papaverine has been researched along with Heart Failure in 18 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We clarified the optimal measuring procedure for FFR for SFA lesions and investigated the necessary dose of papaverine for inducing maximal hyperemia in SFA lesions." | 3.83 | Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease. ( Araki, M; Hirano, K; Ishimori, H; Ito, Y; Kobayashi, N; Muramatsu, T; Nakano, M; Sakai, T; Tsukahara, R; Yamawaki, M, 2016) |
| "The authors realized a retrospective clinical-statistical study about 121 cases of acute myocardial infarction (AMI), treated in the Department of general medicine with a pharmacological association of Lysine acetylsalicylate--Erythrityl tetranitrate--Papaverine hydrochloride, with the purpose of obtaining a vasodilatation on coronary arteries and a platelet antiaggregation, in the light of the new etiopathogenetic views about the prolonged coronary spasm and the platelet aggregation, in some cases of myocardial infarction with or without thrombosis." | 3.66 | [Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review]. ( Carile, L; Di Falco, C; Laquaglia, GA; Marchionni, F; Martone, P, 1982) |
| "Milrinone (Win 47203) is a dipyridine related to amrinone, which is about 20-50 times as effective as amrinone when assayed on cardiac contractility." | 1.27 | The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog. ( Farah, A; Kabela, E; Mendez, R; Pastelin, G, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, N | 1 |
| Hirano, K | 1 |
| Nakano, M | 1 |
| Ito, Y | 1 |
| Sakai, T | 1 |
| Ishimori, H | 1 |
| Yamawaki, M | 1 |
| Araki, M | 1 |
| Tsukahara, R | 1 |
| Muramatsu, T | 1 |
| MAZZONE, O | 1 |
| BLASI, A | 1 |
| STRANO, A | 1 |
| KOBAYASHI, T | 1 |
| TAKEUCHI, M | 1 |
| Wimmer, H | 1 |
| Spesshardt, K | 1 |
| Chekman, IS | 1 |
| Kazak, LI | 1 |
| Denisiuk, VI | 1 |
| Pastelin, G | 1 |
| Mendez, R | 1 |
| Kabela, E | 1 |
| Farah, A | 1 |
| Carile, L | 1 |
| Laquaglia, GA | 1 |
| Martone, P | 1 |
| Marchionni, F | 1 |
| Di Falco, C | 1 |
| Leshchinskiĭ, LA | 1 |
| Pimenov, LT | 1 |
| Trusov, VV | 1 |
| Grassi, G | 1 |
| Giannattasio, C | 1 |
| Failla, M | 1 |
| Pesenti, A | 1 |
| Peretti, G | 1 |
| Marinoni, E | 1 |
| Fraschini, N | 1 |
| Vailati, S | 1 |
| Mancia, G | 1 |
| Lindsay, DC | 1 |
| Holdright, DR | 1 |
| Clarke, D | 1 |
| Anand, IS | 1 |
| Poole-Wilson, PA | 1 |
| Collins, P | 1 |
| Suehiro, K | 1 |
| Shimizu, J | 1 |
| Yi, GH | 1 |
| Gu, A | 1 |
| Wang, J | 1 |
| Keren, G | 1 |
| Burkhoff, D | 1 |
| McNamara, RF | 1 |
| Schmid, PG | 2 |
| Schmidt, JA | 1 |
| Lund, DD | 1 |
| Bhatnagar, RK | 1 |
| Mayer, HE | 1 |
| Mark, AL | 1 |
| Heistad, DD | 1 |
| Abboud, FM | 1 |
| Witty, RT | 1 |
| Davis, JO | 1 |
| Shade, RE | 1 |
| Johnson, JA | 1 |
| Prewitt, RL | 1 |
| Giertz, H | 1 |
| Hahn, F | 1 |
| Rowe, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for papaverine and Heart Failure
| Article | Year |
|---|---|
[Mechanisms of the therapeutic action of vasodilator agents in cardiac insufficiency (review of the literature)].
Topics: Adrenergic alpha-Antagonists; Animals; Coronary Disease; Dogs; Heart Failure; Humans; Muscle Relaxan | 1981 |
Responses of the coronary circulation to physiologic changes and pharmacologic agents.
Topics: Angina Pectoris; Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Epin | 1974 |
16 other studies available for papaverine and Heart Failure
| Article | Year |
|---|---|
Measuring Procedure and Maximal Hyperemia in the Assessment of Fractional Flow Reserve for Superficial Femoral Artery Disease.
Topics: Aged; Cardiology; Coronary Stenosis; Endovascular Procedures; Female; Femoral Artery; Heart Failure; | 2016 |
[Research on the capillaroscopic picture in subjects with manifestations of cardio-respiratory insufficiency. Action of papaverine].
Topics: Capillaries; Cardiovascular System; Heart Failure; Humans; Microscopic Angioscopy; Papaverine; Respi | 1963 |
[THE THERAPEUTIC PRESCRIPTION IN CIRCULATORY INSUFFICIENCY].
Topics: Cardiac Glycosides; Central Nervous System Stimulants; Diet; Diet Therapy; Diuretics; Heart Failure; | 1963 |
[REHABILITATION IN HEART DISEASE].
Topics: Acenocoumarol; Dipyridamole; Electrocardiography; Geriatrics; Heart Defects, Congenital; Heart Disea | 1963 |
[The treatment of heart diseases from various causes with the combination preparation Spasmo-Guttacor].
Topics: Coronary Disease; Heart Failure; Humans; Papaverine; Phenobarbital; Plants, Medicinal; Quinidine | 1966 |
[Effect of antibradykinin preparations and nicotinic acid on the microcirculation and blood oxygen balance of ischemic heart disease patients in the initial stage of heart failure].
Topics: Adult; Aged; Bradykinin; Chromonar; Coronary Disease; Diphenhydramine; Dipyrone; Drug Therapy, Combi | 1983 |
The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.
Topics: Animals; Cardiotonic Agents; Dinitrophenols; Dogs; Heart; Heart Failure; Milrinone; Nifedipine; Papa | 1983 |
[Clinical and statistical study of 121 cases of acute myocardial infarct from 1976 to 1981 (month of April). Critical review].
Topics: Adult; Aged; Aspirin; Coronary Vessels; Erythrityl Tetranitrate; Female; Heart Failure; Humans; Lysi | 1982 |
[Changes in renal hemodynamics and renal function in patients with cardiac insufficiency treated with vasodilators].
Topics: Bencyclane; Dipyridamole; Heart Failure; Humans; Kidney; Papaverine; Renal Circulation; Vasodilator | 1981 |
Sympathetic modulation of radial artery compliance in congestive heart failure.
Topics: Adult; Blood Pressure; Compliance; Heart Failure; Humans; Hypertension; Papaverine; Phenylephrine; R | 1995 |
Endothelial control of lower limb blood flow in chronic heart failure.
Topics: Acetylcholine; Female; Heart Failure; Humans; Leg; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide | 1996 |
Selective renal vasodilation and active renal artery perfusion improve renal function in dogs with acute heart failure.
Topics: Acute Disease; Animals; Diuretics; Dogs; Drug Synergism; Furosemide; Heart Failure; Injections; Kidn | 2001 |
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Fai | 1979 |
Differences in the regulation of vascular resistance in guinea pigs with right and left heart failure.
Topics: Angiotensin II; Animals; Aorta; Arterial Occlusive Diseases; Blood Gas Analysis; Cardiomegaly; Elect | 1977 |
Mechanisms regulating renin release in dogs with thoracic caval constriction.
Topics: Angiotensin II; Animals; Ascites; Blood Pressure; Constriction; Creatinine; Disease Models, Animal; | 1972 |
[On the effect of mepyramine and papaverine on guinea pig anaphylactic shock, with special attention to protracted shock].
Topics: Anaphylaxis; Animals; Guinea Pigs; Heart; Heart Failure; Histamine H1 Antagonists; Lung; Ovalbumin; | 1967 |