensive vascular hypertrophy attenuates the development of hypertension." | 3.69 | Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats. ( Black, MJ; Bobik, A; Kanellakis, P, 1997) |
| "The effects of age, atherosclerosis, hypertension, and hypercholesterolemia on vascular function of the coronary circulation were studied by subselective intracoronary infusions of acetylcholine, which releases endothelium-derived relaxing factor, and papaverine, which directly relaxes vascular smooth muscle, in normal patients (n = 18; no risk factors for coronary artery disease), in patients with evidence of early atherosclerosis but normal cholesterol levels and normal blood pressure (n = 12), in patients with hypertension without left ventricular hypertrophy (n = 12), and in patients with hypercholesterolemia (n = 20)." | 3.68 | Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. ( Drexler, H; Just, H; Saurbier, B; Zeiher, AM, 1993) |
| "A total of 132 consecutive patients with erectile impotence underwent extensive evaluation, including vascular evaluation with intracavernous injection of papaverine and penile duplex ultrasonography, to determine the etiology of impotence." | 3.68 | Cigarette smoking and other vascular risk factors in vasculogenic impotence. ( Dunn, JK; Fishman, IJ; Schum, C; Shabsigh, R, 1991) |
| "In order to investigate the involvement of endothelium-derived vasoactive substances in deoxycorticosterone acetate (DOCA)-salt hypertension, the responses to noradrenaline, acetylcholine, sodium nitroprusside and papaverine were studied in the absence and presence of indomethacin." | 3.68 | Indirect evidence for an endothelium-derived contracting factor release in aorta of deoxycorticosterone acetate-salt hypertensive rats. ( Carvalho, MH; Cordellini, S; Fortes, ZB; Nigro, D; Scivoletto, R, 1990) |
| " The potency and efficacy of isoproterenol (ISO) in these arteries were decreased in SHR before and during the development of hypertension as compared with age-matched Wistar Kyoto rats (WKY)." | 3.67 | Diminished beta-adrenoceptor-mediated relaxation of arteries from spontaneously hypertensive rats before and during development of hypertension. ( Aoki, K; Asano, M; Dohi, Y; Fujimoto, S; Matsuda, T, 1987) |
| "Examination of 94 patients with stage II hypertensive disease and 20 rabbits with hypertension showed that in the hypokinetic type of hemodynamics separate medication with dibazol, papaverin hydrochloride and reserpine caused a reduction of arterial pressure in all cases due to a decrease in total peripheral resistance." | 3.66 | [Hemodynamic effects of hypotensive agents under adrenergic block in hypertension]. ( Guseva, NP; Kazak, LI; Prisiazhniuk, MS; Shchepotin, BM, 1981) |
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 3.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| "The influence of two beta-adrenoceptor antagonists, propranolol and pindolol, on the haemodynamic effects of papaverine, isoprenaline and noradrenaline was investigated in 9 male patients with first degree essential hypertension." | 3.66 | Influence of propranolol and pindolol on the haemodynamic effects of papaverine, isoprenaline and noradrenaline in hypertensive patients. ( Chu, D; Cocco, G; Haeusler, G; Schweda, E; Strozzi, C, 1980) |
| "The case of a patient with an anterior communicating artery aneurysm, who received intracisternal papaverine by instillation after aneurysm clipping, is reported." | 2.47 | Association of acute onset hypertension and tachycardia following intracisternal papaverine administration during intracranial aneurysm surgery: a case report and review of the literature. ( Agrawal, S; Sahu, S; Srivastava, VK, 2011) |
| "Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance." | 1.32 | Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. ( Fukudome, T; Hamasaki, S; Ishida, S; Kataoka, T; Minagoe, S; Mizoguchi, E; Ninomiya, Y; Okui, H; Otsuji, Y; Saihara, K; Shinsato, T; Tei, C, 2004) |
| " Cumulative dose-response curves to bradykinin induced an important vasodilation in NTRs, with a maximal response that remained unaffected in the presence of either NNLA (30 pmol/I), indomethacin (10 pmol/l) or the two combined." | 1.31 | Altered coronary dilation in deoxycorticosterone acetate-salt hypertension. ( de Champlain, J; Lamontagne, D; Millette, E, 2000) |
| "Indomethacin treatment did not correct the altered response to norepinephrine in mesenteric preparations studied in vivo in situ." | 1.28 | Indirect evidence for an endothelium-derived contracting factor released in arterioles of deoxycorticosterone acetate salt hypertensive rats. ( de Carvalho, MH; Fortes, ZB; Nigro, D; Scivoletto, R, 1990) |
| " In response to intra-arterial injections of norepinephrine, hypertensive pigs (n = 8) demonstrated shifts in the dose-response curves to the left and lower vasoconstrictor thresholds than controls (n = 10)." | 1.26 | Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig. ( Berecek, KH; Bohr, DF, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 84 (72.41) | 18.7374 |
| 1990's | 22 (18.97) | 18.2507 |
| 2000's | 4 (3.45) | 29.6817 |
| 2010's | 6 (5.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Havera, HJ | 1 |
| Vidrio, H | 1 |
| Huang, TL | 1 |
| Mayence, A | 1 |
| Vanden Eynde, JJ | 1 |
| Ismail, A | 1 |
| Tabari, AM | 1 |
| Alhasan, SU | 1 |
| Abdullahi, A | 1 |
| Hosoo, S | 1 |
| Koyama, M | 1 |
| Kato, M | 1 |
| Hirata, T | 1 |
| Yamaguchi, Y | 1 |
| Yamasaki, H | 1 |
| Wada, A | 1 |
| Wada, K | 1 |
| Nishibe, S | 1 |
| Nakamura, K | 1 |
| Hill, JV | 1 |
| Findon, G | 1 |
| Appelhoff, RJ | 1 |
| Endre, ZH | 1 |
| Bruno, RM | 1 |
| Sudano, I | 1 |
| Ghiadoni, L | 1 |
| Masi, L | 1 |
| Taddei, S | 1 |
| Srivastava, VK | 1 |
| Agrawal, S | 1 |
| Sahu, S | 1 |
| Didion, SP | 1 |
| Ryan, MJ | 1 |
| Baumbach, GL | 1 |
| Sigmund, CD | 1 |
| Faraci, FM | 2 |
| HERNANDEZ NARROS, V | 1 |
| STANGL, E | 1 |
| HACKENBERG, R | 1 |
| SCHIFIS, M | 1 |
| BASTAROLI, JC | 1 |
| TKACHEV, RA | 1 |
| ALEKSANDROVA, LI | 1 |
| PROKHOROVA, ES | 1 |
| SCAPELLATO, L | 1 |
| BRANCATI, B | 1 |
| LUEBECK, I | 1 |
| SUCKOW, KL | 1 |
| HEINE, K | 1 |
| ALBERT, M | 1 |
| KOBAYASHI, T | 1 |
| TAKEUCHI, M | 1 |
| TADROS, FW | 1 |
| HIGAZI, AM | 1 |
| ZAKI, SA | 1 |
| RITTER, U | 1 |
| URANGAIMAZ, FA | 2 |
| TONNELIER, E | 1 |
| KLAUER, D | 1 |
| CHEKERDEMIAN, M | 1 |
| Kataoka, T | 1 |
| Hamasaki, S | 1 |
| Ishida, S | 1 |
| Saihara, K | 1 |
| Okui, H | 1 |
| Fukudome, T | 1 |
| Shinsato, T | 1 |
| Mizoguchi, E | 1 |
| Ninomiya, Y | 1 |
| Otsuji, Y | 1 |
| Minagoe, S | 1 |
| Tei, C | 1 |
| Miyazaki, M | 3 |
| Janczewska, H | 1 |
| Dadkar, NK | 1 |
| Aroskar, VA | 1 |
| Dohadwalla, AN | 1 |
| Shchepotin, BM | 1 |
| Kazak, LI | 3 |
| Guseva, NP | 1 |
| Prisiazhniuk, MS | 1 |
| Shkrobom, SI | 1 |
| Komorovskaia, IaM | 1 |
| Nechaĭ, EE | 1 |
| Gygax, P | 1 |
| Wiernsperger, N | 1 |
| Laher, I | 1 |
| Triggle, CR | 1 |
| Beausang-Linder, M | 1 |
| Lai, FM | 1 |
| Tanikella, T | 1 |
| Thibault, L | 1 |
| Chan, PS | 1 |
| Cervoni, P | 1 |
| Henriksen, O | 1 |
| Skagen, K | 1 |
| Amtorp, O | 1 |
| Hartling, O | 1 |
| Haraldsson, B | 1 |
| Nilsson, H | 1 |
| Folkow, B | 3 |
| Dam, M | 1 |
| Battistin, L | 1 |
| Chu, D | 1 |
| Cocco, G | 1 |
| Schweda, E | 1 |
| Haeusler, G | 1 |
| Strozzi, C | 1 |
| Grassi, G | 1 |
| Giannattasio, C | 1 |
| Failla, M | 1 |
| Pesenti, A | 1 |
| Peretti, G | 1 |
| Marinoni, E | 1 |
| Fraschini, N | 1 |
| Vailati, S | 1 |
| Mancia, G | 3 |
| Dunn, WR | 1 |
| Gardiner, SM | 1 |
| Nahser, PJ | 1 |
| Brown, RE | 1 |
| Oskarsson, H | 1 |
| Winniford, MD | 1 |
| Rossen, JD | 1 |
| Antony, I | 5 |
| Lerebours, G | 3 |
| Nitenberg, A | 5 |
| Lin, JS | 1 |
| Chang, WC | 1 |
| Lui, SM | 1 |
| Klauss, V | 1 |
| Meissner, O | 1 |
| Metz, J | 1 |
| Theisen, K | 1 |
| Mudra, H | 1 |
| Zeiher, AM | 1 |
| Drexler, H | 1 |
| Saurbier, B | 1 |
| Just, H | 2 |
| Egashira, K | 1 |
| Inou, T | 1 |
| Hirooka, Y | 1 |
| Yamada, A | 1 |
| Maruoka, Y | 1 |
| Kai, H | 1 |
| Sugimachi, M | 1 |
| Suzuki, S | 1 |
| Takeshita, A | 1 |
| Sobey, CG | 1 |
| Heistad, DD | 1 |
| Shen, W | 1 |
| Cai, X | 1 |
| Zhang, D | 1 |
| Zhang, X | 1 |
| Zheng, A | 1 |
| Gong, L | 1 |
| Solzbach, U | 1 |
| Hornig, B | 1 |
| Jeserich, M | 1 |
| Black, MJ | 1 |
| Kanellakis, P | 1 |
| Bobik, A | 1 |
| Chemla, D | 1 |
| Millette, E | 1 |
| de Champlain, J | 1 |
| Lamontagne, D | 1 |
| Rapoport, SI | 2 |
| Tiossa, GG | 1 |
| Ishkhanian, GV | 1 |
| Prewitt, RL | 1 |
| Dowell, RF | 1 |
| Brock, TA | 1 |
| Diana, JN | 1 |
| Tomita, M | 1 |
| Gotoh, F | 1 |
| Sato, T | 1 |
| Amano, T | 1 |
| Tanahashi, N | 1 |
| Tanaka, K | 1 |
| Poupon, R | 1 |
| Longchal, C | 1 |
| Darnis, F | 1 |
| Johansson, B | 3 |
| Berecek, KH | 1 |
| Bohr, DF | 1 |
| Panikarskiĭ, VG | 1 |
| Busse, R | 1 |
| Bauer, RD | 1 |
| Summa, Y | 1 |
| Körner, H | 1 |
| Pashch, T | 1 |
| Jaillard, P | 1 |
| Albrecht, I | 2 |
| Hallbäck, M | 3 |
| Julius, S | 2 |
| Lundgren, Y | 3 |
| Stage, L | 1 |
| Weiss, L | 3 |
| Gilbert, JC | 1 |
| Zozulia, IS | 1 |
| Trazzi, S | 2 |
| Omboni, S | 2 |
| Santucciu, C | 1 |
| Parati, G | 2 |
| Mutti, E | 1 |
| Zanchetti, A | 1 |
| Foult, JM | 1 |
| Shabsigh, R | 1 |
| Fishman, IJ | 1 |
| Schum, C | 1 |
| Dunn, JK | 1 |
| Fortes, ZB | 3 |
| Nigro, D | 3 |
| Scivoletto, R | 3 |
| de Carvalho, MH | 1 |
| Müller, SC | 1 |
| el-Damanhoury, H | 1 |
| Rüth, J | 1 |
| Lue, TF | 1 |
| Cordellini, S | 2 |
| Carvalho, MH | 2 |
| Sexton, WL | 1 |
| Korthuis, RJ | 1 |
| Laughlin, MH | 1 |
| Vailly, B | 1 |
| Rougeron, G | 1 |
| Weill, A | 1 |
| Bollack, C | 1 |
| Wicklmayr, M | 1 |
| Rett, K | 1 |
| Baldermann, H | 1 |
| Dietze, G | 1 |
| Fujimoto, S | 2 |
| Dohi, Y | 2 |
| Aoki, K | 2 |
| Matsuda, T | 2 |
| Asano, M | 1 |
| Koźniewska, E | 1 |
| Atakhanov, ShE | 1 |
| Tkhostova, EB | 1 |
| Iurenev, AP | 1 |
| Men'shikov, MIu | 1 |
| Mazaev, AV | 1 |
| Werber, AH | 1 |
| Fink, GD | 1 |
| Levy, JV | 1 |
| Stoclet, JC | 1 |
| Peguet, MF | 1 |
| Waedele, G | 1 |
| Shibata, S | 1 |
| Kurahashi, K | 1 |
| Kuchii, M | 1 |
| Andreev, VN | 1 |
| Pogátsa, G | 1 |
| Dubecz, E | 1 |
| Gábor, G | 1 |
| Geller, M | 1 |
| Souza, PJ | 1 |
| Soares, RV | 1 |
| Luzes, RM | 1 |
| Sekeff, JA | 1 |
| Garetto, G | 1 |
| Hadjiev, D | 1 |
| Eliakim, M | 1 |
| Mor, I | 1 |
| Michaelson, IC | 1 |
| Tarnakin, VM | 1 |
| Furuta, K | 1 |
| Tikhonenko, VM | 1 |
| Okao, S | 1 |
| Nagao, S | 1 |
| Manabe, T | 1 |
| Akioka, T | 1 |
| Mizukawa, N | 1 |
| Zahn, K | 1 |
| Levin, AI | 1 |
| Vaĭnberg, AG | 1 |
| Votcal, BE | 1 |
| Lozinskij, LG | 1 |
| Häggendal, E | 1 |
| Bovill, JG | 1 |
| Clarke, RS | 1 |
| Dundee, JW | 1 |
| Pandit, SK | 1 |
| Moore, J | 1 |
| Pauchant, M | 1 |
| Bernard, JM | 1 |
| Di Maria, G | 1 |
| Faerchtein, I | 1 |
| Ginefra, P | 1 |
| Kastansky, I | 1 |
| Stawiarski, PV | 1 |
| Cwajg, F | 1 |
| Salek Filho, R | 1 |
| Calcagnini, G | 1 |
| Pugliese, F | 1 |
| Critelli, G | 1 |
| Peschle, C | 1 |
| Rizzo, S | 1 |
| Cernigliaro, C | 1 |
| Marini, GP | 1 |
| Vidovszky, T | 1 |
| Simard, D | 1 |
| Olesen, J | 1 |
| Paulson, OB | 1 |
| Lassen, NA | 1 |
| Skinhoj, E | 1 |
| Gromov, LA | 1 |
| Votchal, BE | 1 |
| Zhmurkin, VP | 1 |
| Miasnikov, LA | 1 |
| Metelitsa, VI | 1 |
| Shargorodskiĭ, BM | 1 |
| Grigor'iants, RA | 1 |
| Capitanucci, P | 1 |
| Martinelli, M | 1 |
| De Gregorio, M | 1 |
| Pinacci, U | 1 |
| Guida, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for papaverine and Hypertension
| Article | Year |
|---|---|
Some non-conventional biomolecular targets for diamidines. A short survey.
Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myot | 2014 |
Association of acute onset hypertension and tachycardia following intracisternal papaverine administration during intracranial aneurysm surgery: a case report and review of the literature.
Topics: Acute Disease; Humans; Hypertension; Intracranial Aneurysm; Male; Middle Aged; Papaverine; Tachycard | 2011 |
[Coronary endothelial dysfunction in hypertension].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; Cold Temperature; Coronary Ves | 1997 |
Brain barrier pathology in acute arterial hypertension.
Topics: Animals; Aorta, Thoracic; Blood Proteins; Blood-Brain Barrier; Brain; Capillary Permeability; Cats; | 1976 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
7 trials available for papaverine and Hypertension
| Article | Year |
|---|---|
[Contrast echocardiography in the evaluation of myocardial flow reserve].
Topics: Adult; Aged; Contrast Media; Coronary Circulation; Coronary Disease; Echocardiography; Female; Hemod | 1993 |
Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients.
Topics: Acetylcholine; Adult; Aged; Antioxidants; Arteries; Ascorbic Acid; Coronary Vessels; Drug Therapy, C | 1997 |
Restoration of flow-dependent coronary dilation by ACE inhibition improves papaverine-induced maximal coronary blood flow in hypertensive patients: demonstration that large epicardial coronary arteries are more than conductance vessels.
Topics: Angiotensin-Converting Enzyme Inhibitors; Coronary Angiography; Coronary Circulation; Hemodynamics; | 2000 |
[Therapeutic evaluation of uncomplicated hypertensive crises in emergencies].
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Emergencies; Evaluation Studies as T | 1972 |
[Clinical evaluation of a new pharmacological association with hypotensive effect. Statistical presentation of results].
Topics: Adult; Aged; Antihypertensive Agents; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; D | 1973 |
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; | 1970 |
[Routine in the treatment of hypertension emergencies].
Topics: Barbiturates; Chlorisondamine; Clinical Trials as Topic; Humans; Hypertension; Papaverine; Reserpine | 1965 |
104 other studies available for papaverine and Hypertension
| Article | Year |
|---|---|
Derivatives of 1,3-disubstituted 2,4(1H,3H)-quinazolinediones as possible peripheral vasodilators or antihypertensive agents.
Topics: Animals; Antihypertensive Agents; Dogs; Epinephrine; Female; Hypertension; In Vitro Techniques; Musc | 1979 |
Dynamic and morphologic evaluation of erectile dysfunction on penile doppler sonography and contrast cavernosography.
Topics: Adult; Arteries; Contrast Media; Diabetes Complications; Humans; Hypertension; Impotence, Vasculogen | 2017 |
The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Aorta, Thoracic; Drug Evaluation, Preclinica | 2015 |
Renal autoregulation and passive pressure-flow relationships in diabetes and hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Di | 2010 |
Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin-1; Fem | 2011 |
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen.
Topics: Acetylcholine; Angiotensinogen; Animals; Aorta; Blood Pressure; Chelating Agents; Ditiocarb; Humans; | 2002 |
[Pathogenic treatment of arterial hypertension].
Topics: Antifibrinolytic Agents; Humans; Hypertension; Naphthoquinones; Papaverine; Retinoids; Vitamin K | 1952 |
[Treatment of hypertonia].
Topics: Hypertension; Methenamine; Muscle Hypertonia; Papaverine; Urea | 1953 |
[New perspectives in therapy of hypertonic symptom complex].
Topics: Barbiturates; Humans; Hypertension; Papaverine; Theobromine | 1953 |
[Clinical tests of combined Rauwolfia, bromocholine bromide & papaverine hydrochloride in the treatment of arterial hypertension].
Topics: Alkaloids; Antihypertensive Agents; Bromides; Choline; Humans; Hypertension; Hypnotics and Sedatives | 1958 |
[On the intravenous use of papaverine in acute disorders of brain blood circulation].
Topics: Brain; Cardiovascular System; Humans; Hypertension; Injections, Intravenous; Papaverine; Vascular Di | 1959 |
[MEBUTAMATE ASSOCIATIONS IN ANTIHYPERTENSIVE THERAPY].
Topics: Antihypertensive Agents; Antipsychotic Agents; Carbamates; Ethylenediamines; Humans; Hydralazine; Hy | 1963 |
[POSSIBILITIES OF EXAMINATION OF CEREBRAL CIRCULATION AND ITS CONTROL BY DRUGS WITH REFERENCE TO HEMODYNAMICS].
Topics: Cerebrovascular Circulation; Cerebrovascular Disorders; Diagnosis; Hemodynamics; Humans; Hypertensio | 1963 |
[REHABILITATION IN HEART DISEASE].
Topics: Acenocoumarol; Dipyridamole; Electrocardiography; Geriatrics; Heart Defects, Congenital; Heart Disea | 1963 |
THE PATHOGENESIS OF CEREBRAL VASCULAR DISEASE.
Topics: Acetylcholine; Adolescent; Cerebrovascular Disorders; Dogs; Hematoma; Hematoma, Subdural; Hypertensi | 1964 |
[DIAGNOSIS AND TREATMENT OF PANCREATITIS].
Topics: Amylases; Anti-Bacterial Agents; Antibiotics, Antitubercular; Atropine; Chyle; Clinical Enzyme Tests | 1963 |
[THERAPEUTICS OF ARTERIAL HYPERTENSION IN PREGNANCY].
Topics: Female; Guanethidine; Hibernation; Humans; Hydralazine; Hypertension; Hypothermia, Induced; Maternal | 1964 |
Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy.
Topics: Acetylcholine; Aged; Blood Flow Velocity; Cardiac Volume; Coronary Angiography; Coronary Artery Dise | 2004 |
Measurement of cerebral blood flow by ultrasonic Doppler technique. Effects of several vasodilators on cerebral circulation, with special reference to aminophylline, nicotinic-acid and papaverine.
Topics: Aged; Aminophylline; Blood Flow Velocity; Blushing; Carotid Arteries; Cerebrovascular Circulation; H | 1966 |
Measurement of cerebral blood flow by ultasonic Doppler technique. Hemodynamic correlation of internal carotid artery and vertebral artery.
Topics: Adult; Aged; Aging; Blood Flow Velocity; Carotid Arteries; Cerebral Hemorrhage; Cerebrovascular Circ | 1966 |
Measurement of cerebral blood flow by ultrasonic Doppler technique. Hemodynamic correlation between cerebral and peripheral-ophthalmic artery.
Topics: Adult; Aged; Aging; Brachial Artery; Carotid Arteries; Cerebral Arteries; Cerebrovascular Circulatio | 1966 |
[Effect of metabolic acidosis on the action of hypotensive substances].
Topics: Acetylcholine; Acidosis; Animals; Cats; Histamine; Hypertension; Infusions, Parenteral; Lactates; Pa | 1967 |
Peripheral vascular smooth muscle relaxation in normotensive and hypertensive rats.
Topics: Adenosine; Animals; Desoxycorticosterone; Hypertension; Isoproterenol; Male; Mesenteric Arteries; Mu | 1980 |
[Hemodynamic effects of hypotensive agents under adrenergic block in hypertension].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Animals; Benzimidazoles; Dru | 1981 |
[Changes in the systemic hemodynamics of patients with chronic cerebrovascular insufficiency].
Topics: Adult; Aged; Aminophylline; Cerebrovascular Circulation; Cerebrovascular Disorders; Dextrans; Drug T | 1980 |
[Effect of papaverine on systemic and cerebral hemodynamics in atherosclerosis complicated by chronic cerebral circulatory insufficiency].
Topics: Aged; Blood Circulation Time; Blood Pressure; Cerebrovascular Disorders; Female; Humans; Hypertensio | 1984 |
Hypotension induced changes in cerebral microflow and EEG and their pharmacological alterations.
Topics: Animals; Blood Pressure; Brain Ischemia; Cats; Cerebrovascular Circulation; Electroencephalography; | 1983 |
Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats.
Topics: Animals; Blood Pressure; Cocaine; Dose-Response Relationship, Drug; Hypertension; In Vitro Technique | 1984 |
Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine.
Topics: Acetazolamide; Animals; Cerebrovascular Circulation; Electric Stimulation; Epoprostenol; Eye; Female | 1982 |
Effects of different stages of aortic coarctation hypertension on aortic contraction and relaxation in rats.
Topics: Animals; Aorta; Aorta, Abdominal; Aorta, Thoracic; Body Weight; Hypertension; Isoproterenol; Ligatio | 1980 |
Augmented vasoconstrictor response to changes in vascular transmural pressure in patients with essential arterial hypertension.
Topics: Adult; Female; Follow-Up Studies; Humans; Hypertension; Hypertrophy; Male; Middle Aged; Muscle, Smoo | 1981 |
Structurally reduced distensibility of cardiovascular low-pressure' compartments in primary hypertension, as studied in spontaneously hypertensive rats (SHR).
Topics: Animals; Blood Pressure; Blood Volume; Cardiovascular Physiological Phenomena; Hindlimb; Hypertensio | 1981 |
[Clinical evaluation of the effectiveness of papaverine in the long-term therapy of cerebral ischemia].
Topics: Adult; Brain Diseases; Carotid Artery Diseases; Cerebrovascular Disorders; Delayed-Action Preparatio | 1981 |
Influence of propranolol and pindolol on the haemodynamic effects of papaverine, isoprenaline and noradrenaline in hypertensive patients.
Topics: Adult; Blood Pressure; Drug Interactions; Heart Rate; Hemodynamics; Humans; Hypertension; Isoprotere | 1980 |
Sympathetic modulation of radial artery compliance in congestive heart failure.
Topics: Adult; Blood Pressure; Compliance; Heart Failure; Humans; Hypertension; Papaverine; Phenylephrine; R | 1995 |
Structural and functional properties of isolated, pressurized, mesenteric resistance arteries from a vasopressin-deficient rat model of genetic hypertension.
Topics: Animals; Hypertension; Male; Mesenteric Arteries; Microcirculation; Norepinephrine; Papaverine; Rats | 1995 |
Maximal coronary flow reserve and metabolic coronary vasodilation in patients with diabetes mellitus.
Topics: Adenosine; Coronary Circulation; Coronary Vessels; Diabetes Mellitus; Female; Humans; Hypertension; | 1995 |
Loss of flow-dependent coronary artery dilatation in patients with hypertension.
Topics: Adult; Blood Flow Velocity; Coronary Angiography; Coronary Vessels; Female; Humans; Hypertension; Is | 1995 |
The change of penile blood thromboxane B2 and prostacyclin after intracavernous injection of vasoactive drugs for the treatment of arteriogenic impotence.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Alprostadil; Diabetes Complications; Epoprostenol; Erecti | 1994 |
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
Topics: Acetylcholine; Adult; Age Factors; Arteriosclerosis; Blood Pressure; Cardiac Catheterization; Corona | 1993 |
Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.
Topics: Acetylcholine; Adult; Age Factors; Aged; Analysis of Variance; Arteriosclerosis; Blood Pressure; Cor | 1993 |
Angiotensin-converting enzyme inhibition restores flow-dependent and cold pressor test-induced dilations in coronary arteries of hypertensive patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cold Temperature; Coronary Angiography; Co | 1996 |
Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats.
Topics: Animals; ATP-Binding Cassette Transporters; Basilar Artery; Hypertension; Ion Channel Gating; KATP C | 1997 |
Abnormal coronary flow reserve in patients with angina pectoris and hypertensive left ventricular hypertrophy.
Topics: Angina Pectoris; Blood Flow Velocity; Coronary Circulation; Female; Humans; Hypertension; Hypertroph | 1996 |
Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Antihypertensiv | 1997 |
Altered coronary dilation in deoxycorticosterone acetate-salt hypertension.
Topics: Animals; Bradykinin; Coronary Circulation; Coronary Vessels; Desoxycorticosterone; Eicosanoids; Endo | 2000 |
Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain Chemistry; Brain Edema; Carotid Artery, Internal; Co | 1978 |
[Comparative effectiveness of treatment of neurocirculatory asthenia of hypertensive type by various methods].
Topics: Benzimidazoles; Drug Therapy, Combination; Electric Stimulation Therapy; Evaluation Studies as Topic | 1978 |
Structural vascular adaptations during the developmental stages of hypertension in the spontaneously hypertensive rat.
Topics: Aging; Animals; Blood Pressure; Captopril; Cardiac Output; Hypertension; Male; Papaverine; Pentolini | 1979 |
Effect of DOCA-NaCl hypertension on pre- and postcapillary resistance in isolated hindlimbs of dogs.
Topics: Animals; Capillaries; Desoxycorticosterone; Dogs; Hindlimb; Hypertension; Male; Muscle, Smooth; Papa | 1979 |
Distensibility of cerebral vessels in response to acute hypertension in cats.
Topics: Acute Disease; Animals; Brain; Cats; Hypertension; Norepinephrine; Papaverine; Vasodilation | 1979 |
[Chronic hepatitis after long-term administration of papaverine (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Humans; Hypertension; Middle Aged; | 1978 |
Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig.
Topics: Animals; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Implan | 1977 |
[Problems in treatment of autonomic disorders accompanying hypertensive disease].
Topics: Adult; Autonomic Nervous System; Benzimidazoles; Caffeine; Calcium; Female; Gluconates; Humans; Hype | 1977 |
Opening of the blood-brain barrier by acute hypertension.
Topics: Acute Disease; Animals; Blood Pressure; Blood-Brain Barrier; Hypertension; Metaraminol; Papaverine; | 1976 |
Comparison of the visco-elastic properties of the tail artery in spontaneously hypertensive and normotensive rats.
Topics: Animals; Arteries; Elasticity; Hypertension; Male; Muscle, Smooth; Norepinephrine; Papaverine; Rats; | 1976 |
[Pavaverine cromesilate, vascular protector study in arterial hypertension].
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Papaverine | 1976 |
Arterial pressure, cardiac output and systemic resistance before and after pithing in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Denervation; Dye Dilution Technique; | 1975 |
[Basic treatment of hemodynamic and metabolic disorders in cardiovascular disease].
Topics: Coronary Disease; Hemodynamics; Humans; Hypertension; Papaverine | 1975 |
[Hypotensive effect of combination of reserpine and papaverine].
Topics: Animals; Cats; Drug Therapy, Combination; Hypertension; Papaverine; Reserpine | 1975 |
[Use of papaverine and euphyllin in the complex treatment of hypertensive disease].
Topics: Adult; Aminophylline; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension; Male | 1976 |
Variability in arterial diameter and compliance: compliance modulation reserve.
Topics: Adult; Arteries; Blood Pressure; Compliance; Female; Humans; Hypertension; Male; Papaverine; Radial | 1992 |
Acute modulation of arterial compliance in mild essential hypertension.
Topics: Adult; Arm; Arteries; Blood Pressure; Brachial Artery; Compliance; Humans; Hypertension; Middle Aged | 1991 |
[Coronary reserve in treated hypertension with persistent left ventricular hypertrophy].
Topics: Cardiomegaly; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Hypertension; Middle Age | 1991 |
Cigarette smoking and other vascular risk factors in vasculogenic impotence.
Topics: Diabetes Mellitus; Erectile Dysfunction; Humans; Hypertension; Male; Papaverine; Penile Erection; Pe | 1991 |
Indirect evidence for an endothelium-derived contracting factor released in arterioles of deoxycorticosterone acetate salt hypertensive rats.
Topics: Animals; Arterioles; Blood Pressure; Desoxycorticosterone; Endothelins; Hypertension; In Vitro Techn | 1990 |
Hypertension and impotence.
Topics: Antihypertensive Agents; Diabetes Complications; Erectile Dysfunction; Humans; Hypertension; Male; M | 1991 |
Indirect evidence for an endothelium-derived contracting factor release in aorta of deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Desoxycorticosterone; Endothelins; Endothelium, Vascular; H | 1990 |
Vascular flow capacity of hindlimb skeletal muscles in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Capillary Permeability; Hindlimb; Humans; Hypertension; Isoproterenol; Musc | 1990 |
[Epilepsy and hypertensive crisis after intracavernous injection of metaraminol in the treatment of priapism secondary to a papaverine test].
Topics: Epilepsy; Humans; Hypertension; Male; Metaraminol; Middle Aged; Papaverine; Priapism | 1989 |
The kallikrein/kinin system in the pathogenesis of hypertension in diabetes mellitus.
Topics: Amino Acids; Bradykinin; Diabetes Complications; Diabetes Mellitus; Glucose; Humans; Hypertension; I | 1989 |
Altered vascular beta adrenoceptor-mediated relaxation in deoxycorticosterone-salt hypertensive rats.
Topics: Animals; Atenolol; Bucladesine; Butoxamine; Desoxycorticosterone; Fenoterol; Hypertension; Isoproter | 1988 |
Diminished beta-adrenoceptor-mediated relaxation of arteries from spontaneously hypertensive rats before and during development of hypertension.
Topics: Albuterol; Animals; Arteries; Dinoprost; Hydroxydopamines; Hypertension; Isoproterenol; Male; Nitrop | 1987 |
Enhanced reactivity towards flunarizine in cerebrovascular bed of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Cerebrovascular Circulation; Flunarizine; Hypertension; Papaverine | 1988 |
[Calcium metabolism in arterial hypertension. II. Changes in thrombocyte sensitivity to verapamil].
Topics: Adult; Aged; Blood Platelets; Calcium; Drug Interactions; Epinephrine; Humans; Hypertension; In Vitr | 1988 |
Reactivity of aorta and mesenteric microvessels to drugs in spontaneously hypertensive rats: role of the endothelium.
Topics: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Endothelium; Female; Hypertension; In Vitro Techniqu | 1987 |
Continuous measurement of hindquarter resistance changes to nerve stimulation and intraarterial drug administration in rats.
Topics: Acetylcholine; Animals; Blood Pressure; Electric Stimulation; Extracorporeal Circulation; Hindlimb; | 1985 |
Differences in papaverine inhibition of prostaglandin-induced contraction of aortic strips from normal and spontaneously hypertensive rats (SHR).
Topics: Animals; Aorta, Thoracic; Blood Pressure; Hypertension; In Vitro Techniques; Muscle Contraction; Mus | 1974 |
[Influence of metacorticoid hypertension on sensitivity of the isolated rat aorta to Ba2 ions and to papaverine].
Topics: Animals; Aorta; Barium; Calcium; Diazoxide; Hypertension; Mineralocorticoids; Papaverine; Rats | 1970 |
A possible etiology of contractility impairment of vascular smooth muscle from spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Barium; Blood Pressure; Calcium; Cobalt; Hypertension; In | 1973 |
[Treatment of the patients with hypertension by reserpine, ganglionic-blocking and other hypotensive agents].
Topics: Adult; Antihypertensive Agents; Female; Ganglionic Blockers; Humans; Hypertension; Hypnotics and Sed | 1967 |
Blood-brain barrier dysfunction in acute arterial hypertension after papaverine-induced vasodilatation.
Topics: Albumins; Animals; Antipyrine; Azo Compounds; Blood-Brain Barrier; Brain; Capillary Permeability; Ca | 1974 |
Haemodynamic responses to drotaverine and noradrenaline in the dog.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Dogs; Drug Interactions; Female; Hemodynamics | 1974 |
Assessment of pharmacologic effects on the retinal circulation of hypertensive subjects by a quantitative method.
Topics: Adult; Aged; Aminophylline; Blood Pressure; Female; Fluorescein Angiography; Fundus Oculi; Guanethid | 1972 |
[Controlled hypotensive therapy in hypertensive crises under emergency conditions].
Topics: Antihypertensive Agents; Benzimidazoles; Chlorpromazine; Drug Combinations; Emergencies; Female; Hum | 1972 |
[Clinical-pathological investigation on retinal and cerebral hemodynamics].
Topics: Adolescent; Adult; Age Factors; Aged; Amino Alcohols; Benzoates; Blood Pressure; Blood Volume; Cereb | 1972 |
[Use of the ganglionic blocking agent pyrilene together with other hypotensive agents].
Topics: Animals; Antihypertensive Agents; Cats; Hypertension; Papaverine; Pempidine; Rabbits; Reserpine | 1973 |
[Effects of a cerebral vasodilator agent (Praxilene) on cerebral hemodynamics in acute intracranial hypertension and cerebral edema].
Topics: Animals; Blood Pressure; Brain Edema; Carbon Dioxide; Cerebrovascular Circulation; Diethylamines; Do | 1973 |
The distensibility of the resistance vessels in spontaneously hypertensive rats (SHR) as compared with normotensive control rats (NCR).
Topics: Animals; Barium; Blood Pressure; Blood Vessels; Hindlimb; Hypertension; Muscle Tonus; Muscle, Smooth | 1974 |
Analysis of design and reactivity of series-coupled vascular sections in spontaneously hypertensive rats (SHR).
Topics: Animals; Blood Pressure; Blood Vessels; Capillary Resistance; Hemodynamics; Hypertension; Norepineph | 1974 |
The effects of vasoactive drugs on the retinal circulation.
Topics: Bis-Trimethylammonium Compounds; Bromides; Ergoloid Mesylates; Heparin; Hydralazine; Hypertension; N | 1966 |
[Action of nitroglycerin and intravenous injections of papaverine on the contractile function of the heart in patients with coronary circulatory disorders].
Topics: Adult; Aged; Coronary Disease; Female; Heart; Humans; Hypertension; Injections, Intravenous; Male; M | 1969 |
Effect of increased intravascular pressure on the blood-brain barrier to protein in dogs.
Topics: Animals; Blood Transfusion, Autologous; Blood-Brain Barrier; Capillary Permeability; Cerebral Arteri | 1972 |
Clinical studies of induction agents. 38. Effect of premedicants and supplements on ketamine anaesthesia.
Topics: Adult; Analgesics; Anesthesia; Atropine; Benperidol; Blood Pressure; Cyclohexanes; Diazepam; Dreams; | 1971 |
[Treatment of arterial hypertension with an association of reserpiline, theophylline and papaverine].
Topics: Adult; Aged; Drug Combinations; Humans; Hypertension; Middle Aged; Papaverine; Secologanin Tryptamin | 1971 |
[Use of radionuclides in the study of the regional distribution of pulmonary perfusion and ventilation].
Topics: Acetylcholine; Age Factors; Ethylenediamines; Humans; Hypertension; Hypoxia; Lung; Lung Compliance; | 1971 |
[Change in renal blood flow, glomerular filtrate and of diuresis induced by the administration of aminophylline in young subjects with so-called essential arterial hypertension].
Topics: Adult; Aminophylline; Blood Circulation; Diuresis; Glomerular Filtration Rate; Humans; Hypertension; | 1969 |
[Comparative study on the vasodilatory activities of bencyclane and papaverine by cerebral angiography].
Topics: Adult; Aged; Brain Neoplasms; Cerebral Angiography; Cycloheptanes; Diagnosis, Differential; Female; | 1970 |
Regional cerebral blood flow and its regulation in dementia.
Topics: Adult; Aged; Alcohol Amnestic Disorder; Biopsy; Blood Flow Velocity; Brain; Carbon Dioxide; Cerebral | 1971 |
[The effect of papaverine on the cardiovascular system in various age groups].
Topics: Adolescent; Adult; Age Factors; Aged; Animals; Cardiovascular System; Female; Humans; Hypertension; | 1967 |
Some data on the pharmacodynamics of the cerebral venous and arterial tone.
Topics: Aminophylline; Antihypertensive Agents; Caffeine; Cerebrovascular Circulation; Humans; Hypertension; | 1968 |
[Results of a clinico-experimental study of the preparation Galidor in the treatment of chronic coronary insufficiency].
Topics: Angina Pectoris; Animals; Coronary Disease; Cycloheptanes; Dogs; Hemodynamics; Humans; Hypertension; | 1968 |
[Rheographic study of the activity of some vasoactive drugs on peripheral arterial circulation].
Topics: Adult; Aged; Antihypertensive Agents; Arteriosclerosis Obliterans; Blood Circulation; Cerebrovascula | 1968 |
[New theories and clinal demonstratioof the activity and usefulness of chlorthalidone-reserpine in the treatment of hypertensive diseases].
Topics: Adult; Aged; Chlorthalidone; Drug Synergism; Ergotamine; Female; Humans; Hypertension; Male; Middle | 1968 |