papaverine has been researched along with Hypercholesterolemia in 12 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of age, atherosclerosis, hypertension, and hypercholesterolemia on vascular function of the coronary circulation were studied by subselective intracoronary infusions of acetylcholine, which releases endothelium-derived relaxing factor, and papaverine, which directly relaxes vascular smooth muscle, in normal patients (n = 18; no risk factors for coronary artery disease), in patients with evidence of early atherosclerosis but normal cholesterol levels and normal blood pressure (n = 12), in patients with hypertension without left ventricular hypertrophy (n = 12), and in patients with hypercholesterolemia (n = 20)." | 3.68 | Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. ( Drexler, H; Just, H; Saurbier, B; Zeiher, AM, 1993) |
| "Papaverine was used to determine coronary vascular reserve." | 1.29 | Effects of hypercholesterolaemia on physiological recruitment of coronary vascular reserve in swine. ( Bergelson, BA; Ruocco, NA; Yu, TK, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kadioglu, A | 1 |
| Oktar, T | 1 |
| Kandirali, E | 1 |
| Kendirci, M | 1 |
| Sanli, O | 1 |
| Ozsoy, C | 1 |
| Egashira, K | 2 |
| Takeshita, A | 2 |
| Dupouy, P | 2 |
| Geschwind, HJ | 2 |
| Pelle, G | 2 |
| Gallot, D | 2 |
| Larrazet, F | 1 |
| el Ghalid, A | 1 |
| Dubois-Randé, JL | 2 |
| Zeiher, AM | 3 |
| Drexler, H | 3 |
| Saurbier, B | 1 |
| Just, H | 2 |
| Inou, T | 1 |
| Hirooka, Y | 1 |
| Yamada, A | 1 |
| Maruoka, Y | 1 |
| Kai, H | 1 |
| Sugimachi, M | 1 |
| Suzuki, S | 1 |
| Bergelson, BA | 1 |
| Yu, TK | 1 |
| Ruocco, NA | 1 |
| Shiode, N | 1 |
| Kato, M | 1 |
| Nakayama, K | 1 |
| Shinohara, K | 1 |
| Kurokawa, J | 1 |
| Yamagata, T | 1 |
| Matsuura, H | 1 |
| Kajiyama, G | 1 |
| Wollschläger, H | 1 |
| Cohen, RA | 1 |
| Zitnay, KM | 1 |
| Haudenschild, CC | 1 |
| Cunningham, LD | 1 |
| McCalden, TA | 1 |
| Nath, RG | 1 |
1 trial available for papaverine and Hypercholesterolemia
| Article | Year |
|---|---|
Beneficial effect of cholesterol-lowering therapy on endothelium-dependent coronary vasodilation in patients with hypercholesterolemia.
Topics: Acetylcholine; Coronary Vessels; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitrates; | 1995 |
11 other studies available for papaverine and Hypercholesterolemia
| Article | Year |
|---|---|
Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction.
Topics: Adult; Aged; Diabetes Complications; Erectile Dysfunction; Humans; Hypercholesterolemia; Impotence, | 2004 |
[Evaluation of coronary vasomotricity by intracoronary ultrasonography].
Topics: Aged; Cold Temperature; Coronary Vessels; Endothelium, Vascular; Female; Humans; Hypercholesterolemi | 1994 |
Assessment of coronary vasomotion by intracoronary ultrasound.
Topics: Aged; Blood Flow Velocity; Case-Control Studies; Cold Temperature; Coronary Artery Disease; Coronary | 1993 |
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
Topics: Acetylcholine; Adult; Age Factors; Arteriosclerosis; Blood Pressure; Cardiac Catheterization; Corona | 1993 |
Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.
Topics: Acetylcholine; Adult; Age Factors; Aged; Analysis of Variance; Arteriosclerosis; Blood Pressure; Cor | 1993 |
Effects of hypercholesterolaemia on physiological recruitment of coronary vascular reserve in swine.
Topics: Animals; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Vessels; Endocardium; Endotheliu | 1996 |
Effect of adenosine triphosphate on human coronary circulation.
Topics: Adenosine Triphosphate; Blood Flow Velocity; Cardiac Catheterization; Chest Pain; Coronary Angiograp | 1998 |
Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia.
Topics: Acetylcholine; Adult; Aged; Coronary Circulation; Coronary Vessels; Endothelins; Endothelium, Vascul | 1991 |
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.
Topics: Acetylcholine; Cold Temperature; Coronary Angiography; Coronary Artery Disease; Coronary Circulation | 1991 |
Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.
Topics: Animals; Calcimycin; Coronary Vessels; Dinoprost; Endothelium, Vascular; Hypercholesterolemia; Nitro | 1988 |
Mechanisms of vascular supersensitivity in hypercholesterolemia.
Topics: Animals; Arteries; Basilar Artery; Biomechanical Phenomena; Blood Vessels; Calcium; Calcium Chloride | 1989 |