papaverine and Hyperemia
papaverine has been researched along with Hyperemia in 70 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 7.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| "The purpose of this study was to assess the hyperemic effects of papaverine and dopamine in the renal microcirculation of hypertensive patients with renal artery stenosis (RAS)." | 7.81 | Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis. ( Derkacz, A; Gosławska, K; Mazur, G; Mysiak, A; Początek, K; Podgórski, M; Poręba, R; Protasiewicz, M; Szymańska-Chabowska, A; Witkowski, A, 2015) |
| "Caffeine attenuates intravenous adenosine-induced hyperemia in FFR measurement." | 7.80 | Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014) |
| "This study examined the imaging results and kinetics of technetium 99m teboroxime after its intracoronary injection during papaverine-induced coronary hyperemia in patients with one-vessel disease before and after coronary angioplasty." | 7.69 | Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia. ( Branzi, A; Corbelli, C; Fallani, F; Heo, J; Iskandrian, AS; Magnani, B; Marzocchi, A; Monetti, N; Piovaccari, G; Tartagni, F; Zannoli, R, 1996) |
| " BAP and FAP were measured at rest, and then during vasodilation produced by postischemic reactive hyperemia and intra-arterial injection of papaverine." | 7.67 | Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation. ( Hobson, RW; Jamil, Z; Lee, BC; Lynch, TG; Padberg, FT, 1985) |
| "Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP." | 5.56 | Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020) |
| "Aminophylline pretreatment reduced reactive hyperemia below the control level even in the presence of an intracoronary infusion of adenosine." | 5.27 | Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion. ( Abe, Y; Hyodo, T; Nakatsu, T; Saito, D; Takeda, K; Tani, H; Ueeda, M; Yamada, N, 1985) |
| " Intracoronary papaverine (PAP) is the most potent vasodilator used for the achievement of maximal hyperemia." | 4.02 | Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement. ( Anai, R; Araki, M; Inoue, K; Kataoka, M; Miura, T; Naka, Y; Okabe, H; Setoyama, K; Sonoda, S, 2021) |
| "We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements." | 3.96 | Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine. ( Iwasaki, K; Nakayama, M; Tanaka, N; Yamashita, J, 2020) |
| " Resting Pd/Pa ratio (ratio of mean distal to lesion and mean proximal pressures) and translesional systolic pressure gradient were obtained and FFR and hyperemic translesional systolic and mean pressure gradients (HSG and HMG) were registered after papaverine induced maximum hyperemia-pre and poststent implantation." | 3.88 | Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis. ( Alves, CMR; Barbosa, AHP; Batista, MC; Caixeta, A; Carvalho, AC; Gomes Júnior, MPM; Pestana, JOM, 2018) |
| "FFR measured by postocclusional hyperemia (FFRoccl) caused by balloon occlusion after percutaneous coronary intervention was compared with FFR measured by drug-induced hyperemia (FFR measured by intravenous ATP; and FFR measured by intracoronary papaverine injection [FFRpap]) in 98 lesions from 98 patients." | 3.85 | Postocclusional Hyperemia for Fractional Flow Reserve After Percutaneous Coronary Intervention. ( Hirakawa, A; Hirata, T; Kamiya, H; Kawasaki, M; Kawase, Y; Kikuchi, J; Matsuo, H; Okamoto, S; Okubo, M; Omori, H; Ota, H; Suzuki, T; Tanigaki, T, 2017) |
| "Objective Measuring the fractional flow reserve (FFR) requires the induction of coronary hyperemia, usually with adenosine, adenosine triphosphate (ATP), or papaverine." | 3.85 | Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions. ( Fujii, Y; Hayashi, Y; Hironobe, N; Kagawa, Y; Kato, Y; Kawase, T; Okimoto, T; Shiode, N; Tamekiyo, H; Ueda, Y; Yamane, K, 2017) |
| " We clarified the optimal measuring procedure for FFR for SFA lesions and investigated the necessary dose of papaverine for inducing maximal hyperemia in SFA lesions." | 3.83 | Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. ( Araki, M; Hirano, K; Ishimori, H; Ito, Y; Kobayashi, N; Muramatsu, T; Nakano, M; Sakai, T; Tsukahara, R; Yamawaki, M, 2016) |
| "The purpose of this study was to assess the hyperemic effects of papaverine and dopamine in the renal microcirculation of hypertensive patients with renal artery stenosis (RAS)." | 3.81 | Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis. ( Derkacz, A; Gosławska, K; Mazur, G; Mysiak, A; Początek, K; Podgórski, M; Poręba, R; Protasiewicz, M; Szymańska-Chabowska, A; Witkowski, A, 2015) |
| "The primary aim of this study was to validate the assessment of IMR in a large animal model, and the secondary aim was to compare two doses of intracoronary papaverine, 5 and 10 mg, for induction of maximal hyperemia and its evolution over time." | 3.80 | Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model. ( Cacela, D; Cardim, N; Carrapiço, B; Cavaco-Gonçalves, S; Cruz Ferreira, R; Fiarresga, A; Oliveira, E; Selas, M, 2014) |
| " During angiography, the p-FFR was measured using a pressure guidewire after administration of papaverine to induce hyperemia." | 3.80 | Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index. ( Ebisawa, S; Hioki, H; Ikeda, U; Izawa, A; Koyama, J; Miura, T; Miyashita, Y; Motoki, H; Tomita, T, 2014) |
| "Caffeine attenuates intravenous adenosine-induced hyperemia in FFR measurement." | 3.80 | Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement. ( Matsuda, T; Matsumoto, H; Mikuri, M; Nakatsuma, K; Shimada, T; Ushimaru, S; Yamazaki, T, 2014) |
| " Intrarenal papaverine neither prolonged the QT interval nor induced ventricular arrhythmias and the safety of which will need to be corroborated in a large study." | 3.76 | Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements. ( Fahsah, I; Jevans, AJ; Kapoor, N; Karim, R; Leesar, MA, 2010) |
| "Provided sufficient dosages are used, ATP, adenosine, and papaverine (but not contrast medium) induce maximal hyperemia and are therefore suitable to assess fractional flow reserve." | 3.72 | Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. ( Barbato, E; Bartunek, J; Bech, JW; De Bruyne, B; Heyndrickx, GR; Pijls, NH; Wijns, W, 2003) |
| " Intracoronary papaverine (20 mg) was used to induce hyperemia." | 3.72 | Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve. ( Balsam, LB; Caffarelli, AD; Cooke, DT; Farouque, HM; Fearon, WF; Fitzgerald, PJ; Robbins, RC; Yeung, AC; Yock, PG, 2003) |
| "This study sought to elucidate serial changes in microvascular integrity during papaverine-induced hyperemia in the risk area for myocardial infarction." | 3.71 | Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography. ( Fujiwara, H; Hayashi, Y; Imazu, M; Okimoto, T; Otsuka, M; Sakuma, T; Sumii, K, 2001) |
| " Infusion of L-arginine augmented the reactive hyperemia and the endothelium-dependent relaxation in response to acetylcholine administration." | 3.69 | [The role of nitric oxide in the development of reactive hyperemia in the coronary bed]. ( Sagach, VF; Tkachenko, MN, 1994) |
| "This study examined the imaging results and kinetics of technetium 99m teboroxime after its intracoronary injection during papaverine-induced coronary hyperemia in patients with one-vessel disease before and after coronary angioplasty." | 3.69 | Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia. ( Branzi, A; Corbelli, C; Fallani, F; Heo, J; Iskandrian, AS; Magnani, B; Marzocchi, A; Monetti, N; Piovaccari, G; Tartagni, F; Zannoli, R, 1996) |
| " BAP and FAP were measured at rest, and then during vasodilation produced by postischemic reactive hyperemia and intra-arterial injection of papaverine." | 3.67 | Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation. ( Hobson, RW; Jamil, Z; Lee, BC; Lynch, TG; Padberg, FT, 1985) |
| "Two patients showed signs of elevated intracranial pressure after the procedures and also had ASrO2 readings exceeding 15%; measures to lower arterial hypertension reduced SrO2 in these patients." | 2.72 | [Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty]. ( Carrero, E; Fàbregas, N; Fontanals, J; Rodríguez, L; Salvador, L; Valero, R, 2006) |
| "Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals." | 2.67 | Effects of adenosine on human coronary arterial circulation. ( Christensen, BV; Laxson, DD; Wilson, RF; Wyche, K; Zimmer, S, 1990) |
| "Caffeine was ingested at <12 hours in 85 patients, at 12-24 hours in 35 patients, and at >24 hours in 89 patients." | 1.62 | Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine. ( Hosonuma, M; Inoue, K; Kondo, S; Masaki, R; Matsumoto, H; Ogura, K; Oishi, Y; Okada, N; Sakai, K; Sato, S; Sekimoto, T; Shinke, T; Sumida, A; Takahashi, H; Tanaka, H; Tsujita, H; Tsukamoto, S, 2021) |
| "Nicorandil 2 mg is a safe and practical alternative for patients who consume caffeine-containing products before the test or have contraindications for adenosine/ATP." | 1.56 | Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine. ( Arai, T; Masaki, R; Matsumoto, H; Mikuri, M; Ogura, K; Oishi, Y; Okada, N; Sakai, R; Shinke, T; Tanaka, H, 2020) |
| "Hyperemia was induced by administration of intrarenal papavarine." | 1.33 | Renal fractional flow reserve: a hemodynamic evaluation of moderate renal artery stenoses. ( Almagor, Y; Bashir, R; Meerkin, D; Rosenfield, K; Shalman, E; Subramanian, R; White, CJ, 2005) |
| "Hyperemia is unnecessary and not useful for predicting > 50% stenosis." | 1.29 | Analysis and comparison of pressure gradients and ratios for predicting iliac stenosis. ( Archie, JP, 1994) |
| "Furthermore, reactive hyperemia after a 40-second occlusion did not differ between the LAD and the circumflex artery (n = 8)." | 1.28 | Prolonged impairment of coronary vasodilation after reversible ischemia. Evidence for microvascular "stunning". ( Bolli, R; Jeroudi, MO; Triana, JF, 1990) |
| "Aminophylline pretreatment reduced reactive hyperemia below the control level even in the presence of an intracoronary infusion of adenosine." | 1.27 | Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion. ( Abe, Y; Hyodo, T; Nakatsu, T; Saito, D; Takeda, K; Tani, H; Ueeda, M; Yamada, N, 1985) |
Research
Studies (70)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (34.29) | 18.7374 |
| 1990's | 15 (21.43) | 18.2507 |
| 2000's | 11 (15.71) | 29.6817 |
| 2010's | 14 (20.00) | 24.3611 |
| 2020's | 6 (8.57) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Inoue, K | 2 |
| Sonoda, S | 1 |
| Naka, Y | 1 |
| Okabe, H | 1 |
| Setoyama, K | 1 |
| Miura, T | 2 |
| Anai, R | 1 |
| Araki, M | 2 |
| Kataoka, M | 1 |
| Tanaka, H | 2 |
| Matsumoto, H | 4 |
| Takahashi, H | 2 |
| Hosonuma, M | 1 |
| Sato, S | 1 |
| Ogura, K | 2 |
| Oishi, Y | 2 |
| Masaki, R | 2 |
| Sakai, K | 1 |
| Sekimoto, T | 1 |
| Kondo, S | 1 |
| Tsujita, H | 1 |
| Tsukamoto, S | 1 |
| Sumida, A | 1 |
| Okada, N | 2 |
| Shinke, T | 3 |
| Nakayama, M | 2 |
| Tanaka, N | 2 |
| Yamashita, J | 1 |
| Iwasaki, K | 2 |
| Uchiyama, T | 1 |
| Hijikata, N | 1 |
| Kobori, Y | 1 |
| Mikuri, M | 3 |
| Arai, T | 1 |
| Sakai, R | 1 |
| Mizukami, T | 1 |
| Sonck, J | 1 |
| Gallinoro, E | 1 |
| Kodeboina, M | 1 |
| Canvedra, A | 1 |
| Nagumo, S | 1 |
| Bartunek, J | 3 |
| Wyffels, E | 1 |
| Vanderheyden, M | 1 |
| De Bruyne, B | 4 |
| Collet, C | 1 |
| Shiode, N | 3 |
| Okimoto, T | 3 |
| Tamekiyo, H | 2 |
| Kawase, T | 2 |
| Yamane, K | 2 |
| Kagawa, Y | 2 |
| Fujii, Y | 2 |
| Ueda, Y | 2 |
| Hironobe, N | 2 |
| Kato, Y | 2 |
| Hayashi, Y | 3 |
| Ruzsa, Z | 1 |
| Róna, S | 1 |
| Tóth, GG | 1 |
| Sótonyi, P | 1 |
| Bertrand, OF | 1 |
| Nemes, B | 1 |
| Merkely, B | 1 |
| Hüttl, K | 1 |
| Kawase, Y | 1 |
| Omori, H | 1 |
| Kawasaki, M | 1 |
| Tanigaki, T | 1 |
| Hirata, T | 1 |
| Okamoto, S | 1 |
| Ota, H | 1 |
| Kikuchi, J | 1 |
| Okubo, M | 1 |
| Kamiya, H | 1 |
| Hirakawa, A | 1 |
| Suzuki, T | 1 |
| Matsuo, H | 1 |
| Gomes Júnior, MPM | 1 |
| Alves, CMR | 1 |
| Barbosa, AHP | 1 |
| Caixeta, A | 1 |
| Batista, MC | 1 |
| Pestana, JOM | 1 |
| Carvalho, AC | 1 |
| Fiarresga, A | 1 |
| Selas, M | 1 |
| Oliveira, E | 1 |
| Cavaco-Gonçalves, S | 1 |
| Cacela, D | 1 |
| Carrapiço, B | 1 |
| Cardim, N | 1 |
| Cruz Ferreira, R | 1 |
| Hioki, H | 1 |
| Miyashita, Y | 1 |
| Ebisawa, S | 1 |
| Motoki, H | 1 |
| Izawa, A | 1 |
| Tomita, T | 1 |
| Koyama, J | 1 |
| Ikeda, U | 1 |
| Nakatsuma, K | 1 |
| Shimada, T | 2 |
| Ushimaru, S | 2 |
| Yamazaki, T | 2 |
| Matsuda, T | 2 |
| Miki, K | 1 |
| Fujii, K | 1 |
| Fukunaga, M | 1 |
| Nishimura, M | 1 |
| Horimatsu, T | 1 |
| Saita, T | 1 |
| Tamaru, H | 1 |
| Imanaka, T | 1 |
| Shibuya, M | 1 |
| Ohyanagi, M | 1 |
| Masuyama, T | 1 |
| Protasiewicz, M | 1 |
| Początek, K | 1 |
| Poręba, R | 1 |
| Derkacz, A | 1 |
| Podgórski, M | 1 |
| Gosławska, K | 1 |
| Szymańska-Chabowska, A | 1 |
| Mazur, G | 1 |
| Mysiak, A | 1 |
| Witkowski, A | 1 |
| Kobayashi, N | 1 |
| Hirano, K | 1 |
| Nakano, M | 1 |
| Ito, Y | 1 |
| Sakai, T | 1 |
| Ishimori, H | 1 |
| Yamawaki, M | 1 |
| Tsukahara, R | 1 |
| Muramatsu, T | 1 |
| Takahashi, N | 1 |
| Kawada, T | 1 |
| Ilsar, R | 1 |
| Chawantanpipat, C | 1 |
| Chan, KH | 1 |
| Waugh, R | 1 |
| Hennessy, A | 1 |
| Celermajer, DS | 1 |
| Ng, MK | 1 |
| Kapoor, N | 1 |
| Fahsah, I | 1 |
| Karim, R | 1 |
| Jevans, AJ | 1 |
| Leesar, MA | 1 |
| Kern, MJ | 4 |
| Pijls, NH | 4 |
| Barbato, E | 3 |
| Bech, JW | 2 |
| Wijns, W | 2 |
| Heyndrickx, GR | 2 |
| STEIN, ID | 1 |
| Fearon, WF | 1 |
| Farouque, HM | 1 |
| Balsam, LB | 1 |
| Caffarelli, AD | 1 |
| Cooke, DT | 1 |
| Robbins, RC | 1 |
| Fitzgerald, PJ | 1 |
| Yeung, AC | 1 |
| Yock, PG | 1 |
| Subramanian, R | 1 |
| White, CJ | 1 |
| Rosenfield, K | 1 |
| Bashir, R | 1 |
| Almagor, Y | 1 |
| Meerkin, D | 1 |
| Shalman, E | 1 |
| Aarnoudse, W | 1 |
| Geven, M | 1 |
| Botman, KJ | 1 |
| Manoharan, G | 1 |
| Lameire, N | 1 |
| Verhamme, K | 1 |
| Madaric, J | 1 |
| Tielbeele, X | 1 |
| Rodríguez, L | 1 |
| Salvador, L | 1 |
| Valero, R | 1 |
| Carrero, E | 1 |
| Fontanals, J | 1 |
| Fàbregas, N | 1 |
| McGeoch, RJ | 1 |
| Oldroyd, KG | 1 |
| Brian, JE | 1 |
| Gocio, JC | 1 |
| Barnes, RW | 1 |
| Azorin, J | 1 |
| Lesperance, J | 1 |
| Frija, J | 1 |
| Grenier, A | 1 |
| Bourassa, MG | 1 |
| Leont'eva, GV | 1 |
| Nosova, VP | 1 |
| Klauss, V | 1 |
| Mudra, H | 1 |
| Sbarouni, E | 1 |
| Meissner, O | 1 |
| Metz, J | 1 |
| Theisen, K | 1 |
| Sagach, VF | 1 |
| Tkachenko, MN | 1 |
| Karacagil, S | 1 |
| Granbo, A | 1 |
| Almgren, B | 1 |
| Ljungman, C | 1 |
| Bergqvist, D | 1 |
| Giller, CA | 1 |
| Purdy, P | 1 |
| Giller, A | 1 |
| Batjer, HH | 1 |
| Kopitnik, T | 1 |
| Archie, JP | 1 |
| Suryapranata, H | 1 |
| Zijlstra, F | 2 |
| MacLeod, DC | 1 |
| van den Brand, M | 1 |
| de Feyter, PJ | 1 |
| Serruys, PW | 2 |
| Lamm, C | 1 |
| Albertsson, P | 1 |
| Dohnal, M | 1 |
| Tylén, U | 1 |
| Emanuelsson, H | 1 |
| Tartagni, F | 1 |
| Fallani, F | 1 |
| Corbelli, C | 1 |
| Monetti, N | 1 |
| Piovaccari, G | 1 |
| Marzocchi, A | 1 |
| Zannoli, R | 1 |
| Branzi, A | 1 |
| Magnani, B | 1 |
| Heo, J | 1 |
| Iskandrian, AS | 1 |
| van der Voort, PH | 1 |
| van Hagen, E | 1 |
| Hendrix, G | 1 |
| van Gelder, B | 1 |
| Yang, G | 1 |
| Iadecola, C | 1 |
| Kato, M | 1 |
| Nakayama, K | 1 |
| Shinohara, K | 1 |
| Kurokawa, J | 1 |
| Yamagata, T | 1 |
| Matsuura, H | 1 |
| Kajiyama, G | 1 |
| Sensier, YJ | 1 |
| Thrush, AJ | 1 |
| Loftus, I | 1 |
| Evans, DH | 1 |
| London, NJ | 1 |
| Dreier, JP | 1 |
| Petzold, G | 1 |
| Tille, K | 1 |
| Lindauer, U | 1 |
| Arnold, G | 1 |
| Heinemann, U | 1 |
| Einhäupl, KM | 1 |
| Dirnagl, U | 1 |
| Sakuma, T | 1 |
| Otsuka, M | 1 |
| Fujiwara, H | 1 |
| Sumii, K | 1 |
| Imazu, M | 1 |
| Downey, HF | 1 |
| Bashour, FA | 1 |
| Boatwright, RB | 1 |
| Parker, PE | 1 |
| Kechejian, SJ | 1 |
| Myhre, HO | 3 |
| Dedichen, H | 2 |
| Tatineni, S | 1 |
| Deligonul, U | 2 |
| Aguirre, F | 2 |
| Donohue, T | 1 |
| Bach, R | 1 |
| Wilson, RF | 1 |
| Wyche, K | 1 |
| Christensen, BV | 1 |
| Zimmer, S | 1 |
| Laxson, DD | 1 |
| Bolli, R | 1 |
| Triana, JF | 1 |
| Jeroudi, MO | 1 |
| Shustova, NIa | 2 |
| Dik, IG | 1 |
| Nedoshivin, VP | 1 |
| Levtov, VA | 2 |
| Pearson, AC | 1 |
| Labovitz, AJ | 1 |
| Vandormael, M | 1 |
| Gudipati, C | 1 |
| Shuvaeva, VN | 1 |
| Chuĭkin, AE | 1 |
| Hodgson, JM | 1 |
| Williams, DO | 1 |
| Hugenholtz, PG | 1 |
| Padberg, FT | 1 |
| Hobson, RW | 1 |
| Lynch, TG | 1 |
| Lee, BC | 1 |
| Jamil, Z | 1 |
| Saito, D | 1 |
| Hyodo, T | 1 |
| Takeda, K | 1 |
| Abe, Y | 1 |
| Tani, H | 1 |
| Yamada, N | 1 |
| Ueeda, M | 1 |
| Nakatsu, T | 1 |
| Eikens, E | 3 |
| Wilcken, DE | 3 |
| Honda, N | 1 |
| Morikawa, A | 1 |
| Nihei, H | 1 |
| Aizawa, C | 1 |
| Yoshitoshi, Y | 1 |
| Mohrman, DE | 1 |
| Sparks, HV | 1 |
| Tominaga, S | 1 |
| Watanabe, K | 1 |
| Nakamura, T | 1 |
| Winbury, MM | 1 |
| Howe, BB | 1 |
| Hefner, MA | 1 |
| Hardung, V | 1 |
| Laszt, L | 1 |
| Huber, P | 1 |
Clinical Trials (6)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)[NCT02184117] | 763 participants (Actual) | Observational | 2014-07-31 | Completed | |||
| Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities. A Multicentre[NCT04777513] | 450 participants (Anticipated) | Observational [Patient Registry] | 2020-08-06 | Recruiting | |||
| A Prospective, Multi-center Clinical Trial for Evaluating the Effectiveness and Safety of Coronary Angiography-Derived Index of Microcirculatory Resistance Measured Online by a Coronary Functional Measurement System[NCT05009667] | 116 participants (Actual) | Observational | 2021-10-14 | Completed | |||
| Kidney Transplantation and Renal and Myocardial Perfusion[NCT02960802] | 60 participants (Anticipated) | Interventional | 2017-01-01 | Active, not recruiting | |||
| Outcomes in Femoropopliteal Disease Stratified by Translesional Pressure Gradient[NCT02387658] | 25 participants (Actual) | Observational | 2015-02-06 | Completed | |||
| Diagnostic Accuracy in Left Ventricular Systolic Dysfunction for Identifying Coronary Artery Disease With Dobutamine Versus Adenosine Non-invasive Stress Cardiac Magnetic Resonance Evaluation[NCT03661827] | 69 participants (Actual) | Interventional | 2019-02-05 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for papaverine and Hyperemia
| Article | Year |
|---|---|
Pharmacological options for inducing maximal hyperaemia during studies of coronary physiology.
Topics: Adenosine; Adenosine Triphosphate; Animals; Caffeine; Coronary Stenosis; Dobutamine; Fractional Flow | 2008 |
Trials
3 trials available for papaverine and Hyperemia
| Article | Year |
|---|---|
[Behaviour of near-infrared cerebral oximetry readings during percutaneous carotid angioplasty].
Topics: Aged; Angioplasty, Balloon; Blood Pressure; Brain Ischemia; Carotid Artery, Internal; Carotid Stenos | 2006 |
The effects of ionic and nonionic radiographic contrast media on coronary hyperemia in patients during coronary angiography.
Topics: Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Diatrizoate Meglumine; Female; Huma | 1992 |
Effects of adenosine on human coronary arterial circulation.
Topics: Adenosine; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Dose-Response Relationship, | 1990 |
Other Studies
66 other studies available for papaverine and Hyperemia
| Article | Year |
|---|---|
Clinical Efficacy of Intracoronary Papaverine After Nicorandil Administration for Safe and Optimal Fractional Flow Reserve Measurement.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Control Studies; Coronary Angiography; Coronary | 2021 |
Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine.
Topics: Adenosine; Caffeine; Coronary Angiography; Coronary Stenosis; Fractional Flow Reserve, Myocardial; H | 2021 |
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine.
Topics: Aged; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Dose-Response Relationship, Drug; E | 2020 |
Effect of QTU prolongation on hyperemic instantaneous wave-free ratio value: a prospective single-center study.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Blood Flow Velocity; Cardiac Catheterization; Coron | 2020 |
Feasibility of intracoronary nicorandil for inducing hyperemia on fractional flow reserve measurement: Comparison with intracoronary papaverine.
Topics: Coronary Angiography; Coronary Circulation; Coronary Stenosis; Feasibility Studies; Fractional Flow | 2020 |
Duration of Hyperemia With Intracoronary Administration of Papaverine.
Topics: Aged; Coronary Stenosis; Coronary Vessels; Female; Fractional Flow Reserve, Myocardial; Humans; Hype | 2021 |
A Comparison between the Instantaneous Wave-free Ratio and Resting Distal Coronary Artery Pressure/Aortic Pressure and the Fractional Flow Reserve: The Diagnostic Accuracy Can Be Improved by the Use of both Indices.
Topics: Aged; Aorta; Arterial Pressure; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Fe | 2017 |
Fractional flow reserve in below the knee arteries with critical limb ischemia and validation against gold-standard morphologic, functional measures and long term clinical outcomes.
Topics: Aged; Angiography; Angioplasty, Balloon; Blood Pressure; Blood Pressure Determination; Critical Illn | 2018 |
Postocclusional Hyperemia for Fractional Flow Reserve After Percutaneous Coronary Intervention.
Topics: Adenosine Triphosphate; Administration, Intravenous; Aged; Aged, 80 and over; Balloon Occlusion; Car | 2017 |
Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis.
Topics: Adult; Angioplasty, Balloon; Catheterization, Peripheral; Computed Tomography Angiography; Female; H | 2018 |
Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: description and validation of an animal model.
Topics: Animals; Coronary Circulation; Diagnostic Techniques, Cardiovascular; Disease Models, Animal; Hypere | 2014 |
Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis: a comparison with the post-exercise ankle-brachial index.
Topics: Aged; Ankle Brachial Index; Arterial Pressure; Constriction, Pathologic; Exercise Test; Feasibility | 2014 |
Effect of caffeine on intravenous adenosine-induced hyperemia in fractional flow reserve measurement.
Topics: Adenosine; Administration, Oral; Aged; Blood Pressure; Caffeine; Coronary Angiography; Coronary Sten | 2014 |
Assessment of lower limb flow and adequate intra-arterial papaverine doses to achieve maximal hyperemia in elder subjects.
Topics: Aged; Blood Pressure; Female; Heart Rate; Humans; Hyperemia; Injections, Intra-Arterial; Leg; Male; | 2015 |
Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis.
Topics: Aged; Dopamine; Female; Humans; Hyperemia; Kidney; Male; Microcirculation; Middle Aged; Papaverine; | 2015 |
Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease.
Topics: Aged; Cardiology; Coronary Stenosis; Endovascular Procedures; Female; Femoral Artery; Heart Failure; | 2016 |
Is Caffeine Abstention Necessary Before Adenosine-Induced Fractional Flow Reserve Measurement?
Topics: Adenosine; Caffeine; Fractional Flow Reserve, Myocardial; Humans; Hyperemia; Papaverine; Prospective | 2015 |
Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions.
Topics: Adenosine; Aged; Contrast Media; Coronary Angiography; Coronary Artery Disease; Female; Fractional F | 2017 |
Measurement of pulmonary flow reserve in higher primates.
Topics: Adenosine; Animals; Blood Flow Velocity; Female; Heart Rate; Hyperemia; Male; Microcirculation; Micr | 2009 |
Physiological assessment of renal artery stenosis: comparisons of resting with hyperemic renal pressure measurements.
Topics: Aged; Aorta; Arrhythmias, Cardiac; Biomarkers; Blood Pressure; Blood Pressure Determination; Chi-Squ | 2010 |
Can we apply coronary physiologic methods to renal artery stenosis assessment?
Topics: Biomarkers; Blood Pressure; Blood Pressure Determination; Coronary Circulation; Coronary Stenosis; H | 2010 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans.
Topics: Adenosine; Adenosine Triphosphate; Contrast Media; Coronary Angiography; Coronary Circulation; Coron | 2003 |
A MEDICAL APPRAISAL OF THERAPY FOR OCCLUSIVE ARTERIAL DISEASE.
Topics: Arteriosclerosis Obliterans; Blood Flow Velocity; Blood Vessel Prosthesis; Blood Vessel Prosthesis I | 1964 |
Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Coronary Stenosis; Disease Model | 2003 |
Renal fractional flow reserve: a hemodynamic evaluation of moderate renal artery stenoses.
Topics: Aged; Angiography; Cohort Studies; Female; Hemodynamics; Humans; Hyperemia; Linear Models; Male; Mid | 2005 |
Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Blood Flow Velocity; Coronary Angiography; Coronary Stenosi | 2005 |
Assessment of renal flow and flow reserve in humans.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure; Dopamine; Female; Fenoldopam; Heart Rate; Humans; | 2006 |
Intraoperative assessment of aortoiliac stenosis: role of papaverine-induced hyperemia.
Topics: Aortic Valve Stenosis; Arterial Occlusive Diseases; Blood Pressure Determination; Blood Vessel Prost | 1984 |
[Study of the hyperemic reserve of the myocardium with the aid of papaverine].
Topics: Animals; Constriction; Coronary Circulation; Coronary Vessels; Dogs; Hyperemia; Papaverine | 1983 |
[Characteristic features of the functioning of arteriolovenular anastomoses in pharmacological arterial hyperemia].
Topics: Aminophylline; Animals; Arterioles; Arteriovenous Anastomosis; Collateral Circulation; Hyperemia; Ma | 1982 |
Myocardial contrast echocardiography for assessment of papaverine vasodilator response in patients with angiographically normal coronary arteries and in patients after orthotopic heart transplantation.
Topics: Adult; Aged; Contrast Media; Coronary Angiography; Coronary Circulation; Dose-Response Relationship, | 1995 |
[The role of nitric oxide in the development of reactive hyperemia in the coronary bed].
Topics: Acetylcholine; Animals; Arginine; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Hyperemia; | 1994 |
The effect of postocclusion reactive hyperaemia, papaverine and nifedipine on duplex derived haemodynamic parameters of infrainguinal bypass grafts.
Topics: Aged; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Blood Vessel Prosthesis; Female; Graft Occ | 1995 |
Elevated transcranial Doppler ultrasound velocities following therapeutic arterial dilation.
Topics: Adult; Aneurysm, Ruptured; Angioplasty, Balloon; Blood Flow Velocity; Carotid Artery Diseases; Cereb | 1995 |
Analysis and comparison of pressure gradients and ratios for predicting iliac stenosis.
Topics: Arterial Occlusive Diseases; Blood Pressure; Constriction, Pathologic; Femoral Artery; Forecasting; | 1994 |
Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction.
Topics: Angiography, Digital Subtraction; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Cir | 1994 |
Assessment of coronary artery stenosis during PTCA by measurement of the trans-stenotic pressure gradient. Comparison with quantitative coronary angiography.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Coronary Angiography; Coronary Circulation; Co | 1995 |
Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Disease; Feasibility Studies; Heart; Humans; Hyperemi | 1996 |
Comparison of intravenous adenosine to intracoronary papaverine for calculation of pressure-derived fractional flow reserve.
Topics: Adenosine; Adult; Aged; Blood Flow Velocity; Cardiac Catheterization; Coronary Circulation; Female; | 1996 |
Obligatory role of NO in glutamate-dependent hyperemia evoked from cerebellar parallel fibers.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Electric Stimulation; Enzyme Inhibi | 1997 |
Effect of adenosine triphosphate on human coronary circulation.
Topics: Adenosine Triphosphate; Blood Flow Velocity; Cardiac Catheterization; Chest Pain; Coronary Angiograp | 1998 |
A comparison of colour duplex ultrasonography, papaverine testing and common femoral Doppler waveform analysis for assessment of the aortoiliac arteries.
Topics: Aged; Aged, 80 and over; Aortic Diseases; Arterial Occlusive Diseases; Blood Flow Velocity; Female; | 2000 |
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats.
Topics: Animals; Brain; Cortical Spreading Depression; Drug Combinations; Electrophysiology; Enzyme Inhibito | 2001 |
Optimal time for predicting myocardial viability after successful primary angioplasty in acute myocardial infarction: a study using myocardial contrast echocardiography.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Contrast Media; Coronary Circulation; Echoc | 2001 |
Uniformity of transmural perfusion in anesthetized dogs with maximally dilated coronary circulations.
Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Electromagnetic Ph | 1975 |
Reactive hyperemia of the lower limb. Experimental and clinical studies.
Topics: Animals; Blood Pressure; Hindlimb; Humans; Hyperemia; Leg; Oxygen; Papaverine; Rabbits; Regional Blo | 1975 |
Reactive hyperaemia of the human lower limb. A comparison between the effect of tourniquet occlusion, selective arterial occlusion and intra-arterial papaverine injection.
Topics: Femoral Artery; Humans; Hyperemia; Leg; Middle Aged; Occlusive Dressings; Papaverine; Regional Blood | 1975 |
Interpretation of cardiac pathophysiology from pressure waveform analysis: coronary hemodynamics, Part III: Coronary hyperemia.
Topics: Adenosine; Blood Flow Velocity; Cardiac Catheterization; Contrast Media; Coronary Circulation; Coron | 1992 |
Prolonged impairment of coronary vasodilation after reversible ischemia. Evidence for microvascular "stunning".
Topics: Adenosine; Animals; Blood Pressure; Coronary Disease; Coronary Vessels; Dogs; Heart Rate; Hemodynami | 1990 |
[Blood supply of skeletal muscles in reactive hyperemia].
Topics: Animals; Arteries; Blood Volume; Cats; Hyperemia; Muscles; Papaverine | 1989 |
Effects of pharmacologic coronary hyperemia on echocardiographic left ventricular function in patients with single vessel coronary artery disease.
Topics: Angiography; Coronary Circulation; Coronary Disease; Coronary Vessels; Echocardiography; Heart; Hear | 1989 |
[Effect of an increase in the blood flow through the vessels of skeletal muscle on its functional indices and oxygen demand].
Topics: Acetylcholine; Animals; Cats; Hyperemia; Lactates; Muscle Contraction; Muscles; Oxygen; Oxygen Consu | 1988 |
Superiority of intracoronary papaverine to radiographic contrast for measuring coronary flow reserve in patients with ischemic heart disease.
Topics: Blood Flow Velocity; Cardiac Catheterization; Cineradiography; Contrast Media; Coronary Angiography; | 1987 |
Papaverine: the ideal coronary vasodilator for investigating coronary flow reserve? A study of timing, magnitude, reproducibility, and safety of the coronary hyperemic response after intracoronary papaverine.
Topics: Aged; Coronary Circulation; Female; Humans; Hyperemia; Injections, Intra-Arterial; Male; Middle Aged | 1986 |
Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation.
Topics: Aortic Diseases; Arterial Occlusive Diseases; Blood Pressure; Brachial Artery; Femoral Artery; Human | 1985 |
Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion.
Topics: Adenosine; Aminophylline; Animals; Arterial Occlusive Diseases; Cardiac Catheterization; Coronary Ci | 1985 |
Myocardial reactive hyperemia and coronary vascular reactivity in the dog.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Coronary Circu | 1973 |
Proceedings: Reactive hyperaemia in the dog heart: assessment of post-hyperaemic coronary vascular reactivity and of the effects of temporarily restricting arterial inflow.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Dogs; Heart; Hyperemia; Muscle, Smooth; | 1973 |
Reactive hyperaemia in the dog heart: studies on mechanisms.
Topics: Adenosine; Aminophylline; Animals; Blood Pressure; Coronary Circulation; Dipyridamole; Dogs; Heart R | 1974 |
Postocclusive vascular responses in isolated perfused kidney of rabbits.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Carbon Dioxide; Constriction; Dilatation; Hydrogen | 1972 |
Role of potassium ions in the vascular response to a brief tetanus.
Topics: Animals; Capillaries; Dilatation; Dogs; Hyperemia; Mathematics; Models, Biological; Muscle Contracti | 1974 |
Haemodynamic factors in the oedema of arterial reconstructions.
Topics: Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Edema; Foot; Hemodynamics; Humans; Hyperemia; | 1972 |
Properties of exercise and reactive hyperemias in canine hindlimb muscles under constant pressure perfusion.
Topics: Animals; Arteries; Blood Volume; Cats; Dogs; Electric Stimulation; Female; Hindlimb; Hyperemia; Male | 1973 |
Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates.
Topics: Aminophylline; Animals; Aorta; Biophysical Phenomena; Biophysics; Blood Circulation; Blood Flow Velo | 1969 |
[Investigations on the dynamics of carotid circulation by means of impedance determinations].
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carotid Arteries; Dogs; Elasticity; Hemodynamics; | 1971 |
[Clinical and angiographic diagnosis of cerebrovascular diseases].
Topics: Adult; Blood Flow Velocity; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Ce | 1969 |