Page last updated: 2024-11-02

papaverine and Hyperemia

papaverine has been researched along with Hyperemia in 70 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research Excerpts

ExcerptRelevanceReference
"We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements."7.96Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020)
"The purpose of this study was to assess the hyperemic effects of papaverine and dopamine in the renal microcirculation of hypertensive patients with renal artery stenosis (RAS)."7.81Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis. ( Derkacz, A; Gosławska, K; Mazur, G; Mysiak, A; Początek, K; Podgórski, M; Poręba, R; Protasiewicz, M; Szymańska-Chabowska, A; Witkowski, A, 2015)
"Caffeine attenuates intravenous adenosine-induced hyperemia in FFR measurement."7.80Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014)
"This study examined the imaging results and kinetics of technetium 99m teboroxime after its intracoronary injection during papaverine-induced coronary hyperemia in patients with one-vessel disease before and after coronary angioplasty."7.69Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia. ( Branzi, A; Corbelli, C; Fallani, F; Heo, J; Iskandrian, AS; Magnani, B; Marzocchi, A; Monetti, N; Piovaccari, G; Tartagni, F; Zannoli, R, 1996)
" BAP and FAP were measured at rest, and then during vasodilation produced by postischemic reactive hyperemia and intra-arterial injection of papaverine."7.67Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation. ( Hobson, RW; Jamil, Z; Lee, BC; Lynch, TG; Padberg, FT, 1985)
"Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP."5.56Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020)
"Aminophylline pretreatment reduced reactive hyperemia below the control level even in the presence of an intracoronary infusion of adenosine."5.27Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion. ( Abe, Y; Hyodo, T; Nakatsu, T; Saito, D; Takeda, K; Tani, H; Ueeda, M; Yamada, N, 1985)
" Intracoronary papaverine (PAP) is the most potent vasodilator used for the achievement of maximal hyperemia."4.02Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement. ( Anai, R; Araki, M; Inoue, K; Kataoka, M; Miura, T; Naka, Y; Okabe, H; Setoyama, K; Sonoda, S, 2021)
"We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements."3.96Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020)
" Resting Pd/Pa ratio (ratio of mean distal to lesion and mean proximal pressures) and translesional systolic pressure gradient were obtained and FFR and hyperemic translesional systolic and mean pressure gradients (HSG and HMG) were registered after papaverine induced maximum hyperemia-pre and poststent implantation."3.88Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis. ( Alves, CMR; Barbosa, AHP; Batista, MC; Caixeta, A; Carvalho, AC; Gomes Júnior, MPM; Pestana, JOM, 2018)
"FFR measured by postocclusional hyperemia (FFRoccl) caused by balloon occlusion after percutaneous coronary intervention was compared with FFR measured by drug-induced hyperemia (FFR measured by intravenous ATP; and FFR measured by intracoronary papaverine injection [FFRpap]) in 98 lesions from 98 patients."3.85Postocclusional Hyperemia for Fractional Flow Reserve After Percutaneous Coronary Intervention. ( Hirakawa, A; Hirata, T; Kamiya, H; Kawasaki, M; Kawase, Y; Kikuchi, J; Matsuo, H; Okamoto, S; Okubo, M; Omori, H; Ota, H; Suzuki, T; Tanigaki, T, 2017)
"Objective Measuring the fractional flow reserve (FFR) requires the induction of coronary hyperemia, usually with adenosine, adenosine triphosphate (ATP), or papaverine."3.85Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions. ( Fujii, Y; Hayashi, Y; Hironobe, N; Kagawa, Y; Kato, Y; Kawase, T; Okimoto, T; Shiode, N; Tamekiyo, H; Ueda, Y; Yamane, K, 2017)
" We clarified the optimal measuring procedure for FFR for SFA lesions and investigated the necessary dose of papaverine for inducing maximal hyperemia in SFA lesions."3.83Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. ( Araki, M; Hirano, K; Ishimori, H; Ito, Y; Kobayashi, N; Muramatsu, T; Nakano, M; Sakai, T; Tsukahara, R; Yamawaki, M, 2016)
"The purpose of this study was to assess the hyperemic effects of papaverine and dopamine in the renal microcirculation of hypertensive patients with renal artery stenosis (RAS)."3.81Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis. ( Derkacz, A; Gosławska, K; Mazur, G; Mysiak, A; Początek, K; Podgórski, M; Poręba, R; Protasiewicz, M; Szymańska-Chabowska, A; Witkowski, A, 2015)
"The primary aim of this study was to validate the assessment of IMR in a large animal model, and the secondary aim was to compare two doses of intracoronary papaverine, 5 and 10 mg, for induction of maximal hyperemia and its evolution over time."3.80Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model. ( Cacela, D; Cardim, N; Carrapiço, B; Cavaco-Gonçalves, S; Cruz Ferreira, R; Fiarresga, A; Oliveira, E; Selas, M, 2014)
" During angiography, the p-FFR was measured using a pressure guidewire after administration of papaverine to induce hyperemia."3.80Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index. ( Ebisawa, S; Hioki, H; Ikeda, U; Izawa, A; Koyama, J; Miura, T; Miyashita, Y; Motoki, H; Tomita, T, 2014)
"Caffeine attenuates intravenous adenosine-induced hyperemia in FFR measurement."3.80Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014)
" Intrarenal papaverine neither prolonged the QT interval nor induced ventricular arrhythmias and the safety of which will need to be corroborated in a large study."3.76Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements. ( Fahsah, I; Jevans, AJ; Kapoor, N; Karim, R; Leesar, MA, 2010)
"Provided sufficient dosages are used, ATP, adenosine, and papaverine (but not contrast medium) induce maximal hyperemia and are therefore suitable to assess fractional flow reserve."3.72Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. ( Barbato, E; Bartunek, J; Bech, JW; De Bruyne, B; Heyndrickx, GR; Pijls, NH; Wijns, W, 2003)
" Intracoronary papaverine (20 mg) was used to induce hyperemia."3.72Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve. ( Balsam, LB; Caffarelli, AD; Cooke, DT; Farouque, HM; Fearon, WF; Fitzgerald, PJ; Robbins, RC; Yeung, AC; Yock, PG, 2003)
"This study sought to elucidate serial changes in microvascular integrity during papaverine-induced hyperemia in the risk area for myocardial infarction."3.71Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography. ( Fujiwara, H; Hayashi, Y; Imazu, M; Okimoto, T; Otsuka, M; Sakuma, T; Sumii, K, 2001)
" Infusion of L-arginine augmented the reactive hyperemia and the endothelium-dependent relaxation in response to acetylcholine administration."3.69[The role of nitric oxide in the development of reactive hyperemia in the coronary bed]. ( Sagach, VF; Tkachenko, MN, 1994)
"This study examined the imaging results and kinetics of technetium 99m teboroxime after its intracoronary injection during papaverine-induced coronary hyperemia in patients with one-vessel disease before and after coronary angioplasty."3.69Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia. ( Branzi, A; Corbelli, C; Fallani, F; Heo, J; Iskandrian, AS; Magnani, B; Marzocchi, A; Monetti, N; Piovaccari, G; Tartagni, F; Zannoli, R, 1996)
" BAP and FAP were measured at rest, and then during vasodilation produced by postischemic reactive hyperemia and intra-arterial injection of papaverine."3.67Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation. ( Hobson, RW; Jamil, Z; Lee, BC; Lynch, TG; Padberg, FT, 1985)
"Two patients showed signs of elevated intracranial pressure after the procedures and also had ASrO2 readings exceeding 15%; measures to lower arterial hypertension reduced SrO2 in these patients."2.72[Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty]. ( Carrero, E; Fàbregas, N; Fontanals, J; Rodríguez, L; Salvador, L; Valero, R, 2006)
"Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals."2.67Effects of adenosine on human coronary arterial circulation. ( Christensen, BV; Laxson, DD; Wilson, RF; Wyche, K; Zimmer, S, 1990)
"Caffeine was ingested at <12 hours in 85 patients, at 12-24 hours in 35 patients, and at >24 hours in 89 patients."1.62Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine. ( Hosonuma, M; Inoue, K; Kondo, S; Masaki, R; Matsumoto, H; Ogura, K; Oishi, Y; Okada, N; Sakai, K; Sato, S; Sekimoto, T; Shinke, T; Sumida, A; Takahashi, H; Tanaka, H; Tsujita, H; Tsukamoto, S, 2021)
"Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP."1.56Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020)
"Hyperemia was induced by administration of intrarenal papavarine."1.33Renal fractional flow reserve: a hemodynamic evaluation of moderate renal artery stenoses. ( Almagor, Y; Bashir, R; Meerkin, D; Rosenfield, K; Shalman, E; Subramanian, R; White, CJ, 2005)
"Hyperemia is unnecessary and not useful for predicting > 50% stenosis."1.29Analysis and comparison of pressure gradients and ratios for predicting iliac stenosis. ( Archie, JP, 1994)
"Furthermore, reactive hyperemia after a 40-second occlusion did not differ between the LAD and the circumflex artery (n = 8)."1.28Prolonged impairment of coronary vasodilation after reversible ischemia. Evidence for microvascular "stunning". ( Bolli, R; Jeroudi, MO; Triana, JF, 1990)
"Aminophylline pretreatment reduced reactive hyperemia below the control level even in the presence of an intracoronary infusion of adenosine."1.27Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion. ( Abe, Y; Hyodo, T; Nakatsu, T; Saito, D; Takeda, K; Tani, H; Ueeda, M; Yamada, N, 1985)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199024 (34.29)18.7374
1990's15 (21.43)18.2507
2000's11 (15.71)29.6817
2010's14 (20.00)24.3611
2020's6 (8.57)2.80

Authors

AuthorsStudies
Inoue, K2
Sonoda, S1
Naka, Y1
Okabe, H1
Setoyama, K1
Miura, T2
Anai, R1
Araki, M2
Kataoka, M1
Tanaka, H2
Matsumoto, H4
Takahashi, H2
Hosonuma, M1
Sato, S1
Ogura, K2
Oishi, Y2
Masaki, R2
Sakai, K1
Sekimoto, T1
Kondo, S1
Tsujita, H1
Tsukamoto, S1
Sumida, A1
Okada, N2
Shinke, T3
Nakayama, M2
Tanaka, N2
Yamashita, J1
Iwasaki, K2
Uchiyama, T1
Hijikata, N1
Kobori, Y1
Mikuri, M3
Arai, T1
Sakai, R1
Mizukami, T1
Sonck, J1
Gallinoro, E1
Kodeboina, M1
Canvedra, A1
Nagumo, S1
Bartunek, J3
Wyffels, E1
Vanderheyden, M1
De Bruyne, B4
Collet, C1
Shiode, N3
Okimoto, T3
Tamekiyo, H2
Kawase, T2
Yamane, K2
Kagawa, Y2
Fujii, Y2
Ueda, Y2
Hironobe, N2
Kato, Y2
Hayashi, Y3
Ruzsa, Z1
Róna, S1
Tóth, GG1
Sótonyi, P1
Bertrand, OF1
Nemes, B1
Merkely, B1
Hüttl, K1
Kawase, Y1
Omori, H1
Kawasaki, M1
Tanigaki, T1
Hirata, T1
Okamoto, S1
Ota, H1
Kikuchi, J1
Okubo, M1
Kamiya, H1
Hirakawa, A1
Suzuki, T1
Matsuo, H1
Gomes Júnior, MPM1
Alves, CMR1
Barbosa, AHP1
Caixeta, A1
Batista, MC1
Pestana, JOM1
Carvalho, AC1
Fiarresga, A1
Selas, M1
Oliveira, E1
Cavaco-Gonçalves, S1
Cacela, D1
Carrapiço, B1
Cardim, N1
Cruz Ferreira, R1
Hioki, H1
Miyashita, Y1
Ebisawa, S1
Motoki, H1
Izawa, A1
Tomita, T1
Koyama, J1
Ikeda, U1
Nakatsuma, K1
Shimada, T2
Ushimaru, S2
Yamazaki, T2
Matsuda, T2
Miki, K1
Fujii, K1
Fukunaga, M1
Nishimura, M1
Horimatsu, T1
Saita, T1
Tamaru, H1
Imanaka, T1
Shibuya, M1
Ohyanagi, M1
Masuyama, T1
Protasiewicz, M1
Początek, K1
Poręba, R1
Derkacz, A1
Podgórski, M1
Gosławska, K1
Szymańska-Chabowska, A1
Mazur, G1
Mysiak, A1
Witkowski, A1
Kobayashi, N1
Hirano, K1
Nakano, M1
Ito, Y1
Sakai, T1
Ishimori, H1
Yamawaki, M1
Tsukahara, R1
Muramatsu, T1
Takahashi, N1
Kawada, T1
Ilsar, R1
Chawantanpipat, C1
Chan, KH1
Waugh, R1
Hennessy, A1
Celermajer, DS1
Ng, MK1
Kapoor, N1
Fahsah, I1
Karim, R1
Jevans, AJ1
Leesar, MA1
Kern, MJ4
Pijls, NH4
Barbato, E3
Bech, JW2
Wijns, W2
Heyndrickx, GR2
STEIN, ID1
Fearon, WF1
Farouque, HM1
Balsam, LB1
Caffarelli, AD1
Cooke, DT1
Robbins, RC1
Fitzgerald, PJ1
Yeung, AC1
Yock, PG1
Subramanian, R1
White, CJ1
Rosenfield, K1
Bashir, R1
Almagor, Y1
Meerkin, D1
Shalman, E1
Aarnoudse, W1
Geven, M1
Botman, KJ1
Manoharan, G1
Lameire, N1
Verhamme, K1
Madaric, J1
Tielbeele, X1
Rodríguez, L1
Salvador, L1
Valero, R1
Carrero, E1
Fontanals, J1
Fàbregas, N1
McGeoch, RJ1
Oldroyd, KG1
Brian, JE1
Gocio, JC1
Barnes, RW1
Azorin, J1
Lesperance, J1
Frija, J1
Grenier, A1
Bourassa, MG1
Leont'eva, GV1
Nosova, VP1
Klauss, V1
Mudra, H1
Sbarouni, E1
Meissner, O1
Metz, J1
Theisen, K1
Sagach, VF1
Tkachenko, MN1
Karacagil, S1
Granbo, A1
Almgren, B1
Ljungman, C1
Bergqvist, D1
Giller, CA1
Purdy, P1
Giller, A1
Batjer, HH1
Kopitnik, T1
Archie, JP1
Suryapranata, H1
Zijlstra, F2
MacLeod, DC1
van den Brand, M1
de Feyter, PJ1
Serruys, PW2
Lamm, C1
Albertsson, P1
Dohnal, M1
Tylén, U1
Emanuelsson, H1
Tartagni, F1
Fallani, F1
Corbelli, C1
Monetti, N1
Piovaccari, G1
Marzocchi, A1
Zannoli, R1
Branzi, A1
Magnani, B1
Heo, J1
Iskandrian, AS1
van der Voort, PH1
van Hagen, E1
Hendrix, G1
van Gelder, B1
Yang, G1
Iadecola, C1
Kato, M1
Nakayama, K1
Shinohara, K1
Kurokawa, J1
Yamagata, T1
Matsuura, H1
Kajiyama, G1
Sensier, YJ1
Thrush, AJ1
Loftus, I1
Evans, DH1
London, NJ1
Dreier, JP1
Petzold, G1
Tille, K1
Lindauer, U1
Arnold, G1
Heinemann, U1
Einhäupl, KM1
Dirnagl, U1
Sakuma, T1
Otsuka, M1
Fujiwara, H1
Sumii, K1
Imazu, M1
Downey, HF1
Bashour, FA1
Boatwright, RB1
Parker, PE1
Kechejian, SJ1
Myhre, HO3
Dedichen, H2
Tatineni, S1
Deligonul, U2
Aguirre, F2
Donohue, T1
Bach, R1
Wilson, RF1
Wyche, K1
Christensen, BV1
Zimmer, S1
Laxson, DD1
Bolli, R1
Triana, JF1
Jeroudi, MO1
Shustova, NIa2
Dik, IG1
Nedoshivin, VP1
Levtov, VA2
Pearson, AC1
Labovitz, AJ1
Vandormael, M1
Gudipati, C1
Shuvaeva, VN1
Chuĭkin, AE1
Hodgson, JM1
Williams, DO1
Hugenholtz, PG1
Padberg, FT1
Hobson, RW1
Lynch, TG1
Lee, BC1
Jamil, Z1
Saito, D1
Hyodo, T1
Takeda, K1
Abe, Y1
Tani, H1
Yamada, N1
Ueeda, M1
Nakatsu, T1
Eikens, E3
Wilcken, DE3
Honda, N1
Morikawa, A1
Nihei, H1
Aizawa, C1
Yoshitoshi, Y1
Mohrman, DE1
Sparks, HV1
Tominaga, S1
Watanabe, K1
Nakamura, T1
Winbury, MM1
Howe, BB1
Hefner, MA1
Hardung, V1
Laszt, L1
Huber, P1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)[NCT02184117]763 participants (Actual)Observational2014-07-31Completed
Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities. A Multicentre[NCT04777513]450 participants (Anticipated)Observational [Patient Registry]2020-08-06Recruiting
A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Coronary Angiography-Derived Index of Microcirculatory Resistance Measured Online by a Coronary Functional Measurement System[NCT05009667]116 participants (Actual)Observational2021-10-14Completed
Kidney Transplantation and Renal and Myocardial Perfusion[NCT02960802]60 participants (Anticipated)Interventional2017-01-01Active, not recruiting
Outcomes in Femoropopliteal Disease Stratified by Translesional Pressure Gradient[NCT02387658]25 participants (Actual)Observational2015-02-06Completed
Diagnostic Accuracy in Left Ventricular Systolic Dysfunction for Identifying Coronary Artery Disease With Dobutamine Versus Adenosine Non-invasive Stress Cardiac Magnetic Resonance Evaluation[NCT03661827]69 participants (Actual)Interventional2019-02-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for papaverine and Hyperemia

ArticleYear
Pharmacological options for inducing maximal hyperaemia during studies of coronary physiology.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2008, Feb-01, Volume: 71, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Caffeine; Coronary Stenosis; Dobutamine; Fractional Flow

2008

Trials

3 trials available for papaverine and Hyperemia

ArticleYear
[Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:10

    Topics: Aged; Angioplasty, Balloon; Blood Pressure; Brain Ischemia; Carotid Artery, Internal; Carotid Stenos

2006
The effects of ionic and nonionic radiographic contrast media on coronary hyperemia in patients during coronary angiography.
    American heart journal, 1992, Volume: 123, Issue:3

    Topics: Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Diatrizoate Meglumine; Female; Huma

1992
Effects of adenosine on human coronary arterial circulation.
    Circulation, 1990, Volume: 82, Issue:5

    Topics: Adenosine; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Dose-Response Relationship,

1990

Other Studies

66 other studies available for papaverine and Hyperemia

ArticleYear
Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement.
    International heart journal, 2021, Sep-30, Volume: 62, Issue:5

    Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Control Studies; Coronary Angiography; Coronary

2021
Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021, Dec-03, Volume: 17, Issue:11

    Topics: Adenosine; Caffeine; Coronary Angiography; Coronary Stenosis; Fractional Flow Reserve, Myocardial; H

2021
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine.
    Cardiovascular intervention and therapeutics, 2020, Volume: 35, Issue:4

    Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Dose-Response Relationship, Drug; E

2020
Effect of QTU prolongation on hyperemic instantaneous wave-free ratio value: a prospective single-center study.
    Heart and vessels, 2020, Volume: 35, Issue:7

    Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Blood Flow Velocity; Cardiac Catheterization; Coron

2020
Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine.
    International journal of cardiology, 2020, 09-01, Volume: 314

    Topics: Coronary Angiography; Coronary Circulation; Coronary Stenosis; Feasibility Studies; Fractional Flow

2020
Duration of Hyperemia With Intracoronary Administration of Papaverine.
    Journal of the American Heart Association, 2021, 02-02, Volume: 10, Issue:3

    Topics: Aged; Coronary Stenosis; Coronary Vessels; Female; Fractional Flow Reserve, Myocardial; Humans; Hype

2021
A Comparison between the Instantaneous Wave-free Ratio and Resting Distal Coronary Artery Pressure/Aortic Pressure and the Fractional Flow Reserve: The Diagnostic Accuracy Can Be Improved by the Use of both Indices.
    Internal medicine (Tokyo, Japan), 2017, Volume: 56, Issue:7

    Topics: Aged; Aorta; Arterial Pressure; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Fe

2017
Fractional flow reserve in below the knee arteries with critical limb ischemia and validation against gold-standard morphologic, functional measures and long term clinical outcomes.
    Cardiovascular revascularization medicine : including molecular interventions, 2018, Volume: 19, Issue:2

    Topics: Aged; Angiography; Angioplasty, Balloon; Blood Pressure; Blood Pressure Determination; Critical Illn

2018
Postocclusional Hyperemia for Fractional Flow Reserve After Percutaneous Coronary Intervention.
    Circulation. Cardiovascular interventions, 2017, Volume: 10, Issue:12

    Topics: Adenosine Triphosphate; Administration, Intravenous; Aged; Aged, 80 and over; Balloon Occlusion; Car

2017
Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2018, 03-01, Volume: 91, Issue:4

    Topics: Adult; Angioplasty, Balloon; Catheterization, Peripheral; Computed Tomography Angiography; Female; H

2018
Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2014, Volume: 33, Issue:4

    Topics: Animals; Coronary Circulation; Diagnostic Techniques, Cardiovascular; Disease Models, Animal; Hypere

2014
Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2014, Volume: 21, Issue:5

    Topics: Aged; Ankle Brachial Index; Arterial Pressure; Constriction, Pathologic; Exercise Test; Feasibility

2014
Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement.
    The Journal of invasive cardiology, 2014, Volume: 26, Issue:11

    Topics: Adenosine; Administration, Oral; Aged; Blood Pressure; Caffeine; Coronary Angiography; Coronary Sten

2014
Assessment of lower limb flow and adequate intra-arterial papaverine doses to achieve maximal hyperemia in elder subjects.
    Cardiovascular intervention and therapeutics, 2015, Volume: 30, Issue:3

    Topics: Aged; Blood Pressure; Female; Heart Rate; Humans; Hyperemia; Injections, Intra-Arterial; Leg; Male;

2015
Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis.
    Journal of the American Society of Hypertension : JASH, 2015, Volume: 9, Issue:1

    Topics: Aged; Dopamine; Female; Humans; Hyperemia; Kidney; Male; Microcirculation; Middle Aged; Papaverine;

2015
Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease.
    Journal of atherosclerosis and thrombosis, 2016, Volume: 23, Issue:1

    Topics: Aged; Cardiology; Coronary Stenosis; Endovascular Procedures; Female; Femoral Artery; Heart Failure;

2016
Is Caffeine Abstention Necessary Before Adenosine-Induced Fractional Flow Reserve Measurement?
    Journal of the American College of Cardiology, 2015, Oct-27, Volume: 66, Issue:17

    Topics: Adenosine; Caffeine; Fractional Flow Reserve, Myocardial; Humans; Hyperemia; Papaverine; Prospective

2015
Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions.
    Internal medicine (Tokyo, Japan), 2017, Volume: 56, Issue:3

    Topics: Adenosine; Aged; Contrast Media; Coronary Angiography; Coronary Artery Disease; Female; Fractional F

2017
Measurement of pulmonary flow reserve in higher primates.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:8

    Topics: Adenosine; Animals; Blood Flow Velocity; Female; Heart Rate; Hyperemia; Male; Microcirculation; Micr

2009
Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, Nov-01, Volume: 76, Issue:5

    Topics: Aged; Aorta; Arrhythmias, Cardiac; Biomarkers; Blood Pressure; Blood Pressure Determination; Chi-Squ

2010
Can we apply coronary physiologic methods to renal artery stenosis assessment?
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, Nov-01, Volume: 76, Issue:5

    Topics: Biomarkers; Blood Pressure; Blood Pressure Determination; Coronary Circulation; Coronary Stenosis; H

2010
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron

2003
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron

2003
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron

2003
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron

2003
A MEDICAL APPRAISAL OF THERAPY FOR OCCLUSIVE ARTERIAL DISEASE.
    Angiology, 1964, Volume: 15

    Topics: Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Vessel Prosthesis; Blood Vessel Prosthesis I

1964
Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve.
    Circulation, 2003, Nov-04, Volume: 108, Issue:18

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Coronary Stenosis; Disease Model

2003
Renal fractional flow reserve: a hemodynamic evaluation of moderate renal artery stenoses.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2005, Volume: 64, Issue:4

    Topics: Aged; Angiography; Cohort Studies; Female; Hemodynamics; Humans; Hyperemia; Linear Models; Male; Mid

2005
Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease.
    The American journal of cardiology, 2005, Dec-15, Volume: 96, Issue:12

    Topics: Adenosine; Adrenergic alpha-Antagonists; Blood Flow Velocity; Coronary Angiography; Coronary Stenosi

2005
Assessment of renal flow and flow reserve in humans.
    Journal of the American College of Cardiology, 2006, Feb-07, Volume: 47, Issue:3

    Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Dopamine; Female; Fenoldopam; Heart Rate; Humans;

2006
Intraoperative assessment of aortoiliac stenosis: role of papaverine-induced hyperemia.
    The Journal of the Arkansas Medical Society, 1984, Volume: 81, Issue:7

    Topics: Aortic Valve Stenosis; Arterial Occlusive Diseases; Blood Pressure Determination; Blood Vessel Prost

1984
[Study of the hyperemic reserve of the myocardium with the aid of papaverine].
    Annales de chirurgie, 1983, Volume: 37, Issue:2

    Topics: Animals; Constriction; Coronary Circulation; Coronary Vessels; Dogs; Hyperemia; Papaverine

1983
[Characteristic features of the functioning of arteriolovenular anastomoses in pharmacological arterial hyperemia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 94, Issue:11

    Topics: Aminophylline; Animals; Arterioles; Arteriovenous Anastomosis; Collateral Circulation; Hyperemia; Ma

1982
Myocardial contrast echocardiography for assessment of papaverine vasodilator response in patients with angiographically normal coronary arteries and in patients after orthotopic heart transplantation.
    Zeitschrift fur Kardiologie, 1995, Volume: 84, Issue:10

    Topics: Adult; Aged; Contrast Media; Coronary Angiography; Coronary Circulation; Dose-Response Relationship,

1995
[The role of nitric oxide in the development of reactive hyperemia in the coronary bed].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1994, Volume: 80, Issue:2

    Topics: Acetylcholine; Animals; Arginine; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Hyperemia;

1994
The effect of postocclusion reactive hyperaemia, papaverine and nifedipine on duplex derived haemodynamic parameters of infrainguinal bypass grafts.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 1995, Volume: 9, Issue:1

    Topics: Aged; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Vessel Prosthesis; Female; Graft Occ

1995
Elevated transcranial Doppler ultrasound velocities following therapeutic arterial dilation.
    Stroke, 1995, Volume: 26, Issue:1

    Topics: Adult; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Carotid Artery Diseases; Cereb

1995
Analysis and comparison of pressure gradients and ratios for predicting iliac stenosis.
    Annals of vascular surgery, 1994, Volume: 8, Issue:3

    Topics: Arterial Occlusive Diseases; Blood Pressure; Constriction, Pathologic; Femoral Artery; Forecasting;

1994
Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction.
    Circulation, 1994, Volume: 89, Issue:3

    Topics: Angiography, Digital Subtraction; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Cir

1994
Assessment of coronary artery stenosis during PTCA by measurement of the trans-stenotic pressure gradient. Comparison with quantitative coronary angiography.
    European heart journal, 1995, Volume: 16, Issue:10

    Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Coronary Angiography; Coronary Circulation; Co

1995
Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia.
    American heart journal, 1996, Volume: 132, Issue:5

    Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Disease; Feasibility Studies; Heart; Humans; Hyperemi

1996
Comparison of intravenous adenosine to intracoronary papaverine for calculation of pressure-derived fractional flow reserve.
    Catheterization and cardiovascular diagnosis, 1996, Volume: 39, Issue:2

    Topics: Adenosine; Adult; Aged; Blood Flow Velocity; Cardiac Catheterization; Coronary Circulation; Female;

1996
Obligatory role of NO in glutamate-dependent hyperemia evoked from cerebellar parallel fibers.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2

    Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Electric Stimulation; Enzyme Inhibi

1997
Effect of adenosine triphosphate on human coronary circulation.
    Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:10

    Topics: Adenosine Triphosphate; Blood Flow Velocity; Cardiac Catheterization; Chest Pain; Coronary Angiograp

1998
A comparison of colour duplex ultrasonography, papaverine testing and common femoral Doppler waveform analysis for assessment of the aortoiliac arteries.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2000, Volume: 20, Issue:1

    Topics: Aged; Aged, 80 and over; Aortic Diseases; Arterial Occlusive Diseases; Blood Flow Velocity; Female;

2000
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats.
    The Journal of physiology, 2001, Mar-01, Volume: 531, Issue:Pt 2

    Topics: Animals; Brain; Cortical Spreading Depression; Drug Combinations; Electrophysiology; Enzyme Inhibito

2001
Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography.
    The American journal of cardiology, 2001, Mar-15, Volume: 87, Issue:6

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Contrast Media; Coronary Circulation; Echoc

2001
Uniformity of transmural perfusion in anesthetized dogs with maximally dilated coronary circulations.
    Circulation research, 1975, Volume: 37, Issue:1

    Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Electromagnetic Ph

1975
Reactive hyperemia of the lower limb. Experimental and clinical studies.
    Journal of the Oslo city hospitals, 1975, Volume: 25, Issue:10

    Topics: Animals; Blood Pressure; Hindlimb; Humans; Hyperemia; Leg; Oxygen; Papaverine; Rabbits; Regional Blo

1975
Reactive hyperaemia of the human lower limb. A comparison between the effect of tourniquet occlusion, selective arterial occlusion and intra-arterial papaverine injection.
    Acta chirurgica Scandinavica, 1975, Volume: 141, Issue:6

    Topics: Femoral Artery; Humans; Hyperemia; Leg; Middle Aged; Occlusive Dressings; Papaverine; Regional Blood

1975
Interpretation of cardiac pathophysiology from pressure waveform analysis: coronary hemodynamics, Part III: Coronary hyperemia.
    Catheterization and cardiovascular diagnosis, 1992, Volume: 26, Issue:3

    Topics: Adenosine; Blood Flow Velocity; Cardiac Catheterization; Contrast Media; Coronary Circulation; Coron

1992
Prolonged impairment of coronary vasodilation after reversible ischemia. Evidence for microvascular "stunning".
    Circulation research, 1990, Volume: 67, Issue:2

    Topics: Adenosine; Animals; Blood Pressure; Coronary Disease; Coronary Vessels; Dogs; Heart Rate; Hemodynami

1990
[Blood supply of skeletal muscles in reactive hyperemia].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1989, Volume: 75, Issue:4

    Topics: Animals; Arteries; Blood Volume; Cats; Hyperemia; Muscles; Papaverine

1989
Effects of pharmacologic coronary hyperemia on echocardiographic left ventricular function in patients with single vessel coronary artery disease.
    Journal of the American College of Cardiology, 1989, Volume: 13, Issue:5

    Topics: Angiography; Coronary Circulation; Coronary Disease; Coronary Vessels; Echocardiography; Heart; Hear

1989
[Effect of an increase in the blood flow through the vessels of skeletal muscle on its functional indices and oxygen demand].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1988, Volume: 74, Issue:12

    Topics: Acetylcholine; Animals; Cats; Hyperemia; Lactates; Muscle Contraction; Muscles; Oxygen; Oxygen Consu

1988
Superiority of intracoronary papaverine to radiographic contrast for measuring coronary flow reserve in patients with ischemic heart disease.
    American heart journal, 1987, Volume: 114, Issue:4 Pt 1

    Topics: Blood Flow Velocity; Cardiac Catheterization; Cineradiography; Contrast Media; Coronary Angiography;

1987
Papaverine: the ideal coronary vasodilator for investigating coronary flow reserve? A study of timing, magnitude, reproducibility, and safety of the coronary hyperemic response after intracoronary papaverine.
    Catheterization and cardiovascular diagnosis, 1986, Volume: 12, Issue:5

    Topics: Aged; Coronary Circulation; Female; Humans; Hyperemia; Injections, Intra-Arterial; Male; Middle Aged

1986
Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation.
    The American surgeon, 1985, Volume: 51, Issue:4

    Topics: Aortic Diseases; Arterial Occlusive Diseases; Blood Pressure; Brachial Artery; Femoral Artery; Human

1985
Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion.
    The American journal of physiology, 1985, Volume: 248, Issue:6 Pt 2

    Topics: Adenosine; Aminophylline; Animals; Arterial Occlusive Diseases; Cardiac Catheterization; Coronary Ci

1985
Myocardial reactive hyperemia and coronary vascular reactivity in the dog.
    Circulation research, 1973, Volume: 33, Issue:3

    Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Coronary Circu

1973
Proceedings: Reactive hyperaemia in the dog heart: assessment of post-hyperaemic coronary vascular reactivity and of the effects of temporarily restricting arterial inflow.
    The Journal of physiology, 1973, Volume: 234, Issue:2

    Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Dogs; Heart; Hyperemia; Muscle, Smooth;

1973
Reactive hyperaemia in the dog heart: studies on mechanisms.
    Advances in cardiology, 1974, Volume: 12, Issue:0

    Topics: Adenosine; Aminophylline; Animals; Blood Pressure; Coronary Circulation; Dipyridamole; Dogs; Heart R

1974
Postocclusive vascular responses in isolated perfused kidney of rabbits.
    The American journal of physiology, 1972, Volume: 222, Issue:6

    Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Carbon Dioxide; Constriction; Dilatation; Hydrogen

1972
Role of potassium ions in the vascular response to a brief tetanus.
    Circulation research, 1974, Volume: 35, Issue:3

    Topics: Animals; Capillaries; Dilatation; Dogs; Hyperemia; Mathematics; Models, Biological; Muscle Contracti

1974
Haemodynamic factors in the oedema of arterial reconstructions.
    Scandinavian journal of thoracic and cardiovascular surgery, 1972, Volume: 6, Issue:3

    Topics: Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Edema; Foot; Hemodynamics; Humans; Hyperemia;

1972
Properties of exercise and reactive hyperemias in canine hindlimb muscles under constant pressure perfusion.
    The Tohoku journal of experimental medicine, 1973, Volume: 111, Issue:1

    Topics: Animals; Arteries; Blood Volume; Cats; Dogs; Electric Stimulation; Female; Hindlimb; Hyperemia; Male

1973
Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 168, Issue:1

    Topics: Aminophylline; Animals; Aorta; Biophysical Phenomena; Biophysics; Blood Circulation; Blood Flow Velo

1969
[Investigations on the dynamics of carotid circulation by means of impedance determinations].
    Angiologica, 1971, Volume: 8, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Carotid Arteries; Dogs; Elasticity; Hemodynamics;

1971
[Clinical and angiographic diagnosis of cerebrovascular diseases].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1969, Volume: 24, Issue:5

    Topics: Adult; Blood Flow Velocity; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Ce

1969