papaverine has been researched along with Hypercapnia in 16 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 7.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| " With Ringer solution superfusion, CBF increased with hypercapnia (+134 +/- 7%; PCO2 = 50-60 mmHg) and topical application of 10 microM ACh (+35 +/- 3%), the NO donor S-nitroso-N-acetylpenicillamine (SNAP, 500 microM; +66 +/- 6%), or 1 mM papaverine (+100 +/- 6%; n = 5)." | 3.70 | Superoxide-dependent cerebrovascular effects of homocysteine. ( Iadecola, C; Slungaard, A; Vercellotti, GM; Zhang, F, 1998) |
| "The effect of unilateral, electrical stimulation of the cervical sympathetic chain in rabbits anesthetized with pentobarbital sodium and vasodilated by hypercapnia, acetazolamide, papaverine or PGI2 was investigated to determine to what extent the sympathetic nerves to the brain and the eye cause vasoconstriction and prevent overperfusion in previously vasodilated animals." | 3.66 | Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine. ( Beausang-Linder, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frydrychowski, AF | 1 |
| Gumiński, W | 1 |
| Rojewski, M | 1 |
| Kaczmarek, J | 1 |
| Juzwa, W | 1 |
| Zhang, F | 4 |
| Sprague, SM | 1 |
| Farrokhi, F | 1 |
| Henry, MN | 1 |
| Son, MG | 1 |
| Vollmer, DG | 1 |
| Kidoguchi, K | 1 |
| Tamaki, M | 1 |
| Mizobe, T | 1 |
| Koyama, J | 1 |
| Kondoh, T | 1 |
| Kohmura, E | 1 |
| Sakurai, T | 1 |
| Yokono, K | 1 |
| Umetani, K | 1 |
| Beausang-Linder, M | 1 |
| Iadecola, C | 4 |
| Xu, X | 1 |
| Slungaard, A | 1 |
| Vercellotti, GM | 1 |
| Higashi, K | 1 |
| Katayama, S | 1 |
| Wilson, DA | 1 |
| Traystman, RJ | 1 |
| Rapela, CE | 1 |
| Kazda, S | 1 |
| Wüllenweber, R | 1 |
| Handa, J | 1 |
| Meyer, JS | 1 |
| Yoshida, K | 1 |
| Kaiser, D | 1 |
| Nadjafian, C | 1 |
| Werner, E | 1 |
| Keszler, H | 1 |
| Oppelt, A | 1 |
| Sliz, K | 1 |
| Vyska, K | 1 |
| Mentzel, H | 1 |
16 other studies available for papaverine and Hypercapnia
| Article | Year |
|---|---|
Technical foundations for noninvasive assessment of changes in the width of the subarachnoid space with near-infrared transillumination-backscattering sounding (NIR-TBSS).
Topics: Algorithms; Animals; Cerebrovascular Circulation; Head; Heart Rate; Humans; Hypercapnia; Hypoxia; Li | 2002 |
Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury.
Topics: Animals; Blood Pressure; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Cortical Sprea | 2002 |
In vivo X-ray angiography in the mouse brain using synchrotron radiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Carotid Arteries; Ca | 2006 |
Effects of sympathetic stimulation on cerebral and ocular blood flow. Modification by hypertension, hypercapnia, acetazolamide, PGI2 and papaverine.
Topics: Acetazolamide; Animals; Cerebrovascular Circulation; Electric Stimulation; Epoprostenol; Eye; Female | 1982 |
SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebrovascular Circulation; Cyclic GMP; Hypercapnia; | 1994 |
Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Cerebrovascular Circulation; Dose-Re | 1996 |
Superoxide-dependent cerebrovascular effects of homocysteine.
Topics: Acetylcholine; Animals; Brain; Cerebrovascular Circulation; Homocysteine; Hypercapnia; Male; Nitric | 1998 |
Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?
Topics: Animals; Arginine; Brain; Hypercapnia; Male; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Pa | 1992 |
Effects of hypercapnia and papaverine on cerebrospinal fluid formation and choroid plexus blood flow.
Topics: Animals; Carbon Dioxide; Cerebral Cortex; Cerebrospinal Fluid; Choroid Plexus; Dogs; Hypercapnia; Pa | 1985 |
Transient analysis of the canine cerebrovascular response to carbon dioxide.
Topics: Animals; Arteries; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Hypercapn | 1985 |
Proceedings: The influence of PACO2 on the cerebral and peripheral vasodilatory action of papaverin.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Hemodynamics; Hypercapni | 1974 |
"Intracerebral steal" in man recorded by a heat clearance technique.
Topics: Aminophylline; Animals; Astrocytoma; Blood Pressure; Brain Edema; Brain Injuries; Brain Neoplasms; C | 1968 |
Regional pharmacologic responses of the vertebral and internal carotid arteries.
Topics: Acetylcholine; Animals; Bemegride; Blood Flow Velocity; Carbon Dioxide; Carotid Arteries; Epinephrin | 1966 |
[Effect of Perphyllon A on gas exchange, energy balance and peripheral oxygen supply of the newborn].
Topics: Acidosis; Humans; Hypercapnia; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Oxygen Consumpt | 1969 |
Cerebral circulation and resuscitation.
Topics: Aged; Blood Flow Velocity; Blood Volume Determination; Carotid Arteries; Cerebrovascular Circulation | 1968 |
[Asphyxia neonatorum. II. Treatment with vasodilator and vagolytic agents].
Topics: Acidosis, Respiratory; Asphyxia Neonatorum; Atropine; Blood Circulation; Humans; Hypercapnia; Hypoxi | 1966 |